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  • Hindawi Limited  (26)
  • 1
    Online Resource
    Online Resource
    Experimental and Numerical Investigations on the Ignition of RBCC Gas-Oxygen/Kerosene Rocket Ejector
    Hindawi Limited ; 2021
    In:  International Journal of Aerospace Engineering Vol. 2021 ( 2021-11-9), p. 1-13
    Details
    In: International Journal of Aerospace Engineering, Hindawi Limited, Vol. 2021 ( 2021-11-9), p. 1-13
    Abstract: The rocket ejector refers to a core component of a rocket-based combined cycle (RBCC) engine. The ignition is of critical significance for rocket ejection. Reliable and stable ignition crucially determines the normal operation of the engine. In this paper, a thrust chamber with coaxial swirl injector for the RBCC rocket ejection was developed and tested. Gas oxygen (GOX) and kerosene acted as propellants. As revealed from the test results, the process of ignition pressurizing comprised four phases. The oxygen prefilling time before ignition slightly impacted the ignition time, whereas it affected the peak pressure of ignition. In a confined range, the peak pressure decreased as the prefilling time was extended. The ignition was simulated by building a numerical model, and the results well complied with the experimentally achieved results. The numerical model is capable of specifically indicating the position of the kernel of fire and the process of flame propagation. The simulation results reveal that the propellant could form a combustible condition within 4 ms. The kernel was 6 mm away from the injector, located at the oxygen and kerosene mixing interface and approaching the upper wall. The above results reflected the vital role of the central recirculation zone formed by the prefilled oxygen. The ignition energy was transported near the injector under the convection effect, which ignited the stoichiometric mixture, and the entire ignition could reach a stable state within 20 ms. The numerical model which was developed in this paper can help clarify the combustion mechanism.
    Type of Medium: Online Resource
    ISSN: 1687-5974 , 1687-5966
    URL: Article
    DOI: 10.1155/2021/7002104
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2397583-0
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  • 2
    Online Resource
    Online Resource
    Spatholobus suberectus Column Extract Inhibits Estrogen Receptor Positive Breast Cancer via Suppressing ER MAPK PI3K/AKT Pathway
    Hindawi Limited ; 2016
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2016 ( 2016), p. 1-13
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2016 ( 2016), p. 1-13
    Abstract: Although Chinese herbal compounds have long been alternatively applied for cancer treatment in China, their treatment effects have not been sufficiently investigated. The Chinese herb Spatholobus suberectus is commonly prescribed to cancer patients. HPLC analysis has shown that the main components of Spatholobus suberectus are flavonoids that can be classified as phytoestrogens, having a structure similar to estrogen. This study was designed to investigate the effects of Spatholobus suberectus column extract (SSCE) on the estrogen receptor-positive (ER+) breast cancer cell line MCF-7 and its possible molecular mechanism. In our study, MTT assay was performed to evaluate cell viability. The results show that SSCE (80, 160, and 320  μ g/ml) significantly decreased the viability of MCF-7 cells. SSCE also triggered apoptosis, arrested the cell cycle at the G0/G1 phase, and inhibited cell migration. A dual-luciferase reporter system showed that SSCE suppressed intranuclear p-ER activity; Western blot analysis confirmed the repressed expression of phosphorylated-ER alpha (p-ER α ), ERK1/2, p-ERK1/2, AKT, p-AKT, p-mTOR, PI3K, and p-PI3K, indicating that SSCE suppressed the MAPK PI3K/AKT signaling pathway. Collectively, our results suggest that SSCE causes apoptosis, an arrest in the G0/G1 phase, and a decrease in migration in ER+ MCF-7 cells via hypoactivity of the ER and suppression of the MAPK PI3K/AKT pathway.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2016/2934340
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2148302-4
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  • 3
    Online Resource
    Online Resource
    A Wideband Waveguide Antenna with Nearly Equal E- and H-Plane Radiation Patterns
    Hindawi Limited ; 2013
    In:  International Journal of Antennas and Propagation Vol. 2013 ( 2013), p. 1-8
    Details
    In: International Journal of Antennas and Propagation, Hindawi Limited, Vol. 2013 ( 2013), p. 1-8
    Abstract: A novel wideband waveguide antenna with excellent performance is proposed, which is composed of a coaxial-waveguide transition and an open-ended rectangular waveguide loaded with a pair of horizontal umbrella-shaped metallic brims. The brims perpendicular to two broad walls of the waveguide are constructed to modulate the antenna to radiate nearly identical E- and H-plane radiation patterns. A wideband impedance matching performance is achieved with a fractional bandwidth of 40% through the introduction of short-stepped ladders. The antenna has the advantages of simple structure, symmetric radiation pattern, low-cross polarization, moderate back lobe, and almost constant beamwidth.
