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  • Hindawi Limited  (50)
  • 1
    Online Resource
    Online Resource
    Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling
    Hindawi Limited ; 2020
    In:  Oxidative Medicine and Cellular Longevity Vol. 2020 ( 2020-06-12), p. 1-15
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2020 ( 2020-06-12), p. 1-15
    Abstract: Pulmonary arterial hypertension (PAH) is a lethal disease generally characterized by pulmonary artery remodeling. Mitochondrial metabolic disorders have been implicated as a critical regulator of excessively proliferative- and apoptosis-resistant phenotypes in pulmonary artery smooth muscle cells (PASMCs). Dichloroacetate (DCA) is an emerging drug that targets aerobic glycolysis in tumor cells. Atorvastatin (ATO) is widely used for hyperlipemia in various cardiovascular diseases. Considering that DCA and ATO regulate glucose and lipid metabolism, respectively, we hypothesized that the combination of DCA and ATO could be a potential treatment for PAH. A notable decrease in the right ventricular systolic pressure accompanied by reduced right heart hypertrophy was observed in the DCA/ATO combination treatment group compared with the monocrotaline treatment group. The DCA/ATO combination treatment alleviated vascular remodeling, thereby suppressing excessive PASMC proliferation and macrophage infiltration. In vitro, both DCA and ATO alone reduced PASMC viability by upregulating oxidative stress and lowering mitochondrial membrane potential. Surprisingly, when combined, DCA/ATO was able to decrease the levels of reactive oxygen species and cell apoptosis without compromising PASMC proliferation. Furthermore, suppression of the p38 pathway through the specific inhibitor SB203580 attenuated cell death and oxidative stress at a level consistent with that of DCA/ATO combination treatment. These observations suggested a complementary effect of DCA and ATO on rescuing PASMCs from a PAH phenotype through p38 activation via the regulation of mitochondrial-related cell death and oxidative stress. DCA in combination with ATO may represent a novel therapeutic strategy for PAH treatment.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2020/6973636
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2455981-7
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  • 2
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    Online Resource
    Review on Reactive Power and Voltage Optimization of Active Distribution Network with Renewable Distributed Generation and Time-Varying Loads
    Hindawi Limited ; 2021
    In:  Mathematical Problems in Engineering Vol. 2021 ( 2021-11-23), p. 1-18
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2021 ( 2021-11-23), p. 1-18
    Abstract: With a high proportion of renewable distributed generation and time-varying load connected to the distribution network, great challenges have appeared in the reactive power optimization control of the active distribution networks. This paper first introduces the characteristics of active distribution networks, the mechanism and research status of wind power, photovoltaic, and other renewable distributed generators, and time-varying loads participating in reactive power and voltage optimization. Then, the paper summarizes the methods of reactive power optimization and voltage regulation of active distribution network, including multi-timescale voltage optimization, coordinated optimization of network reconfiguration and reactive power optimization, coordinated optimization of active and reactive power optimization based on model predictive control, hierarchical and zoning control of reactive power, and voltage and power electronic switch voltage regulation. The pros and cons of the reactive power optimization algorithms mentioned above are summarized. Finally, combined with the development trend of the energy Internet, the future directions of reactive power and voltage control technology in the active distribution network are discussed.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2021/1196369
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 3
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    Metabonomic Study on the Plasma of High-Fat Diet-Induced Dyslipidemia Rats Treated with Ge Gen Qin Lian Decoction by Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry
    Hindawi Limited ; 2021
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2021 ( 2021-6-5), p. 1-16
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2021 ( 2021-6-5), p. 1-16
    Abstract: Gegen Qinlian decoction (GGQLD) has a definite effect on T2DM in clinic, and it has the effect of lowering blood sugar, improving insulin resistance, and improving the blood lipid level of rats with dyslipidemia, but the intervention mechanism of GGQLD on dyslipidemia has not been clarified. The changes in endogenous metabolites in the plasma of high-fat diet-induced dyslipidemia rats treated with Ge Gen Qin Lian Decoction (GGQLD) were studied to elucidate the therapeutic effects and mechanism of action of GGQLD in dyslipidemia. Based on ultrahigh-performance liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS), the metabolic profiles of rat serum samples were collected. The rat model of dyslipidemia was induced by a 60% fat-fed high-fat diet. After feeding the rats with a high-fat diet for 4 weeks, dyslipidemia appeared. After 5 weeks of GGQLD (14.85 g kg−1) administration, the metabonomics of rats’ plasma samples in the normal group, model group, and administration group were analyzed. Mass profiler professional (MPP), SIMCA-P 14.1, and Graphpad prism 6.0 software were used combined