GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Hindawi Limited  (18)
  • 1
    Online Resource
    Online Resource
    Analysis of Lateral Dynamic Response of Caisson Foundation in Layered Clayey Soils considering Scour-Hole Dimensions
    Hindawi Limited ; 2020
    In:  Shock and Vibration Vol. 2020 ( 2020-10-16), p. 1-11
    Details
    In: Shock and Vibration, Hindawi Limited, Vol. 2020 ( 2020-10-16), p. 1-11
    Abstract: As a cross-sea or river deep-water foundation, it is clear that the caisson foundation will be subjected to significant lateral dynamic loads due to winds or waves and suffer from scouring under its long-term effect. In order to obtain the scour effect on the dynamic response of the foundation, an analytical model describing the scour-hole effect in terms of scour depth, scour width, and slope angle was constructed. Combined with the nonlinear Winkler theory, a method for the dynamic response of the caisson foundation considering the scour-hole dimensions was proposed. Comparisons against the results from the dynamic FEM demonstrate the reliability of this method. The effects of the scour width, slope angle, and scour depth on the dynamic response of the caisson were discussed. The results show that the scour depth affects the dynamic displacement and resonant frequency of the foundation most, whereas the scour width does less and the slope angle does the least; the dynamic response of caisson can be approximated as the case of the slope angle 5° and the scour width 5B when the slope angle is less than 5° and the scour width is greater than 5B, respectively; the effects of scour width and slope angle on the dynamic response of caisson have the similar change pattern in the displacement and resonant frequency when the scour depth is different. However, the effect of amplitude on dynamic response shows a nonlinear increase trend when the scour depth is relatively large.
    Type of Medium: Online Resource
    ISSN: 1875-9203 , 1070-9622
    URL: Article
    DOI: 10.1155/2020/8827498
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2070162-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer
    Hindawi Limited ; 2017
    In:  Disease Markers Vol. 2017 ( 2017-12-28), p. 1-11
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2017 ( 2017-12-28), p. 1-11
    Abstract: Deregulation of G protein-coupled receptor kinase 3 (GRK3), which belongs to a subfamily of kinases called GRKs, acts as a promoter mechanism in some cancer types. Our study found that GRK3 was significantly overexpressed in 162 pairs of colon cancer tissues than in the matched noncancerous mucosa ( P 〈 0.01 ). Based on immunohistochemistry staining of TMAs, GRK3 was dramatically stained positive in primary colon cancer (130/180, 72.22%), whereas it was detected minimally or negative in paired normal mucosa specimens (50/180, 27.78%). Overexpression of GRK3 was closely correlated with AJCC stage ( P = 0.001 ), depth of tumor invasion ( P 〈 0.001 ), lymph node involvement ( P = 0.004 ), distant metastasis ( P = 0.016 ), and histologic differentiation ( P = 0.004 ). Overexpression of GRK3 is an independent prognostic indicator that correlates with poor survival in colon cancer patients. Consistent with this, downregulation of GRK3 exhibited decreased cell growth index, reduction in colony formation ability, elevated cell apoptosis rate, and impaired colon tumorigenicity in a xenograft model. Hence, a specific overexpression of GRK3 was observed in colon cancer, GRK3 potentially contributing to progression by mediating cancer cell proliferation and functions as a poor prognostic indicator in colon cancer and potentially represent a novel therapeutic target for the disease.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2017/1202710
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2033253-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Corrigendum to “Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer”
    Hindawi Limited ; 2020
    In:  Disease Markers Vol. 2020 ( 2020-10-14), p. 1-1
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2020 ( 2020-10-14), p. 1-1
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2020/1245645
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2033253-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Recent Advances in Wireless Communication Protocols for Internet of Things
    Hindawi Limited ; 2017
    In:  Wireless Communications and Mobile Computing Vol. 2017 ( 2017), p. 1-2
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2017 ( 2017), p. 1-2
    Type of Medium: Online Resource
    ISSN: 1530-8669 , 1530-8677
    URL: Article
    DOI: 10.1155/2017/8791485
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2045240-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    An Operational Safety Evaluation Method for Manned Transport Aircraft and Large UAV in Mixed Airspace
    Hindawi Limited ; 2021
    In:  Mathematical Problems in Engineering Vol. 2021 ( 2021-4-8), p. 1-12
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2021 ( 2021-4-8), p. 1-12