    Type of Medium: Online Resource
    ISSN: 1687-5869 , 1687-5877
    URL: Article
    DOI: 10.1155/2013/608393
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2397585-4
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  • 4
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    Online Resource
    UP3005, a Botanical Composition Containing Two Standardized Extracts of Uncaria gambir and Morus alba , Improves Pain Sensitivity and Cartilage Degradations in Monosodium Iodoacetate-Induced Rat OA Disease Model
    Hindawi Limited ; 2015
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2015 ( 2015), p. 1-10
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2015 ( 2015), p. 1-10
    Abstract: Osteoarthritis (OA) is a multifactorial disease primarily noted by cartilage degradation in association with inflammation that causes significant morbidity, joint pain, stiffness, and limited mobility. Present-day management of OA is inadequate due to the lack of principal therapies proven to be effective in hindering disease progression where symptomatic therapy focused approach masks the actual etiology leading to irreversible damage. Here, we describe the effect of UP3005, a composition containing a proprietary blend of two standardized extracts from the leaf of Uncaria gambir and the root bark of Morus alba , in maintaining joint structural integrity and alleviating OA associated symptoms in monosodium-iodoacetate- (MIA-) induced rat OA disease model. Pain sensitivity, micro-CT, histopathology, and glycosaminoglycans (GAGs) level analysis were conducted. Diclofenac at 10 mg/kg was used as a reference compound. UP3005 resulted in almost a complete inhibition in proteoglycans degradation, reductions of 16.6% (week 4), 40.5% (week 5), and 22.0% (week 6) in pain sensitivity, statistically significant improvements in articular cartilage matrix integrity, minimal visual subchondral bone damage, and statistically significant increase in bone mineral density when compared to the vehicle control with MIA. Therefore, UP3005 could potentially be considered as an alternative therapy from natural sources for the treatment of OA and/or its associated symptoms.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2015/785638
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2148302-4
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  • 5
    Online Resource
    Online Resource
    Identification and pathogenicity of Plesiomonas shigelloides from Acipenser dabryanus in China
    Hindawi Limited ; 2021
    In:  Aquaculture Research Vol. 52, No. 5 ( 2021-05), p. 2286-2293
    Details
    In: Aquaculture Research, Hindawi Limited, Vol. 52, No. 5 ( 2021-05), p. 2286-2293
    Type of Medium: Online Resource
    ISSN: 1355-557X , 1365-2109
    URL: Issue
    URL: Article
    DOI: 10.1111/are.v52.5
    DOI: 10.1111/are.15080
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2207423-5
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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  • 6
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    Online Resource
    Uncoupling Protein 2 Drives Myocardial Dysfunction in Murine Models of Septic Shock
    Hindawi Limited ; 2019
    In:  BioMed Research International Vol. 2019 ( 2019-04-04), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2019 ( 2019-04-04), p. 1-10
    Abstract: Cardiac dysfunction is a major component of sepsis-induced multiorgan failure in critical care units. Uncoupling protein 2 (UCP2) involves immune response, regulation of oxidative stress, and maintenance of mitochondrial membrane potential as well as energy production. However, whether and how UCP2 plays roles in the development of septic cardiac dysfunction are largely unknown. Here, intraperitoneal injection of LPS significantly activated UCP2 expression accompanied by a significant decrease of cardiac function and caused a significantly lower survival rate in mice. Of note, knockdown of UCP2 through a cardiotropic adenoassociated viral vector carrying a short hairpin RNA (shRNA) specifically targeting the UCP2 evoked resistance to LPS-triggered septic cardiac dysfunction and lethality in vivo . Moreover, UCP2 deficiency ameliorated the reduced levels of intracellular ATP in the LPS-challenged heart tissues and preserved mitochondrial membrane potential loss in primary adult mouse cardiomyocytes in LPS-challenged animals. Mechanistically, we confirmed that the inhibition of UCP2 promoted autophagy in response to LPS, as shown by an increase in LC3II and a decrease in p62. At last, the autophagy inhibitor 3-MA abolished UCP2 knockdown-afforded cardioprotective effects. Those results indicate that UCP2 drives septic cardiac dysfunction and that the targeted induction of UCP2-mediated autophagy may have important therapeutic potential.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2019/9786101