with METLIN biological database and human metabolite database HMDB to screen and identify endogenous biomarkers. Metaboanalyst 4.0 software was used by combining with HMDB and KEGG databases; the enrichment and metabolic pathway of biomarkers were analyzed to explore the metabolic mechanism of dyslipidemia rats induced by high-fat diet and the intervention mechanism of Gegen Qinlian decoction. After 5 weeks of administration of GGQLD, the levels of serum TC and TG were significantly decreased ( P 〈 0.05 , P 〈 0.01 ), while HDL-C and LDL-C were not significantly affected. After administration, the food intake of rats in the administration group decreased gradually, and the change trend of body weight gradually slowed down. The metabonomics of rat plasma samples results showed that 23 potential biomarkers including α-linolenic acid, arachidonic acid, and lysophosphatidylcholine were significantly changed in positive ion mode. Studies have shown that GGQLD has a significant lipid-lowering effect on dyslipidemia rats induced by a high-fat diet, and its preventive mechanism is related to tryptophan metabolism, fatty acid biosynthesis, α-linolenic acid metabolism, arachidonic acid, and glycerophosphatidyl metabolism pathway.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2021/6692456
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2148302-4
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  • 4
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    A comparison for the effects of raw, smoked, and smoked and brined areca nut extracts on the immune and inflammatory responses in the Kunming mice
    Hindawi Limited ; 2020
    In:  Journal of Food Biochemistry Vol. 44, No. 8 ( 2020-08)
    Details
    In: Journal of Food Biochemistry, Hindawi Limited, Vol. 44, No. 8 ( 2020-08)
    Type of Medium: Online Resource
    ISSN: 0145-8884 , 1745-4514
    URL: Issue
    URL: Article
    DOI: 10.1111/jfbc.v44.8
    DOI: 10.1111/jfbc.13319
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2174913-9
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  • 5
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    Online Resource
    Reversibility of β -Cell-Specific Transcript Factors Expression by Long-Term Caloric Restriction in db/db Mouse
    Hindawi Limited ; 2016
    In:  Journal of Diabetes Research Vol. 2016 ( 2016), p. 1-11
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2016 ( 2016), p. 1-11
    Abstract: Type 2 diabetes (T2D) is characterized by β -cell dedifferentiation, but underlying mechanisms remain unclear. The purpose of the current study was to explore the mechanisms of β -cell dedifferentiation with and without long-term control of calorie intake. We used a diabetes mouse model (db/db) to analyze the changes in the expression levels of β -cell-specific transcription factors (TFs) and functional factors with long-term caloric restriction (CR). Our results showed that chronic euglycemia was maintained in the db/db mice with long-term CR intervention, and β -cell dedifferentiation was significantly reduced. The expression of Glut2, Pdx1, and Nkx6.1 was reversed, while MafA expression was significantly increased with long-term CR. GLP-1 pathway was reactivated with long-term CR. Our work showed that the course of β -cell dedifferentiation can intervene by long-term control of calorie intake. Key β -cell-specific TFs and functional factors play important roles in maintaining β -cell differentiation. Targeting these factors could optimize T2D therapies.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2016/6035046
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2711897-6
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  • 6
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    Design of flexible dual‐band antenna and metamaterial structure for wearable body area network
    Hindawi Limited ; 2022
    In:  International Journal of RF and Microwave Computer-Aided Engineering Vol. 32, No. 5 ( 2022-05)
    Details
    In: International Journal of RF and Microwave Computer-Aided Engineering, Hindawi Limited, Vol. 32, No. 5 ( 2022-05)
    Type of Medium: Online Resource
    ISSN: 1096-4290 , 1099-047X
    URL: Issue
    URL: Article
    DOI: 10.1002/mmce.v32.5
    DOI: 10.1002/mmce.23083
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2007326-4
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  • 7
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    Metantenna design with one‐dimensional holographic concept
    Hindawi Limited ; 2021
    In:  International Journal of RF and Microwave Computer-Aided Engineering Vol. 31, No. 3 ( 2021-03)
    Details
    In: International Journal of RF and Microwave Computer-Aided Engineering, Hindawi Limited, Vol. 31, No. 3 ( 2021-03)
    Type of Medium: Online Resource
    ISSN: 1096-4290 , 1099-047X
    URL: Issue
    URL: Article
    DOI: 10.1002/mmce.v31.3
    DOI: 10.1002/mmce.22536
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2007326-4
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  • 8
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    Cardioprotective Effects of Aconite in Isoproterenol-Induced Myocardial Infarction in Rats
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-12-26), p. 1-16
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-12-26), p. 1-16
