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  • Hindawi Limited  (26)
  • 1
    Online Resource
    Online Resource
    Mobile Health (mHealth) technology for improved screening, patient involvement and optimising integrated care in atrial fibrillation: The mAFA (mAF‐App) II randomised trial
    Hindawi Limited ; 2019
    In:  International Journal of Clinical Practice Vol. 73, No. 7 ( 2019-07)
    Details
    In: International Journal of Clinical Practice, Hindawi Limited, Vol. 73, No. 7 ( 2019-07)
    Type of Medium: Online Resource
    ISSN: 1368-5031 , 1742-1241
    URL: Issue
    URL: Article
    DOI: 10.1111/ijcp.2019.73.issue-7
    DOI: 10.1111/ijcp.13352
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2135320-7
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  • 2
    Online Resource
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    Research Progresses of Flash Evaporation in Aerospace Applications
    Hindawi Limited ; 2018
    In:  International Journal of Aerospace Engineering Vol. 2018 ( 2018-12-17), p. 1-15
    Details
    In: International Journal of Aerospace Engineering, Hindawi Limited, Vol. 2018 ( 2018-12-17), p. 1-15
    Abstract: Liquid is overheated and evaporated quickly when it enters into the environment with lower saturation pressure than that corresponding to its initial temperature. This phenomenon is known as the flash evaporation. A natural low-pressure environment and flash evaporation have unique characteristics and superiority in high altitude and outer space. Therefore, flash evaporation is widely used in aerospace. In this paper, spray flash evaporation and jet flash evaporation which are two different forms were introduced. Later, key attentions were paid to applications of flash evaporation in aerospace. For example, the flash evaporation has been used in the thermal control system of an aircraft and the propelling system of a microsatellite and oil supply system of a rocket motor. Finally, the latest progresses in the calculation model and numerical simulation of flash evaporation were elaborated.
    Type of Medium: Online Resource
    ISSN: 1687-5966 , 1687-5974
    URL: Article
    DOI: 10.1155/2018/3686802
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2397583-0
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  • 3
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    Identification of the Metabolic Enzyme Involved Morusin Metabolism and Characterization of Its Metabolites by Ultraperformance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (UPLC/Q-TOF-MS/MS)
    Hindawi Limited ; 2016
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2016 ( 2016), p. 1-10
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2016 ( 2016), p. 1-10
    Abstract: Morusin, the important active component of a traditional Chinese medicine, Morus alba L., has been shown to exhibit many vital pharmacological activities. In this study, six recombinant CYP450 supersomes and liver microsomes were used to perform metabolic studies. Chemical inhibition studies and screening assays with recombinant human cytochrome P450s were also used to characterize the CYP450 isoforms involved in morusin metabolism. The morusin metabolites identified varied greatly among different species. Eight metabolites of morusin were detected in the liver microsomes from pigs (PLMs), rats (RLMs), and monkeys (MLMs) by LC-MS/MS and six metabolites were detected in the liver microsomes from humans (HLMs), rabbits (RAMs), and dogs (DLMs). Four metabolites (M 1 , M 2 , M 5 , and M 7 ) were found in all species and hydroxylation was the major metabolic transformation. CYP1A2, CYP2C9, CYP2D6, CYP2E1, CYP3A4, and CYP2C19 contributed differently to the metabolism of morusin. Compared to other CYP450 isoforms, CYP3A4 played the most significant role in the metabolism of morusin in human liver microsomes. These results are significant to better understand the metabolic behaviors of morusin among various species.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2016/9240103
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2148302-4
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  • 4
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    Online Resource
    Annexin A3 as a Prognostic Biomarker for Breast Cancer: A Retrospective Study
    Hindawi Limited ; 2017
    In:  BioMed Research International Vol. 2017 ( 2017), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-7
