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  • Hindawi Limited  (17)
  • 1
    Online Resource
    Online Resource
    Critical appraisal of the quality and content of clinical practice guidelines for pneumocystis jiroveci pneumonia (PJP) prophylaxis using the AGREE II instrument
    Hindawi Limited ; 2020
    In:  Journal of Clinical Pharmacy and Therapeutics Vol. 45, No. 6 ( 2020-12), p. 1325-1333
    Details
    In: Journal of Clinical Pharmacy and Therapeutics, Hindawi Limited, Vol. 45, No. 6 ( 2020-12), p. 1325-1333
    Type of Medium: Online Resource
    ISSN: 0269-4727 , 1365-2710
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpt.v45.6
    DOI: 10.1111/jcpt.13213
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2006678-8
    SSG: 15,3
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  • 2
    Online Resource
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    Pyroptosis-Related Signature Predicts the Progression of Ulcerative Colitis and Colitis-Associated Colorectal Cancer as well as the Anti-TNF Therapeutic Response
    Hindawi Limited ; 2023
    In:  Journal of Immunology Research Vol. 2023 ( 2023-1-27), p. 1-19
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2023 ( 2023-1-27), p. 1-19
    Abstract: Ulcerative colitis (UC) is a complex intestinal inflammation with an increasing risk of colitis-associated colorectal cancer (CAC). However, the pathogenesis is still unclear between active UC and inactive UC. Recently, it has been reported that pyroptosis-related genes (PRGs) are closely associated with inflammatory disease activity. Nevertheless, the specific roles of PRGs in the progression and treatment of UC and CAC remain unclear. In this study, we identified 30 differentially expressed PRGs based on the immune landscape of active and inactive UC samples. Meanwhile, weighted gene coexpression network analysis was applied to explore important genes associated with active UC. By intersecting with the differentially expressed PRGs, CASP5, GBP1, GZMB, IL1B, and IRF1 were selected as key PRGs to construct a pyroptosis-related signature (PR-signature). Then, logistic regression analysis was performed to validate the PR-signature and establish a pyroptosis-related score (PR-Score). We demonstrated that PR-Score had a powerful ability to distinguish active UC from inactive UC in multiple datasets. Besides, PR-Score was positively correlated with immune cell infiltration and inflammatory microenvironment in UC. Lower PR-Score was associated with a better response to anti-TNF therapy for patients with UC. Additionally, high-PR-Score was found to suppress CAC and improve the survival outcomes of patients with colorectal cancer. Finally, the levels of the PR-signature genes were validated both in vitro and in vivo. These findings can improve our understanding of PRGs in UC and provide new markers for predicting the occurrence of active UC or CAC and the treatment of UC.
    Type of Medium: Online Resource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2023/7040113
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2817541-4
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  • 3
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    Online Resource
    Exploring the Potential Mechanism of Xiaokui Jiedu Decoction for Ulcerative Colitis Based on Network Pharmacology and Molecular Docking
    Hindawi Limited ; 2021
    In:  Journal of Healthcare Engineering Vol. 2021 ( 2021-10-25), p. 1-11
    Details
    In: Journal of Healthcare Engineering, Hindawi Limited, Vol. 2021 ( 2021-10-25), p. 1-11
    Abstract: Introduction. Network pharmacology is in line with the holistic characteristics of TCM and can be used to elucidate the complex network of interactions between disease-specific genes and compounds in TCM herbal medicines. Here, we investigate the pharmacological mechanism of Xiaokui Jiedu decoction (XJD) for the treatment of ulcerative colitis (UC). Methods. The Computational Systems Biology Laboratory Platform (TCMSP) database was searched and screened for the active ingredients of all drugs in XJD. The Uniport database was used to retrieve possible gene targets for the therapeutic effects of XJD. GeneCards, PharmGKB, TTD, and OMIM databases were used to retrieve XJD-related gene targets. A herb-compound-protein network and a protein-protein interaction (PPI) network were constructed, and hub genes were screened for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Finally, molecular docking was performed to validate the interrelationship between disease target proteins and active drug components. Results. A total of 135 XJD potential action targets, 5097 UC-related gene targets, and 103 XJD-UC intersection gene targets were screened. The hub gene targets of XJD that exert therapeutic effects on UC are RB1, MAPK1, TP53, JUN, NR3C1, MAPK3, and ESR1. GO enrichment analysis showed 741 biofunctional enrichments, and KEGG enrichment analysis showed 124 related pathway enrichments. Molecular docking showed that the active components of XJD (β-sitosterol, kaempferol, formononetin, quercetin, and luteolin) showed good binding activities to five of the six hub gene targets. Discussion. The active ingredients of XJD (β-sitosterol, kaempferol, formononetin, quercetin, and luteolin) may regulate the inflammatory and oxidative stress-related pathways of colon cells during the course of UC by binding to the hub gene targets. This may be a potential mechanism of XJD in the treatment of UC.