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2698540-8
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  • 7
    Online Resource
    Online Resource
    Hepatoprotective Activity of Herbal Composition SAL, a Standardize Blend Comprised of Schisandra chinensis , Artemisia capillaris , and Aloe barbadensis
    Hindawi Limited ; 2016
    In:  Journal of Nutrition and Metabolism Vol. 2016 ( 2016), p. 1-10
    Details
    In: Journal of Nutrition and Metabolism, Hindawi Limited, Vol. 2016 ( 2016), p. 1-10
    Abstract: Some botanicals have been reported to possess antioxidative activities acting as scavengers of free radicals rendering their usage in herbal medicine. Here we describe the potential use of “SAL,” a standardized blend comprised of three extracts from Schisandra chinensis , Artemisia capillaris , and Aloe barbadensis , in mitigating chemically induced acute liver toxicities. Acetaminophen and carbon tetrachloride induced acute liver toxicity models in mice were utilized. Hepatic functional tests from serum collected at T24 and hepatic glutathione and superoxide dismutases from liver homogenates were evaluated. Histopathology analysis and merit of blending 3 standardized extracts were also confirmed. Statistically significant and dose-correlated inhibitions in serum ALT ranging from 52.5% ( p = 0.004 ) to 34.6% ( p = 0.05 ) in the APAP and 46.3% ( p 〈 0.001 ) to 29.9% ( p = 0.02 ) in the CCl 4 models were observed for SAL administered at doses of 400–250 mg/kg. Moreover, SAL resulted in up to 60.6% and 80.2% reductions in serums AST and bile acid, respectively. The composition replenished depleted hepatic glutathione in association with an increase of hepatic superoxide dismutase. Unexpected synergistic protection from liver damage was also observed. Therefore, the composition SAL could be potentially utilized as an effective hepatic-detoxification agent for the protection from liver damage.
    Type of Medium: Online Resource
    ISSN: 2090-0724 , 2090-0732
    URL: Article
    DOI: 10.1155/2016/3530971
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2573563-9
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  • 8
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    Online Resource
    Appetite Suppression and Antiobesity Effect of a Botanical Composition Composed of Morus alba , Yerba mate , and Magnolia officinalis
    Hindawi Limited ; 2016
    In:  Journal of Obesity Vol. 2016 ( 2016), p. 1-12
    Details
    In: Journal of Obesity, Hindawi Limited, Vol. 2016 ( 2016), p. 1-12
    Abstract: Background . Obesity and its comorbidities continue to challenge the world at an alarming rate. Although the long term solution lies on lifestyle changes in the form of dieting and exercising, drug, medical food, or dietary supplement interventions are required for those who are already obese. Here we describe a standardized blend composed of extracts from three medicinal plants: Morus alba , Yerba mate , and Magnolia officinalis for appetite suppression and metabolic disorders management. Method . Extracts were standardized to yield a composition designated as UP601. Appetite suppression activity was tested in acute feed intake rat model. Efficacy was evaluated in C57BL/6J mouse models treated with oral doses of 1.3 g/kg/day for 7 weeks. Orlistat at 40 mg/kg/day was used as a positive control. Body compositions of mice were assessed using a dual energy X-ray absorptiometry (DEXA). ELISA was done for insulin, leptin, and ghrelin level quantitation. Nonalcoholic steatohepatitis (NASH) scoring was conducted. Results . Marked acute hypophagia with 81.8, 75.3, 43.9, and 30.9% reductions in food intake at 2, 4, 6, and 24 hours were observed for UP601. Decreases in body weight gain (21.5% compared to the HFD at weeks 7 and 8.2% compared to baseline) and calorie intake (40.5% for the first week) were observed. 75.9% and 46.8% reductions in insulin and leptin, respectively, 4.2-fold increase in ghrelin level, and reductions of 18.6% in cholesterol and 59% in low-density lipoprotein were documented. A percentage body fat of 18.9%, 47.8%, 46.1%, and 30.4% was found for mice treated with normal control, HFD, Orlistat, and UP601, respectively. 59.3% less mesenteric fat pad and improved NASH scores were observed for UP601. Conclusion . UP601, a standardized botanical composition from Morus alba , Yerba mate , and Magnolia officinalis could be used as a natural alternative for appetite suppression, maintaining healthy body weight and metabolism management.