    Abstract: To validate the correlation between ANXA3 expression and prognosis in breast cancer, a retrospective study encompassing 309 breast cancer patients was performed. The expression of ANXA3 was determined by the immunohistochemical examination of tissue sections by the Max Vision™ method. The ANXA3 levels in the patient samples were validated for the prognosis based on age, menopause status, tumor size, tumor node, metastasis stage, the number of lymphatic metastases, oncology grade, and molecular subtyping. An elevated expression of ANXA3 was detected in breast cancer samples, compared to adjacent tissue samples, and significant correlation depending on the number of lymphatic metastases ( P = 0.001 ) and histological grade ( P = 0.004 ) was observed. The number of lymphatic metastases and ANXA3 expression were identified as independent risk factors affecting the disease-free survival and overall survival. Significantly ( P 〈 0.002 ) higher level of ANXA3 was detected in triple-negative breast cancer compared to other subtypes. There was no significant ( P 〉 0.05 ) change in the expression of ANXA3 with respect to age, menopausal status, tumor size, and clinical stage. The findings implicate the expression of ANXA3 with the natural progression of breast cancer and associate it with increased lymphatic metastasis. The study validates the use of ANXA3 as a potential prognosis biomarker for breast cancer.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2017/2603685
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2698540-8
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  • 5
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    Rural Residents in China Are at Increased Risk of Exposure to Tick-Borne Pathogens Anaplasma phagocytophilum and Ehrlichia chaffeensis
    Hindawi Limited ; 2014
    In:  BioMed Research International Vol. 2014 ( 2014), p. 1-11
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2014 ( 2014), p. 1-11
    Abstract: As emerging tick born rickettsial diseases caused by A. phagocytophilum and E. chaffeensis , anaplasmosis and ehrlichiosis have become a serious threat to human and animal health throughout the world. In particular, in China, an unusual transmission of nosocomial cases of human granulocytic anaplasmosis occurred in Anhui Province in 2006 and more recent coinfection case of A. phagocytophilum and E. chaffeensis was documented in Shandong Province. Although the seroprevalence of human granulocytic anaplasmosis (former human granulocytic ehrlichiosis, HGE) has been documented in several studies, these data existed on local investigations, and also little data was reported on the seroprevalence of human monocytic ehrlichiosis (HME) in China. In this cross-sectional epidemiological study, indirect immunofluorescence antibody assay (IFA) proposed by WHO was used to detect A. phagocytophilum and E. chaffeensis IgG antibodies for 7,322 serum samples from agrarian residents from 9 provinces/cities and 819 urban residents from 2 provinces. Our data showed that farmers were at substantially increased risk of exposure. However, even among urban residents, risk was considerable. Seroprevalence of HGA and HME occurred in diverse regions of the country and tended to be the highest in young adults. Many species of ticks were confirmed carrying A. phagocytophilum organisms in China while several kinds of domestic animals including dog, goats, sheep, cattle, horse, wild rabbit, and some small wild rodents were proposed to be the reservoir hosts of A. phagocytophilum . The broad distribution of vector and hosts of the A. phagocytophilum and E. chaffeensis , especially the relationship between the generalized susceptibility of vectors and reservoirs and the severity of the disease’s clinical manifestations and the genetic variation of Chinese HGA isolates in China, is urgently needed to be further investigated.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2014/313867
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2698540-8
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  • 6
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    Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack
    Hindawi Limited ; 2022
    In:  Neural Plasticity Vol. 2022 ( 2022-11-18), p. 1-12
    Details
    In: Neural Plasticity, Hindawi Limited, Vol. 2022 ( 2022-11-18), p. 1-12
    Abstract: Objective. This study is aimed at exploring alteration in motor-related effective connectivity in individuals with transient ischemic attack (TIA). Methods. A total of 48 individuals with TIA and 41 age-matched and sex-matched healthy controls (HCs) were recruited for this study. The participants were scanned using MRI, and their clinical characteristics were collected. To investigate motor-related effective connectivity differences between individuals with TIA and HCs, the bilateral primary motor cortex (M1) was used as the regions of interest (ROIs) to perform a whole-brain Granger causality analysis (GCA). Furthermore, partial correlation was used to evaluate the relationship between GCA values and the clinical characteristics of individuals with TIA. Results. Compared with HCs, individuals with TIA demonstrated alterations in the effective connectivity between M1 and widely distributed brain regions involved in motor, visual, auditory, and sensory integration. In addition, GCA values were significantly correlated with high- and low-density lipoprotein cholesterols in individuals with TIA. Conclusion. This study provides important evidence for the alteration of motor-related effective connectivity in TIA, which reflects the abnormal information flow between different brain regions. This could help further elucidate the pathological mechanisms of motor impairment in individuals with TIA and provide a new perspective for future early diagnosis and intervention for TIA.
