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  • Hindawi Limited  (11)
  • 1
    Online Resource
    Online Resource
    tRNA-Derived Fragments in Podocytes with Adriamycin-Induced Injury Reveal the Potential Mechanism of Idiopathic Nephrotic Syndrome
    Hindawi Limited ; 2020
    In:  BioMed Research International Vol. 2020 ( 2020-06-23), p. 1-12
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-06-23), p. 1-12
    Abstract: Idiopathic nephrotic syndrome (INS) is a disease involving injury to podocytes in the glomerular filtration barrier, and its specific causes have not been elucidated. Transfer RNA-derived fragments (tRFs), products of precise tRNA cleavage, have been indicated to play critical roles in various diseases. Currently, there is no relevant research on the role of tRFs in INS. This study intends to explore the changes in and importance of tRFs during podocyte injury in vitro and to further analyze the potential mechanism of INS. Differentially expressed tRFs in the adriamycin-treated group were identified by high-throughput sequencing and further verified by quantitative RT-PCR. In total, 203 tRFs with significant differential expression were identified, namely, 102 upregulated tRFs and 101 downregulated tRFs ( q 〈 0.05 , ∣ log 2 FC ∣ ≥ 2 ). In particular, AS-tDR-008924, AS-tDR-011690, tDR-003634, AS-tDR-013354, tDR-011031, AS-tDR-001008, and AS-tDR-007319 were predicted to be involved in podocyte injury by targeting the Gpr, Wnt, Rac1, and other genes. Furthermore, gene ontology analysis showed that these differential tRFs were strongly associated with podocyte injury processes such as protein binding, cell adhesion, synapses, the actin cytoskeleton, and insulin-activate receptor activity. KEGG pathway analysis predicted that they participated in the PI3K-Akt signaling pathway, Wnt signaling pathway, and Ras signaling pathway. It was reported that these pathways contribute to podocyte injury. In conclusion, our study revealed that changes in the expression levels of tRFs might be involved in INS. Seven of the differentially expressed tRFs might play important roles in the process of podocyte injury and are worthy of further study.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2020/7826763
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2698540-8
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  • 2
    Online Resource
    Online Resource
    The Value of miR-296 and miR-517c in Evaluating the Prognosis of Patients with Glioma after Radiotherapy and Chemotherapy
    Hindawi Limited ; 2021
    In:  Journal of Oncology Vol. 2021 ( 2021-12-16), p. 1-7
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2021 ( 2021-12-16), p. 1-7
    Abstract: Objective. To explore the value of miR-296 and miR-517c in evaluating the prognosis of patients with glioma after radiotherapy and chemotherapy. Methods. 732 patients with glioma were selected from January 2012 to January 2018. According to the effect of postoperative chemotherapy, the patients were divided into two groups: the effective group and the ineffective group. The serum miR-296, miR-517c, and clinicopathological parameters of the two groups before chemotherapy were compared. The factors affecting the sensitivity of radiotherapy and chemotherapy and the predictive efficacy of miR-296 and miR-517c on the prognosis of patients were analyzed. Results. The expression level of miR-296 in glioma tissue was significantly correlated with tumor pathological grade and depth of invasion ( P 〈 0.05 ), and the expression level of miR-296 in glioma tissue was significantly correlated with tumor pathological grade ( P 〈 0.05 ). Logistic regression analysis showed that tumor size, WHO grade, and serum miR-296 and miR-517c levels were all factors affecting chemosensitivity ( P 〈 0.05 ). The sensitivity, specificity, accuracy, and AUC of serum miR-296 prediction were 76.95%, 89.64%, 85.35%, and 0.891, respectively. The sensitivity, specificity, accuracy, and AUC of serum miR-517c prediction were 72.81%, 86.50%, 82.19%, and 0.739, respectively. Conclusion. miR-296 and miR-517c are closely related to the chemosensitivity and prognosis of glioma patients. High levels of miR-296 and miR-517c can enhance chemosensitivity and serve as reliable indexes to predict the prognosis of patients with glioma.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2021/6082458
