GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Hindawi Limited  (11)
Material
Publisher
  • Hindawi Limited  (11)
Person/Organisation
Language
Years
  • 1
    Online Resource
    Online Resource
    Correlation between Macrophage Polarization and PD-L1-Related Tumor Microenvironmental Alteration and Metastasis in Pancreatic Ductal Adenocarcinoma
    Hindawi Limited ; 2023
    In:  Journal of Oncology Vol. 2023 ( 2023-3-6), p. 1-9
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2023 ( 2023-3-6), p. 1-9
    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor prognosis; nearly 80% patients have regional or distant metastasis when diagnosed. Tumor microenvironment (TME) alteration and epithelial-to-mesenchymal transition (EMT) have been reported to play a key role in cancer metastasis. However, the correlation between TME and EMT was poorly studied in PDAC. This study aims to explore the correlation between EMT markers and TME alteration, mainly including macrophage polarization and PD-L1 expression change, in primary and metastatic PDAC tissues by immunohistochemistry. The results indicated that macrophage polarization was found in metastases with the number of M1 macrophages (CD86+) decreased and M2 (CD163+) increased, though PD-L1 expression did not have a significant alteration. Compared to primary tumors, E-cadherin was significantly lower, while snail was higher, while no difference was found with N-cadherin and ZEB1. Correlation analysis indicated that snail, but not ZEB1, E-cadherin, or N-cadherin, was highly correlated with macrophage polarization. To conclude, the number of CD86+ M1 macrophages was increased while CD163+ M2 macrophages decreased in metastases, with no significant alteration of PD-L1 expression compared to primary tumors. EMT markers—Snail and E-cadherin—but not ZEB1 or N-cadherin, were found to be higher/lower in metastases, which mean that EMT played an important role in PDAC metastasis. Further analysis indicated that snail was highly correlated with M1 to M2 macrophage polarization, which prompted that EMT may be one reason for macrophage polarization induced TME alteration in PDAC metastasis.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2023/7971306
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2461349-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Radio Environment Map Construction by Kriging Algorithm Based on Mobile Crowd Sensing
    Hindawi Limited ; 2019
    In:  Wireless Communications and Mobile Computing Vol. 2019 ( 2019-02-03), p. 1-12
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2019 ( 2019-02-03), p. 1-12
    Abstract: In the IoT era, 5G will enable various IoT services such as broadband access everywhere, high user and devices mobility, and connectivity of massive number of devices. Radio environment map (REM) can be applied to improve the utilization of radio resources for the access control of IoT devices by allocating them reasonable wireless spectrum resources. However, the primary problem of constructing REM is how to collect the large scale of data. Mobile crowd sensing (MCS), leveraging the smart devices carried by ordinary people to collect information, is an effective solution for collecting the radio environment information for building the REM. In this paper, we build a REM collecting prototype system based on MCS to collect the data required by the radio environment information. However, limited by the budget of the platform, it is hard to recruit enough participants to join the sensing task to collect the radio environment information. This will make the radio environment information of the sensing area incomplete, which cannot describe the radio information accuracy. Considering that the Kriging algorithm has been widely used in geostatistics principle for spatial interpolation for Kriging giving the best unbiased estimate with minimized variance, we utilize the Kriging interpolation algorithm to infer complete radio environment information from collected sample radio environment information data. The interpolation performance is analyzed based on the collected sample radio environment information data. We demonstrate experiments to analyze the Kriging interpolation algorithm interpolation results and error and compared them with the nearest neighbor (NN) and the inverse distance weighting (IDW) interpolation algorithms. Experiment results show that the Kriging algorithm can be applied to infer radio environment information data based on the collected sample data and the Kriging interpolation has the least interpolation error.
    Type of Medium: Online Resource
    ISSN: 1530-8669 , 1530-8677
    URL: Article
    DOI: 10.1155/2019/4064201
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2045240-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Unsupervised Portrait Drawing Generation for Free Styles
    Hindawi Limited ; 2023
    In:  International Journal of Intelligent Systems Vol. 2023 ( 2023-9-30), p. 1-10
    Details
    In: International Journal of Intelligent Systems, Hindawi Limited, Vol. 2023 ( 2023-9-30), p. 1-10
    Abstract: Artistic portrait drawing (APDrawing) generation has seen progress in recent years. However, due to the naturally high scarcity and artistry, it is difficult to collect large-scale labeled and paired data and generally divide drawing styles into several specific recognized categories. Existing works suffer from the limited labeled data and naive manual division of drawing styles according to the corresponding artists. They cannot adapt to the actual situations, for example, a single artist might have multiple drawing styles and APDrawings from different artists might share similar styles. In this paper, we propose to use unlabeled and unpaired data and perform the task in an unsupervised manner. Without manual division of drawing styles, we take each portrait drawing as a unique style and introduce self-supervised feature learning to learn free styles for unlabeled portrait drawings. Besides, we devise a style bank and a decoupled cycle structure to take over two main considerations in the task: generation quality and style control. Extensive experiments show that our model is more adaptable to different style inputs than state-of-the-art methods.
