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  • Hindawi Limited  (164)
  • 1
    Online Resource
    Online Resource
    Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
    Hindawi Limited ; 2016
    In:  BioMed Research International Vol. 2016 ( 2016), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-7
    Abstract: Backgrounds . Heme oxygenase-1 (HO-1) has been reported to play a regulatory role in osteoclastogenesis. Bone morphogenetic protein (BMP) pathways induce osteoblastic differentiation and bone remodeling. Aims . To identify serum levels of HO-1, BMP-7, and Runt related-transcription factor 2 (Runx2) in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and to investigate the relationships between HO-1, BMP-7, Runx2, and other common biomarkers for bone metabolism. Results . Serum levels of HO-1 and BMP-7 were revealed to be significantly higher in patients with RA or AS than in healthy controls ( p 〈 0.0 1 ). In RA group, HO-1 was positively correlated with BMP-7, Runx2, and tartrate-resistant acid phosphatase-5b (TRAP-5b) ( p 〈 0.05 , resp.), BMP-7 was positively correlated with Runx2 and TRAP-5b ( p 〈 0.05 , resp.), and Runx2 was negatively correlated with N-terminal midfragment of osteocalcin (NMID) ( p 〈 0.05 ). In AS group, we observed identical correlation between HO-1 and BMP-7, but opposite correlations between BMP-7 and TRAP-5b and between Runx2 and NMID, when comparing with the RA cohort. Conclusion . Our findings suggest that HO-1 and BMP-7 are potential biomarkers for bone metabolism in patients with RA and AS. The different correlations between the bone markers point to distinct differences in bone remodeling pathways in the two types of arthritis.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2016/7870925
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2698540-8
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  • 2
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    Acupotomy Contributes to Suppressing Subchondral Bone Resorption in KOA Rabbits by Regulating the OPG/RANKL Signaling Pathway
    Hindawi Limited ; 2021
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2021 ( 2021-04-26), p. 1-17
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2021 ( 2021-04-26), p. 1-17
    Abstract: Subchondral bone lesions, as the crucial inducement for accelerating cartilage degeneration, have been considered as the initiating factor and the potential therapeutic target of knee osteoarthritis (KOA). Acupotomy, the biomechanical therapy guided by traditional Chinese meridians theory, alleviates cartilage deterioration by correcting abnormal mechanics. Whether this mechanical effect of acupotomy inhibits KOA subchondral bone lesions is indistinct. This study aimed to investigate the effects of acupotomy on inhibiting subchondral bone resorption and to define the possible mechanism in immobilization-induced KOA rabbits. After KOA modeling, 8 groups of rabbits (4w/6w acupotomy, 4w/6w electroacupuncture, 4w/6w model, and 4w/6w control groups) received the indicated intervention for 3 weeks. Histological and bone histomorphometry analyses revealed that acupotomy prevented both cartilage surface erosion and subchondral bone loss. Further, acupotomy suppressed osteoclast activity and enhanced osteoblast activity in KOA subchondral bone, showing a significantly decreased expression of tartrate-resistant acid phosphatase (TRAP), matrix metalloproteinases-9 (MMP-9), and cathepsin K (Ctsk) and a significantly increased expression of osteocalcin (OCN); this regulation may be mediated by blocking the decrease in osteoprotegerin (OPG) and the increase in NF- κ B receptor activated protein ligand (RANKL). These findings indicated that acupotomy inhibited osteoclast activity and promoted osteoblast activity to ameliorate hyperactive subchondral bone resorption and cartilage degeneration in immobilization-induced KOA rabbits, which may be mediated by the OPG/RANKL signaling pathway. Taken together, our results indicate that acupotomy may have therapeutic potential in KOA by restoring the balance between bone formation and bone resorption to attenuate subchondral bone lesions.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2021/8168657
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2148302-4
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  • 3
