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  • Hindawi Limited  (17)
  • 1
    Online Resource
    Online Resource
    Combination Therapy of Chemoembolization and Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis Compared with Chemoembolization Alone: A Propensity Score-Matched Analysis
    Hindawi Limited ; 2021
    In:  BioMed Research International Vol. 2021 ( 2021-7-14), p. 1-13
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2021 ( 2021-7-14), p. 1-13
    Abstract: Background. Survival of patients with portal vein tumor thrombosis (PVTT) is extremely poor; transarterial chemoembolization (TACE) is a treatment for patients with HCC and PVTT. Some studies showed that hepatic arterial infusion chemotherapy (HAIC) might improve the survival of HCC with PVTT. There were few researches of combining TACE with HAIC for patients with HCC and PVTT. Aim. This study was aimed at comparing overall survival (OS) and progression-free survival (PFS) following treatment with conventional transarterial chemoembolization plus hepatic arterial infusion chemotherapy (cTACE-HAIC) or conventional transarterial chemoembolization (cTACE) alone in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT). Methods. From January 2011 to December 2016, 155 patients with HCC and PVTT who received cTACE-HAIC (cTACE-HAIC group) ( n = 86 ) or cTACE alone (cTACE group) ( n = 69 ) were retrospectively evaluated. Propensity score matching (PSM) reduced the confounding bias and yielded 60 matched patient pairs. The tumors’ responses were evaluated using the modified response evaluation criteria in solid tumors (mRECIST). OS and PFS of groups were compared using the Kaplan-Meier method, log-rank test, and Cox proportional hazard regression models. Results. The median follow-up duration was 93 months (range: 1–93 months). The cTACE-HAIC group’s OS (9.0 months) and PFS (6.0 months) were significantly longer than the cTACE group’s OS (5.0 months) and PFS (2.0 months) ( p = 0.018 and p = 0.045 , respectively) in the matched cohort. Multivariate analyses showed that cTACE-HAIC was independently associated with OS (hazard ratio (HR) 0.602, p = 0.010 ) and PFS (HR 0.66, p = 0.038 ). The matched groups did not differ regarding grade 3 or 4 adverse events. Conclusion. cTACE-HAIC was superior to cTACE alone regarding OS and PFS in patients with HCC and PVTT. Treatment-associated toxicities were generally well tolerated.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2021/6670367
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
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  • 2
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    Online Resource
    Curcumin Alleviated Dextran Sulfate Sodium-Induced Colitis by Regulating M1/M2 Macrophage Polarization and TLRs Signaling Pathway
    Hindawi Limited ; 2021
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2021 ( 2021-9-16), p. 1-10
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2021 ( 2021-9-16), p. 1-10
    Abstract: Curcumin has shown good efficacy in mice with experimental colitis and in patients with ulcerative colitis, but the mechanism of action through the regulation of M1/M2 macrophage polarization has not been elaborated. The ulcerative colitis was modeled by dextran sulfate sodium; colitis mice were orally administrated with curcumin (10 mg/kg/day) or 5-ASA (300 mg/kg/day) for 14 consecutive days. After curcumin treatment, the body weight, colon weight and length, colonic weight index, and histopathological damage in colitis mice were effectively improved. The concentrations of proinflammatory cytokines IL-1β, IL-6, and CCL-2 in the colonic tissues of colitis mice decreased significantly, while anti-inflammatory cytokines IL-33 and IL-10 increased significantly. Importantly, macrophage activation was suppressed and M1/M2 macrophage polarization was regulated in colitis mice, and the percentage of CD11b+F4/80+ and CD11b+F4/80+TIM-1+ and CD11b+F4/80+iNOS+ decreased significantly and CD11b+F4/80+CD206+ and CD11b+F4/80+CD163+ increased significantly. Additionally, curcumin significantly downregulated CD11b+F4/80+TLR4+ macrophages and the protein levels of TLR2, TLR4, MyD88, NF-κBp65, p38MAPK, and AP-1 in colitis mice. Our study suggested that curcumin exerted therapeutic effects in colitis mice by regulating the balance of M1/M2 macrophage polarization and TLRs signaling pathway.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2021/3334994
