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  • Hindawi Limited  (22)
  • 1
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    Online Resource
    Comparison of the Efficacy between Conventional Moxibustion and Smoke-Free Moxibustion on Knee Osteoarthritis: A Randomized Controlled Trial
    Hindawi Limited ; 2019
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2019 ( 2019-03-14), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-03-14), p. 1-8
    Abstract: Objective . The aim of this study was to investigate the difference of efficacy between conventional moxibustion (CM) and smoke-free moxibustion (SM) for patients with osteoarthritis of the knee (KOA). Methods . This is a multicentre, randomized, single blinded, parallel-group clinical trial. Patients with KOA were randomly allocated to CM group (69) and SM group (69) in 7 hospitals of China. Moxibustion treatment in 12 sessions over 4 weeks was administrated at 3 acupuncture points (EX-LE4, ST35, and ST36). Patients completed standard questionnaires at baseline and after 2 weeks, 4 weeks, 8 weeks, and 12 weeks. The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) from the baseline to 4 weeks. The secondary outcomes include Visual Analogue Scale (VAS) and Patient Global Assessment score (PGA). Results . Analyses showed that the WOMAC score improved in pain (95% CI,-0.1[-1.2 to 0.9], p=0.76), stiffness (95% CI,-0.1 [-0.5 to 0.3] , p=0.71), and function (95% CI, 2.2 [-1.3 to 5.8], p=0.22) compared between the two groups at 4 weeks, as well as the VAS score (95% CI,0.1 [-0.3 to 0.6] , p=0.60). Similar results presented at 8 and 12 weeks. No statistically significant difference was observed between CM and SM groups for outcome measurements. Conclusions . It suggested that smoke generated during moxibustion treatment does not affect the efficacy of moxibustion in the treatment of KOA, which should be taken into account to be removed for the sake of reducing environmental pollution or moxa smoke exposure of acupuncturists or patients. This trial is registered with Clinical Trials.gov, NCT02772055 .
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2019/1291947
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2148302-4
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  • 2
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    The Time Course of Perceptual Closure of Incomplete Visual Objects: An Event-Related Potential Study
    Hindawi Limited ; 2020
    In:  Computational Intelligence and Neuroscience Vol. 2020 ( 2020-10-6), p. 1-7
    Details
    In: Computational Intelligence and Neuroscience, Hindawi Limited, Vol. 2020 ( 2020-10-6), p. 1-7
    Abstract: Perceptual organization is an important part of visual and auditory information processing. In the case of visual occlusion, whether the loss of information in images could be recovered and thus perceptually closed affects object recognition. In particular, many elderly subjects have defects in object recognition ability, which may be closely related to the abnormalities of perceptual functions. This phenomenon even can be observed in the early stage of dementia. Therefore, studying the neural mechanism of perceptual closure and its relationship with sensory and cognitive processing is important for understanding how the human brain recognizes objects, inspiring the development of neuromorphic intelligent algorithms of object recognition. In this study, a new experiment was designed to explore the realistic process of perceptual closure under occlusion and intact conditions of faces and building. The analysis of the differences in ERP components P1, N1, and Ncl indicated that the subjective awareness of perceptual closure mainly occurs in Ncl, but incomplete information has been processed and showed different manners compared to complete stimuli in N170 for facial materials. Although occluded, faces, but not buildings, still maintain the specificity of perceptual processing. The Ncl by faces and buildings did not show significant differences in both amplitude and latency, suggesting a “completing” process regardless of categorical features.
