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  • Hindawi Limited  (11)
  • 1
    Online Resource
    Online Resource
    Fibrous Extracellular Spheroids in an Endoscopic Ultrasound-Guided Pancreatic Fine Needle Aspiration Correlating to a Gyriform Pancreatic Endocrine Tumor with a Unique Cobblestone Pavement Growth Pattern
    Hindawi Limited ; 2019
    In:  Case Reports in Pathology Vol. 2019 ( 2019-10-17), p. 1-8
    Details
    In: Case Reports in Pathology, Hindawi Limited, Vol. 2019 ( 2019-10-17), p. 1-8
    Abstract: Pancreatic neuroendocrine neoplasms (PanNENs) are uncommon tumors. Fine needle aspiration (FNA) samples from PanNENs are typically of high cellularity and lack necrosis. In cytology slides from these tumors, dyscohesive cells are usually reported with variably round to oval to plasmacytoid forms exhibiting coarsely granular chromatin and showing immunoreactivity for synaptophysin. We present an unusual, and to our knowledge not previously described, example of an FNA of a PanNEN with large extracellular fibrous spheroids containing intrinsic fibroblasts and rimmed by small to intermediate sized neoplastic epithelial cells with high nuclear cytoplasmic ratios. The cytomorphology of the PanNEN in this case was in some ways reminiscent of that expected in adenoid cystic carcinomas of the salivary glands that most often contain large extracellular globules of basement membrane material and a somewhat biphasic population of lesional cells. The cytomorphology in this case was found to correlate well with the resection specimen histomorphology of an exaggerated gyriform pattern of growth resulting in a unique cobblestone-pavement like microscopic appearance. Knowledge of this potential cytomorphology will aid the cytology community through recognition and reporting of this previously undescribed pattern in an uncommon disease.
    Type of Medium: Online Resource
    ISSN: 2090-6781 , 2090-679X
    URL: Article
    DOI: 10.1155/2019/1701072
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2648758-5
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  • 2
    Online Resource
    Online Resource
    Fibrous Variant of Hashimoto’s Thyroiditis as a Diagnostic Pitfall in Thyroid Pathology
    Hindawi Limited ; 2013
    In:  Case Reports in Endocrinology Vol. 2013 ( 2013), p. 1-5
    Details
    In: Case Reports in Endocrinology, Hindawi Limited, Vol. 2013 ( 2013), p. 1-5
    Type of Medium: Online Resource
    ISSN: 2090-6501 , 2090-651X
    URL: Article
    DOI: 10.1155/2013/308908
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2627633-1
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  • 3
    Online Resource
    Online Resource
    Outcomes of Chronic Hepatitis C Therapy in Patients Treated in Community Versus Academic Centres in Canada: Final Results of APPROACH (A Prospective Study of Peginterferon alfa-2a and Ribavirin at Academic and Community Centres in Canada)
    Hindawi Limited ; 2011
    In:  Canadian Journal of Gastroenterology Vol. 25, No. 9 ( 2011), p. 503-510
    Details
    In: Canadian Journal of Gastroenterology, Hindawi Limited, Vol. 25, No. 9 ( 2011), p. 503-510
    Abstract: BACKGROUND: In patients chronically infected with the hepatitis C virus (HCV), it is not established whether viral outcomes or health-related quality of life (HRQoL) differ between individuals treated at academic or community centres. METHODS: In the present observational study, adults with chronic HCV were treated with peginterferon alfa-2a 180 μg/week plus ribavirin at 45 Canadian centres (16 academic, 29 community). The primary efficacy end point was sustained virological response (SVR). Other outcome measures included HRQoL (assessed using the 36-item Short-Form Health Survey), heath resource use, and workplace productivity and absences within a 60-day interval. RESULTS: In treatment-naive patients infected with HCV genotype 1, significantly higher SVR rates were achieved in those treated at academic (n=54) compared with community (n=125) centres (52% versus 32% [P=0.01]), although rates of dosage reduction and treatment discontinuation were similar across settings. SVR rates among patients infected with genotype 2/3 were similar between academic (n=59) and community (n=100) centres (64% versus 67% [P=0.73] ). Following antiviral therapy, patients with genotype 1 who achieved an SVR (n=67) had significantly higher mean scores on the physical (P=0.005) and mental components of the 36-item Short-Form Health Survey (P=0.043) compared with those without an SVR (n=111). In contrast, HRQoL scores were similar in HCV genotype 2/3 patients with and without an SVR. There were no differences in workplace productivity or absences between patients with and without an SVR. The most frequently used health care resources by all patients were visits and phone calls to hepatitis nurses, and general practice or walk-in clinics. CONCLUSION: Patients infected with HCV genotype 1 achieved higher SVR rates when treated at academic rather than community centres in Canada. The reasons for this difference require additional investigation.