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2461349-6
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  • 3
    Online Resource
    Online Resource
    Dynamic of Friction Coupling Independently Rotating Wheels for High Speed
    Hindawi Limited ; 2017
    In:  Shock and Vibration Vol. 2017 ( 2017), p. 1-8
    Details
    In: Shock and Vibration, Hindawi Limited, Vol. 2017 ( 2017), p. 1-8
    Abstract: A new lateral coupling structure with independently rotating wheels (IRW) is proposed, and longitudinal creepage is obtained by replacing the gear pair with the friction pair to synchronize the rotation speed of left and right wheels. The auxiliary wheelset made up of two friction wheels can be placed either under the primary suspension or on the frame. Vehicles dynamics models with three different kinds of bogies are developed, including friction coupling bogie with independently rotating wheels (FCIRW-bogie), bogie with independently rotating wheels (IRW-bogie), and bogie with rigid wheelsets, and their guiding and resetting capability when negotiating large-radius curves are compared and analyzed. Results show that FCIRW has the advantages of both IRW and rigid wheelset. On the straight track, FCIRW has sufficient wheel-rail longitudinal creep force to assist the reset; its critical speed is much higher than that of the rigid wheelset. On the curved track, the whole vehicle wear power of FCIRW-bogie vehicle is about 2/3 of the rigid axle level.
    Type of Medium: Online Resource
    ISSN: 1070-9622 , 1875-9203
    URL: Article
    DOI: 10.1155/2017/7456598
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2070162-7
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  • 4
    Online Resource
    Online Resource
    Study on the Characteristics of Traction Forces Difference Asymmetric Steering Bogies
    Hindawi Limited ; 2016
    In:  Shock and Vibration Vol. 2016 ( 2016), p. 1-10
    Details
    In: Shock and Vibration, Hindawi Limited, Vol. 2016 ( 2016), p. 1-10
    Abstract: This article comes up with a new concept of applying the difference between traction forces on front and rear wheelsets to guiding control, as well as the design of a new type of structurally simple asymmetrical radial bogies, which lead to the proposition of traction forces difference-steering asymmetric radial bogies. The traction forces difference-steering asymmetric radial bogies are referred to as TFDA-bogies, in which the difference of longitudinal creep forces between front and rear wheels produces radial steering of both wheelsets. The concept of traction difference is incorporated into guiding control and bogie structure is also simplified in the form of asymmetrical radial bogies. Angle sensors are mounted to facilitate the change of electric currents of the front and rear traction motors to control the guiding mechanism so that wheelsets can adopt the radial position. With SIMPACK, the multibody dynamics analysis software, three whole vehicle models of TFDA-bogies, radial bogies, and conventional bogies are set up and comparative analyses are made on the lead wheel angle of attack, lead wheel lateral force, lead wheel friction power, and total vehicle friction power under idle running condition and traction condition, respectively. Results show that TFDA-bogies are radial bogies with simplified structure.
