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  • Hindawi Limited  (4)
  • 1
    Online Resource
    Online Resource
    The Distribution and Origin of Carbonate Cements in Deep-Buried Sandstones in the Central Junggar Basin, Northwest China
    Hindawi Limited ; 2017
    In:  Geofluids Vol. 2017 ( 2017), p. 1-13
    Details
    In: Geofluids, Hindawi Limited, Vol. 2017 ( 2017), p. 1-13
    Abstract: Extremely high porosities and permeabilities are commonly discovered in the sandstones of the Xishanyao Formation in the central Junggar Basin with the burial depth greater than 5500 m, from which hydrocarbons are currently being produced. High content of carbonate cements (up to 20%) is also observed in a similar depth range. Our study aimed to improve our understanding on the origin of carbonate cements in the Xishanyao Formation, in order to provide insights into the existence of high porosity sandstones at greater depths. Integrated analyses including petrographic analysis, isotopic analysis, fluid-inclusion, and core analysis were applied to investigate the distribution and origin of carbonate cements and the influence of high fluid pressure on reservoir quality. Textural evidences demonstrate that there are two generations of carbonate cements, precipitated at the temperature of 90°C and 120°C, respectively. The carbonate cements with low δ C P D B 13 ranging from −19.07 to - 8.95 ‰ dominantly occurred near the overpressure surface and especially accumulated at approximately 100 m below the surface. Our interpretation is that high content of carbonate cements is significantly influenced by early carbonate cements dissolution and migration under overpressure. Dissolution of plagioclase resulted in the development of internal pores and porosities of as much as 10% at 6500 m depth presumably.
    Type of Medium: Online Resource
    ISSN: 1468-8115 , 1468-8123
    URL: Article
    DOI: 10.1155/2017/1020648
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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    Online Resource
  • 2
    Online Resource
    Online Resource
    miR-23b Negatively Regulates Sepsis-Induced Inflammatory Responses by Targeting ADAM10 in Human THP-1 Monocytes
    Hindawi Limited ; 2019
    In:  Mediators of Inflammation Vol. 2019 ( 2019-10-31), p. 1-13
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2019 ( 2019-10-31), p. 1-13
    Abstract: Background . Previous studies have demonstrated pivotal roles of disintegrin and metalloproteinase 10 (ADAM10) in the pathogenesis of sepsis. MicroRNA- (miR-) 23b has emerged as an anti-inflammatory factor that prevents multiple autoimmune diseases. However, the underlying mechanisms of miR-23b in the regulation of ADAM10 and sepsis remain uncharacterized. Methods . The expression levels of ADAM10 and miR-23b were detected by quantitative RT-PCR and western blot analysis. Cytokine production and THP-1 cell apoptosis were measured by enzyme-linked immunosorbent and annexin V apoptosis assays. Bioinformatics analyses and qRT-PCR, western blot, and luciferase reporter assays were performed to identify ADAM10 as the target gene of miR-23b. Results . miR-23b expression was downregulated in the peripheral blood mononuclear cells of sepsis patients and LPS-induced THP-1 cells and was negatively correlated with the expression of ADAM10 and inflammatory cytokines. miR-23b regulated ADAM10 expression by directly binding to the 3 ′ -UTR of ADAM10 mRNA. The overexpression of miR-23b alleviated the LPS-stimulated production of inflammatory cytokines (TNF- α , IL-1 β , and IL-6) and apoptosis by targeting ADAM10 in THP-1 cells. The inhibitor or knockdown of ADAM10 elicited effects similar to those of miR-23b on THP-1 cells upon LPS stimulation. Conclusions. The present study demonstrated that miR-23b negatively regulated LPS-induced inflammatory responses by targeting ADAM10. The molecular regulatory mechanism of miR-23b in ADAM10 expression and sepsis-induced inflammatory consequences may provide potential therapeutic targets for sepsis.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2019/5306541
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2008065-7
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  • 3
    Online Resource
    Online Resource
    Transplantation Site Affects the Outcomes of Adipose-Derived Stem Cell-Based Therapy for Retinal Degeneration
