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  • 1
    Online Resource
    Online Resource
    Prediction of Hepatocellular Carcinoma Prognosis and Immune Cell Infiltration Using Gene Signature Associated with Inflammatory Response
    Hindawi Limited ; 2022
    In:  Computational and Mathematical Methods in Medicine Vol. 2022 ( 2022-1-7), p. 1-24
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2022 ( 2022-1-7), p. 1-24
    Abstract: It has been demonstrated that the inflammatory response influences cancer development and can be used as a prognostic biomarker in various tumors. However, the relevance of genes associated with inflammatory responses in hepatocellular carcinoma (HCC) remains unknown. The Cancer Genome Atlas (TCGA) database was analyzed using weighted gene coexpression network analysis (WGCNA) and differential analysis to discover essential inflammatory response-related genes (IFRGs). Cox regression studies, both univariate and multivariate, were employed to develop a prognostic IFRGs signature. Additionally, Gene Set Enrichment Analysis (GSEA) was used to deduce the biological function of the IFRGs signature. Finally, we estimated immune cell infiltration using a single sample GSEA (ssGSEA) and x-cell. Our results revealed that, among the major HCC IFRGs, two (DNASE1L3 and KLKB1) were employed to create a predictive IFRG signature. The IFRG signature could correctly predict overall survival (O.S) as per Kaplan-Meier time-dependent roc curves analysis. It was also linked to pathological tumor stage and T stage and might be used as a prognostic predictor in HCC. GSEA analysis concluded that the IFRG signature might influence the immune response in HCC. Immunological cell infiltration and immune checkpoint molecule expression differed in the high-risk and low-risk groups. As a result of our findings, DNASILE may play a role in the tumor microenvironment. However, more research is necessary to confirm the role of DNASE1L3 and KLKB1.
    Type of Medium: Online Resource
    ISSN: 1748-6718 , 1748-670X
    URL: Article
    DOI: 10.1155/2022/2415129
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2256917-0
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  • 2
    Online Resource
    Online Resource
    Spectrum of SLC20A2 , PDGFRB , PDGFB , and XPR1 mutations in a large cohort of patients with primary familial brain calcification
    Hindawi Limited ; 2019
    In:  Human Mutation Vol. 40, No. 4 ( 2019-04), p. 392-403
    Details
    In: Human Mutation, Hindawi Limited, Vol. 40, No. 4 ( 2019-04), p. 392-403
    Type of Medium: Online Resource
    ISSN: 1059-7794 , 1098-1004
    URL: Issue
    URL: Article
    DOI: 10.1002/humu.2019.40.issue-4
    DOI: 10.1002/humu.23703
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 1498165-8
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    The Postoperative Effects of Patellar Eversion in Total Knee Arthroplasty: An Updated Systematic Review and Meta-Analysis
    Hindawi Limited ; 2022
    In:  BioMed Research International Vol. 2022 ( 2022-4-28), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2022 ( 2022-4-28), p. 1-10
    Abstract: Background. During total knee arthroplasty (TKA), surgeons mobilize the patella to facilitate clear visualization of the articular surfaces and allow better prosthesis placement. According to the manipulation, this manipulation can be divided into patellar eversion and noneversion. However, the effect of patellar eversion in TKA is controversial, with substantial variability in clinical practice. This systematic review is aimed at assessing the adverse effects of patellar eversion and patellar noneversion duration in TKA. Methods. This updated systematic literature review identified randomized controlled trials comparing patellar eversion and noneversion durations in TKA. Two investigators independently extracted data and evaluated the quality of the studies. A meta-analysis was performed using RevMan version 5.3. Results. Nine studies with a total of 608 patients (730 knees) were included. Of these, 374 knees were classified in the eversion group and 356 knees in the noneversion group. The quality of the studies was high. The results showed that patellar eversion could increase the postoperative complication rate ( relative   risk   RR = 1.67 ; 95% confidence interval [CI], 1.09–2.54; P = 0.02 ) and postoperative pain before discharge ( mean   deviation   MD = 0.19 ; 95% CI, 0.04–0.34; P = 0.01 ), compared to noneversion. Additionally, patellar eversion could prolong the time until the patient is able to raise the leg while straightened ( MD = 0.42 ; 95% CI, 0.24–0.59; P 〈 0.00001 ) and increase the length of stay ( MD = 0.65 ; 95% CI, 0.05–1.25; P = 0.03 ). However, patellar eversion did not influence postoperative pain at 1 year ( MD = 0.02 ; 95% CI, -0.23–0.28; P = 0.85 ), operative time ( MD = − 2.66 ; 95% CI, -8.84–3.52; P = 0.40 ), recovery of quadriceps force throughout the follow-up period, and Insall–Salvati ratio ( MD = − 0.04 ; 95% CI, [-0.11–0.02]; P = 0.23 ). Conclusions. The patellar eversion could increase the postoperative complication rate and postoperative pain. Current evidence supports the avoidance of patellar eversion in TKA. Further large-sample and long-term trials are required to validate these results.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2022/2454337
