In:
The Scientific World JOURNAL, Hindawi Limited, Vol. 10 ( 2010), p. 2254-2264
Abstract:
An increase in intracellular Ca 2+ concentration is one of the major initial steps in B-cell activation that occurs within minutes after antigen receptor (BCR) engagement. In recent years, significant advances have been made in characterizing molecular mechanisms of Ca 2+ signaling in lymphocytes, although the majority of work was done on T cells. This mini-review discusses several underexplored areas of Ca 2+ signaling in B cells: (1) Ca 2+ signaling in immune synapse and multifaceted Ca 2+ responses within a single cell, (2) source of Ca 2+ involved in Ca 2+ -dependent protein phosphorylation events and the role of store-operated influx, (3) role of BCR coreceptors in Ca 2+ signaling, and (4) Ca 2+ signaling and maintenance of B-cell tolerance and clinical significance of Ca 2+ signaling alterations.
Type of Medium:
Online Resource
ISSN:
1537-744X
DOI:
10.1100/tsw.2010.219
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2010
detail.hit.zdb_id:
2075968-X
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