    Type of Medium: Online Resource
    ISSN: 1098-111X , 0884-8173
    URL: Article
    DOI: 10.1155/2023/9601261
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2002369-8
    SSG: 24,1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    A data‐driven adversarial examples recognition framework via adversarial feature genomes
    Hindawi Limited ; 2022
    In:  International Journal of Intelligent Systems Vol. 37, No. 9 ( 2022-09), p. 6438-6462
    Details
    In: International Journal of Intelligent Systems, Hindawi Limited, Vol. 37, No. 9 ( 2022-09), p. 6438-6462
    Type of Medium: Online Resource
    ISSN: 0884-8173 , 1098-111X
    URL: Issue
    URL: Article
    DOI: 10.1002/int.v37.9
    DOI: 10.1002/int.22850
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2002369-8
    SSG: 24,1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Experimental Study on High-Pressure Air Blasting Fracture for Coal and Rock Mass
    Hindawi Limited ; 2019
    In:  Advances in Civil Engineering Vol. 2019 ( 2019-03-17), p. 1-10
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2019 ( 2019-03-17), p. 1-10
    Abstract: In order to research on the issue of high-pressure gas blasting fracture deeply, a high-pressure gas blasting cracking experimental system was established; the effects of gas pressure and gas volume on the morphology of crack growth were studied; the p - t curve of pressure in the blasting process with time was obtained; and the mechanism of high-pressure gas blasting cracking was analyzed in this paper. The conclusion has shown that the stage of effect of high-pressure gas blasting on the test block includes three stages: the gas jet impact stage, the crack initiation and development stage, and the perforation fracture stage. In the design of gas pressure of 5 MPa, the experimental block only produces one longitudinal main crack. As the gas pressure increases to 7.5 MPa and 10 MPa, besides forming one longitudinal main crack, a transverse main crack is formed with further expanded 4–6 secondary cracks. In the same design of gas pressure regardless of volume size, each pressure variation stage has the same length, and the experimental block of the cracking pressure is basically the same. With the higher design pressure, the cracking pressure and the fracture pressure are higher. In the same design of gas pressure, with the larger gas volume, the fracture pressure required for the experimental block is smaller.
    Type of Medium: Online Resource
    ISSN: 1687-8086 , 1687-8094
    URL: Article
    DOI: 10.1155/2019/9613563
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2449760-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    The Role of Mitochondria in Liver Ischemia-Reperfusion Injury: From Aspects of Mitochondrial Oxidative Stress, Mitochondrial Fission, Mitochondrial Membrane Permeable Transport Pore Formation, Mitophagy, and Mitochondria-Related Protective Measures
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-7-5), p. 1-12
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-7-5), p. 1-12
    Abstract: Ischemia-reperfusion injury (IRI) has indeed been shown as a main complication of hepatectomy, liver transplantation, trauma, and hypovolemic shock. A large number of studies have confirmed that microvascular and parenchymal damage is mainly caused by reactive oxygen species (ROS), which is considered to be a major risk factor for IRI. Under normal conditions, ROS as a kind of by-product of cellular metabolism can be controlled at normal levels. However, when IRI occurs, mitochondrial oxidative phosphorylation is inhibited. In addition, oxidative respiratory chain damage leads to massive consumption of adenosine triphosphate (ATP) and large amounts of ROS. Additionally, mitochondrial dysfunction is involved in various organs and tissues in IRI. On the one hand, excessive free radicals induce mitochondrial damage, for instance, mitochondrial structure, number, function, and energy metabolism. On the other hand, the disorder of mitochondrial fusion and fission results in further reduction of the number of mitochondria so that it is not enough to clear excessive ROS, and mitochondrial structure changes to form mitochondrial membrane permeable transport pores (mPTPs), which leads to cell necrosis and apoptosis, organ failure, and metabolic dysfunction, increasing morbidity and mortality. According to the formation mechanism of IRI, various substances have been discovered or synthesized for specific targets and cell signaling pathways to inhibit or slow the damage of liver IRI to the body. Here, based on the development of this field, this review describes the role of mitochondria in liver IRI, from aspects of mitochondrial oxidative stress, mitochondrial fusion and fission, mPTP formation, and corresponding protective measures. Therefore, it may provide references for future clinical treatment and research.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/6670579
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Coinfection of parvovirus and astrovirus in gout‐affected goslings
    Hindawi Limited ; 2020
    In:  Transboundary and Emerging Diseases Vol. 67, No. 6 ( 2020-11), p. 2830-2838
    Details
