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  • Hindawi Limited  (23)
  • 1
    Online Resource
    Online Resource
    Pathogenic Streptococcus strains employ novel escape strategy to inhibit bacteriostatic effect mediated by mammalian peptidoglycan recognition protein
    Hindawi Limited ; 2017
    In:  Cellular Microbiology Vol. 19, No. 7 ( 2017-07), p. e12724-
    Details
    In: Cellular Microbiology, Hindawi Limited, Vol. 19, No. 7 ( 2017-07), p. e12724-
    Type of Medium: Online Resource
    ISSN: 1462-5814
    URL: Article
    DOI: 10.1111/cmi.12724
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2019990-9
    SSG: 12
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  • 2
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    The forced air cooling heat dissipation performance of different battery pack bottom duct
    Hindawi Limited ; 2018
    In:  International Journal of Energy Research Vol. 42, No. 12 ( 2018-10-10), p. 3823-3836
    Details
    In: International Journal of Energy Research, Hindawi Limited, Vol. 42, No. 12 ( 2018-10-10), p. 3823-3836
    Type of Medium: Online Resource
    ISSN: 0363-907X
    URL: Issue
    URL: Article
    DOI: 10.1002/er.v42.12
    DOI: 10.1002/er.4114
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 1480879-1
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  • 3
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    Plate flat heat pipe and liquid-cooled coupled multistage heat dissipation system of Li-ion battery
    Hindawi Limited ; 2019
    In:  International Journal of Energy Research Vol. 43, No. 3 ( 2019-03-10), p. 1133-1141
    Details
    In: International Journal of Energy Research, Hindawi Limited, Vol. 43, No. 3 ( 2019-03-10), p. 1133-1141
    Type of Medium: Online Resource
    ISSN: 0363-907X
    URL: Issue
    URL: Article
    DOI: 10.1002/er.v43.3
    DOI: 10.1002/er.4341
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 1480879-1
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  • 4
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    Propionibacterium acnes Induces Intervertebral Disc Degeneration by Promoting iNOS/NO and COX-2/PGE 2 Activation via the ROS-Dependent NF- κ B Pathway
    Hindawi Limited ; 2018
    In:  Oxidative Medicine and Cellular Longevity Vol. 2018 ( 2018-08-19), p. 1-12
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2018 ( 2018-08-19), p. 1-12
    Abstract: Accumulating evidence suggests that Propionibacterium acnes ( P. acnes ) is a novel pathogenic factor promoting intervertebral disc degeneration (IVDD). However, the underlying mechanisms by which P. acnes induces IVDD have been unclear. In this study, we quantified the severity of IVDD, as well as the expressions of inducible nitric oxide synthase (iNOS)/nitric oxide (NO) and cyclooxygenase (COX-2)/prostaglandin (PGE 2 ) in human intervertebral discs (IVDs) infected with P. acnes . Compared with P. acnes -negative IVDs, P. acnes -positive IVDs showed increased iNOS/NO and COX-2/PGE 2 activity concomitant with more severe IVDD. In order to detect the potential correlation between iNOS/NO expression, COX-2/PGE 2 expression, and IVDD, we developed a P. acnes -induced IVDD rat model and found that the upregulation of iNOS/NO and COX-2/PGE 2 was essential to the occurrence of P. acnes -induced IVDD. This finding was supported by the fact that the inhibition of iNOS/NO and COX-2/PGE 2 activity ameliorated IVDD significantly, as evidenced by restored aggrecan and collagen II expression both in vivo and in vitro . Mechanistically, we found that P. acnes induced iNOS/NO and COX-2/PGE 2 expressions via a reactive oxygen species- (ROS-) dependent NF- κ B cascade. Furthermore, NADPH oxidase participated in P. acnes -induced ROS, iNOS/NO, and COX-2/PGE 2 expressions. Overall, these findings further validated the involvement of P. acnes in the pathology of IVDD and provided evidence that P. acnes -induced iNOS/NO and COX-2/PGE 2 activation via the ROS-dependent NF- κ B pathway is likely responsible for the pathology of IVDD.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2018/3692752
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2455981-7
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  • 5
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    Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro
    Hindawi Limited ; 2019
    In:  Oxidative Medicine and Cellular Longevity Vol. 2019 ( 2019-11-30), p. 1-18
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2019 ( 2019-11-30), p. 1-18
    Abstract: Diabetic cardiomyopathy (DCM) is one of the common cardiovascular complications in patients with diabetes. Accumulating evidence has demonstrated that DCM is thoroughly related to mitochondrial energy impairment and increases the generation of reactive oxygen species (ROS). Therefore, an ongoing study is developing strategies to protect cardiac mitochondria from diabetic complications, especially from hyperglycemia. Phosphocreatine (PCr) plays a major metabolic role in cardiac muscular cells including intracellular concentration of ATP which affects the activity of the myocardium. We hypothesized that PCr might improve oxidative phosphorylation and electron transport capacity in mitochondria impaired by hyperglycemia in vivo and in vitro. Also, we aimed to evaluate the protective effect of PCr against DCM through the JAK2/STAT3 signaling pathway. The mitochondrial respiratory capacity from rats and H9C2 cells was measured by high-resolution respirometry (HRR). Expressions of proteins Bax, Bcl-2, caspase 3, caspase 9, cleaved caspase 3, and cleaved caspase 9, as well as JAK2/STAT3 signaling pathways, were determined by western blotting. ROS generation and mitochondrial membrane potential (MMP) were measured with fluorescent probes. Type 1 diabetes mellitus was induced in Wistar male rats by a single intraperitoneal injection of streptozotocin (STZ) (80 mg/kg body weight). Our results revealed that PCr possessed protective effects against DCM injury by improving the mitochondrial bioenergetics and by positively exerting protective effects against DCM in vivo and in vitro, not only improving diabetes symptom, resulting in changes of cardiac tissue using hematoxylin and eosin (H & E) stain, but also ameliorating biochemical changes. Moreover, PCr increased Bcl-2, caspase 3, and caspase 9 protein expressions and decreased Bax, cleaved caspase 3, and cleaved caspase 9 expressions as well as the JAK2/STAT3 signaling pathway. In conclusion, PCr improves mitochondrial functions and exerts an antiapoptotic effect in vivo and in vitro exposed to oxidative stress by hyperglycemia through the JAK2/STAT3 signaling pathway. Our findings suggest that PCr medication is a possible therapeutic strategy for cardioprotection.