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  • 1
    Online Resource
    Online Resource
    Effects of Propranolol on Neurodevelopmental Outcomes in Patients with Infantile Hemangioma: A Case-Control Study
    Hindawi Limited ; 2018
    In:  BioMed Research International Vol. 2018 ( 2018), p. 1-6
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2018 ( 2018), p. 1-6
    Abstract: Background . The aim of this study was to examine whether oral propranolol has any effect on neurodevelopment outcomes in young children with problematic infantile hemangiomas (IHs). Methods. Thirty-six children with a diagnosis of problematic IH who were treated with oral propranolol were compared with 34 healthy children with no history of propranolol therapy. Patients received propranolol therapy for at least 3 months. Gesell developmental schedules (GDS) were used to evaluate neurodevelopment outcomes in the two groups. The scores of each GDS domain were compared between the two groups. Results. There were no significant differences in developmental quotient (DQ) values for any of the five domains between the patients and healthy controls ( P 〈 0.05 ) . Multiple stepwise regression analyses showed that none of the domains in the control group were influenced by the children’s gender or age ( P 〈 0.05 ) . In addition, we found that gender, age at the initiation of therapy, age at the time of the neurodevelopment test, and treatment duration had no effect on any domain of the GDS in the patient group ( P 〉 0.05 ) . Conclusion. Propranolol has no obvious effect on neurodevelopmental outcomes in children. Early treatment and treatment duration had no negative effect on central nervous system (CNS) development.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2018/5821369
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2698540-8
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  • 2
    Online Resource
    Online Resource
    Serum Fibroblast Growth Factor 21 Levels Are Correlated with the Severity of Diabetic Retinopathy
    Hindawi Limited ; 2014
    In:  Journal of Diabetes Research Vol. 2014 ( 2014), p. 1-6
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2014 ( 2014), p. 1-6
    Abstract: The aim of the study was to assess serum fibroblast growth factor 21 (FGF21) concentrations in Chinese type 2 diabetic patients with and without retinopathy and to assess the association between FGF21 and the severity of retinopathy. 117 diabetic patients were compared with 68 healthy controls. Fasting blood glucose, serum total cholesterol, serum triglycerides, serum insulin, and serum FGF21 levels were estimated. FGF21 concentrations in the patients were significantly higher than those in control. In the patient group there was a significant positive correlation between FGF21, insulin level, and homeostasis model assessment index. Serum FGF21 concentrations in patients with proliferative diabetic retinopathy or nonproliferative diabetic retinopathy were significantly higher than those in patients without diabetic retinopathy. When the presence of diabetes was defined as the final variable in the conditional logistic regression model with the FGF21 concentration as the continuous variable, FGF21 was significantly involved in the model. This study shows that the increase in serum concentration of FGF21 was associated with the severity of diabetic retinopathy and suggests that FGF21 may play a role in the pathogenesis of diabetic retinopathy and its degree.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2014/929756
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2711897-6
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  • 3
    Online Resource
    Online Resource
    The Quantum Well of One-Dimensional Photonic Crystals
    Hindawi Limited ; 2015
    In:  Advances in Condensed Matter Physics Vol. 2015 ( 2015), p. 1-5
    Details
    In: Advances in Condensed Matter Physics, Hindawi Limited, Vol. 2015 ( 2015), p. 1-5
    Abstract: We have studied the transmissivity of one-dimensional photonic crystals quantum well (QW) with quantum theory approach. By calculation, we find that there are photon bound states in the QW structure ( B A ) 6 ( B B A B B ) n ( A B ) 6 , and the numbers of the bound states are equal to n + 1 . We have found that there are some new features in the QW, which can be used to design optic amplifier, attenuator, and optic filter of multiple channel.