    Type of Medium: Online Resource
    ISSN: 1687-5273 , 1687-5265
    URL: Article
    DOI: 10.1155/2020/8825197
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2388208-6
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  • 3
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    Nonviral Gene Targeting at rDNA Locus of Human Mesenchymal Stem Cells
    Hindawi Limited ; 2013
    In:  BioMed Research International Vol. 2013 ( 2013), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2013 ( 2013), p. 1-10
    Abstract: Background . Genetic modification, such as the addition of exogenous genes to the MSC genome, is crucial to their use as cellular vehicles. Due to the risks associated with viral vectors such as insertional mutagenesis, the safer nonviral vectors have drawn a great deal of attention. Methods . VEGF, bFGF, vitamin C, and insulin-transferrin-selenium-X were supplemented in the MSC culture medium. The cells’ proliferation and survival capacity was measured by MTT, determination of the cumulative number of cells, and a colony-forming efficiency assay. The plasmid pHr2-NL was constructed and nucleofected into MSCs. The recombinants were selected using G418 and characterized using PCR and Southern blotting. Results . BFGF is critical to MSC growth and it acted synergistically with vitamin C, VEGF, and ITS-X, causing the cells to expand significantly. The neomycin gene was targeted to the rDNA locus of human MSCs using a nonviral human ribosomal targeting vector. The recombinant MSCs retained multipotential differentiation capacity, typical levels of hMSC surface marker expression, and a normal karyotype, and none were tumorigenic in nude mice. Conclusions . Exogenous genes can be targeted to the rDNA locus of human MSCs while maintaining the characteristics of MSCs. This is the first nonviral gene targeting of hMSCs.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2013/135189
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2698540-8
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  • 4
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    An SIW filtering antenna array with quasi-elliptic gain response based on intercavity bypass coupling : An SIW Filtering Antenna Array
    Hindawi Limited ; 2016
    In:  International Journal of RF and Microwave Computer-Aided Engineering Vol. 26, No. 3 ( 2016-03), p. 191-198
    Details
    In: International Journal of RF and Microwave Computer-Aided Engineering, Hindawi Limited, Vol. 26, No. 3 ( 2016-03), p. 191-198
    Type of Medium: Online Resource
    ISSN: 1096-4290
    URL: Issue
    URL: Article
    DOI: 10.1002/mmce.v26.3
    DOI: 10.1002/mmce.20952
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2007326-4
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  • 5
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    Effect of dietary l ‐carnitine on growth performance and antioxidant response in Amur minnow ( Phoxinus lagowskii Dybowskii)
    Hindawi Limited ; 2019
    In:  Aquaculture Nutrition Vol. 25, No. 4 ( 2019-08), p. 749-760
    Details
    In: Aquaculture Nutrition, Hindawi Limited, Vol. 25, No. 4 ( 2019-08), p. 749-760
    Type of Medium: Online Resource
    ISSN: 1353-5773 , 1365-2095
    URL: Issue
    URL: Article
    DOI: 10.1111/anu.2019.25.issue-4
    DOI: 10.1111/anu.12892
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2019893-0
    SSG: 21,3
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  • 6
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    Hepatoprotective Effect and Potential Mechanism of Aqueous Extract from Phyllanthus emblica on Carbon-Tetrachloride-Induced Liver Fibrosis in Rats
    Hindawi Limited ; 2021
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2021 ( 2021-10-19), p. 1-12
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2021 ( 2021-10-19), p. 1-12
    Abstract: Liver fibrosis is a pathological variation caused by almost all chronic liver injuries. As an edible and medicinal natural resource, Phyllanthus emblica (PE) has been reported to possess hepatoprotective, antioxidant, and anti-inflammatory activities and may have an ameliorating effect on hepatic fibrosis. To investigate the protective effect of the aqueous extract of PE (AEPE) against liver fibrosis and to uncover its related mechanisms, the chemical profile of AEPE was characterized by high performance liquid chromatography (HPLC) and sulfuric acid-phenol method. Ameliorative effects of different doses of AEPE were investigated in carbon-tetrachloride- (CCl4-) induced liver fibrosis rats by analyzing biochemical markers, morphologic pathology, and related proteins expression in liver tissue. The results indicated that AEPE (1.8, 3.6 g/kg) could significantly reduce levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), collagen