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2019/6521218
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2455981-7
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  • 6
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    Online Resource
    Integrative Analysis of m6A RNA Methylation Regulators and the Tumor Immune Microenvironment in Non-Small-Cell Lung Cancer
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-2-9), p. 1-34
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-2-9), p. 1-34
    Abstract: Background. Non-small-cell lung cancer (NSCLC) is a major component of lung cancer and is significantly correlated with poor prognosis. N6-methyladenosine (m6A) RNA methylation is closely related to the occurrence, progression, and prognosis of cancer. The potential biological functions and mechanisms of m6A RNA methylation in the immune microenvironment are still unclear. Methods. We assessed m6A RNA methylation modification patterns in 1326 NSCLC patient samples based on 20 m6A regulators, linking these clusters to the tumor microenvironment and immune cell infiltration. The m6Ascore was created to quantify the m6A modification patterns of individual tumors. We then assessed the value of NSCLC patients in terms of clinical prognosis and immunotherapy response. Results. According to different mRNA expression levels, two different m6A clusters were identified. m6A aggregation was significantly associated with clinical prognostic characteristics, the tumor microenvironment, and immune-related biological processes. Fifteen differential genes were screened based on these two m6A clusters, and to further investigate the mechanisms of action of these differential genes, they were subjected to unsupervised clustering analysis, which classified them into four different genomic isoforms. Prognostic analysis indicated that the survival advantage of the m6A gene cluster A modification mode was significantly prominent. We continued to construct the m6Ascore, which was used as a scoring tool to evaluate tumor typing, immunity, and prognosis. Patients with a low m6Ascore showed a significant survival advantage, and the group with a low m6Ascore had a better prognosis predicted by immunotherapy. The anti-PD-1/L1 immunotherapy cohort showed that a lower m6Ascore was associated with higher efficacy of immunotherapy. Conclusions. The results suggest that m6A RNA methylation regulators make an important difference in the tumor immune microenvironment of patients with NSCLC. m6A gene characterization and the construction of the m6Ascore provide us with a richer understanding of m6A RNA methylation modification patterns in NSCLC patients and help to predict clinical prognosis and immunotherapeutic response.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/2989200
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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  • 7
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    Research on the Optimization of Automobile Plastic Front Frame Structure
    Hindawi Limited ; 2022
    In:  Advances in Materials Science and Engineering Vol. 2022 ( 2022-8-16), p. 1-19
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2022 ( 2022-8-16), p. 1-19
    Abstract: Plastic instead of steel technology is one of the important means of automotive lightweighting, which can greatly reduce the weight of the car while ensuring the same performance of the product. For the lightweighting of the automotive all-plastic front-end frame structure, the initial structural design of the front-end frame was carried out by HyperMesh; based on the compromise planning method and entropy weight method, the compromise planning method with weight coefficients was used to unify the planning of each subobjective to obtain the integrated response function, and the minimization of the integrated response function was the objective. The main considerations were the lock limit crash load, the cushion area load, and the pedestrian protection impact load under typical operating conditions, the shape optimization, and topology optimization, respectively. The mass of the sheet metal front-end frame was reduced from the original 10.5 kg to 6.8 kg—a weight reduction of 35.24%. The front-end frame was extracted and the mid-plane was repaired by HyperMesh, the complete mid-plane was meshed, loads and properties were added to the mesh, the front-end frame was subjected to static and modal analysis in the OptiStruct module, and the stiffness and intrinsic frequency were verified. The results show that the smallest first-order mode in the modal analysis is 57.38 Hz, which is much larger than the 30 Hz required before design. The fatigue analysis of the front-end frame was then performed using N-code to derive the damage results; it is concluded that its life is 6122 s, much larger than the specified 1200 s. Through the verification of the relevant resonance test, it is judged that the performance of the test part meets the actual requirements comprehensively by checking the status after the test.