    Abstract: Background. Myocardial infarction (MI) is a severe clinical condition caused by decreased or complete cessation of blood flow to a portion of the myocardium. Aconite, the lateral roots of Aconitum carmichaelii Debx., is a well-known Chinese medicine for treatment of heart failure and related cardiac diseases. The present study is aimed at investigating the cardioprotective effect of aconite on isoproterenol- (ISO)- induced MI. Methods. The qualitative analysis of aqueous extracts from brained aconite (AEBA) was conducted by HPLC. A rat model of MI induced by ISO was established to examine the effects of AEBA. The cardiac function was assessed by echocardiography. The serum levels of SOD, CK-MB, cTnT, and cTnI were detected to estimate myocardial injury. The pathological changes of heart tissue were evaluated by 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin-eosin (HE) staining, and Masson’s trichrome staining. The expressions of abnormal vascular remodeling and hypoxia-related components and the levels of inflammation-associated genes and proteins were detected by RT-qPCR, western blotting, and immunofluorescence. Results. The contents of benzoylaconine, benzoylmesaconine, benzoylhypacoitine, and hypaconitine in AEBA were 1.35 μg/g, 37.35 μg/g, 57.10 μg/g, and 2.46 μg/g, respectively. AEBA obviously improved heart function through promoting echocardiographic parameters, radial strain, and circumferential strain. The data of TTC staining, HE staining, and Masson’s trichrome staining disclosed that AEBA could significantly reduce infarct size, inhibit inflammatory cell infiltration, and decrease the myocardial fibrosis. Moreover, AEBA distinctly suppressed the serum levels of SOD, MDA, CK-MB, cTnT, and cTnI in ISO-induced rats. The results of RT-qPCR indicated that AEBA inhibited the expressions of hypoxia- and inflammation-related genes, including VEGF, PKM2, GLUT-1, LDHA, TNF-α, IL-1β, IL-6, and COX2. In addition, the western blotting and immunofluorescence analyses further confirmed the results of RT-qPCR. Conclusion. In summary, our results indicate that the AEBA could improve ISO-induced myocardial infarction by promoting cardiac function, alleviating myocardial hypoxia, and inhibiting inflammatory response and fibrosis in heart tissue.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/1090893
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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  • 9
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    Online Resource
    A Fuzzy-Set Qualitative Comparative Analysis of Factors Influencing Servitization Transformation Performance in Chinese Manufacturing Enterprises
    Hindawi Limited ; 2022
    In:  Discrete Dynamics in Nature and Society Vol. 2022 ( 2022-9-15), p. 1-10
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2022 ( 2022-9-15), p. 1-10
    Abstract: The development of manufacturing industry affects the operation of Chinese economy, and it is necessary to study the possible configuration paths of servitization transformation to support sustainable development. Based on previous studies of manufacturing servitization transformation, it is extended to explore multifactor combinations which affects servitization transformation performance. This paper constructs technology-organization-environment (TOE) framework of servitization transformation performance evaluation and uses fuzzy-set Qualitative Comparative Analysis (fsQCA) method to analyze the key factors and mechanism of servitization transformation with the data of 28 Chinese manufacturing enterprises. The results reveal that the six major factors are not the necessary conditions, and single-factor cannot effectively promote servitization transformation of Chinese manufacturing enterprises. There are four configurations which can be divided into three paths to improve servitization transformation performance. Based on the results of analysis, it proposes strategies to promote the development of Chinese manufacturing enterprises, such as developing targeted servitization strategies, enhancing technology development, and improving technology applications. The findings reveal the mechanism of multiple factors behind the evolution of manufacturing servitization transformation and take useful suggestions for the high-level development of Chinese manufacturing enterprises.
    Type of Medium: Online Resource
    ISSN: 1607-887X , 1026-0226
    URL: Article
    DOI: 10.1155/2022/9408274
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033014-5
    SSG: 11
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  • 10
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    Update on Pharmacological Activities, Security, and Pharmacokinetics of Rhein
    Hindawi Limited ; 2021
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2021 ( 2021-8-17), p. 1-18
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2021 ( 2021-8-17), p. 1-18
    Abstract: Rhein, belonging to anthraquinone compounds, is one of the main active components of rhubarb and Polygonum multiflorum. Rhein has a variety of pharmacological effects, such as cardiocerebral protective effect, hepatoprotective effect, nephroprotective effect, anti-inflammation effect, antitumor effect, antidiabetic effect, and others. The mechanism is interrelated and complex, referring to NF-κB, PI3K/Akt/MAPK, p53, mitochondrial-mediated signaling pathway, oxidative stress signaling pathway, and so on. However, to some extent, its clinical application is limited by its poor water solubility and low bioavailability. Even more, rhein has potential liver and kidney toxicity. Therefore, in this paper, the pharmacological effects of rhein and its mechanism, pharmacokinetics, and safety studies were reviewed, in order to provide reference for the development and application of rhein.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2021/4582412
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2148302-4
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