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  • Hindawi Limited  (17)
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  • Hindawi Limited  (17)
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  • 1
    Online-Ressource
    Online-Ressource
    TIPE1 Suppresses Growth and Metastasis of Ovarian Cancer
    Hindawi Limited ; 2021
    In:  Journal of Oncology Vol. 2021 ( 2021-6-3), p. 1-10
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2021 ( 2021-6-3), p. 1-10
    Kurzfassung: TIPE1, a newly identified member in TIPE (TNFAIP8) family, plays an important role in tumorigenesis and immune regulation, but its role in ovarian cancer, especially in tumor metastasis, remains unknown. In the current study, we aimed to reveal the protein expression spectrum of TIPE1 in normal human tissues and explored its relationship with metastasis in ovarian cancer. The results of IHC staining showed that TIPE1 protein was not only detected in cytoplasm in most human tissues but also expressed in both cytoplasm and nucleus in squamous epithelium and some epithelial-derived cells with secretory functions, such as esophagus, cervix uteri and ovary, and thyroid gland. Moreover, TIPE1 protein was downregulated in ovarian cancer tissues compared with that in the paracancerous. More importantly, TIPE1 suppressed tumorigenesis and metastasis of ovarian cancer in vitro and in vivo, as evidence shows its ability to suppress growth, colony formation, migration, and epithelial-mesenchymal transition (EMT) of ovarian cancer. Taken together, our results demonstrate the suppressor role of TIPE1 in ovarian cancer metastasis, indicating TIPE1 might be a metastasis predictor and a novel therapeutic target for ovarian cancer.
    Materialart: Online-Ressource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2021/5538911
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2021
    ZDB Id: 2461349-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Liensinine Inhibits Cell Growth and Blocks Autophagic Flux in Nonsmall-Cell Lung Cancer
    Hindawi Limited ; 2022
    In:  Journal of Oncology Vol. 2022 ( 2022-7-1), p. 1-17
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2022 ( 2022-7-1), p. 1-17
    Kurzfassung: Liensinine is a bioactive component of Plumula Nelumbinis extracted from the green embryo of the mature seeds of Nelumbonaceae and exhibits therapeutic functions and noteworthy anti-tumor effects in recent studies. However, the potential anti-tumor property and the underlying mechanisms of liensinine in nonsmall-cell lung cancer (NSCLC) have not been illustrated. In this study, we demonstrated that liensinine has the potential anti-tumor property, and it could inhibit growth of NSCLC in vitro and in vivo. In addition, we found that although it induced significant accumulation of autophagosomes, liensinine could quench them for degradation and blocked autophagic flux. Importantly, we observed that liensinine inhibited the normal function of mitochondrial energy supply and impaired the lysosomal function. This research firstly provides a possibility insight that liensinine could be a novel therapeutic strategy for NSCLC.
    Materialart: Online-Ressource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2022/1533779
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2461349-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Endothelial Progenitor Cells Affect the Growth and Apoptosis of Renal Cells by Secreting Microvesicles Carrying Dysregulated miR-205 and miR-206
    Hindawi Limited ; 2023
    In:  Disease Markers Vol. 2023 ( 2023-2-16), p. 1-21
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2023 ( 2023-2-16), p. 1-21
    Kurzfassung: Background. This study investigated the mechanism of microRNA (miRNA, miR) in microvesicles (MVs) secreted by endothelial progenitor cells (EPCs) involved in renal function in vivo and in vitro injury repair of rat primary kidney cells (PRKs). Methods. Gene Expression Omnibus analysis of potential target miRNAs in nephrotic rats. Real-time quantitative polymerase chain reaction verified the correlation of these miRNAs and screened the effective target miRNAs and their downstream putative target mRNAs. Western blot analyzes the protein levels of DEAD-box helicase 5 (DDX5) and the activation of the proapoptotic factor caspase-3/9 (cleaved). Dil-Ac-LDL staining, immunofluorescence, and a transmission electron microscope (TEM) were used to identify the successful isolation of EPCs and PRKs and the morphology of MVs. Cell Counting Kit-8 was used to detect the effect of miRNA-mRNA on the proliferation of PRKs. Standard biochemical kits were used to detect biochemical indicators in rat blood and urine. Dual-luciferase analysis of miRNA binding to mRNA was conducted. The effect of miRNA-mRNA interaction on the apoptosis level of PRKs was analyzed by flow cytometry. Results. A total of 13 rat-derived miRNAs were potential therapeutic targets, and miR-205 and miR-206 were screened as the targets of this study. We found that the EPC-MVs alleviated the increase of blood urea nitrogen and urinary albumin excretion and the decrease in creatinine clearance caused by hypertensive nephropathy in vivo. The effect of MVs in improving renal function indicators was promoted by miR-205 and miR-206 and inhibited by knockdown of expressed miR-205 and miR-206. In vitro, angiotensin II (Ang II) promoted growth inhibition and apoptosis of PRKs, and similarly, dysregulated miR-205 and miR-206 affected the induction of Ang II. We then observed that miR-205 and miR-206 cotargeted the downstream target DDX5 and regulated its transcriptional activity and translational levels, while also reducing the activation of proapoptotic factors caspase-3/9. Overexpressed DDX5 reversed the effects of miR-205 and miR-206. Conclusion. By upregulating the expression of miR-205 and miR-206 in MVs secreted by EPC, the transcriptional activity of DDX5 and the activation of caspase-3/9 can be inhibited, thereby promoting the growth of PRKs and protecting the injury caused by hypertensive nephropathy.