    Type of Medium: Online Resource
    ISSN: 2040-2309 , 2040-2295
    URL: Article
    DOI: 10.1155/2021/1536337
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2545054-2
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  • 4
    Online Resource
    Online Resource
    Characterization of drug‐related problems and associated factors in ambulatory patients in China
    Hindawi Limited ; 2020
    In:  Journal of Clinical Pharmacy and Therapeutics Vol. 45, No. 5 ( 2020-10), p. 1058-1065
    Details
    In: Journal of Clinical Pharmacy and Therapeutics, Hindawi Limited, Vol. 45, No. 5 ( 2020-10), p. 1058-1065
    Type of Medium: Online Resource
    ISSN: 0269-4727 , 1365-2710
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpt.v45.5
    DOI: 10.1111/jcpt.13161
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2006678-8
    SSG: 15,3
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  • 5
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    Self‐management among type 2 diabetes patients via the WeChat application: A systematic review and meta‐analysis
    Hindawi Limited ; 2021
    In:  Journal of Clinical Pharmacy and Therapeutics Vol. 46, No. 1 ( 2021-02), p. 4-16
    Details
    In: Journal of Clinical Pharmacy and Therapeutics, Hindawi Limited, Vol. 46, No. 1 ( 2021-02), p. 4-16
    Type of Medium: Online Resource
    ISSN: 0269-4727 , 1365-2710
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpt.v46.1
    DOI: 10.1111/jcpt.13264
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2006678-8
    SSG: 15,3
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  • 6
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    Online Resource
    Research on Speech Enhancement Algorithm of Multiresolution Cochleagram Based on Skip Connection Deep Neural Network
    Hindawi Limited ; 2022
    In:  Journal of Sensors Vol. 2022 ( 2022-5-9), p. 1-15
    Details
    In: Journal of Sensors, Hindawi Limited, Vol. 2022 ( 2022-5-9), p. 1-15
    Abstract: The speech enhancement effect of traditional deep learning algorithms is not ideal under low signal-to-noise ratios (SNR). Skip connections-deep neural network (Skip-DNN) improves the traditional deep neural network (DNN) by adding skip connections between each layer of the neural network to solve the degradation problem of DNN. In this paper, the Multiresolution Cochleagram (MRCG) features in the gammachirp transform domain are denoised to obtain the improved MRCG (I-MRCG). The noise reduction method adopts the Minimum Mean-Square Error Short-Time Spectral Amplitude Estimator (MMSE-STSA) and takes I-MRCG as the input feature and Skip-DNN as the training network to improve the speech enhancement effect of the model. This paper also proposes an improved source-to-distortion ratio (SDR) loss function. When the loss function uses the improved SDR, it will improve the performance of Skip-DNN speech enhancement model. The experiments in this paper are performed on the Edinburgh dataset. When using I-MRCG as the input feature of Skip-DNN, the average perceptual evaluation of speech quality (PESQ) is 2.9137, and the average short-time objective intelligibility (STOI) is 0.8515. Compared with MRCG as Skip-DNN input features, the improvements are 0.91% and 0.71%, respectively. When the improved SDR is used as the loss function of the speech model, the average PESQ is 2.9699 and the average STOI is 0.8547. Compared with other loss functions, the improved SDR has a better enhancement effect when used as the loss function of the speech enhancement model.
    Type of Medium: Online Resource
    ISSN: 1687-7268 , 1687-725X
    URL: Article
    DOI: 10.1155/2022/5208372
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2397931-8
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  • 7
    Online Resource
    Online Resource
    Adjuvant Therapy of Oral Chinese Herbal Medicine for Menopausal Depression: A Systematic Review and Meta-Analysis
    Hindawi Limited ; 2018
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2018 ( 2018-06-11), p. 1-14
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2018 ( 2018-06-11), p. 1-14
    Abstract: Objective. The aim of this meta-analysis was to evaluate the effectiveness of oral Chinese herbal medicine (OCHM) combined with pharmacotherapy for menopausal depression. Methods. The electronic databases were searched from their inception to December 25, 2016, comprising PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure (CNKI), Wanfang database, and Chinese Biomedical (CBM) database. Randomized controlled trials investigating the effectiveness of OCHM combined with pharmacotherapy for the people with menopausal depression were eligible. Risk of bias was evaluated according to the Cochrane handbook. Meta-analyses were performed to pool the effect size. Heterogeneity and publication bias were also examined. Results . Twenty-two RCTs with 1770 participants were included in the review. None of the studies used placebo as the control and the risk of bias was high in blinding the participants and personnel. Overall, the meta-analysis demonstrated that adjuvant therapy of OCHM was effective in reducing the Hamilton Rating Scale for Depression (HAMD) scores compared to pharmacotherapy (MD = −3.75; 95% CI = −5.22, −2.29; P 〈 0.00001). The meta-analysis also suggested that OCHM adjuvant therapy for menopausal depression was superior to pharmacotherapy in terms of response rate of reducing HAMD scores (RR = 1.17; 95% CI = 1.10, 1.25; I2 = 55%). Conclusions . OCHM may provide additional effectiveness to pharmacotherapy for the people with menopausal depression. RCTs including the placebo control were required to further determine the additional efficacy of OCHM for menopausal depression.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2018/7420394
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2148302-4