    Type of Medium: Online Resource
    ISSN: 1687-8108 , 1687-8124
    URL: Article
    DOI: 10.1155/2015/959546
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2501251-4
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  • 4
    Online Resource
    Online Resource
    Ma Xing Shi Gan Decoction Protects against PM2.5-Induced Lung Injury through Suppression of Epithelial-to-Mesenchymal Transition (EMT) and Epithelial Barrier Disruption
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-06-17), p. 1-17
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-06-17), p. 1-17
    Abstract: This research was designed to explore the effect of Ma Xing Shi Gan decoction (MXD) in alleviating particulate matter less than 2.5  μ m in diameter (PM2.5) induced lung injury from the perspective of epithelial barrier protection and inhibition of epithelial-to-mesenchymal transition (EMT). Rats were exposed to PM2.5 to establish a lung injury model in vivo, and a PM2.5-stimulated primary cultured type II alveolar epithelial cell model was introduced in vitro. Our results indicated that MXD alleviated the weight loss and pathologic changes and improved the epithelial barrier dysfunction. MXD also significantly inhibited the TGF- β /Smad3 pathway, increased the level of ZO-1 and claudin-5, and reversed the EMT process. Notably, the protection of MXD was abolished by TGF- β in vitro. Our results indicated that MXD has a protection against PM2.5-induced lung injury. The proposed mechanism is reversing PM2.5-induced EMT through inhibiting TGF- β /Smad3 pathway and then upregulating the expression of tight-junction proteins.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2020/7176589
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
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  • 5
    Online Resource
    Online Resource
    The Importance of the Prenyl Group in the Activities of Osthole in Enhancing Bone Formation and Inhibiting Bone Resorption In Vitro
    Hindawi Limited ; 2014
    In:  International Journal of Endocrinology Vol. 2014 ( 2014), p. 1-16
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2014 ( 2014), p. 1-16
    Abstract: Osteoporosis treatment always aimed at keeping the balance of bone formation and bone resorption. Recently, prenyl group in natural products has been proposed as an active group to enhance the osteogenesis process. Osthole has both the prenyl group and bone-protective activities, but the relationship is still unknown. In this study we found that osthole exerted a potent ability to promote proliferation and osteogenic function of rat bone marrow stromal cells and osteoblasts, including improved cell viability, alkaline phosphatase activity, enhanced secretion of collagen-I, bone morphogenetic protein-2, osteocalcin and osteopontin, stimulated mRNA expression of insulin-like growth factor-1, runt-related transcription factor-2, osterix, OPG (osteoprotegerin), RANKL (receptor activator for nuclear factor- κ B ligand), and the ratio of OPG/RANKL, as well as increasing the formation of mineralized nodules. However, 7-methoxycoumarin had no obvious effects. Osthole also inhibited osteoclastic bone resorption to a greater extent than 7-methoxycoumarin, as shown by a lower tartrate-resistant acid phosphatase activity and lower number and smaller area of resorption pits. Our findings demonstrate that osthole could be a potential agent to stimulate bone formation and inhibit bone resorption, and the prenyl group plays an important role in these bone-protective effects.
    Type of Medium: Online Resource
    ISSN: 1687-8337 , 1687-8345
    URL: Article
    DOI: 10.1155/2014/921954
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2502951-4
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  • 6
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    Online Resource
    Attention Neural Network for Biomedical Word Sense Disambiguation
    Hindawi Limited ; 2022
    In:  Discrete Dynamics in Nature and Society Vol. 2022 ( 2022-1-10), p. 1-14
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2022 ( 2022-1-10), p. 1-14
    Abstract: In order to improve the disambiguation accuracy of biomedical words, this paper proposes a disambiguation method based on the attention neural network. The biomedical word is viewed as the center. Morphology, part of speech, and semantic information from 4 adjacent lexical units are extracted as disambiguation features. The attention layer is used to generate a feature matrix. Average asymmetric convolutional neural networks (Av-ACNN) and bidirectional long short-term memory (Bi-LSTM) networks are utilized to extract features. The softmax function is applied to determine the semantic category of the biomedical word. At the same time, CNN, LSTM, and Bi-LSTM are applied to biomedical WSD. MSH corpus is adopted to optimize CNN, LSTM, Bi-LSTM, and the proposed method and testify their disambiguation performance. Experimental results show that the average disambiguation accuracy of the proposed method is improved compared with CNN, LSTM, and Bi-LSTM. The average disambiguation accuracy of the proposed method achieves 91.38%.
    Type of Medium: Online Resource
    ISSN: 1607-887X , 1026-0226
    URL: Article
    DOI: 10.1155/2022/6182058
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033014-5
    SSG: 11
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  • 7
    Online Resource
    Online Resource
    An Improved Numerical Model of Shield Tunnel with Double Lining and Its Applications
    Hindawi Limited ; 2015
    In:  Advances in Materials Science and Engineering Vol. 2015 ( 2015), p. 1-15
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2015 ( 2015), p. 1-15
    Abstract: Based on the existing numerical models of shield tunnel with double lining, an improved numerical model is developed and its rationality is verified by a similar model test. In the improved numerical model, lining, joint, and junction surface, respectively, are simulated by beam, spring, and a combination of compression bar and spring. Through the comparison of the numerical analysis results of the improved model and existing models, it turns out that the defects or problems in the existing numerical models are resolved; tension appearance on the contact surface and junction surface and the abrupt change of bending moment in linings are solved in the improved model because the compression bar element and the coupling technology of node displacement in the junction surface is applied. Therefore, the improved numerical model could be applied to analyze double lining with waterproof on the junction surface and separation of the junction surface under an unfavorable load. In this paper, the parameter formulas of element stiffness, applicable to the junction surface and contact surface of double lining, are given definitely, and the influence of the element amount of junction surface on the analysis results is discussed. Based on the improved numerical model, the mechanical behavior of the double lining of the Huangpu River Tunnel in China is studied, and some conclusions are obtained as follows. (1) The thickness increase of the double lining will clearly increase its bending moment, but it has little influence on its axial force. (2) The allocation proportion of the bending moment between the segment lining and secondary lining has no linear relationship with the ratio of the lining thickness.