    Type of Medium: Online Resource
    ISSN: 1687-8442 , 1687-8434
    URL: Article
    DOI: 10.1155/2022/2340342
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2501025-6
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  • 8
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    A Combination of Peppermint Oil and Caraway Oil for the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis
    Hindawi Limited ; 2019
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2019 ( 2019-11-14), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-11-14), p. 1-8
    Abstract: A combination of peppermint oil and caraway oil (POCO) with its unique properties has been shown clinical benefits for FD. However, the potent statistical data to confirm its effects are lacking. This meta-analysis thus aimed at evaluating the efficacy and safety of POCO compared with placebo in treating patients with FD. We searched CENTRAL, PubMed, EMBASE (Ovid), Web of Science, Google Scholar, China National Knowledge Infrastructure database, Wanfang, and VIP databases for randomized clinical trials (RCTs) up to June 2019. Dichotomous data were shown as a risk ratio (RR) with 95% confidence intervals (CIs). All data were analyzed by Review Manager 5.2 software. The search identified 382 citations, and 5 RCTs (578 participants) were included. POCO showed a statistically significant effect in global improvement of FD symptoms (RR for not much or very much improvement 0.59, 95% CI: 0.49 to 0.71, P 〈 0.00001 , I 2 36%, NNT 3) and improvement in epigastric pain (RR 1.61, 95% CI: 1.28 to 2.03, P 〈 0.0001 , I 2 0%, NNT 3). There were no significant differences in the total number of adverse events between POCO and placebo (NNH 40). In conclusion, this is the first meta-analysis to assess the effects of POCO in FD. POCO is an effective and safe short-term treatment for FD. However, current findings are based on smaller sample sizes and low/very low quality of the evidence. More well-designed RCTs with large sample sizes of FD patients are required.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2019/7654947
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2148302-4
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  • 9
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    Optimization ultrasound‐assisted extraction of anthocyanins from cranberry using response surface methodology coupled with genetic algorithm and identification anthocyanins with HPLC‐MS 2
    Hindawi Limited ; 2021
    In:  Journal of Food Processing and Preservation Vol. 45, No. 7 ( 2021-07)
    Details
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 45, No. 7 ( 2021-07)
    Type of Medium: Online Resource
    ISSN: 0145-8892 , 1745-4549
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpp.v45.7
    DOI: 10.1111/jfpp.15378
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2175273-4
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  • 10
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    Scientific Evidence of Chinese Herbal Medicine (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis
    Hindawi Limited ; 2022
    In:  Gastroenterology Research and Practice Vol. 2022 ( 2022-3-14), p. 1-8
    Details
    In: Gastroenterology Research and Practice, Hindawi Limited, Vol. 2022 ( 2022-3-14), p. 1-8
    Abstract: Objectives. Gegen Qinlian decoction (GQD), a Chinese herbal compound, has been widely used in the treatment of ulcerative colitis (UC) in China. However, evidence from systematic reviews (SRs)/meta-analyses (MAs) of GQD in UC remains highly controversial. To collate, evaluate, and synthesize the current evidence, we carried out this study. Methods. SRs/MAs of GQD for UC were obtained from eight databases. Methodological Quality of Systematic Reviews 2 (AMSTAR-2) was utilized to appraise the methodological quality, Preferred Reporting Item for Systematic Reviews and Meta-Analyses (PRISMA) for reporting quality, and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) for evidence quality. Results. Four eligible SRs/MAs were obtained. According to AMSTAR 2, all SRs/MAs were graded as critically low quality. According to PRISMA checklist, all SRs/MAs failed to report the information of protocol and registration. With GRADE, no outcome measure with high-quality evidence was found, and the evidence quality for outcome measures was in the moderate to critically low levels. Conclusions. GQD with conventional medicine (CM) seems to be more effective in UC than CM alone. This finding provides a new alternative strategy for the treatment of UC. However, owing to the limitations of the evidence provided by the included SRs/MAs, this conclusion must be treated with caution.
    Type of Medium: Online Resource
    ISSN: 1687-630X , 1687-6121
    URL: Article
    DOI: 10.1155/2022/7942845
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2435460-0
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