    Type of Medium: Online Resource
    ISSN: 1070-9622 , 1875-9203
    URL: Article
    DOI: 10.1155/2016/7230326
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2070162-7
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  • 5
    Online Resource
    Online Resource
    Efficacy of Navigated Laser Photocoagulation for Chronic Central Serous Chorioretinopathy: A Retrospective Observational Study
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-4-20), p. 1-8
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-4-20), p. 1-8
    Abstract: Background. No consensus has been reached regarding the management of central serous chorioretinopathy (CSCR). We aimed to investigate the efficacy of navigated laser treatment for chronic CSCR and changes in the morphology of the retinal pigment epithelium (RPE). In this retrospective observational study, 19 patients with subjective symptoms admitted to the Nanjing Medical University Affiliated Eye Hospital were included between January 2021 and August 2021. All patients underwent visual acuity and optical coherence tomography (OCT) examination during follow-up. Fluorescein angiography (FA) was performed at baseline and at the final follow-up to confirm the dye leakage sites. The mean logMAR BCVA at baseline and at the end of follow-up was 0.49 ± 0.24 and 0.24 ± 0.15 , respectively. The mean logMAR BCVA 3 months after treatment was significantly better than that before treatment ( p = 0.002 ). Significant improvements were observed in central macular thickness (CMT) and subfoveal choroidal thickness (SFCT) after navigated laser photocoagulation ( p 〈 0.0001 ). Subretinal fluid was completely resolved in 13 (68%) of 19 eyes at 3 months. RPE lesions on OCT images showed RPE detachment in 17 eyes (61.5%), small protrusion of the RPE layer in 5 eyes (7.5%), and a rough RPE layer in 4 eyes (31%). After laser treatment, 9 points (35%) showed retinal detachment, and 10 (38.5%) regions showed an irregular RPE layer. An irregularly protruded RPE layer was also observed in different regions of the leakage spot in 5 (19%) eyes, and RPE defects were seen in 2 (7.5%) eyes. Navigated laser photocoagulation for chronic CSCR can achieve substantial anatomical and visual improvement. OCT outcomes may provide new information to facilitate understanding of the mechanism of chronic CSCR. Navigated laser photocoagulation should be chosen as an optimal treatment option in patients with chronic CSCR who cannot afford photodynamic therapy.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/7792291
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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  • 6
    Online Resource
    Online Resource
    Analysis of the Bacterial Spectrum and Key Clinical Factors of Biliary Tract Infection in Patients with Malignant Obstructive Jaundice after PTCD
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-7-30), p. 1-6
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-7-30), p. 1-6
    Abstract: Objective. To analyze the bacterial spectrum and key clinical factors associated with biliary tract infections following percutaneous transhepatic cholangial drainage (PTCD) for malignant obstructive jaundice (MOJ). Methods. This retrospective study comprised patients with MOJ who were treated with PTCD from 1st June 2016 to 31st December 2020. Patient clinical data, development of postprocedure biliary tract infections, spectrum of pathogenic bacteria, and drug sensitivity were analyzed, focusing on antibiotic drug resistance and identifying key associated risk factors for postoperative biliary tract infections. Results. Of the 528 study patients, 80 were diagnosed with postoperative biliary tract infections, 58 of whom had pathogenic bacteria detected in their bile samples. A total of 90 strains of pathogenic bacteria and 3 strains of fungi were detected; the top 4 were Escherichia coli, Klebsiella pneumoniae, Enterococcus faecium, and Pseudomonas aeruginosa. By univariate analysis, a positive bile culture following PTCD was closely correlated with both the location and degree of preoperative obstruction and the preoperative bilirubin level. Moreover, the results of logistic regression analysis concluded that complete obstruction and a high preoperative total bilirubin level prior to PTCD were independent risk factors for a positive bile culture following PTCD. Conclusion. Biliary tract infections following PTCD for MOJ were principally due to Escherichia coli, and bacteria in the bile were statistically more likely to be detected in patients with complete obstruction and high preoperative bilirubin levels.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/1026254
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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  • 7
    Online Resource
    Online Resource
    Use of Oxalic Acid-Modified Rice Husk for the Adsorption of Neutral Red from Aqueous Solutions
    Hindawi Limited ; 2010
    In:  Adsorption Science & Technology Vol. 28, No. 7 ( 2010-08), p. 641-656
    Details
    In: Adsorption Science & Technology, Hindawi Limited, Vol. 28, No. 7 ( 2010-08), p. 641-656
    Type of Medium: Online Resource
    ISSN: 0263-6174 , 2048-4038
    URL: Article
    DOI: 10.1260/0263-6174.28.7.641
    RVK:
    VA 1500
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2010
    detail.hit.zdb_id: 2017917-0
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  • 8
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    Online Resource
    The Role of Symptom Duration and Serologic Factors in the Relapse of IgG4-Related Ophthalmic Disease following Surgery: A Retrospective Cohort Study