    Materialart: Online-Ressource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2023/4397829
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2023
    ZDB Id: 2033253-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Overturning Axis Selection in Curved Box-Girder Bridges with Single-Column Piers
    Hindawi Limited ; 2018
    In:  Mathematical Problems in Engineering Vol. 2018 ( 2018), p. 1-9
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2018 ( 2018), p. 1-9
    Kurzfassung: This study was conducted to theoretically analyze the overturning axes of curved box-girder bridges with three equal spans and single-column piers per the influence of curvature radius and bearing eccentricity on overturning axis. The theoretical analysis is verified by a model bridge experiment. The results show that overturning axis can be effectively determined according to the connecting line of either bearings at the central piers or outmost bearings at abutments as influenced by curvature radius and bearing eccentricity. In other words, no bearings are outside of overturning axis. All the bearings but the two on the overturning axis are located on the inner side of the axis. For curved bridges with multispans and single-column or double-column piers, the overturning axis is characterized by the connecting line of the two adjacent outmost bearings.
    Materialart: Online-Ressource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2018/9206138
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2018
    ZDB Id: 2014442-8
    SSG: 11
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Blood Pressure Variability Is Associated with Hearing and Hearing Loss: A Population-Based Study in Males
    Hindawi Limited ; 2019
    In:  International Journal of Hypertension Vol. 2019 ( 2019-02-03), p. 1-9
    Details
    In: International Journal of Hypertension, Hindawi Limited, Vol. 2019 ( 2019-02-03), p. 1-9
    Kurzfassung: Blood pressure (BP) has been well documented to be associated with hearing loss previously. However, the role of blood pressure variability (BPV, representing BP fluctuation over a time period) on hearing remains unknown. We aimed to evaluate the relationship between BPV and hearing in Chinese population. We included 8646 male subjects from a population-based study (the Kailuan study). BP was measured every two years at routine physical examinations from 2006 to 2015. Based on five annual BP measurements, BPV was estimated by standard deviation of BP (SD), coefficient of the variation of BP (CV), and variation independent of mean of BP (VIM). Hearing was estimated by pure-tone average threshold (PTA) at low, intermediate, and high frequencies in the year of 2014. Regression models were used to evaluate the relationship between BPV and hearing. The results showed that PTAs and percentages of hearing loss at low, intermediate, and high frequencies grew gradually with increasing systolic SD (SSD) (p 〈 0.05). After adjusting for multiple covariates, multivariate regression analyses demonstrated that variations of SBP (SSD, SCV, and V I M S B P ) were all positively correlated with PTA at intermediate and high frequencies (p 〈 0.05). Each SD increase in SSD, SCV, and V I M S B P was also positively associated with hearing loss at intermediate and high frequencies. No significant correlation was observed between variations of DBP and hearing. These findings suggest that increase in long-term BPV is associated with hearing and hearing loss. Trial registration number: Kailuan study ( ChiCTRTNC-11001489 ).
    Materialart: Online-Ressource
    ISSN: 2090-0384 , 2090-0392
    URL: Article
    DOI: 10.1155/2019/9891025
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2019
    ZDB Id: 2573167-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Numerical Solutions of Stochastic Differential Delay Equations with Poisson Random Measure under the Generalized Khasminskii-Type Conditions
    Hindawi Limited ; 2012
    In:  Abstract and Applied Analysis Vol. 2012 ( 2012), p. 1-24
    Details
    In: Abstract and Applied Analysis, Hindawi Limited, Vol. 2012 ( 2012), p. 1-24
    Kurzfassung: The Euler method is introduced for stochastic differential delay equations (SDDEs) with Poisson random measure under the generalized Khasminskii-type conditions which cover more classes of such equations than before. The main aims of this paper are to prove the existence of global solutions to such equations and then to investigate the convergence of the Euler method in probability under the generalized Khasminskii-type conditions. Numerical example is given to indicate our results.