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2698540-8
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  • 4
    Online Resource
    Online Resource
    Effect of Weightlessness on the 3D Structure Formation and Physiologic Function of Human Cancer Cells
    Hindawi Limited ; 2019
    In:  BioMed Research International Vol. 2019 ( 2019-04-03), p. 1-17
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2019 ( 2019-04-03), p. 1-17
    Abstract: With the rapid development of modern medical technology and the deterioration of living environments, cancer, the most important disease that threatens human health, has attracted increasing concerns. Although remarkable achievements have been made in tumor research during the past several decades, a series of problems such as tumor metastasis and drug resistance still need to be solved. Recently, relevant physiological changes during space exploration have attracted much attention. Thus, space exploration might provide some inspiration for cancer research. Using on ground different methods in order to simulate microgravity, structure and function of cancer cells undergo many unique changes, such as cell aggregation to form 3D spheroids, cell-cycle inhibition, and changes in migration ability and apoptosis. Although numerous better experiments have been conducted on this subject, the results are not consistent. The reason might be that different methods for simulation have been used, including clinostats, random positioning machine (RPM) and rotating wall vessel (RWV) and so on. Therefore, we review the relevant research and try to explain novel mechanisms underlying tumor cell changes under weightlessness.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2019/4894083
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2698540-8
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  • 5
    Online Resource
    Online Resource
    Implicit Ishikawa Approximation Methods for Nonexpansive Semigroups in CAT(0) Spaces
    Hindawi Limited ; 2013
    In:  Abstract and Applied Analysis Vol. 2013 ( 2013), p. 1-8
    Details
    In: Abstract and Applied Analysis, Hindawi Limited, Vol. 2013 ( 2013), p. 1-8
    Abstract: This paper is devoted to the convergence of the implicit Ishikawa iteration processes for approximating a common fixed point of nonexpansive semigroup in CAT(0) spaces. We obtain the Δ -convergence results of the implicit Ishikawa iteration sequences for a family of nonexpansive mappings in CAT(0) spaces. Under certain and different conditions, we also get the strong convergence theorems of implicit Ishikawa iteration sequences for nonexpansive semigroups in the CAT(0) spaces. The results presented in this paper extend and generalize some previous results.
    Type of Medium: Online Resource
    ISSN: 1085-3375 , 1687-0409
    URL: Article
    DOI: 10.1155/2013/503198
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2064801-7
    SSG: 17,1
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  • 6
    Online Resource
    Online Resource
    Well-Posedness by Perturbations for Variational-Hemivariational Inequalities
    Hindawi Limited ; 2012
    In:  Journal of Applied Mathematics Vol. 2012 ( 2012), p. 1-18
    Details
    In: Journal of Applied Mathematics, Hindawi Limited, Vol. 2012 ( 2012), p. 1-18
    Abstract: We generalize the concept of well-posedness by perturbations for optimization problem to a class of variational-hemivariational inequalities. We establish some metric characterizations of the well-posedness by perturbations for the variational-hemivariational inequality and prove their equivalence between the well-posedness by perturbations for the variational-hemivariational inequality and the well-posedness by perturbations for the corresponding inclusion problem.
    Type of Medium: Online Resource
    ISSN: 1110-757X , 1687-0042
    URL: Article
    DOI: 10.1155/2012/804032
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2578385-3
    SSG: 17,1
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  • 7
    Online Resource
    Online Resource
    A System of Generalized Variational-Hemivariational Inequalities with Set-Valued Mappings
    Hindawi Limited ; 2013
    In:  Journal of Applied Mathematics Vol. 2013 ( 2013), p. 1-9
    Details
    In: Journal of Applied Mathematics, Hindawi Limited, Vol. 2013 ( 2013), p. 1-9
    Abstract: By using surjectivity theorem of pseudomonotone and coercive operators rather than the KKM theorem and fixed point theorem used in recent literatures, we obtain some conditions under which a system of generalized variational-hemivariational inequalities concerning set-valued mappings, which includes as special cases many problems of hemivariational inequalities studied in recent literatures, is solvable. As an application, we prove an existence theorem of solutions for a system of generalized variational-hemivariational inequalities involving integrals of Clarke's generalized directional derivatives.
