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  • 1
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    Online Resource
    Efficacy and Safety of Single-Session Radiofrequency Ablation in Treating Benign Thyroid Nodules: A Short-Term Prospective Cohort Study
    Hindawi Limited ; 2021
    In:  International Journal of Endocrinology Vol. 2021 ( 2021-9-11), p. 1-7
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2021 ( 2021-9-11), p. 1-7
    Abstract: Objective. The aims of this study are to evaluate the safety and efficacy of RFA in the treatment of benign thyroid nodule(s) and to find independent factors related to the volume reduction rate of the nodule(s). Materials and Methods. This short-term prospective study from a single medical center was conducted on 93 benign thyroid nodules in 93 patients treated with RFA. Two basic techniques were used: the trans-isthmic approach and moving-shot technique. Clinical and ultrasonography examinations were performed at 1- and 3-month follow-up after the treatment session. Primary outcomes included volume reduction ratio (VRR) at 1-month and 3-month follow-ups; secondary outcomes were therapeutic success rate and complications. Multiple linear regression analysis was used to determine independent factors associated with VRR. Results. A final sample of 78 patients with 78 nodules, given participant rate 83.8% (including 60 solid nodules, 16 predominantly cystic nodules, and 2 thyroid cysts), was followed up for 3 months. The mean volume reduction ratio was 41.47% and 64.72% after 1-month and 3-month follow-ups, respectively. The therapeutic success rate was 30.8% at 1-month and 84.6% at 3-month follow-ups. Symptom score and cosmetic score improved significantly. There was no change in thyroid function tests. Two minor complications (transient voice change) were found. The multiple linear regression analysis showed that the internal component of the nodules significantly related to the VRR during the 3-month follow-up (β = 23.00; 95%CI (7.59–38.45)). Conclusion. RFA was demonstrated as a safe and effective option for benign thyroid nodules treatment. It can be used as an alternative treatment with encouraging results.
    Type of Medium: Online Resource
    ISSN: 1687-8345 , 1687-8337
    URL: Article
    DOI: 10.1155/2021/7556393
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2502951-4
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  • 2
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    Silver and Gold Nanoparticles from Limnophila rugosa Leaves: Biosynthesis, Characterization, and Catalytic Activity in Reduction of Nitrophenols
    Hindawi Limited ; 2021
    In:  Journal of Nanomaterials Vol. 2021 ( 2021-5-20), p. 1-11
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2021 ( 2021-5-20), p. 1-11
    Abstract: This study describes a simple green method for the synthesis of Limnophila rugosa leaf-extract-capped silver and gold nanoparticles without using any expensive toxic reductant or stabilizer. The noble metal nanoparticles were characterized by Fourier transform infrared (FTIR) microscopy, powder X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray analysis (EDX), high-resolution transmission electron microscopy (HR-TEM), selected area electron diffraction (SAED), and dynamic light scattering (DLS) method. It has been found that the biosynthesized silver and gold nanoparticles are nearly spherical in shape with a mean particle size distribution of 87.5 nm and 122.8 nm, respectively. XRD and SAED patterns confirmed the crystalline nanostructure of the metal nanoparticles. FTIR spectra revealed the functional groups of biomolecules presented in the extract possibly responsible for reducing metallic ions and stabilizing formed nanoparticles. The biosynthesized metal nanoparticles have potential application in catalysis. Compared to previous reports, Limnophila rugosa leaf-extract-capped silver and gold nanoparticles exhibited a good catalytic activity in the reduction of several derivatives of nitrophenols including 1,4-dinitrobenzene, 2-nitrophenol, 3-nitrophenol, and 4-nitrophenol.
    Type of Medium: Online Resource
    ISSN: 1687-4129 , 1687-4110
    URL: Article
    DOI: 10.1155/2021/5571663
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2229480-6
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  • 3
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    Preparation and Characterization of Polyamidoamine G2.0-Hematin as a Biocatalyst for Fabricating Catecholic Gelatin Hydrogel
    Hindawi Limited ; 2021
    In:  International Journal of Polymer Science Vol. 2021 ( 2021-3-30), p. 1-13
    Details
    In: International Journal of Polymer Science, Hindawi Limited, Vol. 2021 ( 2021-3-30), p. 1-13
    Abstract: In this study, we report that an enzyme-mimicking biocatalyst polyamidoamine (PAMAM) dendrimer G2.0-hematin (G2.0-He) was fabricated successfully. The chemical structure of G2.0-He was verified by 1H NMR and FT-IR spectroscopy. G2.0-He exhibited a size distribution from 11.6 ± 1.7   nm to 12.5 ± 2.9   nm and a zeta potential from 32.5 mV to 25.6 mV along with the enhancement of the hematin conjugation degree. The relative activity of G2.0-He was evaluated based on pyrogallol oxidation reactions at pH = 7 . The results showed that G2.0-He was more stable than horseradish peroxidase (HRP) enzyme in high H2O2 concentrations. The HRP-mimic ability of G2.0-He was also confirmed by the catalyzation when preparing catecholic gelatin hydrogels under mild conditions. Moreover, our results also revealed that these hydrogels performed with excellent cytocompatibility in an in vitro study and could be used as a potential scaffold for adhesion and proliferation of fibroblast cells. The obtained results indicated that G2.0-He is a suitable platform for altering the HRP enzyme in several biomedical applications.