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    A novel mutation impairing the tertiary structure and stability of γC-crystallin (CRYGC) leads to cataract formation in humans and zebrafish lens
    Hindawi Limited ; 2012
    In:  Human Mutation Vol. 33, No. 2 ( 2012-02), p. 391-401
    Details
    In: Human Mutation, Hindawi Limited, Vol. 33, No. 2 ( 2012-02), p. 391-401
    Type of Medium: Online Resource
    ISSN: 1059-7794
    URL: Article
    DOI: 10.1002/humu.21648
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 1498165-8
    SSG: 12
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  • 4
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    Extended Ultimate-Pit-Limit Methodology for Optimizing Surface-to-Underground Mining Transition in Metal Mines
    Hindawi Limited ; 2022
    In:  Advances in Civil Engineering Vol. 2022 ( 2022-1-13), p. 1-9
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2022 ( 2022-1-13), p. 1-9
    Abstract: The transition from surface mining to underground is a critical issue for metal mines. The commonly cited procedure cored by ultimate-pit-limit (UPL) methodology is restricted to maximize the profit from both surface and underground mining, due to the absence of the integration of the profit from either of them. Under the target for such maximization, this study proposes a new optimization approach, which directly relates the design of open-pit limit and underground stopes, by equalizing the marginal profit from either surface or underground mining. The variation of the crown pillar size is involved in this approach. The proposed approach is applied to the Dagushan iron mine, and results show the total profit increased from 3.79 billion CNYs (original design by conventional UPL methodology) to 4.17 billion CNYs (optimal design by the proposed approach), by 9.91%. Moreover, the marginal profit from surface and underground mining, as well as total profit, of all possible designs of surface-to-underground mining transition in Dagushan iron mine is calculated to validate the proposed approach. When the marginal profits satisfy the criterion of the proposed approach, the maximum value of the total profit appears, and this demonstrates the proposed approach is robust to maximize the total profit in surface-to-underground mining transition. This work contributes to existing literature studies primarily from practical aspect, by providing a unified approach to optimize the transition from surface to underground mining.
    Type of Medium: Online Resource
    ISSN: 1687-8094 , 1687-8086
    URL: Article
    DOI: 10.1155/2022/2753991
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2449760-5
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  • 5
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    Online Resource
    A New Radar Echo Generation Model for Ultra-Low Altitude Targets in Far-Field Conditions
    Hindawi Limited ; 2022
    In:  International Journal of Antennas and Propagation Vol. 2022 ( 2022-10-6), p. 1-11
    Details
    In: International Journal of Antennas and Propagation, Hindawi Limited, Vol. 2022 ( 2022-10-6), p. 1-11
    Abstract: This paper proposed a new radar echo simulation method for ultra-low altitude targets in far-field conditions. Based on the electromagnetic (EM) scattering calculation of target and environment, combined with the weighted four-path model, the scattering data of target, environment, and multipath are obtained. The Range-Doppler ring partitioning method is used to determine the size of the minimum resolution units, and then the environment is divided into several scattering elements. By using the method of temporal decomposition, the wide-time pulse is decomposed into a plurality of narrow pulse signals, and the narrow pulses act on scattering elements with different distances and orientations in space. The total echo is obtained by a linear superposition of the responses of each scattering unit. In addition, the numerical results with different parameters, including signal bandwidths, target types, and target height, are simulated and analysed. The simulation results demonstrate that the proposed method can provide a better description of the scattering characteristics of sea-skimming targets in complex scenes in far-field conditions. Meanwhile, it can be applied to the detection and recognition of ultra-low altitude targets above the sea surface.