    Type of Medium: Online Resource
    ISSN: 1110-757X , 1687-0042
    URL: Article
    DOI: 10.1155/2013/305068
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2578385-3
    SSG: 17,1
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  • 8
    Online Resource
    Online Resource
    Meta-Analysis of Visual Evoked Potential and Parkinson’s Disease
    Hindawi Limited ; 2018
    In:  Parkinson's Disease Vol. 2018 ( 2018-07-11), p. 1-8
    Details
    In: Parkinson's Disease, Hindawi Limited, Vol. 2018 ( 2018-07-11), p. 1-8
    Abstract: Background . Previous studies suggested that visual evoked potential (VEP) was impaired in patients with Parkinson’s disease (PD), but the results were inconsistent. Methods . We conducted a systematic review and meta-analysis to explore whether the VEP was significantly different between PD patients and healthy controls. Case-control studies of PD were selected through an electronic search of the databases PubMed, Embase, and the Cochrane Central Register of Controlled Trials. We calculated the pooled weighted mean differences (WMDs) and 95% confidence intervals (CIs) between individuals with PD and controls using the random-effects model. Results . Twenty case-control studies which met our inclusion criteria were included in the final meta-analysis. We found that the P100 latency in PD was significantly higher compared with healthy controls (pooled WMD = 6.04, 95% CI: 2.73 to 9.35, P = 0.0003 , n = 20 ). However, the difference in the mean amplitude of P100 was not significant between the two groups (pooled WMD = 0.64, 95% CI: −0.06 to 1.33, P = 0.07 ) based on 10 studies with the P100 amplitude values available. Conclusions . The higher P100 latency of VEP was observed in PD patients, relative to healthy controls. Our findings suggest that electrophysiological changes and functional defect in the visual pathway of PD patients are important to our understanding of the pathophysiology of visual involvement in PD.
    Type of Medium: Online Resource
    ISSN: 2090-8083 , 2042-0080
    URL: Article
    DOI: 10.1155/2018/3201308
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2573854-9
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  • 9
    Online Resource
    Online Resource
    Ion jet generation in the ultraintense laser interactions with rear-side concave target
    Hindawi Limited ; 2010
    In:  Laser and Particle Beams Vol. 28, No. 2 ( 2010-06), p. 351-359
    Details
    In: Laser and Particle Beams, Hindawi Limited, Vol. 28, No. 2 ( 2010-06), p. 351-359
    Abstract: In this paper, the ion jet generation from the interaction of an ultraintense laser pulse and a rear-side concave target is investigated analytically using a simple fluid model. We find that the ion expanding surface at the rear-side is distorted due to a strong charge-separation field, and that this distortion becomes dramatic with a singular cusp shown on the central axis at a critical time. The variation of the transverse ion velocity and the relative ion density diverge on the cusp, signaling the emergence of an on-axis ion jet. We have obtained analytical expressions for the critical time and the maximum velocity of the ion jet, and suggested an optimum shape for generating a collimated energetic ion jet. The above theoretical analysis has been verified by particle-in-cell (PIC) numerical simulations.
    Type of Medium: Online Resource
    ISSN: 0263-0346 , 1469-803X
    URL: Article
    DOI: 10.1017/S0263034610000303
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2010
    detail.hit.zdb_id: 2021816-3
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  • 10
    Online Resource
    Online Resource
    A Semiconductor Bridge Electrical Explosive Device Online Firing Quality Identification Algorithm
    Hindawi Limited ; 2020
    In:  Mathematical Problems in Engineering Vol. 2020 ( 2020-11-20), p. 1-7
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2020 ( 2020-11-20), p. 1-7
    Abstract: When qualified explosive devices fire the explosive agent unsuccessfully, on-site testers cannot diagnose fast and accurately whether it is the firing quality problem of the electrical explosive devices or explosive agent by using traditional test methods. And, if the explosive agent is fired unsuccessfully, generally, the only way is to test the explosive device by on-site testers themselves. In order to protect the on-site testers’ safety, this paper proposes an electrical explosive device firing quality identification algorithm based on HHT (Hilbert–Huang transform) of the explosive time series. Obtaining an explosive current time series during the firing process of electrical explosive devices by the explosive equipment, the IMFs (intrinsic mode functions) and a residual function of the explosive current time series are obtained by EMD (empirical mode decomposition), the feature vector, which is the energy characteristic values of the IMFs and residual function by Hilbert transformation, is the input of SVM (support vector machine), and the fired failure explosive device is identified as an excellent performance product or performance failure product by the trained SVM. Finally, semiconductor explosive devices are tested to verify the proposed algorithm, and the results show that the EMD-SVM algorithm can identify effectively the firing quality of firing explosive devices.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2020/1638705
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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