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2148302-4
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  • 3
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    Online Resource
    Hepatoid Adenocarcinoma of Stomach: Emphasis on the Clinical Relationship with Alpha-Fetoprotein-Positive Gastric Cancer
    Hindawi Limited ; 2019
    In:  BioMed Research International Vol. 2019 ( 2019-12-13), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2019 ( 2019-12-13), p. 1-9
    Abstract: Aims . Both hepatoid adenocarcinoma of stomach (HAS) and alpha-fetoprotein-positive gastric cancer (AFPGC) are rare but aggressive subtypes of gastric cancer, but few studies focus on the clinicopathologic differences and prognostic factors between them because of their rarity and histologic overlap. And the significance of AFP level in HAS prognosis was not well studied. Methods . 41 patients with AFPGC and 52 patients with HAS were included in this study. The clinicopathologic features were compared by Chi-square analysis. Prognostic factors for overall survival (OS) and disease-free survival (DFS) were analyzed with the Kaplan-Meier method. Results . The patients with HAS were of a younger age compared with AFPGC, and nearly 60% of tumor located in the gastric antrum and the gastric fundus of cardia. The OS of AFPGC was shorter than that of HAS, due to a higher rate of metastasis. Furthermore, the survival analysis showed that HAS with high AFP expression (AFP High HAS) had a significantly poorer OS compared to HAS with low AFP expression (AFP Low HAS) ( P = 0.046 ). Conclusions . Compared with AFPGC, the patients of HAS were of a younger age and had less rate of liver and other organ metastasis. The serum AFP level was a sensitive prognostic indicator for OS. Therefore, much attention should be paid to AFP High HAS in clinical practice.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2019/6710428
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2698540-8
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  • 4
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    Sishen Pill Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis with Spleen-Kidney Yang Deficiency Syndromes: Role of Gut Microbiota, Fecal Metabolites, Inflammatory Dendritic Cells, and TLR4/NF-κB Pathway
    Hindawi Limited ; 2022
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2022 ( 2022-10-3), p. 1-20
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2022 ( 2022-10-3), p. 1-20
    Abstract: Sishen pill (SSP) is an old Chinese medicine used to treat colitis with spleen-kidney-yang deficiency (SKYD) syndromes. However, its exact mechanism of action has not yet been fully elucidated. The aim of this study was to evaluate the effects and potential mechanisms of SSP on colitis with SKYD syndromes in mice. Colitis with SKYD syndromes was induced by rhubarb, hydrocortisone, and dextran sulfate sodium (DSS), and treatment was provided with SSP. Flow cytometry was performed to examine the inflammatory dendritic cell (infDC) regulations of SSP. The changes in the gut microbiota (GM) and fecal metabolites post-SSP treatment were investigated using the combination of 16S rRNA sequencing and untargeted metabolomics. Additionally, we also examined whether SSPs could regulate the infDCs by modifying TLR4/NF-κB signaling pathways. Compared with the DSS group, the disease activity index, colonic weight, index of colonic