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  • Hindawi Limited  (76)
  • 1
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    Online Resource
    ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress
    Hindawi Limited ; 2014
    In:  BioMed Research International Vol. 2014 ( 2014), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2014 ( 2014), p. 1-9
    Abstract: Fibroblast growth factor 21 (FGF21) is an important endogenous regulator involved in the regulation of glucose and lipid metabolism. FGF21 expression is strongly induced in animal and human subjects with metabolic diseases, but little is known about the molecular mechanism. Endoplasmic reticulum (ER) stress plays an essential role in metabolic homeostasis and is observed in numerous pathological processes, including type 2 diabetes, overweight, nonalcoholic fatty liver disease (NAFLD). In this study, we investigate the correlation between the expression of FGF21 and ER stress. We demonstrated that TG-induced ER stress directly regulated the expression and secretion of FGF21 in a dose- and time-dependent manner. FGF21 is the target gene for activating transcription factor 4 (ATF4) and CCAAT enhancer binding protein homologous protein (CHOP). Suppression of CHOP impaired the transcriptional activation of FGF21 by TG-induced ER stress in CHOP−/− mouse primary hepatocytes (MPH), and overexpression of ATF4 and CHOP resulted in FGF21 promoter activation to initiate the transcriptional programme. In mRNA stability assay, we indicated that ER stress increased the half-life of mRNA of FGF21 significantly. In conclusion, FGF21 expression is regulated by ER stress via ATF- and CHOP-dependent transcriptional mechanism and posttranscriptional mechanism, respectively.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2014/807874
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2698540-8
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  • 2
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    Online Resource
    A Packet Scheduling Method Based on Dynamic Adjustment of Service Priority for Electric Power Wireless Communication Network
    Hindawi Limited ; 2020
    In:  Wireless Communications and Mobile Computing Vol. 2020 ( 2020-11-1), p. 1-13
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2020 ( 2020-11-1), p. 1-13
    Abstract: With the development of the energy Internet, power communication services are heterogeneous, and different power communication services have different business priorities. The power communication services with different priorities have different requirements for network bandwidth and real-time performance. For traditional unified service, a scheduling method cannot meet these service requirements at the same time, and electric power communication network cannot guarantee the quality of service. Therefore, how to make full use of the time-varying characteristics of communication resources to meet the business needs of different priorities and achieve the goals of high resource utilization and transmission quality has become one of the urgent problems in the power communication network. For this reason, in order to adapt to the real-time congestion of the network, we have designed a packet scheduling method based on the dynamic adjustment of service priority, which dynamically adjusts the priority of the power service on the node; in addition, an evaluation method for the trust value of wireless forwarding nodes is introduced to improve the security of data transmission; and finally, we valuate the channel quality to establish a reasonable and efficient packet scheduling mechanism for services of different priorities. Simulation results show that this method improves the communication performance of high-priority services and improves the spectrum resource utilization of the entire system.
    Type of Medium: Online Resource
    ISSN: 1530-8677 , 1530-8669
    URL: Article
    DOI: 10.1155/2020/8869898
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2045240-8
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  • 3
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    Online Resource
    Prognostic Analysis of Elderly Patients with Multiple Organ Dysfunction Syndrome Undergoing Invasive Mechanical Ventilation
    Hindawi Limited ; 2020
    In:  Journal of Healthcare Engineering Vol. 2020 ( 2020-03-19), p. 1-7
    Details
    In: Journal of Healthcare Engineering, Hindawi Limited, Vol. 2020 ( 2020-03-19), p. 1-7
    Abstract: Objective . To prospectively investigate early prognostic assessments of patients with Multiple Organ Dysfunction Syndrome in the Elderly (MODSE) who were receiving invasive mechanical ventilation (IMV). Methods . The clinical data of 351 patients were enrolled prospectively between January 2013 and January 2018. The Acute Physiology and Chronic Health Evaluation II (APACHE II), APACHE III, Simplified Acute Physiology Score (SAPS II), and Multiple Organ Dysfunction Score (MODS) were calculated. According to the outcome of 28-day, the patients were divided into survivors and nonsurvivors. Additionally, based on whether weaning could be implemented, all patients were divided into a successful-weaning group and a failure-to-wean group. Results . According to the prognosis, the areas under the receiver operating characteristic curve of the APACHE II, APACHE III, SAPS II, and MODS scoring systems were 0.837, 0.833, 0.784, and 0.860, respectively. MODS exhibited the highest sensitivity, whereas APACHE II showed the highest specificity, and successful weaning was conducive to ameliorating patients’ prognosis. Multivariate logistic regression analyses revealed that underlying lung disease, plasma albumin, serum creatinine level, number of failing organs, and IMV duration were related to prognosis of weaning, with odds ratios (ORs) of 1.447, 0.820, 1.603, 2.374, and 3.105, respectively. Conclusions . The APACHE II, APACHE III, SAPS II, and MODS systems could perform excellent prognostic assessment for patients with Multiple Organ Dysfunction Syndrome in the elderly. Underlying lung disease, plasma albumin, serum creatinine, number of failing organs, and IMV duration were independent prognostic factors of weaning in MODSE patients with invasive mechanical ventilation.