    Type of Medium: Online Resource
    ISSN: 1687-5877 , 1687-5869
    URL: Article
    DOI: 10.1155/2022/5145743
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2397585-4
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  • 6
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    The emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus with additional 120aa deletion in Nsp2 region in Jiangxi, China
    Hindawi Limited ; 2018
    In:  Transboundary and Emerging Diseases Vol. 65, No. 6 ( 2018-12), p. 1740-1748
    Details
    In: Transboundary and Emerging Diseases, Hindawi Limited, Vol. 65, No. 6 ( 2018-12), p. 1740-1748
    Type of Medium: Online Resource
    ISSN: 1865-1674
    URL: Issue
    URL: Article
    DOI: 10.1111/tbed.2018.65.issue-6
    DOI: 10.1111/tbed.12947
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2414822-2
    SSG: 22
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  • 7
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    Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-10-28), p. 1-21
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-10-28), p. 1-21
    Abstract: Abnormal vascular smooth muscle cell (VSMC) proliferation has an important role in the pathogenesis of both atherosclerosis restenosis and hypertension. Vascular endothelial growth factor (VEGF) has been shown to stimulate VSMC proliferation. In addition, angiogenesis is one of the hallmarks of cancerous growth. VEGF is the key modulator for the initial stages of angiogenesis that acts through the endothelial-specific receptor tyrosine kinases (VEGFRs). VEGFR-2 blockage is a good approach for suppression of angiogenesis. In order to discover novel VEGFR-2 TK inhibitors, we have designed and synthesized three new series of pyridine-containing compounds. The new compounds were all screened against a panel of three cell lines (HepG-2, HCT-116, and MCF-7). Promising results encouraged us to additionally evaluate the most active members for their in vitro VEGFR-2 inhibitory effect. Compound 7a, which is the most potent candidate, revealed a significant increase in caspase-3 level by 7.80-fold when compared to the control. In addition, Bax and Bcl-2 concentration levels showed an increase in the proapoptotic protein Bax (261.4 Pg/ml) and a decrease of the antiapoptotic protein Bcl-2 (1.25 Pg/ml) compared to the untreated cells. Furthermore, compound 7a arrested the cell cycle in the G2/M phase with induction of apoptosis. The immunomodulatory effect of compound 7a, the most active member, showed a reduction in TNF-α by 87%. Also, compound 7a caused a potent inhibitory effect on smooth muscle proliferation. Docking studies were also performed to get better insights into the possible binding mode of the target compounds with VEGFR-2 active sites.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/8321400
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
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  • 8
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    Helicid Reverses the Effect of Overexpressing NCALD, Which Blocks the sGC/cGMP/PKG Signaling Pathway in the CUMS-Induced Rat Model
    Hindawi Limited ; 2021
    In:  Journal of Healthcare Engineering Vol. 2021 ( 2021-12-11), p. 1-12
    Details
    In: Journal of Healthcare Engineering, Hindawi Limited, Vol. 2021 ( 2021-12-11), p. 1-12
    Abstract: Background. Increasing evidence has shown that apoptosis in the hippocampus is closely related to depressive-like behavior. We previously reported that helicid had good antidepressant activities, which manifested as the alleviation of depression-like behaviors and the reversal of the high expression of neurocalcin delta (NCALD) in chronic unpredictable mild stress (CUMS) rats. The aim of this study was, therefore, to characterize the antidepressant-like effects and underlying mechanism of helicid on CUMS rats by silencing NCALD and using rescue experiments. Methods. We developed the CUMS rat model using CUMS stimulation from week 0 to week 6. The rats were treated with helicid, or NCALD silenced, then we overexpressed NCALD using adeno-associated virus. We also measured the protein levels of sGCα1, sGCβ1, PKG1/2, and cleaved caspase-3 in hippocampal tissues using western blotting and measured cGMP using an ELISA. Results. Treating CUMS rats by silencing NCALD or by the administration of helicid improved the depressive-like behavior. The levels of proteins, including sGC, PKG, cleaved caspase-3, and cGMP, in hippocampus all decreased. NCALD overexpression reversed these decreases and reversed the alleviation of depression-like behaviors in CUMS rats. Limitation. We only detected the antidepressant effects of helicid in the hippocampus; therefore, other parts of brain should also be studied. Conclusions. Inhibition of NCALD, as well as helicid administration, alleviated antidepressant-like behavior by regulating the expressions of apoptotic cytokines and the sGC/cGMP/PKG signaling pathway. Overexpressing NCALD reversed the amelioration effects of silenced NCALD and helicid administration.