    Hindawi Limited ; 2020
    In:  Stem Cells International Vol. 2020 ( 2020-01-06), p. 1-12
    Details
    In: Stem Cells International, Hindawi Limited, Vol. 2020 ( 2020-01-06), p. 1-12
    Abstract: Adipose-derived stem cells (ASCs) have shown a strong protective effect on retinal degenerative diseases (RDD) after being transplanted into the subretinal space in an animal model. Recently, several clinical trials have been conducted to treat RDD with intravitreal transplantation of stem cells, including ASCs. However, the outcomes of the clinical trials were not satisfactory. To investigate if the transplantation site alters the outcome of stem cell-based therapy for RDD, we isolated rat ASCs (rASCs) and labeled them with green fluorescent protein. Autologous rASCs were grafted into the vitreous chamber or subretinal space in a rat RDD model induced by sodium iodate (SI). The electric response was recorded by ERG. The anatomic structure of the retina was observed in cryosections of rat eyes at posttransplantation weeks 1, 2, and 4. Neural retina apoptosis and epiretinal membrane- (ERM-) like structure formation were investigated by immunostaining. The intravitreal transplantation of rASCs resulted in an extinguished electric response, although the rosette formation and apoptosis of neural retina were reduced. However, the rASCs that grafted in the subretinal space protected the retina from the damage caused by SI, including a partial recovering of the electric response and a reduction in rosette formation. Intravitreally grafted rASCs formed a membrane, resulting in retina folding at the injection site. Müller cells, retinal pigment epithelial cells, and microglial cells migrated from the retina to the rASC-formed membrane and subsequently formed an ERM-like structure. Furthermore, vitreous fluid promoted rASC migration, and rASC-conditioned medium enhanced Müller cell migration as indicated by in vitro studies. These data suggested that the vitreous chamber is not a good transplantation site for ASC-based therapy for RDD and that a deliberate decision should be made before transplantation of stem cells into the vitreous chamber to treat RDD in clinical trials.
    Type of Medium: Online Resource
    ISSN: 1687-966X , 1687-9678
    URL: Article
    DOI: 10.1155/2020/9625798
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2573856-2
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  • 4
    Online Resource
    Online Resource
    Positive Relationship between Total Antioxidant Status and Chemokines Observed in Adults
    Hindawi Limited ; 2014
    In:  Oxidative Medicine and Cellular Longevity Vol. 2014 ( 2014), p. 1-6
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2014 ( 2014), p. 1-6
    Abstract: Objective . Human evidence is limited regarding the interaction between oxidative stress biomarkers and chemokines, especially in a population of adults without overt clinical disease. The current study aims to examine the possible relationships of antioxidant and lipid peroxidation markers with several chemokines in adults. Methods . We assessed cross-sectional associations of total antioxidant status (TAS) and two lipid peroxidation markers malondialdehyde (MDA) and thiobarbituric acid reactive substances (TBARS) with a suite of serum chemokines, including CXCL-1 (GRO- α ), CXCL-8 (IL-8), CXCL-10 (IP-10), CCL-2 (MCP-1), CCL-5 (RANTES), CCL-8 (MCP-2), CCL-11 (Eotaxin-1), and CCL-17 (TARC), among 104 Chinese adults without serious preexisting clinical conditions in Beijing before 2008 Olympics. Results . TAS showed significantly positive correlations with MCP-1 ( r = 0.15751 , P = 0.0014 ), MCP-2 ( r = 0.3721 , P = 0.0001 ), Eotaxin-1 ( r = 0.39598 , P 〈 0 . 0001 ), and TARC ( r = 0.27149 , P = 0.0053 ). The positive correlations remained unchanged after controlling for age, sex, body mass index, smoking, and alcohol drinking status. No associations were found between any of the chemokines measured in this study and MDA or TBARS. Similar patterns were observed when the analyses were limited to nonsmokers. Conclusion . Total antioxidant status is positively associated with several chemokines in this adult population.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2014/693680
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2455981-7
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