    Type of Medium: Online Resource
    ISSN: 0835-7900
    URL: Article
    DOI: 10.1155/2011/698780
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2011
    detail.hit.zdb_id: 2762184-4
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  • 4
    Online Resource
    Online Resource
    Spontaneous Clearance of Hepatitis C after Liver and Renal Transplantation
    Hindawi Limited ; 2009
    In:  Canadian Journal of Gastroenterology Vol. 23, No. 4 ( 2009), p. 265-267
    Details
    In: Canadian Journal of Gastroenterology, Hindawi Limited, Vol. 23, No. 4 ( 2009), p. 265-267
    Abstract: Spontaneous clearance of hepatitis C virus (HCV) is rare in immunocompromised patients, such as those who have undergone organ transplantation. It has been recognized that patients receiving liver transplantation for HCV-related disease have decreased graft and patient survival compared with those transplanted for other etiologies. There is a growing trend toward treating HCV recurrence aggressively after liver transplantation. For other organ transplant recipients with concurrent HCV, treatment is not often an option, given the high rates of graft rejection and loss secondary to interferon and its immunomodulatory effects. Although spontaneous clearance of HCV has been reported in recipients of solitary liver and renal transplants, a common factor arising in these cases has been previous exposure to interferon. To date, no reports of spontaneous clearance of HCV RNA have been reported in a multiorgan transplant recipient. A case of spontaneous clearance of HCV RNA in an immunocompromised patient, within five months of simultaneous liver and kidney retransplantation is described. Importantly, this patient had no previous exposure to interferon.
    Type of Medium: Online Resource
    ISSN: 0835-7900
    URL: Article
    DOI: 10.1155/2009/912848
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2009
    detail.hit.zdb_id: 2762184-4
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  • 5
    Online Resource
    Online Resource
    Burden of Disease and Cost of Chronic Hepatitis C Virus Infection in Canada
    Hindawi Limited ; 2014
    In:  Canadian Journal of Gastroenterology and Hepatology Vol. 28, No. 5 ( 2014), p. 243-250
    Details
    In: Canadian Journal of Gastroenterology and Hepatology, Hindawi Limited, Vol. 28, No. 5 ( 2014), p. 243-250
    Abstract: BACKGROUND: Chronic infection with hepatitis C virus (HCV) is a major cause of cirrhosis, hepatocellular carcinoma and liver transplantation. OBJECTIVE: To estimate the burden of HCV-related disease and costs from a Canadian perspective. METHODS: Using a system dynamic framework, the authors quantified the HCV-infected population, disease progression and costs in Canada between 1950 and 2035. Specifically, 36 hypothetical, ageand sex-defined cohorts were tracked to define HCV prevalence, complications and direct medical costs (excluding the cost of antivirals). Model assumptions and costs were extracted from the literature with an emphasis on Canadian data. No incremental increase in antiviral treatment over current levels was assumed, despite the future availability of potent antivirals. RESULTS: The estimated prevalence of viremic hepatitis C cases peaked in 2003 at 260,000 individuals (uncertainty interval 192,460 to 319,880), reached 251,990 (uncertainty interval 177,890 to 314,800) by 2013 and is expected to decline to 188,190 (uncertainty interval 124,330 to 247,200) in 2035. However, the prevalence of advanced liver disease is increasing. The peak annual number of patients with compensated cirrhosis (n=36,210), decompensated cirrhosis (n=3380), hepatocellular carcinoma (n=2220) and liver-related deaths (n=1880) are expected to occur between 2031 and 2035. During this interval, an estimated 32,460 HCV-infected individuals will die of liver-related causes. Total health care costs associated with HCV (excluding treatment) are expected to increase by 60% from 2013 until the peak in 2032, with the majority attributable to cirrhosis and its complications (81% in 2032 versus 56% in 2013). The lifetime cost for an individual with HCV infection in 2013 was estimated to be $64,694. CONCLUSIONS: Although the prevalence of HCV in Canada is decreasing, cases of advanced liver disease and health care costs continue to rise. These results will facilitate disease forecasting, resource planning and the development of rational management strategies for HCV in Canada.
