In:
International Journal of Alzheimer's Disease, Hindawi Limited, Vol. 2011 ( 2011), p. 1-7
Abstract:
We examined the usefulness of brief neuropsychological tests and serum Aβ as a predictive test for detecting MCI/AD in older adults. Serum Aβ levels were measured from 208 subjects who were cognitively normal at enrollment and blood draw. Twenty-eight of the subjects subsequently developed MCI ( n=18 ) or AD ( n=10 ) over the follow-up period. Baseline measures of global cognition, memory, language fluency, and serum Aβ 1–42 and the ratio of serum Aβ 1–42 /Aβ 1–40 were significant predictors for future MCI/AD using Cox regression with demographic variables, APOE ε4, vascular risk factors, and specific medication as covariates. An optimal sensitivity of 85.2% and specificity of 86.5% for predicting MCI/AD was achieved using ROC analyses. Brief neuropsychological tests and measurements of Aβ 1–42 obtained via blood warrants further study as a practical and cost effective method for wide-scale screening for identifying older adults who may be at-risk for pathological cognitive decline.
Type of Medium:
Online Resource
ISSN:
2090-0252
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2011
detail.hit.zdb_id:
2573333-3
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