IV (Col IV), type III precollagen (PCIII), hyaluronic acid (HA), laminin (LN), malondialdehyde (MDA), nitric oxide (NO), protein carbonyl (PC), tumor necrosis factor-α(TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and hydroxyproline (Hyp) and increase the levels of superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT). Hematoxylin-eosin (H & E), Sirius red, and Masson staining showed AEPE-treated improved fibrotic lesions and inflammatory cell infiltration. Meanwhile, AEPE treatment also significantly downregulates the expression of α-smooth muscle actin (α-SMA) and transforming growth factor-β1 (TGF-β1) in the liver tissue and serum, respectively. In conclusion, AEPE possesses curative efficacy against liver fibrosis through its antioxidant, anti-inflammatory, and antifibrotic effects.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2021/5345821
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2148302-4
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  • 7
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    A Context-Aware Assisted WiFi Positioning Method
    Hindawi Limited ; 2021
    In:  Wireless Communications and Mobile Computing Vol. 2021 ( 2021-8-23), p. 1-9
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2021 ( 2021-8-23), p. 1-9
    Abstract: With the convenience brought by Location-based service (LBS), users’ requirements for indoor positioning accuracy are getting higher than ever. However, many traditional indoor WiFi positioning methods may result in limited positioning accuracy because of the limited information of Received Signal Strength (RSS) of WiFi signal. This paper proposed a context-aware assisted WiFi positioning method (CAA-PM), which uses context information (i.e., light and sound) to assist WiFi-RSS for indoor positioning and uses an improved variable weight dynamic KNN fingerprint identification algorithm (VWD-KNN). Finally, experiments are carried out by using the dataset collected in both a closed laboratory and an open long corridor, and it is shown that the proposed algorithm substantially improves the localization accuracy comparing with other three classical algorithms.
    Type of Medium: Online Resource
    ISSN: 1530-8677 , 1530-8669
    URL: Article
    DOI: 10.1155/2021/6683456
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045240-8
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  • 8
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    Identification of Crucial lncRNAs for Luminal A Breast Cancer through RNA Sequencing
    Hindawi Limited ; 2022
    In:  International Journal of Endocrinology Vol. 2022 ( 2022-6-2), p. 1-14
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2022 ( 2022-6-2), p. 1-14
    Abstract: Background. The growing body of evidence indicates aberrant expression of long noncoding RNAs (lncRNAs) in breast cancer. Nevertheless, a few studies have focused on identifying key lncRNAs for patients with luminal A breast cancer. In our study, we tried to find key lncRNAs and mRNAs in luminal A breast cancer. Methods. RNA sequencing was performed to identify differentially expressed mRNAs (DEmRNAs) and differentially expressed lncRNAs (DElncRNAs) in luminal A breast cancer. The protein-protein interaction (PPI), DElncRNA-DEmRNA coexpression, DElncRNA-nearby DEmRNA interaction networks, and functional annotation were performed to uncover the function of DEmRNAs. Online databases were used to validate the RNA sequencing result. The diagnostic value of candidate mRNAs was evaluated by receiver operating characteristic (ROC) curve analysis. Results. A total number of 1451 DEmRNAs and 272 DElncRNAs were identified. Several hub proteins were identified in the PPI network, including TUBB3, HIST2H3C, MCM2, MYOC, NEK2, LIPE, FN1, FOXJ1, S100A7, and DLK1. In the DElncRNA-DEmRNA coexpression, some hub lncRNAs were identified, including AP001528.2, LINC00968, LINC02202, TRHDE-AS1, LINC01140, AL354707.1, AC097534.1, MIR222HG, and AL662844.4. The mRNA expression result of TFF1, COL10A1, LEP, PLIN1, PGM5-AS1, and TRHDE-AD1 in the GSE98793 was consistent with the RNA sequencing result. The protein expression results of TUBB3, MCM2, MYOC, FN1, S100A7, and TFF1 were consistent with the mRNA expression result COL10A1, LEP, PLIN1, PGM5-AS1, and TRHDE-AD1 were capable of discriminating luminal A breast cancer and normal controls. Four lncRNA-nearby and coexpressed mRNA pairs of HOXC-AS3-HOXC10, AC020907.2-FXYD1, AC026461.1-MT1X, and AC132217.1-IGF2 were identified. AMPK (involved LIPE and LEP) and PPAR (involved PLIN1) were two significantly enriched pathways in luminal A breast cancer. Conclusion. This study could be helpful in unraveling the pathogenesis and providing novel therapeutic strategies for luminal A breast cancer.