    Type of Medium: Online Resource
    ISSN: 2040-2295 , 2040-2309
    URL: Article
    DOI: 10.1155/2020/6432048
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2545054-2
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  • 4
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    Acoustic Velocity Log Numerical Simulation and Saturation Estimation of Gas Hydrate Reservoir in Shenhu Area, South China Sea
    Hindawi Limited ; 2013
    In:  The Scientific World Journal Vol. 2013 ( 2013), p. 1-13
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2013 ( 2013), p. 1-13
    Abstract: Gas hydrate model and free gas model are established, and two-phase theory (TPT) for numerical simulation of elastic wave velocity is adopted to investigate the unconsolidated deep-water sedimentary strata in Shenhu area, South China Sea. The relationships between compression wave (P wave) velocity and gas hydrate saturation, free gas saturation, and sediment porosity at site SH2 are studied, respectively, and gas hydrate saturation of research area is estimated by gas hydrate model. In depth of 50 to 245 m below seafloor (mbsf), as sediment porosity decreases, P wave velocity increases gradually; as gas hydrate saturation increases, P wave velocity increases gradually; as free gas saturation increases, P wave velocity decreases. This rule is almost consistent with the previous research result. In depth of 195 to 220 mbsf, the actual measurement of P wave velocity increases significantly relative to the P wave velocity of saturated water modeling, and this layer is determined to be rich in gas hydrate. The average value of gas hydrate saturation estimated from the TPT model is 23.2%, and the maximum saturation is 31.5%, which is basically in accordance with simplified three-phase equation (STPE), effective medium theory (EMT), resistivity log (Rt), and chloride anomaly method.
    Type of Medium: Online Resource
    ISSN: 1537-744X
    URL: Article
    DOI: 10.1155/2013/101459
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2075968-X
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  • 5
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    Online Resource
    Comparison of metabolism substances in Cordyceps sinensis and Cordyceps militaris cultivated with tussah pupa based on LC‐MS
    Hindawi Limited ; 2021
    In:  Journal of Food Biochemistry Vol. 45, No. 6 ( 2021-06)
    Details
    In: Journal of Food Biochemistry, Hindawi Limited, Vol. 45, No. 6 ( 2021-06)
    Type of Medium: Online Resource
    ISSN: 0145-8884 , 1745-4514
    URL: Issue
    URL: Article
    DOI: 10.1111/jfbc.v45.6
    DOI: 10.1111/jfbc.13735
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2174913-9
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  • 6
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    Research on the Thermal Aging Behaviors of LDPE/TiO 2 Nanocomposites
    Hindawi Limited ; 2017
    In:  Journal of Nanomaterials Vol. 2017 ( 2017), p. 1-11
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2017 ( 2017), p. 1-11
    Abstract: The ability of antithermal aging of LDPE/TiO 2 nanocomposites was investigated through SEM, FTIR, DSC, and dielectric properties in this paper. The results of SEM images showed that the thermal aging had a significant influence on the structure of Pure-LDPE and LDPE/TiO 2 samples. The measurement of FTIR showed that the content of hydroxyl and carboxyl increased with thermal aging, but the time of emerging aging characteristic peaks for the LDPE/TiO 2 samples was delayed. The DSC measurement indicated that filling TiO 2 nanoparticles changed the crystallization behavior of LDPE, played a role of heterogeneous nucleation during the process of recrystallization, and improved the crystallinity of LDPE/TiO 2 . Similarly, the aged LDPE/TiO 2 samples had lower permittivity and dissipation factor compared to the aged Pure-LDPE samples. All the results had indicated the LDPE/TiO 2 samples had the significant ability of antithermal aging, especially the LDPE/TiO 2 -0.5 samples with good dispersion of nanoparticles. A new model was proposed to illustrate the antithermal aging behaviors of LDPE/TiO 2 samples, which shows that the TiO 2 nanoparticles play a role of “crosslinking points” between LDPE molecular chains, increasing the density of crystal structure and reducing oxygen diffusion into materials to break molecular structure.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2017/5048382
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2229480-6
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  • 7
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    Albumin–Globulin Ratio Is an Independent Determinant of 28-Day Mortality in Patients with Critical Illness
    Hindawi Limited ; 2021
    In:  Disease Markers Vol. 2021 ( 2021-8-25), p. 1-5
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2021 ( 2021-8-25), p. 1-5