    In: Transboundary and Emerging Diseases, Hindawi Limited, Vol. 67, No. 6 ( 2020-11), p. 2830-2838
    Type of Medium: Online Resource
    ISSN: 1865-1674 , 1865-1682
    URL: Issue
    URL: Article
    DOI: 10.1111/tbed.v67.6
    DOI: 10.1111/tbed.13652
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2414822-2
    SSG: 22
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Research on the Pore Evolution of Oil Shale under Different Thermal Treatment Temperatures Using NMR and FE-SEM Methods
    Hindawi Limited ; 2023
    In:  Geofluids Vol. 2023 ( 2023-5-15), p. 1-18
    Details
    In: Geofluids, Hindawi Limited, Vol. 2023 ( 2023-5-15), p. 1-18
    Abstract: Underground in situ pyrolysis for oil shale extraction is currently significant; the evolutions in microstructure, porosity, and permeability parameters are essential factors in evaluating the productivity of oil shale after pyrolysis. With the underground oil shale reservoir core, obtained from Jimsar Sag in the Junggar Basin in China, as the research object, the samples were subjected to the treatment at different high temperatures (400°C, 500°C, 600°C, and 700°C). The NMR and FE-SEM experiments on oil shale samples were conducted; the T 2 relaxation spectra, pore size distribution, and porosity and permeability variation were analyzed; and the relationships between movable fluid saturation and porosity and permeability were established, respectively. The results showed that when the thermal treatment temperature increased, the porosity and permeability of oil shale rose continuously but showed different laws. With the temperature being lower than 400°C, the porosity increased slowly, and the growth rate of porosity increased rapidly when the thermal treatment temperature was higher than 500°C. In the pyrolysis temperature range of 25°C~400°C, the growth rate of permeability was relatively slow. With the continuously enhancing temperature (500°C~600°C), the growth rate of permeability accelerated rapidly. When the temperature continued to rise (700°C), the increase of permeability began to slow down. There is a nonlinear correlation between porosity and movable fluid saturation and an approximately linear correlation between permeability and movable fluid saturation. The findings showed that 600°C was the suitable temperature for the pyrolysis of oil shale.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2023/6101374
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2045012-6
    SSG: 13
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Identification of Genes Universally Differentially Expressed in Gastric Cancer
    Hindawi Limited ; 2021
    In:  BioMed Research International Vol. 2021 ( 2021-1-21), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2021 ( 2021-1-21), p. 1-9
    Abstract: Owing to the remarkable heterogeneity of gastric cancer (GC), population-level differentially expressed genes (DEGs) identified using case-control comparison cannot indicate the dysregulated frequency of each DEG in GC. In this work, first, the individual-level DEGs were identified for 1,090 GC tissues without paired normal tissues using the RankComp method. Second, we directly compared the gene expression in a cancer tissue to that in paired normal tissue to identify individual-level DEGs among 448 paired cancer-normal gastric tissues. We found 25 DEGs to be dysregulated in more than 90% of 1,090 GC tissues and also in more than 90% of 448 GC tissues with paired normal tissues. The 25 genes were defined as universal DEGs for GC. Then, we measured 24 paired cancer-normal gastric tissues by RNA-seq to validate them further. Among the universal DEGs, 4 upregulated genes (BGN, E2F3, PLAU, and SPP1) and 1 downregulated gene (UBL3) were found to be cancer genes already documented in the COSMIC or F-Census databases. By analyzing protein-protein interaction networks, we found 12 universally upregulated genes, and we found that their 284 direct neighbor genes were significantly enriched with cancer genes and key biological pathways related to cancer, such as the MAPK signaling pathway, cell cycle, and focal adhesion. The 13 universally downregulated genes and 16 direct neighbor genes were also significantly enriched with cancer genes and pathways related to gastric acid secretion. These universal DEGs may be of special importance to GC diagnosis and treatment targets, and they may make it easier to study the molecular mechanisms underlying GC.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2021/7326853
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Research on optimization of power line carrier communication routing algorithm for low‐voltage distribution network
    Hindawi Limited ; 2021
    In:  International Transactions on Electrical Energy Systems Vol. 31, No. 11 ( 2021-11)
    Details
    In: International Transactions on Electrical Energy Systems, Hindawi Limited, Vol. 31, No. 11 ( 2021-11)
    Type of Medium: Online Resource
    ISSN: 2050-7038 , 2050-7038
    URL: Issue
    URL: Article
    DOI: 10.1002/etep.v31.11
    DOI: 10.1002/2050-7038.12656
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2702272-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...