weight, and colonic injury scores, as well as the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-12p70 decreased significantly in the DSS + SSP group, while free triiodothyronine (FT3), free tetraiodothyronine (FT4), testosterone (TESTO), body weight change, colonic length, and the levels of IL-10 increased. Also, SSP decreased the amounts of CD103+CD11c+iNOS+, CD103+CD11c+TNF-α+, CD11c+CD103+CD324+, CD103+CD11c+MHC-II+, and CD103+CD11c+CD115+. Interestingly, 16S rRNA sequencing and untargeted metabolomics showed that SSP treatment restored the dysbiosis of GM and improved the dysfunction in fecal metabolism in colitis mice with SKYD syndromes. Correlation analysis indicated that the modulatory effects of SSP on FT3, FT4, IL-10, colonic weight index, CD103+CD11c+TNF-α+, CD103+CD11c+MHC-II+, and 13 common differential metabolites were related to alterations in the abundance of Parvibacter, Aerococcus, norank_f_Lachnospiraceae, Lachnospiraceae_UCG-006, Akkermansia, and Rhodococcus in the GM. In addition, SSP markedly inhibited the activation of the TLR4, MyD88, TRAF6, TAB2, and NF-κBp65 proteins and activated IκB. These results indicate that SSP can effectively alleviate colitis mice with SKYD syndrome by regulating infDCs, GM, fecal metabolites, and TLR4/NF-κB signaling pathways.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2022/6132289
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2148302-4
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  • 5
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    Clinical course and treatment efficacy of COVID‐19 near Hubei Province, China: A multicentre, retrospective study
    Hindawi Limited ; 2020
    In:  Transboundary and Emerging Diseases Vol. 67, No. 6 ( 2020-11), p. 2971-2982
    Details
    In: Transboundary and Emerging Diseases, Hindawi Limited, Vol. 67, No. 6 ( 2020-11), p. 2971-2982
    Type of Medium: Online Resource
    ISSN: 1865-1674 , 1865-1682
    URL: Issue
    URL: Article
    DOI: 10.1111/tbed.v67.6
    DOI: 10.1111/tbed.13674
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2414822-2
    SSG: 22
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  • 6
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    Online Resource
    Determination of volatile flavor compounds in raw and treated duck meats of different body parts
    Hindawi Limited ; 2022
    In:  Journal of Food Biochemistry Vol. 46, No. 6 ( 2022-06)
    Details
    In: Journal of Food Biochemistry, Hindawi Limited, Vol. 46, No. 6 ( 2022-06)
    Type of Medium: Online Resource
    ISSN: 0145-8884 , 1745-4514
    URL: Issue
    URL: Article
    DOI: 10.1111/jfbc.v46.6
    DOI: 10.1111/jfbc.13908
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2174913-9
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  • 7
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    A New Instrument for Testing Wind Erosion by Soil Surface Shape Change
    Hindawi Limited ; 2009
    In:  Applied and Environmental Soil Science Vol. 2009 ( 2009), p. 1-3
    Details
    In: Applied and Environmental Soil Science, Hindawi Limited, Vol. 2009 ( 2009), p. 1-3
    Abstract: Wind erosion, a primary cause of soil degeneration, is a problem in arid and semiarid areas throughout the world. Many methods are available to study soil erosion, but there is no an effective method for making quantitative measurements in the field. To solve this problem, we have developed a new instrument that can measure the change in the shape of the soil surface, allowing quick quantification of wind erosion. In this paper, the construction and principle of the new instrument are described. Field experiments are carried out using the instrument, and the data are analyzed. The erosion depth is found to vary by 11% compared to the average for measurement areas ranging from   to  . The results show that the instrument is convenient and reliable for quantitatively measuring wind erosion in the field.