    Type of Medium: Online Resource
    ISSN: 1687-9430 , 1687-9422
    URL: Article
    DOI: 10.1155/2021/5563229
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2520688-6
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  • 4
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    Folate-Conjugated Chitosan-Pluronic P123 Nanogels: Synthesis and Characterizations towards Dual Drug Delivery
    Hindawi Limited ; 2019
    In:  Journal of Nanomaterials Vol. 2019 ( 2019-12-21), p. 1-14
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2019 ( 2019-12-21), p. 1-14
    Abstract: In this study, a self-assembled nanogel-based pluronic P123-grafted chitosan-folate (CP-FA) was fabricated as a paclitaxel/curcumin codelivery system. 1 H-NMR and TGA proved that the fabricating method of CP-FA was successful. Dynamic light scattering (DLS), zeta potentials, and transmission electron microscopy (TEM) exposed that CP-FA nanoparticles had a uniform size with a diameter of around 16.27 ± 2.01 nm in the colloidal solution and had better sustainable stability at a lower concentration than P123 due to the moderate positive potential value ( 39.43 ± 3.45 mV) and the lower critical micelle concentration (0.036 mg/ml). Dual drugs were loaded with CP-FA nanogels via self-assembly by the hydrophobic interaction between both hydrophobic therapeutic compounds (PTX and Cur) and the hydrophobic segment of the P123 copolymer. The high hydrophobicity of the segment induced a great loading efficacy of up to 98.63 ± 0.42 of PTX and 97.82 ± 0.48 of Cur. In addition, the CP-FA nanogels exposed superior effects in a controlled release of these encapsulated therapeutic compounds for a long period of time. The anticancer activity of the dual-drug delivery system was evaluated using human breast cancer cell lines (MCF-7) via the IC50 value to compare with the PTX-loading CP-FA nanogel. The obtained results suggested that CP-FA/PTX-Cur displayed a remarkable improvement in anticancer activity at an IC50 value of 5.74 ± 0.23 nM which was higher than that of CP-FA/PTX ( IC 50 = 8.20 ± 1.41 nM) due to the synergistic effect of both PTX and Cur. Thereby, a dual-drug delivery-system-based CP-FA of PTX and Cur has been proposed as a promising candidate in cancer therapy.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2019/1067821
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
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  • 5
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    Effects of Dietary Inclusion of Canthaxanthin- and α-Tocopherol-Loaded Liposomes on Growth and Muscle Pigmentation of Rainbow Trout (Oncorhynchus mykiss)
    Hindawi Limited ; 2021
    In:  Journal of Food Quality Vol. 2021 ( 2021-2-26), p. 1-11
    Details
    In: Journal of Food Quality, Hindawi Limited, Vol. 2021 ( 2021-2-26), p. 1-11
    Abstract: Dietary inclusion of canthaxanthin, a common carotenoid pigment, has been long practiced in aquaculture to give the favorable flesh color in farmed salmonids. However, carotenoids are associated with limited solubility and poor physicochemical stability, and their dose in fish feed is widely regulated. In this study, we included canthaxanthin- and α-tocopherol-loaded liposomes into fish diets and evaluated the effects of supplemented fish feed on fish growth, color, nutrition, and canthaxanthin deposition in fillets of cultured rainbow trout (Oncorhynchus mykiss). The liposomes were fabricated using lecithin as phospholipids with the initial concentrations (IC = mcanthaxanthin/mlipids, % wt/wt) of canthaxanthin at 0.1%, 0.5%, and 1.0%. Particle size characterization showed that liposome mean sizes were 109.70 ± 6.36, 105.10 ± 8.41, and 109.20 ± 5.66 nm (mean ± SD; n = 3), respectively, corresponding with liposomes synthesized at canthaxanthin IC = 0.1%, IC = 0.5%, and IC = 1%. The polydispersity index (PDI) of all samples remained lower than 0.2. There were no significant differences in the mean size and PDI between blank lecithin liposome and canthaxanthin- and α-tocopherol-loaded liposomes. The encapsulation efficiency of canthaxanthin- and α-tocopherol-loaded liposomes decreased when increasing the concentration of canthaxanthin in lecithin liposomes, with EE% values of IC = 0.1%, IC = 0.5%, and IC = 1% being 85.3 ± 2.1, 72.9 ± 1.8, and 55.3 ± 2.6, respectively. For fish growth, at the end of the experiment, final weight was significantly higher in fish fed with diet supplemented with 1 g/kg canthaxanthin- and α-tocopherol-loaded liposomes (IC = 0.5%) in comparison to other experimental control groups. The difference in color of the salmon muscle was most apparent after two months of feeding. However, after three months, there was no noticeable change in the color score of the fish muscle, indicating saturation of color of the fish muscle. The above results suggest the potential of canthaxanthin- and a-tocopherol-loaded liposomes as the red pigment in fish aquaculture.