    Abstract: Background. Critical illness in the intensive care unit (ICU) has been a global health priority. Systemic nutritional status has turned out to be related to the prognosis of critically ill patients. The albumin-globulin ratio (AGR) has been reported to be a novel prognostic factor of many diseases. This study is aimed at investigating whether the AGR could predict the mortality risk in critically ill patients. Methods. We enrolled 582 adult patients admitted to the respiratory intensive care unit (RICU). We collected the clinical and laboratory data. X-tile software was used to determine the optimal cut-off values for the AGR. Patients were divided into three groups according to the AGR (low AGR group with AGR 〈 0.8 , medium AGR group with AGR ranging from 0.8 to 1.1, and high AGR group with AGR 〉 1.1 ). Kaplan-Meier analysis was used for survival analysis. A Cox proportional hazard model was applied to the univariate and multivariate analyses for the potential predictors associated with survival. Results. Our present study showed that the AGR was related to the 28-day survival of critically ill patients in the RICU. The rate of pneumonia in the low AGR group was significantly higher than that in the other groups. Patients with a lower AGR present an increased risk of 28-day mortality compared to patients with a higher AGR. Cox regression analysis showed that the AGR might be an independent predictor of prognosis to 28-day survival in critically ill patients in the RICU. Medium and high AGR values remained independently associated with better 28-day survival than low AGR values (HR: 0.484 (0.263-0.892) ( p = 0.02 ); HR: 0.332 (0.166-0.665) ( p = 0.002 )). Conclusion. The AGR might be an independent predictor of prognosis in critically ill patients.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2021/9965124
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2033253-1
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  • 8
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    Successful treatment of angiolymphoid hyperplasia with eosinophilia and Kimura's disease in the same patient with surgery : Treatment of ALHE and Kimura's disease
    Hindawi Limited ; 2014
    In:  Dermatologic Therapy Vol. 27, No. 1 ( 2014-01), p. 36-38
    Details
    In: Dermatologic Therapy, Hindawi Limited, Vol. 27, No. 1 ( 2014-01), p. 36-38
    Type of Medium: Online Resource
    ISSN: 1396-0296
    URL: Issue
    URL: Article
    DOI: 10.1111/dth.2014.27.issue-1
    DOI: 10.1111/dth.12040
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2020064-X
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  • 9
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    Chemical Distance Measurement and System Pharmacology Approach Uncover the Novel Protective Effects of Biotransformed Ginsenoside C-Mc against UVB-Irradiated Photoaging
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-2-9), p. 1-23
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-2-9), p. 1-23
    Abstract: Long-term exposure to ultraviolet light induces photoaging and may eventually increase the risk of skin carcinogenesis. Rare minor ginsenosides isolating from traditional medicine Panax (ginseng) have shown biomedical efficacy as antioxidation and antiphotodamage agents. However, due to the difficulty of component extraction and wide variety of ginsenoside, the identification of active antiphotoaging ginsenoside remains a huge challenge. In this study, we proposed a novel in silico approach to identify potential compound against photoaging from 82 ginsenosides. Specifically, we calculated the shortest distance between unknown and known antiphotoaging ginsenoside set in the chemical space and applied chemical structure similarity assessment, drug-likeness screening, and ADMET evaluation for the candidates. We highlighted three rare minor ginsenosides (C-Mc, Mx, and F2) that possess high potential as antiphotoaging agents. Among them, C-Mc deriving from American ginseng (Panax quinquefolius L.) was validated by wet-lab experimental assays and showed significant antioxidant and cytoprotective activity against UVB-induced photodamage in human dermal fibroblasts. Furthermore, system pharmacology analysis was conducted to explore the therapeutic targets and molecular mechanisms through integrating global drug-target network, high quality photoaging-related gene profile from multiomics data, and skin tissue-specific expression protein network. In combination with in vitro assays, we found that C-Mc suppressed MMP production through regulating the MAPK/AP-1/NF-κB pathway and expedited collagen synthesis via the TGF-β/Smad pathway, as well as enhanced the expression of Nrf2/ARE to hold a balance of endogenous oxidation. Overall, this study offers an effective drug discovery framework combining in silico prediction and in vitro validation, uncovering that ginsenoside C-Mc has potential antiphotoaging properties and might be a novel natural agent for use in oral drug, skincare products, or functional food.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/4691576
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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  • 10
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    Spectrum of SLC20A2 , PDGFRB , PDGFB , and XPR1 mutations in a large cohort of patients with primary familial brain calcification
    Hindawi Limited ; 2019
    In:  Human Mutation Vol. 40, No. 4 ( 2019-04), p. 392-403
    Details
    In: Human Mutation, Hindawi Limited, Vol. 40, No. 4 ( 2019-04), p. 392-403
    Type of Medium: Online Resource
    ISSN: 1059-7794 , 1098-1004
    URL: Issue
    URL: Article
    DOI: 10.1002/humu.2019.40.issue-4
    DOI: 10.1002/humu.23703
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 1498165-8
    SSG: 12
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