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  • 8
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    Ethyl Acetate Extract of Asclepias curassavica Induced Apoptosis in Human Cancer Cells via Activating p38 and JNK MAPK Signaling Pathways
    Hindawi Limited ; 2019
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2019 ( 2019-06-09), p. 1-9
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-06-09), p. 1-9
    Abstract: Background. Asclepias curassavica L . ( Asclepiadaceae ), as a traditional medicinal plant, is used as treatment for tumors in traditional Chinese and Indian medical practice. However, its underlying molecular mechanisms remain largely unresolved. The current study investigated its antitumor activity and the underlying molecular mechanisms. Method. Cell viability was detected by a real-time cell analysis system and MTT assay. Antitumor effect of ethyl acetate extract of Asclepias curassavica (EAAC) on NIC-H1975 tumors in vivo was assessed in BALB/c-nu/nu mouse. Apoptosis was measured using Hoechst33342 staining and Annexin V/PI-staining. Apoptosis-related proteins and MAPK signaling pathways were analyzed based on Western blot assay. Results. EAAC exhibited the highest cytotoxic activity in vitro than other polar parts. Meanwhile, EAAC could inhibit sensitive cell line NIC-H1975 proliferation in a concentration-dependent and time-dependent manner. Furthermore, EAAC had a significant inhibitory effect on NIC-H1975 tumor growth in BALB/c-nu/nu mouse. NIC-H1975 cells showed obvious apoptosis characteristics after EAAC treatment. Fas, caspase family members caspase 3, caspase 9, and caspase 8 showed dose-dependent induction by EAAC treatment, with increasing PARP cleavage. Additionally, EAAC significantly downregulated antiapoptotic proteins Bcl-2, XIAP, survivin, and Mcl-1 and upregulated proapoptosis proteins Bak, Bax, as well as activation of p38 and JNK MAPK signaling pathways. Moreover, inhibiting p38 and JNK MAPK by pharmacological inhibitors abrogated EAAC-induced apoptosis. Conclusion. Our data indicated that EAAC exerted potent antitumor effect both in vitro and in vivo by triggering the apoptotic pathway.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2019/9076269
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2148302-4
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  • 9
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    Modified Whale Optimization Algorithm for Solar Cell and PV Module Parameter Identification
    Hindawi Limited ; 2021
    In:  Complexity Vol. 2021 ( 2021-2-22), p. 1-23
    Details
    In: Complexity, Hindawi Limited, Vol. 2021 ( 2021-2-22), p. 1-23
    Abstract: The whale optimization algorithm (WOA) is a powerful swarm intelligence method which has been widely used in various fields such as parameter identification of solar cells and PV modules. In order to better balance the exploration and exploitation of WOA, we propose a novel modified WOA (MWOA) in which both the mutation strategy based on Levy flight and a local search mechanism of pattern search are introduced. On the one hand, Levy flight can make the algorithm get rid of the local optimum and avoid stagnation; thus, it is able to prevent the algorithm from losing diversity and to increase the global search capability. On the other hand, pattern search, a direct search method, has not only high convergence rate but also good stability, which can boost the local optimization ability of the WOA. Therefore, the combination of these two mechanisms can greatly improve the capability of WOA to obtain the best solution. In addition, MWOA may be employed to estimate parameters in single diode model (SDM), double diode model (DDM), and PV modules and to identify unknown parameters of two different types of PV modules under diverse light irradiance and temperature conditions. The analytical results demonstrate the validity and the practicality of MWOA for estimating parameters of solar cells and PV modules.
    Type of Medium: Online Resource
    ISSN: 1099-0526 , 1076-2787
    URL: Article
    DOI: 10.1155/2021/8878686
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2004607-8
    SSG: 11
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  • 10
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    AP1000 Shield Building Dynamic Response for Different Water Levels of PCCWST Subjected to Seismic Loading considering FSI
    Hindawi Limited ; 2015
    In:  Science and Technology of Nuclear Installations Vol. 2015 ( 2015), p. 1-8
    Details
    In: Science and Technology of Nuclear Installations, Hindawi Limited, Vol. 2015 ( 2015), p. 1-8
    Abstract: Huge water storage tank on the top of many buildings may affect the safety of the structure caused by fluid-structure interaction (FSI) under the earthquake. AP1000 passive containment cooling system water storage tank (PCCWST) placed at the top of shield building is a key component to ensure the safety of nuclear facilities. Under seismic loading, water will impact the wall of PCCWST, which may pose a threat to the integrity of the shield building. In the present study, an FE model of AP1000 shield building is built for the modal and transient seismic analysis considering the FSI. Six different water levels in PCCWST were discussed by comparing the modal frequency, seismic acceleration response, and von Mises stress distribution. The results show the maximum von Mises stress emerges at the joint of shield building roof and water around the air inlet. However, the maximum von Mises stress is below the yield strength of reinforced concrete. The results may provide a reference for design of the AP1000 and CAP1400 in the future.
    Type of Medium: Online Resource
    ISSN: 1687-6075 , 1687-6083
    URL: Article
    DOI: 10.1155/2015/840507
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2397941-0
    SSG: 3,6
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