    Type of Medium: Online Resource
    ISSN: 2090-0708 , 2090-0716
    URL: Article
    DOI: 10.1155/2016/4670818
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2573566-4
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  • 9
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    Online Resource
    Bu Shen Yi Sui Capsules Promote Remyelination by Regulating MicroRNA-219 and MicroRNA-338 in Exosomes to Promote Oligodendrocyte Precursor Cell Differentiation
    Hindawi Limited ; 2022
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2022 ( 2022-4-13), p. 1-19
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2022 ( 2022-4-13), p. 1-19
    Abstract: Remyelination is a refractory feature of demyelinating diseases such as multiple sclerosis (MS). Studies have shown that promoting oligodendrocyte precursor cell (OPC) differentiation, which cannot be achieved by currently available therapeutic agents, is the key to enhancing remyelination. Bu Shen Yi Sui capsule (BSYSC) is a traditional Chinese herbal medicine over many years of clinical practice. We have found that BSYSC can effectively treat MS. In this study, the effects of BSYSC in promoting OPCs differentiation and remyelination were assessed using an experimental autoimmune encephalomyelitis (EAE) model in vivo and cultured OPCs in vitro. The results showed that BSYSC reduced clinical function scores and increased neuroprotection. The expression of platelet-derived growth factor receptor α (PDGFR-α) was decreased and the level of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) was increased in the brains and spinal cords of mice as well as in OPCs after treatment with BSYSC. We further found that BSYSC elevated the expression of miR-219 or miR-338 in the serum exosomes of mice with EAE, thereby suppressing the expression of Sox6, Lingo1, and Hes5, which negatively regulate OPCs differentiation. Therefore, serum exosomes of BSYSC-treated mice (exos-BSYSC) were extracted and administered to OPCs in which miR-219 or miR-338 expression was knocked down by adenovirus, and the results showed that Sox6, Lingo1, and Hes5 expression was downregulated, MBP expression was upregulated, OPCs differentiation was increased, and the ability of OPCs to wrap around neuronal axons was improved. In conclusion, BSYSC may exert clinically relevant effects by regulating microRNA (miR) levels in exosomes and thus promoting the differentiation and maturation of OPCs.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2022/3341481
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2148302-4
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  • 10
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    Protective Effect of Total Panax Notoginseng Saponins on Retinal Ganglion Cells of an Optic Nerve Crush Injury Rat Model
    Hindawi Limited ; 2021
    In:  BioMed Research International Vol. 2021 ( 2021-8-4), p. 1-11
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2021 ( 2021-8-4), p. 1-11
    Abstract: Irreversible loss of retinal ganglion cells (RGCs) is a common pathological feature of various optic nerve degenerative diseases such as glaucoma and ischemic optic neuropathy. Effective protection of RGCs is the key to successful treatment of these diseases. Total Panax notoginseng saponins (TPNS) are the main active component of Panax notoginseng, which has an inhibitory effect on the apoptosis pathway. This study is aimed at assessing the protective effect of TPNS on RGCs of the optic nerve crush (ONC) model of rats and exploring the underlying mechanisms. The intraperitoneal or intravitreal injection of TPNS was used based on the establishment of the rat ONC model. Fifteen days after the injury, the cell membrane fluorescent probe (Fluoro-Gold) was applied to retrograde RGCs through the superior colliculus and obtain the number of surviving RGCs. TUNEL assay was also used to detect the number and density of RGC apoptosis after the ONC model. The expression and distribution of Bcl-2/Bax, c-Jun/P-c-Jun, and P-JNK in the retina were demonstrated by Western blot analysis. After the intervention of TPNS, the rate of cell survival increased in different retinal regions ( p 〈 0.05 ) and the number of apoptosis cells decreased. Regarding the expression of Bcl-2/Bax, c-Jun/P-c-Jun, and P-JNK-related apoptotic proteins, TPNS can reduce the level of apoptosis and play a role in protecting RGCs ( p 〈 0.05 ). These findings indicate that topical administration of TPNS can inhibit cell apoptosis and promote RGC survival in the crushed optic nerve.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2021/4356949
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
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