    Materialart: Online-Ressource
    ISSN: 1085-3375 , 1687-0409
    URL: Article
    DOI: 10.1155/2012/127397
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2012
    ZDB Id: 2064801-7
    SSG: 17,1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    A Stochastic Predator-Prey System with Stage Structure for Predator
    Hindawi Limited ; 2014
    In:  Abstract and Applied Analysis Vol. 2014 ( 2014), p. 1-7
    Details
    In: Abstract and Applied Analysis, Hindawi Limited, Vol. 2014 ( 2014), p. 1-7
    Kurzfassung: The authors introduce stochasticity into a predator-prey system with Beddington-DeAngelis functional response and stage structure for predator. We present the global existence and positivity of the solution and give sufficient conditions for the global stability in probability of the system. Numerical simulations are introduced to support the main theoretical results.
    Materialart: Online-Ressource
    ISSN: 1085-3375 , 1687-0409
    URL: Article
    DOI: 10.1155/2014/518695
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2014
    ZDB Id: 2064801-7
    SSG: 17,1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Stability of Analytic and Numerical Solutions for Differential Equations with Piecewise Continuous Arguments
    Hindawi Limited ; 2012
    In:  Abstract and Applied Analysis Vol. 2012 ( 2012), p. 1-14
    Details
    In: Abstract and Applied Analysis, Hindawi Limited, Vol. 2012 ( 2012), p. 1-14
    Materialart: Online-Ressource
    ISSN: 1085-3375 , 1687-0409
    URL: Article
    DOI: 10.1155/2012/258329
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2012
    ZDB Id: 2064801-7
    SSG: 17,1
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 9
    Online-Ressource
    Online-Ressource
    Numerical Solutions of Stochastic Differential Equations Driven by Poisson Random Measure with Non-Lipschitz Coefficients
    Hindawi Limited ; 2012
    In:  Journal of Applied Mathematics Vol. 2012 ( 2012), p. 1-17
    Details
    In: Journal of Applied Mathematics, Hindawi Limited, Vol. 2012 ( 2012), p. 1-17
    Kurzfassung: The numerical methods in the current known literature require the stochastic differential equations (SDEs) driven by Poisson random measure satisfying the global Lipschitz condition and the linear growth condition. In this paper, Euler's method is introduced for SDEs driven by Poisson random measure with non-Lipschitz coefficients which cover more classes of such equations than before. The main aim is to investigate the convergence of the Euler method in probability to such equations with non-Lipschitz coefficients. Numerical example is given to demonstrate our results.
    Materialart: Online-Ressource
    ISSN: 1110-757X , 1687-0042
    URL: Article
    DOI: 10.1155/2012/675781
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2012
    ZDB Id: 2578385-3
    SSG: 17,1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Clinicopathological Characteristics and Outcomes of Chinese Patients with Scanty Immune Deposits Lupus Nephritis: A Large Cohort Study from a Single Center
    Hindawi Limited ; 2014
    In:  The Scientific World Journal Vol. 2014 ( 2014), p. 1-11
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2014 ( 2014), p. 1-11
    Kurzfassung: Objective . To assess clinicopathological characteristics of lupus nephritis patients with scanty immune deposits. Methods . The data of patients with scanty immune deposits lupus nephritis were retrospectively analyzed. Plasma ANCA and complement components were detected. Results . Among 316 cases with renal biopsy-proven lupus nephritis, 40 cases were diagnosed as scanty immune deposits. There were significantly higher value of serum creatinine ( P = 0.002 ) and lower hemoglobin level ( P = 0.009 ) and higher score of cellular crescents ( P = 0.015 ) in scanty immune deposits group compared with immune complex deposits group. The frequency of positive plasma ANCA was significantly higher in scanty immune deposits group than that in immune complex deposits group (52.5% versus 10.1%, P 〈 0.001 ). As for comparisons of plasma complement components, there were significantly higher levels of C1q ( P = 0.005 ) and Bb ( P = 0.02 ) and lower level of factor H ( P = 0.003 ) in scanty immune deposits group. The ratio of treatment failure was significantly higher in scanty immune deposits group than that in immune deposits group (42.5% versus 19.20%, P = 0.001 ). The renal outcomes were similar between the two groups. Conclusions . Patients with scanty immune deposits lupus nephritis had more severe kidney damage. ANCA and activation of complement alternative pathway might be involved in the pathogenesis of the disease.
    Materialart: Online-Ressource
    ISSN: 2356-6140 , 1537-744X
    URL: Article
    DOI: 10.1155/2014/212597
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2014
    ZDB Id: 2075968-X
    Standort Signatur Einschränkungen Verfügbarkeit
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