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  • 1
    Online Resource
    Online Resource
    Bath Salts: A Newly Recognized Cause of Acute Kidney Injury
    Hindawi Limited ; 2012
    In:  Case Reports in Nephrology Vol. 2012 ( 2012), p. 1-5
    Details
    In: Case Reports in Nephrology, Hindawi Limited, Vol. 2012 ( 2012), p. 1-5
    Abstract: Bath salts are substance of abuse that are becoming more common and are difficult to recognize due to negative toxicology screening. Acute kidney injury due to bath salt use has not previously been described. We present the case of a previously healthy male who developed acute kidney injury and dialysis dependence after bath salt ingestion and insufflation. This was self-reported with negative toxicology screening. Clinical course was marked by severe hyperthermia, hyperkalemia, rhabdomyolysis, disseminated intravascular coagulation, oliguria, and sepsis. We discuss signs and symptoms, differential diagnoses, potential mechanisms of injury, management, and review of the literature related to bath salt toxicity.
    Type of Medium: Online Resource
    ISSN: 2090-6641 , 2090-665X
    URL: Article
    DOI: 10.1155/2012/560854
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2627652-5
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  • 2
    Online Resource
    Online Resource
    Can Antinuclear Antibodies (ANA) be Monoclonal?
    Hindawi Limited ; 2021
    In:  Case Reports in Nephrology Vol. 2021 ( 2021-9-30), p. 1-6
    Details
    In: Case Reports in Nephrology, Hindawi Limited, Vol. 2021 ( 2021-9-30), p. 1-6
    Abstract: Background. Nuclear staining by immunofluorescence in a kidney biopsy is often seen in patients with positive antinuclear antibodies (ANA) in the serum. These ANA are usually polyclonal, but herein we report 9 cases with an unusual finding of monoclonal nuclear staining by immunofluorescence on kidney biopsy. Case Presentation. Nine cases with predominant stain for kappa or lambda light chain were identified by searching the renal pathology laboratory database for the past 10 years. All cases had positive stain for only kappa (six cases) or lambda (three cases) light chain in the nuclei. Eight out of nine cases had positive nuclear IgG stain, and one case had positive nuclear IgA stain. Among cases with positive nuclear IgG staining, six cases were positive for IgG1 subclass, one case was positive for IgG2 subclass, and one case was positive for IgG3 subclass. All patients with positive IgG nuclear stain, who had testing for ANA, had positive ANA. Patients with positive IgG1 subclass did not have monoclonal protein in the serum or urine, but the patient with positive IgG2 subclass and lambda light chain stain in the nuclei had IgG lambda monoclonal gammopathy. Conclusions. We identified a new unique pattern of nuclear stain by immunofluorescence in kidney biopsies that suggests the presence of monoclonal ANA. Workup for underlying monoclonal gammopathy is warranted in such patients.
    Type of Medium: Online Resource
    ISSN: 2090-665X , 2090-6641
    URL: Article
    DOI: 10.1155/2021/7006466
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2627652-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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