    Type of Medium: Online Resource
    ISSN: 1687-8434 , 1687-8442
    URL: Article
    DOI: 10.1155/2015/430879
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2501025-6
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  • 8
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    Online Resource
    EGR1 Enhances Lymphangiogenesis via SOX18-Mediated Activation of JAK2/STAT3 Pathway
    Hindawi Limited ; 2022
    In:  Computational and Mathematical Methods in Medicine Vol. 2022 ( 2022-2-12), p. 1-10
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2022 ( 2022-2-12), p. 1-10
    Abstract: Background. Lymphangiogenesis is a process involved in the pathogenesis of many diseases. Identifying key molecules and pathway targeting this process is critical for lymphatic regeneration-associated disorders. EGR1 is a transcription factor, but its function in lymphangiogenesis is not yet known. This study is aimed at exploring the functional activity and molecular mechanism of EGR1 implicated in lymphangiogenesis. Methods. The CCK-8 method, transwell migration assay, and tube formation assay were used to detect the cell viability, motility, and tube formation of HDLEC cells, respectively. The luciferase reporter assay was applied to detect the impact of EGR1 on SOX18 promoter activity. CHIP assay was used to analyze the direct binding of EGR1 to the SOX18 promoter. qRT-PCR and Western blot analysis were performed to investigate molecules and pathway involved in lymphangiogenesis. Results. The EGR1 ectopic expression markedly increased the cell growth, mobility, tube formation, and the expression of lymphangiogenesis-associated markers (LYVE-1 and PROX1) in HDLEC cells. EGR1 interacted with the SXO18 gene promoter and transcriptionally regulated the SXO18 expression in HDLEC cells. Silencing of SOX18 abrogated the promotional activities of EGR1 on the cell viability, mobility, tube formation, and LYVE-1/PROX1 expression in HDLEC cells. SOX18 overexpression activated JAK/STAT signaling, which resulted in an increase in lymphangiogenesis in HDLEC cells. Conclusions. ERG1 can promote lymphangiogenesis, which is mediated by activating the SOX18/JAK/STAT3 cascade. ERG1 may serve as a promising target for the therapy of lymphatic vessel-related disorders.
    Type of Medium: Online Resource
    ISSN: 1748-6718 , 1748-670X
    URL: Article
    DOI: 10.1155/2022/6448724
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2256917-0
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  • 9
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    Online Resource
    Dietary manganese levels influence growth, manganese bioaccumulation and expression of genes involved in antioxidant response of swimming crab ( Portunus trituberculatus )
    Hindawi Limited ; 2021
    In:  Aquaculture Nutrition Vol. 27, No. 6 ( 2021-12), p. 2600-2611
    Details
    In: Aquaculture Nutrition, Hindawi Limited, Vol. 27, No. 6 ( 2021-12), p. 2600-2611
    Type of Medium: Online Resource
    ISSN: 1353-5773 , 1365-2095
    URL: Issue
    URL: Article
    DOI: 10.1111/anu.v27.6
    DOI: 10.1111/anu.13388
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2019893-0
    SSG: 21,3
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  • 10
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    Localization of Alternating Magnetic Dipole in the Near-Field Zone with Single-Component Magnetometers
    Hindawi Limited ; 2021
    In:  Mathematical Problems in Engineering Vol. 2021 ( 2021-7-6), p. 1-11
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2021 ( 2021-7-6), p. 1-11
    Abstract: Tri-axis magnetometers are widely used to measure magnetic field in engineering of the magnetic localization technology. However, the magnetic field measurement precision is influenced by the nonorthogonal error of tri-axis magnetometers. A locating model of the alternating magnetic dipole in the near-field zone with single-component magnetometers was proposed in this paper. Using the vertical component of the low-frequency magnetic field acquired by at least six single-component magnetometers, the localization of an alternating magnetic dipole could be attributed to the solution for a class of nonlinear unconstrained optimization problem. In order to calculate the locating information of alternating magnetic dipole, a hybrid algorithm combining the Gauss–Newton algorithm and genetic algorithm was applied. The theoretical simulation and field experiment for the localization of alternating magnetic dipole source were carried out, respectively. The positioning result is stable and reliable, indicating that the locating model has better performance and could meet the requirements of actual positioning.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2021/8357981
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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