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-2-26), p. 1-9
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-2-26), p. 1-9
    Abstract: IgG4-related disease (IgG4-RD) affects multiple organs and is characterized by immune-mediated inflammation and fibrosis; IgG-RD affecting orbital tissue is known as IgG4-related ophthalmic disease (IgG4-ROD). This research is aimed at exploring whether symptom duration and common serologic factors, such as IgG, IgE, and eosinophils, are potential risk factors for IgG4-ROD patient relapse after surgery and identifying possible causes of the positive correlation between symptom duration and relapse. This retrospective cohort study included 40 IgG4-ROD patients after surgery. Auxiliary inspection results were obtained before surgery and during follow-up, and relapse risk factors were identified based on previous studies. We used the Spearman rank correlation test to reveal the relationship between symptom duration and relapse time and identified the optimal cutoff value for symptom duration by X-tile. Then, we divided the patients into the long-duration and short-duration groups. Kaplan–Meier survival analyses and log-rank tests were performed to identify the relationship between symptom duration and relapse using X-tile software. Finally, we studied the relationship between previously studied relapse risk factors and symptom duration. The survival curves of the long-duration and short-duration groups were obviously different, and the baseline serum IgG, IgE, and eosinophil levels and asthma concomitant rate were significantly different between the long-duration and short-duration groups. Furthermore, the baseline serum IgG ( r = 0.485 , P = 0.002 ), IgE ( r = 0.350 , P = 0.037 ), and eosinophil ( r = 0.6535 , P 〈 0.0001 ) levels were positively correlated with symptom duration. Our study shows that IgG4-ROD symptom duration is significantly positively correlated with relapse rate and negatively correlated with relapse time. Symptom duration was positively correlated with serum baseline IgG4, IgE, and eosinophil levels and asthma history, which were potential risk factors for disease relapse. We recommended that IgG4-ROD patients with symptom durations greater than 96 months continue to receive maintenance steroid therapy longer than 1 year postsurgery to reduce the relapse rate.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/5651506
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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  • 9
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    Online Resource
    Graphene Channel Liquid Container Field Effect Transistor as pH Sensor
    Hindawi Limited ; 2014
    In:  Journal of Nanomaterials Vol. 2014 ( 2014), p. 1-6
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2014 ( 2014), p. 1-6
    Abstract: Graphene channel liquid container field effect transistor pH sensor with interdigital microtrench for liquid ion testing is presented. Growth morphology and pH sensing property of continuous few-layer graphene (FLG) and quasi-continuous monolayer graphene (MG) channels are compared. The experiment results show that the source-to-drain current of the graphene channel FET has a significant and fast response after adsorption of the measured molecule and ion at the room temperature; at the same time, the FLG response time is less than 4 s. The resolution of MG (0.01) on pH value is one order of magnitude higher than that of FLG (0.1). The reason is that with fewer defects, the MG is more likely to adsorb measured molecule and ion, and the molecules and ions can make the transport property change. The output sensitivities of MG are from 34.5% to 57.4% when the pH value is between 7 and 8, while sensitivity of FLG is 4.75% when the pH = 7 . The sensor fabrication combines traditional silicon technique and flexible electronic technology and provides an easy way to develop graphene-based electrolyte gas sensor or even biological sensors.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2014/547139
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2229480-6
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  • 10
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    Influence of Sublevel Unloading Excavation with Deep Consideration of the Superposition Effect on Deformation of an Existing Tunnel under an Intelligent Geotechnical Concept
    Hindawi Limited ; 2022
    In:  Wireless Communications and Mobile Computing Vol. 2022 ( 2022-1-31), p. 1-10
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2022 ( 2022-1-31), p. 1-10
    Abstract: The construction of a deep and large foundation will inevitably impose stress and deformation on the existing shield tunnel structure. Based on the two-stage analysis and the Pasternak foundation beam model, the analytical solution for the existing tunnel deformation is derived by taking the grouting pressure and water buoyancy into account in the total tunnel deformation. Using FLAC 3D software, based on the soil-structure interaction model, the variation law of the tunnel uplift value under partition excavation of the foundation pit is studied and the variation law of the stress field and displacement field of the tunnel under the MJS method is analyzed and compared. The results of this paper are worthy of reference for similar projects.
    Type of Medium: Online Resource
    ISSN: 1530-8677 , 1530-8669
    URL: Article
    DOI: 10.1155/2022/1400114
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2045240-8
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