    Type of Medium: Online Resource
    ISSN: 1745-4557 , 0146-9428
    URL: Article
    DOI: 10.1155/2021/6653086
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2175284-9
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  • 6
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    Serum and Urine Neutrophil Gelatinase-Associated Lipocalin Levels Measured at Admission Predict Progression to Chronic Kidney Disease in Sepsis-Associated Acute Kidney Injury Patients
    Hindawi Limited ; 2020
    In:  Disease Markers Vol. 2020 ( 2020-08-18), p. 1-8
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2020 ( 2020-08-18), p. 1-8
    Abstract: Background . To evaluate the ratio of acute kidney injury (AKI) to chronic kidney disease (CKD) in sepsis-associated acute kidney injury (SA-AKI) patients of the intensive care unit (ICU) and predictive value of neutrophil gelatinase-associated lipocalin (NGAL) measured at the admission time in the progression of AKI to CKD. Methods . A study of 121 consecutive adult patients admitted to the intensive care unit (ICU) diagnosed as SA-AKI. AKI and CKD were defined based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Glomerular filtration rate (GFR) was calculated by the CKD-EPI formula. Serum and urine NGAL was measured using the BioVendor Human Lipocalin-2/NGAL ELISA with a blood sample taken at hospital admission time. Results . The ratio of AKI to CKD in SA-AKI patients was 22.3%. Mean concentration of serum and urine NGAL in AKI to the CKD group was 790.99 ng/ml and 885.72 ng/ml, higher significantly than those of recovery patients (351.86 ng/ml and 264.68 ng/ml), p 〈 0.001 . eGFR, both serum and urine NGAL had a predictive value for AKI to CKD (eGFR: AUC = 0.857 , Se = 74.1 % , Spe = 92.6 % , p 〈 0.001 . Serum NGAL: AUC = 0.868 , Se = 77.8 % , Spe = 91.5 % . Urine NGAL: AUC = 0.869 , Se = 77.8 % , Spe = 92.6 % , p 〈 0.001 . Conclusion . Serum and urine NGAL, measuring at hospital admission time, were good prognostic biomarkers of AKI to CKD in SA-AKI patients.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2020/8883404
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2033253-1
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  • 7
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    Electrochemical Determination of Triclosan Using ZIF-11/Activated Carbon Derived from the Rice Husk Modified Electrode
    Hindawi Limited ; 2021
    In:  Journal of Nanomaterials Vol. 2021 ( 2021-10-1), p. 1-14
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2021 ( 2021-10-1), p. 1-14
    Abstract: In the present paper, the composite of zeolite imidazolate framework-11 (ZIF-11) and activated carbon derived from rice husks (RHAC) was synthesized. The obtained materials were characterized by XRD, SEM, EDX-mapping, and nitrogen adsorption/desorption isotherms. The final composite ZIF-11/RHAC exhibits an even dispersion of ZIF-11 particles on activated carbon matrix. Herein, an electrochemical sensor based on a ZIF-11/RHAC was developed for a rapid determination of triclosan (TCS). It was found that the oxidation of TCS is irreversible and involves the transfer of one electron. The linear range for TCS detection in the optimized experimental conditions was found to be 0.1-8 μM with the limit of detection of 0.076 μM. Finally, the proposed method was successfully employed to detect TCS in different personal care product samples with high accuracy, which was confirmed by a good agreement between these results and those obtained using high-performance liquid chromatography (HPLC).