    Type of Medium: Online Resource
    ISSN: 2291-2789 , 2291-2797
    URL: Article
    DOI: 10.1155/2014/317623
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2762184-4
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  • 6
    Online Resource
    Online Resource
    Production of clusters and thin films of nitrides, oxides and carbides by pulsed laser ablation and deposition
    Hindawi Limited ; 2004
    In:  International Journal of Photoenergy Vol. 6, No. 1 ( 2004), p. 23-28
    Details
    In: International Journal of Photoenergy, Hindawi Limited, Vol. 6, No. 1 ( 2004), p. 23-28
    Abstract: A short introduction on the principles of laser-matter interaction, material evaporation, plume formation, its reactivity with suitable gases and finally deposition are here illustrated. Experiments by mass spectrometry of formation of clusters, precursors of thin films and nanoparticles of oxides, nitrides and carbides by pulsed laser ablation (PLA) are reported. Pulsed laser ablation of targets combined with an intense atomic source produced by radiofrequency (RF), are discussed in terms of generating chemical reactions or supplying the loss of volatile components.
    Type of Medium: Online Resource
    ISSN: 1110-662X
    URL: Article
    DOI: 10.1155/S1110662X04000042
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2004
    detail.hit.zdb_id: 2028941-8
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  • 7
    Online Resource
    Online Resource
    Photoexcitation in thin films deposited on silicon substrates by reactive pulsed laser ablation
    Hindawi Limited ; 2001
    In:  International Journal of Photoenergy Vol. 3, No. 4 ( 2001), p. 213-216
    Details
    In: International Journal of Photoenergy, Hindawi Limited, Vol. 3, No. 4 ( 2001), p. 213-216
    Abstract: Reactive pulsed laser ablation is a very interesting method to deposit thin films of several materials and compounds such as oxides, nitrides, semiconductors and superconductors. This technique relies on photoablation of pure elements, or a mixture of materials, with simultaneous exposure to a reactive atmosphere. In the case of oxides, reactions between the laser vaporized metals and oxygen lead to the formation of intermediate complexes and finally to oxide thin films. The reactivity of the plume has been already studied by our group in other oxides and nitrides productions and ascertained by Time of Flight Mass Spectrometry measurements [1]. Thin films of semiconducting oxides such as In 2 O 3 , SnO 2 , and multilayers of these two compounds have been deposited by Reactive Pulsed Laser Ablation, with the aim to evaluate the behaviour of such films under variable halogen lamp illumination. Deposition of these thin films has been carried out by a frequency doubled Nd-YAG laser (wavelength = 532 nm) on Silicon (100) substrates. A comparison, among indium oxide, tin oxide, and multilayers of indium and tin oxides, has been performed. The influence of physical parameters, such as substrate temperature and oxygen pressure in the deposition chamber, has been investigated. The deposited films have been characterized by Electric Resistance measurements.