    Type of Medium: Online Resource
    ISSN: 1687-5443 , 2090-5904
    URL: Article
    DOI: 10.1155/2022/2219993
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2236872-3
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  • 7
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    Reduced Activity of HDAC3 and Increased Acetylation of Histones H3 in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis
    Hindawi Limited ; 2018
    In:  Journal of Immunology Research Vol. 2018 ( 2018-10-03), p. 1-10
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2018 ( 2018-10-03), p. 1-10
    Abstract: Aberrant histone acetylation and deacetylation are increasingly thought to play important roles in the pathogenesis of rheumatoid arthritis (RA). However, limited data from studies about the activity of histone deacetylases (HDACs) and histone acetyltransferase (HAT) in RA are controversial. Those conflicting results may be caused by sample size, medication, and age- and sex-matched controls. The aim of this study is to investigate the expression and activity of class I HDACs (1–3.8) and their effects on histone acetylation in peripheral blood mononuclear cells (PBMCs) from RA patients. The expression of class I HDACs in PBMCs from RA patients was decreased in both mRNA and protein levels in comparison with HCs. The nuclear HAT activities were dramatically increased. Further, we found HDAC3 activity to be the most significantly reduced in overall reduction of HDACs in the RA group. The extent of total histone H3, but not H4, acetylation in PBMCs from RA patients was increased compared to that in healthy controls (HCs) ( p 〈 0.01 ). In RA PBMCs, the activity and expression of class I HDACs are decreased, which is accompanied with enhanced HAT activity. An altered balance between HDAC and HAT activity was found in RA PBMCs.
    Type of Medium: Online Resource
    ISSN: 2314-8861 , 2314-7156
    URL: Article
    DOI: 10.1155/2018/7313515
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2817541-4
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  • 8
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    Online Resource
    Cover Image, Volume 42, Issue 4
    Hindawi Limited ; 2018
    In:  Journal of Food Processing and Preservation Vol. 42, No. 4 ( 2018-04), p. e13634-
    Details
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 42, No. 4 ( 2018-04), p. e13634-
    Type of Medium: Online Resource
    ISSN: 0145-8892
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpp.2018.42.issue-4
    DOI: 10.1111/jfpp.13634
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2175273-4
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  • 9
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    Online Resource
    Adaptive Geometry Images for Remeshing
    Hindawi Limited ; 2017
    In:  International Journal of Digital Multimedia Broadcasting Vol. 2017 ( 2017), p. 1-15
    Details
    In: International Journal of Digital Multimedia Broadcasting, Hindawi Limited, Vol. 2017 ( 2017), p. 1-15
    Abstract: Geometry images are a kind of completely regular remeshing methods for mesh representation. Traditional geometry images have difficulties in achieving optimal reconstruction errors and preserving manually selected geometric details, due to the limitations of parametrization methods. To solve two issues, we propose two adaptive geometry images for remeshing triangular meshes. The first scheme produces geometry images with the minimum Hausdorff error by finding the optimization direction for sampling points based on the Hausdorff distance between the original mesh and the reconstructed mesh. The second scheme produces geometry images with higher reconstruction precision over the manually selected region-of-interest of the input mesh, by increasing the number of sampling points over the region-of-interest. Experimental results show that both schemes give promising results compared with traditional parametrization-based geometry images.
    Type of Medium: Online Resource
    ISSN: 1687-7578 , 1687-7586
    URL: Article
    DOI: 10.1155/2017/2724184
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2448904-9
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  • 10
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    Investigation on the Secondary Generation of Natural Gas Hydrates in Horizontal Wellbore Caused by Pressure Jump during the Depressurization Development of Hydrate Bearing Layers
    Hindawi Limited ; 2020
    In:  Geofluids Vol. 2020 ( 2020-10-20), p. 1-14
    Details
    In: Geofluids, Hindawi Limited, Vol. 2020 ( 2020-10-20), p. 1-14
    Abstract: When the depressurization development of a hydrate-bearing layer is initiated, the temperature of the near-wellbore formation quickly decreases to near the equilibrium temperature due to the dissociation of natural gas hydrate Therefore, the secondary generation of natural gas hydrates in the wellbore easily occurs if pressure jumps to a high value due to the changes of production rates or shutdown of the well. Though hydrate generation in the process of high-pressure drilling and gas and water transportation has been widely investigated, the secondary generation of natural gas hydrates caused by pressure jump during the depressurization development process is not fully understood. In this study, the multiphase pipe flow of a horizontal well, the Vyniauskas–Bishnoi generation dynamics of natural gas hydrate, and a decomposition dynamics model developed by Kim and Bishnoi are combined to build a set of horizontal well gas–liquid–solid three-phase flow models, which consider the phase transition in the wellbore and distinguished the secondary hydrate generation area in the wellbore under different temperature and pressure conditions. The results show that when the toe-end pressure is 7 MPa and the environment temperature is 6.4°C, the secondary hydrate generation exists in the horizontal section of the horizontal well, and the maximum hydrate flow velocity in the wellbore is 0.044 m3/d. A high toe-end pressure, low environment temperature, and high gas output will result in a greater hydrate generation in the wellbore, and the wellbore pressure will have a remarkable influence on the amount generated and its range.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2020/8815455
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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