In:
Journal of Diabetes Research, Hindawi Limited, Vol. 2016 ( 2016), p. 1-6
Abstract:
Aim. To determine the diabetic foot ulcer incidence and examine its association with microangiopathy complications, including diabetic retinopathy (DR) and albuminuria (Alb), in type 2 diabetes patients. Methods. This was a retrospective cohort study of 1,305 patients with type 2 diabetes who were assigned to the following groups: Category 1, normoalbuminuria without DR ( n = 712 ); Category 2, Alb without DR ( n = 195 ); Category 3, normoalbuminuria with DR ( n = 185 ); and Category 4, Alb with DR ( n = 213 ). Cox proportional hazard models were used to compare the risks of developing diabetic foot ulcers across the categories. Results . During 14,249 person-years of follow-up, 50 subjects developed diabetic foot ulcers, with incidence rates of 1.6/1,000, 1.5/1,000, 3.4/1,000, and 12.5/1,000 person-years in Categories 1, 2, 3, and 4, respectively. After adjusting for the presence of diabetic neuropathy and macroangiopathy, the hazard ratios and 95% confidence intervals (CIs) for the risk of diabetic foot ulcer development were 0.66 (95% CI, 0.18–2.36), 1.72 (95% CI, 0.67–4.42), and 3.17 (95% CI, 1.52–6.61) in Categories 2, 3, and 4, respectively, compared with Category 1. Conclusion . The presence of DR and Alb significantly increases the risk of diabetic foot ulcer development.
Type of Medium:
Online Resource
ISSN:
2314-6745
,
2314-6753
DOI:
10.1155/2016/5938540
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2016
detail.hit.zdb_id:
2711897-6
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