    Abstract: To improve the predictive ability in trajectory of large unmanned aerial vehicle (UAV) and the calculation performance in complicated circumstances with mixed airspace, multiple aircraft types, and joint operations, the concept of phased trajectory deviation (PTD) is introduced and a corresponding minimal interval algorithm (PTD-MI) is set up. This algorithm is capable of deriving the minimal interval between various aircraft types according to the crosswind impacts and the UAV characteristics at different flight phases and thus achieves the effective safety evaluation in airspace operation. To demonstrate the rationality and generality of the proposed algorithm, several simulation experiments are conducted. Based on the experimental results, flight procedure protection area is plotted by PTD-MI algorithm and compared with that generated by Ground-Based Augmentation System (GBAS). Results indicate that the proposed algorithm is capable of deriving a more scientific basis for airspace assignment and outperform GBAS in dealing with wide-area space problems. And, compared with GBAS, PTD-MI algorithm shows a more stable calculation performance and is easier to output the results. PTD-MI algorithm is proposed under the flight safety regulation designed by the International Civil Aviation Organization (ICAO) and designed to provide effective technical supports for the safe and normal operations of aircrafts.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2021/6636794
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2014442-8
    SSG: 11
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Analysis and Identification of Students with Financial Difficulties: A Behavioural Feature Perspective
    Hindawi Limited ; 2020
    In:  Discrete Dynamics in Nature and Society Vol. 2020 ( 2020-06-28), p. 1-18
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2020 ( 2020-06-28), p. 1-18
    Abstract: The identification of students with financial difficulties is one of the main problems in campus data research. Effective and timely identification not only provides convenience to campus administrators but also helps students who are really in financial hardship. The popular using of smart cards makes it possible to identify students with financial difficulties through big data. In this paper, we collect behavioural records from undergraduate students’ smart cards and propose five features by which to associate with students’ poverty level. Based on these features, we proposed the Apriori Balanced Algorithm (ABA) to mine the relationship of poverty level with students’ daily behaviour. Association rules show that students’ poverty level is most closely related to their academic performance, followed by consumption level, diligence level, and life regularity. Finally, we adopted the semisupervised K -means algorithm to more accurately find out students with financial difficulties. Tested by classical classification algorithms, our method has a higher identification rate, which is helpful for university administrators discover students in real financial hardship effectively.
    Type of Medium: Online Resource
    ISSN: 1026-0226 , 1607-887X
    URL: Article
    DOI: 10.1155/2020/2071025
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2033014-5
    SSG: 11
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Global Structure of Positive Solutions of a Discrete Problem with Sign-Changing Weight
    Hindawi Limited ; 2011
    In:  Discrete Dynamics in Nature and Society Vol. 2011 ( 2011), p. 1-12
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2011 ( 2011), p. 1-12
    Abstract: Let T 〉 5 be an integer, T = { 1 , 2 , … , T } . We are concerned with the global structure of positive solutions set of the discrete second-order boundary value problems Δ 2 u ( t - 1 ) + r m ( t ) f ( u ( t ) ) = 0 ,     t ∈ T ,     u ( 0 ) = u ( T + 1 ) = 0 , where r ∈ ℝ is a parameter, m : T → ℝ changes its sign and m ( t ) ≠ 0   for     t ∈ T .
    Type of Medium: Online Resource
    ISSN: 1026-0226 , 1607-887X
    URL: Article
    DOI: 10.1155/2011/624157
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2011
    detail.hit.zdb_id: 2033014-5
    SSG: 11
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Simultaneous Quantitative Determination of Six Caffeoylquinic Acids in Matricaria chamomilla L. with High-Performance Liquid Chromatography
    Hindawi Limited ; 2019
    In:  Journal of Chemistry Vol. 2019 ( 2019-11-03), p. 1-7
    Details
    In: Journal of Chemistry, Hindawi Limited, Vol. 2019 ( 2019-11-03), p. 1-7
    Abstract: A simple and effective method for the simultaneous quantitative analysis of six caffeoylquinic acids (CAs) in Matricaria chamomilla L. ( M. chamomilla ) using high-performance liquid chromatography (HPLC) with diode-array detection (DAD) was established. The chromatographic separation was performed on a Waters XBridge Shield RP C 18 column (4.6 mm × 250 mm, 5  μ m) with the mobile phase of acetonitrile (0.5% phosphoric acid) and water (0.5% phosphoric acid) using a gradient elution at a flow rate of 1.0 mL/min and UV detection at 327 nm. The correlation coefficients of all analytes were 0.999, and the results showed excellent linearity. The lower limits of detection (LLOD) and quantification (LLOQ) of all analytes fall within the range of 0.014∼0.017  μ g/mL and 0.068∼0.086  μ g/mL, respectively. The extraction recoveries of all analytes fall within the range of 100.74%∼101.55%, with relative standard deviation not exceeding 2.83%. The intraday and interday precisions fall within the range of 0.03%∼0.65% and 0.02%∼0.09%, respectively. This validated method was successfully applied to the investigation of 34 samples of M. chamomilla collected from different geographical areas. The results showed that the established method is appropriate for the analysis of the six CAs in M. chamomilla and helpful for quality assessment of capitula of M. chamomilla (CMC), whole herb of M. chamomilla (WHMC), and related herbal formulas.