    Type of Medium: Online Resource
    ISSN: 1687-4129 , 1687-4110
    URL: Article
    DOI: 10.1155/2021/8486962
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2229480-6
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  • 8
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    Simultaneous Determination of Zn(II), Cd(II), Pb(II), and Cu(II) Using Differential Pulse Anodic Stripping Voltammetry at a Bismuth Film-Modified Electrode
    Hindawi Limited ; 2019
    In:  Advances in Materials Science and Engineering Vol. 2019 ( 2019-04-17), p. 1-11
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2019 ( 2019-04-17), p. 1-11
    Abstract: The simultaneous electrochemical determination of Zn(II), Cd(II), Pb(II), and Cu(II) in the aqueous solution has been developed on the basis of the bismuth film glassy carbon electrode (GCE) using differential pulse anodic stripping voltammetry (DP-ASV). The bismuth film electrode (BiFE) was prepared by adding 500 ppb bismuth(III) directly to the sample solution and simultaneously depositing bismuth and the metal analytes on GCE. The optimal operational parameters, namely, accumulation potential (–1.6 V), accumulation time (110 s), pulsed amplitude (0.07 V), and scan rate (0.021 V·s −1 ), were found using a Box–Behnken design. Under the optimum conditions, a linear relationship exists between the current and the concentration of Zn(II), Cd(II), Pb(II), and Cu(II) in the range between 5.0 ppb and 110.0 ppb with the detection limits of 1.07 for Zn(II), 0.93 ppb for Cd(II), 0.65 ppb for Pb(II), and 0.94 ppb for Cu(II) calculated on the basis of a signal-to-noise ratio equal to 3 (S/N = 3). The interference experiments show that Co(II), Ni(II), and Fe(III) have a little influence on the DP-ASV signals of Zn(II), Cd(II), Pb(II), and Cu(II). In addition, a high reproducibility was indicated from small relative standard deviations (1.03%, 1.74%, 1.32%, and 4.74%) for 25 repeated measurements of 15 ppb copper, lead, cadmium, and zinc solutions. BiFE was successfully applied to determine Zn(II), Cd(II), Pb(II), and Cu(II) in river samples, and the results are in a good agreement with those determined with graphite furnace atomic absorption spectrometry (GF-AAS).
    Type of Medium: Online Resource
    ISSN: 1687-8434 , 1687-8442
    URL: Article
    DOI: 10.1155/2019/1826148
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2501025-6
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  • 9
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    Voltammetry Determination of Pb(II), Cd(II), and Zn(II) at Bismuth Film Electrode Combined with 8-Hydroxyquinoline as a Complexing Agent
    Hindawi Limited ; 2019
    In:  Journal of Analytical Methods in Chemistry Vol. 2019 ( 2019-07-03), p. 1-11
    Details
    In: Journal of Analytical Methods in Chemistry, Hindawi Limited, Vol. 2019 ( 2019-07-03), p. 1-11
    Abstract: A novel method was developed for the simultaneous determination of Pb(II), Cd(II), and Zn(II) based on the cathodic stripping response at a bismuth film electrode associated with oxine as a chelating agent. The developed method provided a high and sharp electrochemical response compared with the method without oxine. A linear response of peak currents was observed for Pb(II), Cd(II), and Zn(II) concentration in the range from 2 ppb to 110 ppb. The detection limits of Pb(II), Cd(II), and Zn(II) were 0.45, 0.17, and 0.78 ppb, respectively. This method was successfully applied to the determination of Pb(II), Cd(II), and Zn(II) in lake-water and river-water samples. The metals were detected at the ultratrace level, showing the feasibility of the proposed method for environmental applications.
    Type of Medium: Online Resource
    ISSN: 2090-8865 , 2090-8873
    URL: Article
    DOI: 10.1155/2019/4593135
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2654178-6
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  • 10
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    Blood Pressure Control and Associations with Social Support among Hypertensive Outpatients in a Developing Country
    Hindawi Limited ; 2021
    In:  BioMed Research International Vol. 2021 ( 2021-4-3), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2021 ( 2021-4-3), p. 1-10
    Abstract: Relationships between social support characteristics with blood pressure control and recommended behaviors in Vietnamese hypertensive patients have not been investigated. This study is aimed at examining the role of social support characteristics in hypertension control and behaviors. Patients with hypertension ( n = 220 ) in Hanoi, Vietnam, were recruited into a cross-sectional study. Both functional and structural characteristics of social support and network were examined. Results showed that increasing total network size was related to 52% higher odds of uncontrolled hypertension ( adjusted   OR = 1.52 , 95 % CI = 1.22 − 1.89 ). Higher network sizes on the provision of information support related to advice, emotional support related to decisions, and practical support related to sickness were associated with lower odds of uncontrolled hypertension. Every additional 1% of the percentage of network members having hypertension decreased 2% the odds of uncontrolled hypertension ( adjusted   OR = 0.98 , 95 % CI = 0.96 − 1.00 ). A 1% additional network members who were living in the same household was associated with a decrease of 0.08 point of behavioral adherence score ( coef . = − 0.08 ; 95 % CI = − 0.12 − 0.03 ). Meanwhile, a 1% increase of network members who were friends on the provision of practical support related to sickness and jobs was related to an increase of 0.10 point and 0.19 point of behavioral adherence score ( coef . = 0.10 ; 95 % CI = 0.04 − 0.17 and coef . = 0.19 ; 95 % CI = 0.06 − 0.32 , respectively). The current study suggested that further interventions to improve hypertension management should address the potential effects of social network characteristics.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2021/7420985
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
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