In:
Disease Markers, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
Abstract:
Objective. To investigate the association between bone morphogenetic protein 4 (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without palate (NSCL/P) risk. Methods. Four online databases were researched and the related publications were collected. Odds ratio (OR) with 95% confidence interval (CI) was applied to assess the relationship; publication bias, metaregression, and sensitivity analysis were conducted to guarantee the strength of results. Results. Six published case-control studies were collected. Overall, no significant association between BMP4 rs17563 polymorphism and NSCL/P risk was found. It was notable that significant susceptibility on different ethnicity was observed in the stratified analysis. For Chinese population, the BMP4 rs17563 polymorphism was a significantly increased risk for NSCL/P (C versus T: OR = 1.52, 95% CI = 1.28–1.82, P 〈 0.01 , I 2 = 0 %; CC versus TT: OR = 2.58, 95% CI = 1.74–3.82, P 〈 0.01 , I 2 = 0 %; TC + CC versus TT: OR = 1.45, 95% CI = 1.14–1.84, P 〈 0.01 , I 2 = 0 %; CC versus TT + TC: OR=2.46, 95% CI = 1.46–4.14, P 〈 0.01 , I 2 = 47.0 %). On the contrary, significantly protective effects were found in Brazilian population (C versus T: OR = 0.69, 95% CI = 0.50–0.96, P = 0.03 , I 2 = 68.5 %; TC versus TT: OR = 0.52, 95% CI = 0.40–0.68, P 〈 0.01 , I 2 = 0 %; TC + CC versus TT: OR = 0.52, 95% CI = 0.35–0.78, P 〈 0.010 , I 2 = 54.4 %). Conclusion . This meta-analysis indicated that BMP4 rs17563 polymorphism could play a different role during the development of NSCL/P based on ethnicity diversity.
Type of Medium:
Online Resource
ISSN:
0278-0240
,
1875-8630
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2015
detail.hit.zdb_id:
2033253-1
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