    Type of Medium: Online Resource
    ISSN: 1110-662X
    URL: Article
    DOI: 10.1155/S1110662X01000289
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2001
    detail.hit.zdb_id: 2028941-8
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  • 8
    Online Resource
    Online Resource
    Vardenafil-induced generalized urticaria
    Hindawi Limited ; 2004
    In:  Journal of Clinical Pharmacy and Therapeutics Vol. 29, No. 5 ( 2004-10), p. 483-484
    Details
    In: Journal of Clinical Pharmacy and Therapeutics, Hindawi Limited, Vol. 29, No. 5 ( 2004-10), p. 483-484
    Type of Medium: Online Resource
    ISSN: 0269-4727 , 1365-2710
    URL: Issue
    URL: Article
    DOI: 10.1111/jcp.2004.29.issue-5
    DOI: 10.1111/j.1365-2710.2004.00582.x
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2004
    detail.hit.zdb_id: 2006678-8
    SSG: 15,3
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  • 9
    Online Resource
    Online Resource
    Endoscopic Management of Biliary Complications following Liver Transplantation after Donation from Cardiac Death Donors
    Hindawi Limited ; 2012
    In:  Canadian Journal of Gastroenterology Vol. 26, No. 9 ( 2012), p. 607-610
    Details
    In: Canadian Journal of Gastroenterology, Hindawi Limited, Vol. 26, No. 9 ( 2012), p. 607-610
    Abstract: BACKGROUND Previous studies have shown a higher incidence of biliary complications following donation after cardiac death (DCD) liver transplantation compared with donation after brain death (DBD) liver transplantation. The endoscopic management of ischemic type biliary strictures in patients who have undergone DCD liver transplants needs to be characterized further. METHODS: A retrospective institutional review of all patients who underwent DCD liver transplant from January 2006 to September 2011 was performed. These patients were compared with all patients who underwent DBD liver transplantation in the same time period. A descriptive analysis of all DCD patients who developed biliary complications and their subsequent endoscopic management was also performed. RESULTS: Of the 36 patients who received DCD liver transplants, 25% developed biliary complications compared with 13% of patients who received DBD liver transplants (P=0.062). All DCD allograft recipients who developed biliary complications became symptomatic within three months of transplantation. Ischemic type biliary strictures in DCD allograft recipients included disseminated biliary strictures in two patients, biliary strictures of the hepatic duct bifurcation in three patients and biliary strictures of the donor common hepatic duct in three patients. CONCLUSIONS: There was a trend toward increasing incidence of total biliary complications in recipients of DCD liver allografts compared with those receiving DBD livers, and the rate of diffuse ischemic cholangiopathy was significantly higher. Focal ischemic type biliary strictures can be treated effectively in DCD liver transplant recipients with favourable results. Diffuse ischemic type biliary strictures in DCD liver transplant recipients ultimately requires retransplantation.
    Type of Medium: Online Resource
    ISSN: 0835-7900
    URL: Article
    DOI: 10.1155/2012/346286
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2762184-4
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  • 10
    Online Resource
    Online Resource
    Hyaluronic Acid Inhibits Polycation Induced Cellular Responses
    Hindawi Limited ; 1994
    In:  Mediators of Inflammation Vol. 3, No. 4 ( 1994), p. 287-289
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 3, No. 4 ( 1994), p. 287-289
    Abstract: Positively charged macromolecules cause a variety of pathological events through their electrostatic interaction with anionic sites present on the membrane of target cells. In the present study we have investigated the effect of hyaluronic acid, a negatively charged molecule, on rat paw oedema induced by poly-L-lysine as well as on histamine release from rat mast cells and nitric oxide formation from rabbit aorta, both induced by this polycation. The results indicate that hyaluronic acid is able to suppress these poly-L-lysine induced effects with a mechanism which possibly depends on its negative charges which may balance the effects of positively charged polycations.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/S0962935194000396
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 1994
    detail.hit.zdb_id: 2008065-7
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