    Type of Medium: Online Resource
    ISSN: 1687-8345 , 1687-8337
    URL: Article
    DOI: 10.1155/2022/6577942
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2502951-4
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  • 9
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    Multiobjective Location Model Design Based on Government Subsidy in the Recycling of CDW
    Hindawi Limited ; 2017
    In:  Mathematical Problems in Engineering Vol. 2017 ( 2017), p. 1-9
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2017 ( 2017), p. 1-9
    Abstract: With the generation of a large amount of construction and demolition waste (CDW), many scholars have recently paid more attention to the recycling of CDW. In this paper, we design a classification recycling method based on the degree of CDW availability in the recycling of CDW. Considering the important role of the government in reverse logistics, a model of reverse logistics network based on the trade-off between cost and recycling rate is put forward, which is subject to government subsidy. The model includes the location of classification processing center and ensures the best route of transportation. Then, the improved particle swarm optimization algorithm is applied to solve the model to get Pareto frontier by transforming it into a multiobjective integer-programming problem. As a case study, the results of the statistical modeling used in this study indicate the feasibility of the model. Finally, according to the sensitivity analysis of government’s subsidy, we evaluate the effectiveness of this program and its applicability.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2017/9081628
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 10
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    Patients with Dipper and Nondipper High-Normal Blood Pressure Were Associated with Left Ventricular Mass
    Hindawi Limited ; 2021
    In:  International Journal of Hypertension Vol. 2021 ( 2021-12-21), p. 1-5
    Details
    In: International Journal of Hypertension, Hindawi Limited, Vol. 2021 ( 2021-12-21), p. 1-5
    Abstract: Purpose. High-normal blood pressure has been suggested to associate with target organ damage and higher left ventricular mass index (LVMI). Our aim is to find the association between people with high-normal blood pressure and their left ventricular mass index. Materials and Methods. Given a total of 181 people with office blood pressure, 24-hour ambulatory blood pressure monitoring, 35 of them are normotensive (BP  〈  130/85 mm Hg), and 146 people with high-normal blood pressure (BP 130–139/85–89 mm Hg), divide the high-normal blood pressure group into dipper and nondipper according to their ABPM in 24 hours. All of them were performed with echocardiography to calculate LVMI. Results. After adjusting for potential confounding factors, mean systolic blood pressure (BP) of the nondipper group is (119 + 9) mmHg in 24 h, which is significantly higher ( p   〈  0.05) than in the dipper group (116 + 11) mmHg, indicating the mean systolic BP is associated with the dipper type ( p   〈  0.05); furthermore, the higher nocturnal blood pressure is associated with the nondipper group significantly ( p   〈  0.05), and LVMI ((121 ± 11) g/m2) of the nondipper group is also significantly higher than in the dipper group’s LVMI ((108 ± 12) g/m2) ( p   〈  0.05). The multivariate linear regression analyses revealed significant and independent associations of LVMI with these factors: triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), and coefficient of variation of systolic and diastolic blood pressure in 24 hours. Conclusion. After multiple relevant clinical confounding factors were adjusted, patients with dipper and nondipper high-normal blood pressure had higher LVMI. Abnormalities in circadian blood pressure variability may be associated with the left ventricular hypertrophy.
    Type of Medium: Online Resource
    ISSN: 2090-0392 , 2090-0384
    URL: Article
    DOI: 10.1155/2021/6946418
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2573167-1
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