    Type of Medium: Online Resource
    ISSN: 2090-9063 , 2090-9071
    URL: Article
    DOI: 10.1155/2019/4352832
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2393625-3
    detail.hit.zdb_id: 2703077-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    The Inhibitory Effects of Naringin in a Rat Model of Postoperative Intraperitoneal Adhesion Formation
    Hindawi Limited ; 2022
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2022 ( 2022-1-11), p. 1-10
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2022 ( 2022-1-11), p. 1-10
    Abstract: Background. Many attempts have been made to inhibit the formation of postoperative intraperitoneal adhesions, but the results have been discouraging. Therefore, the identification of effective preventative measures or treatments is of great importance. In this study, the substantial potential of naringin (NG) to reduce peritoneal adhesions was validated in a rat model. Materials and Methods. A rat peritoneal adhesion model was established by abrasion of the cecum and its opposite intraperitoneal region under aseptic surgical conditions. After the operation, three groups of NG-treated rats were given 2 mL of NG by gavage at different concentrations (40, 60, or 80 mg/kg/d). The sham, control, and hyaluronan (HA) groups were given equal volumes of normal saline daily. On the 8th day, all rats were sacrificed 30 min after the administration of an activated carbon solution (10 mL/kg) by oral gavage. Intraperitoneal adhesion formation was adequately evaluated by necropsy, hematoxylin and eosin (HE) staining, Sirius red staining, immunofluorescence staining, enzyme-linked immunosorbent assays, and reactive oxygen species (ROS) probes. The gastrointestinal dynamics of the rats were assessed on the basis of a small intestinal charcoal powder propulsion test and the detection of motilin and gastrin levels in serum. Results. Intraperitoneal adhesions were markedly reduced in the group of rats receiving high-dose NG. Compared with the control group, the high-dose NG group showed clear reductions in inflammatory reactions, oxidative stress, collagen deposition, and fibroblast formation in the adhesion tissue and enhanced gastrointestinal dynamics ( P   〈  0.05). Conclusion. NG alleviated the severity of intraperitoneal adhesions in a rat model by reducing inflammation, oxidative stress, collagen deposition, and fibroblast formation, highlighting the potential of NG as a drug candidate to prevent postoperative peritoneal adhesion formation.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2022/5331537
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2148302-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    CCL3 Promotes Proliferation of Colorectal Cancer Related with TRAF6/NF-κB Molecular Pathway
    Hindawi Limited ; 2022
    In:  Contrast Media & Molecular Imaging Vol. 2022 ( 2022-7-12), p. 1-19
    Details
    In: Contrast Media & Molecular Imaging, Hindawi Limited, Vol. 2022 ( 2022-7-12), p. 1-19
    Abstract: Chemokine C-C motif chemokine ligand 3 (CCL3) plays an important role in the invasion and metastasis of malignant tumors. For developing new therapeutic targets and antitumor drugs, the effect of chemokine CCL3 and the related cytokine network on colorectal cancer should be investigated. This study used cell, tissue, and animal experiments to prove that CCL3 is highly expressed in colorectal cancer and confirmed that CCL3 can promote the proliferation of cancer cells, and its expression is closely related to TRAF6/NF-κB molecular pathway. In addition, protein chip technology was used to examine colorectal cancer tissue samples and identify the key factors of chemokine CCL3 and the toll-like receptors/nuclear factor-κB (TLR/NF-κB) pathway in cancer and metastatic lymph nodes. Furthermore, the lentiviral vector technology was employed for transfection to construct interference and overexpression cell lines. The experimental results reveal the mechanism of CCL3 and TNF receptor-associated factor 6 (TRAF6)/NF-κB pathway-related factors and their effects on the proliferation of colon cancer cells. Finally, the expression and significance of CCL3 in colorectal cancer tissues and its correlation with clinical pathology were studied by immunohistochemistry. Also, the results confirmed that CCL3 and C-C motif chemokine receptor 5 (CCR5) were expressed in adjacent tissues, colorectal cancer tissues, and metastatic cancer. The expression level was correlated with the clinical stage and nerve invasion. The expression of chemokine CCL3 and receptor CCR5 was positively correlated with the expression of TRAF6 and NF-κB and could promote the proliferation, invasion, and migration of colorectal cancer cells through TRAF6 and NF-κB.
    Type of Medium: Online Resource
    ISSN: 1555-4317 , 1555-4309
    URL: Article
    DOI: 10.1155/2022/2387192
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2222967-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...