    Type of Medium: Online Resource
    ISSN: 1687-7667 , 1687-7675
    URL: Article
    DOI: 10.1155/2009/491570
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2009
    detail.hit.zdb_id: 2467232-4
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  • 8
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    Experimental Study on Calculation Method of Drainage Capacity of Drainage Facilities Affected by Overtopping on Artificial Island
    Hindawi Limited ; 2022
    In:  Mathematical Problems in Engineering Vol. 2022 ( 2022-9-16), p. 1-11
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2022 ( 2022-9-16), p. 1-11
    Abstract: The drainage capacity design of offshore artificial island and inland urban drainage facilities have a great differences in the boundary conditions involved. Therefore, in order to ensure the safety and reliability of the drainage facilities of the Shenzhen-Zhongshan channel’s East artificial island under extreme weather conditions, the coastline of the Southwest open section of the artificial island is identified as a subject for carrying out the research study. This island is affected by offshore waves and the superposition of rainstorms, therefore the calculation method of drainage capacity of artificial island drainage facilities is demonstrated in the article. Through the physical model testing based on soft computing techniques, some recommendations are suggested for preserving the environment, where the optimization schemes are meeting the design requirements of wave and landscape based on correlations between them. Secondly, the adjustment of drainage capacity is suggested to analyze the overtopping of waves on the island and then the final scheme meeting the drainage capacity is obtained. By introducing the comprehensive influence coefficient k of overtopping volume and current velocity caused by overtopping under the action of superimposed waves, a new calculation method and simple calculation formula suitable for the drainage capacity in the artificial island are proposed. The proposed method is verified by the drainage capacity test results of the southeast shoreline. The results show that the proposed method has good accuracy and can provide reference for the design and estimation of drainage capacity of similar projects to preserve the environment. The research results based on mathematical problems in engineering not only solve the practical problems of major projects of Shenzhen China channel but also provide valuable inputs for similar projects.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2022/2655727
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 9
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    Performance of a Novel Decentralised Sewage Treatment Reactor
    Hindawi Limited ; 2013
    In:  Journal of Chemistry Vol. 2013 ( 2013), p. 1-6
    Details
    In: Journal of Chemistry, Hindawi Limited, Vol. 2013 ( 2013), p. 1-6
    Abstract: A novel decentralised sewage treatment reactor (DSTR) for treating domestic sewage in rural areas was designed and investigated. The reactor was started aerobically after inoculation with biomass; the amount of initial mixed liquid suspended solids was 1.5 g/L. Oxygen was supplied to the reactor and the dissolved oxygen concentration was maintained at 1.3 ± 0.2 mg/L. The pollutant removal performance was investigated, and the average removal efficiencies of total chemical oxygen demand (TCOD), NH 4 + -N , suspended solids, and turbidity were 76%, 77.15%, 84.17%, and 83.93%, respectively. The DSTR exhibited good performance compared with the traditional activated sludge (AS) reactor. The resistance to impact load of the DSTR was superior to that of the AS reactor during surface load experiments. During the 120 days of operation, no sludge bulking was observed. The DSTR effluent NH 4 + -N and TCOD levels were a little higher than those for the AS reactor, but the disparity was not major.
    Type of Medium: Online Resource
    ISSN: 2090-9063 , 2090-9071
    URL: Article
    DOI: 10.1155/2013/437147
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2393625-3
    detail.hit.zdb_id: 2703077-5
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  • 10
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    Does Intraoperative Ulinastatin Improve Postoperative Clinical Outcomes in Patients Undergoing Cardiac Surgery: A Meta-Analysis of Randomized Controlled Trials
    Hindawi Limited ; 2014
    In:  BioMed Research International Vol. 2014 ( 2014), p. 1-15
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2014 ( 2014), p. 1-15
    Abstract: Introduction . The systematic meta-analysis of randomized controlled trials (RCTs) evaluated the effects of intraoperative ulinastatin on early-postoperative recovery in patients undergoing cardiac surgery. Methods. RCTs comparing intraoperative ulinastatin with placebo in cardiac surgery were searched through PubMed, Cochrane databases, Medline, SinoMed, and the China National Knowledge Infrastructure (1966 to May 20th, 2013). The primary endpoints included hospital mortality, postoperative complication rate, length of stay in intensive care unit, and extubation time. The physiological and biochemical parameters illustrating postoperative cardiac and pulmonary function as well as inflammation response were considered as secondary endpoints. Results. Fifteen RCTs (509 patients) met the inclusion criteria. Ulinastatin did not affect hospital mortality, postoperative complication rate, or ICU length of stay but reduced extubation time. Ulinastatin also increased the oxygenation index on postoperative day 1 and reduced the plasma level of cardiac troponin-I. Additionally, ulinastatin inhibited the increased level of tumor necrosis factor-alpha, polymorphonuclear neutrophil elastase, interleukin-6, and interleukin-8 associated with cardiac surgery. Conclusion. Ulinastatin may be of value for the inhibition of postoperative increased inflammatory agents and most likely provided pulmonary protective effects in cardiac surgery. However, larger adequately powered RCTs are required to define the clinical effect of ulinastatin on postoperative outcomes in cardiac surgery.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2014/630835
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2698540-8
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