    Type of Medium: Online Resource
    ISSN: 2040-2309 , 2040-2295
    URL: Article
    DOI: 10.1155/2021/7168397
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2545054-2
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  • 9
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    Kalman Filter-Based Multitype Measurement Data Fusion for Stress Intensity Factor Evaluation in Marine Structures
    Hindawi Limited ; 2023
    In:  Structural Control and Health Monitoring Vol. 2023 ( 2023-2-9), p. 1-16
    Details
    In: Structural Control and Health Monitoring, Hindawi Limited, Vol. 2023 ( 2023-2-9), p. 1-16
    Abstract: Fracture is the main form of marine structural failure due to the action of waves and oceans. It is necessary to monitor the initiation and extension of cracks in a timely and accurate manner, and the stress intensity factor (SIF) is an important indicator for analysing the propagation of cracks. Based on existing research, this paper combines the calculation method of the SIF based on a single strain gauge (SSG) and maximum crack opening displacement (CMOD) and proposes a method based on the Kalman filter (KF). Numerical simulation and experimental verifications of this method have been carried out. The results show that the method can be used for a variety of configurations of precracked specimens. The KF-based method obtains more accurate results than the SSG-based and CMOD-based methods, and the relative error (RE) is not greater than 1.2%.
    Type of Medium: Online Resource
    ISSN: 1545-2263 , 1545-2255
    URL: Article
    DOI: 10.1155/2023/2743309
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2146618-X
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  • 10
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    Practical Application of Artificial Intelligence Technology in Glaucoma Diagnosis
    Hindawi Limited ; 2022
    In:  Journal of Ophthalmology Vol. 2022 ( 2022-7-31), p. 1-12
    Details
    In: Journal of Ophthalmology, Hindawi Limited, Vol. 2022 ( 2022-7-31), p. 1-12
    Abstract: Purpose. By comparing the performance of different models between artificial intelligence (AI) and doctors, we aim to evaluate and identify the optimal model for future usage of AI. Methods. A total of 500 fundus images of glaucoma and 500 fundus images of normal eyes were collected and randomly divided into five groups, with each group corresponding to one round. The AI system provided diagnostic suggestions for each image. Four doctors provided diagnoses without the assistance of the AI in the first round and with the assistance of the AI in the second and third rounds. In the fourth round, doctor B and doctor D made diagnoses with the help of the AI and the other two doctors without the help of the AI. In the last round, doctor A and doctor B made diagnoses with the help of AI and the other two doctors without the help of the AI. Results. Doctor A, doctor B, and doctor D had a higher accuracy in the diagnosis of glaucoma with the assistance of AI in the second ( p = 0.036 , p = 0.003 , and p ≤ 0.000 ) and the third round ( p = 0.021 , p ≤ 0.000 , and p ≤ 0.000 ) than in the first round. The accuracy of at least one doctor was higher than that of AI in the second and third rounds, in spite of no detectable significance ( p = 0.283 , p = 0.727 , p = 0.344 , and p = 0.508 ). The four doctors’ overall accuracy ( p = 0.004 and p ≤ 0.000 ) and sensitivity ( p = 0.006 and p ≤ 0.000 ) as a whole were significantly improved in the second and third rounds. Conclusions. This “Doctor + AI” model can clarify the role of doctors and AI in medical responsibility and ensure the safety of patients, and importantly, this model shows great potential and application prospects.
    Type of Medium: Online Resource
    ISSN: 2090-0058 , 2090-004X
    URL: Article
    DOI: 10.1155/2022/5212128
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2546525-9
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