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  • Hindawi Limited  (121)
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  • 1
    Online Resource
    Online Resource
    Chinese newborn screening for the incidence of G6PD deficiency and variant of G6PD gene from 2013 to 2017
    Hindawi Limited ; 2020
    In:  Human Mutation Vol. 41, No. 1 ( 2020-01), p. 212-221
    Details
    In: Human Mutation, Hindawi Limited, Vol. 41, No. 1 ( 2020-01), p. 212-221
    Type of Medium: Online Resource
    ISSN: 1059-7794 , 1098-1004
    URL: Issue
    URL: Article
    DOI: 10.1002/humu.v41.1
    DOI: 10.1002/humu.23911
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 1498165-8
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Atorvastatin Treatment for Atrial Fibrillation Reduces Serum High-Sensitivity C-Reactive Protein Levels
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-10
    Abstract: We investigated whether serum hs-CRP levels predict the efficacy of atrial fibrillation (AF) treated with atorvastatin. Bibliographic databases were exhaustively searched for studies relevant to the research topic. Newcastle-Ottawa Scale (NOS) criteria, combined with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS), were applied for study quality assessment. Our meta-analysis identified seven cohort studies (2006~2013), providing information on the change in serum hs-CRP levels in AF patients receiving atorvastatin therapy. After atorvastatin treatment, hs-CRP level in AF patients decreased significantly (SMD = 1.02, 95% CI: 0.58–1.47, P 〈 0.001 ). Subgroup analysis by country and hs-CRP detection methods suggested a negative relationship between atorvastatin treatment and hs-CRP levels among Chinese AF patients (SMD = 1.34, 95% CI: 1.00–1.69, P 〈 0.001 ) and by using ELISA method (SMD = 1.11, 95% CI: 0.51–1.71, P 〈 0.001 ), but not among Turkish population and using INA method (all P 〉 0.05 ). Egger’s test showed no publication bias ( P = 0.450 ). hs-CRP was clearly lowered in AF patients treated with atorvastatin, which may be helpful in the choice of statin agents for AF treatment. However, longer follow-ups are necessary to assess the clinical value of lowering hs-CRP in the clinical setting of AF treatment outcomes.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/402481
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 3
    Online Resource
    Online Resource
    Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology
    Hindawi Limited ; 2018
    In:  PPAR Research Vol. 2018 ( 2018-12-05), p. 1-11
    Details
    In: PPAR Research, Hindawi Limited, Vol. 2018 ( 2018-12-05), p. 1-11
    Abstract: Peroxisome proliferator-activated receptors (PPARs) play vital roles in cardiovascular pathophysiology, such as energy balance, cell proliferation/apoptosis, inflammatory response, and adipocyte differentiation. These vital roles make PPARs potential targets for therapeutic prevention of cardiovascular diseases (CVDs). Emerging evidence indicates that the crosstalk of microRNAs (miRNAs) and PPARs contributes greatly to CVD pathogenesis. PPARs are inhibited by miRNAs at posttranscriptional mechanisms in the progress of pulmonary hypertension and vascular dysfunction involving cell proliferation/apoptosis, communication, and normal function of endothelial cells and vascular smooth muscle cells. In the development of atherosclerosis and stroke, the activation of PPARs could change the transcripts of target miRNA through miRNA signalling. Furthermore, the mutual regulation of PPARs and miRNAs involves cell proliferation/apoptosis, cardiac remodeling, and dysfunction in heart diseases. In addition, obesity, an important cardiovascular risk, is modulated by the regulatory axis of PPARs/miRNAs, including adipogenesis, adipocyte dysfunction, insulin resistance, and macrophage polarization in adipose tissue. In this review, the crosstalk of PPARs and miRNAs and their emerging regulatory roles are summarized in the context of CVDs and risks. This provides an understanding of the underlying mechanism of the biological process related to CVD pathophysiology involving the interaction of PPARs and miRNAs and will lead to the development of PPARs/miRNAs as effective anti-CVD medications.
    Type of Medium: Online Resource
    ISSN: 1687-4757 , 1687-4765
    URL: Article
    DOI: 10.1155/2018/8530371
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2237981-2
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  • 4
    Online Resource
    Online Resource
    Effects of post‐transport rest and electrical stimulation on meat quality of longissimus thoracis muscle of long‐distance transported Simmental bulls
    Hindawi Limited ; 2022
    In:  Journal of Food Processing and Preservation Vol. 46, No. 9 ( 2022-09)
    Details
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 46, No. 9 ( 2022-09)
    Type of Medium: Online Resource
    ISSN: 0145-8892 , 1745-4549
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpp.v46.9
    DOI: 10.1111/jfpp.16029
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2175273-4
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  • 5
    Online Resource
    Online Resource
    Deformation Behavior of Deep Foundation Pit under Both Overloading and Unloading Conditions
    Hindawi Limited ; 2020
    In:  Mathematical Problems in Engineering Vol. 2020 ( 2020-12-22), p. 1-16
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2020 ( 2020-12-22), p. 1-16
    Abstract: A deep foundation pit in a station of the Hangzhou subway is adjacent to new high-rise residential buildings on the north side and to the Evergrande foundation pit being excavated on the south side. This work considers the excavation of the foundation pit in the subway station as the research subject, focuses on the difference of the deformation and Earth pressure between the north side and the south side of the foundation pit under these special working conditions through the analysis of the measured data, and compares it with an ordinary foundation pit. Analyzing the measured data reveals that the horizontal displacement of the retaining wall and the ground settlement are far larger on the north side than on the south side, and both often exceed the deformation alarm value; the deformation of the ordinary foundation pit is between the deformation of the overloaded (north) side and that of the unloaded (south) side of the foundation pit. Moreover, the maximum rate of the horizontal creep of the soil and the maximum rate of the creep caused by the ground settlement on the north side of the foundation pit are larger than those on the south side of the foundation pit; the maximum rate of the horizontal creep of the ordinary foundation pit is between the two. The active Earth pressure on the pit wall on the north side is higher than that on the south side of the foundation pit, and because of the surrounding unloading, passive Earth pressure is generated at the bottom of the pit wall on the south side of the foundation pit, which causes it to shift to the outside of the foundation pit. The settlement of the surrounding high-rise buildings and the settlement of the columns are all within the range of the alarm values; also, the buildings settle evenly. Due to the excavation and unloading on the south side of the foundation pit, the uplift of the columns is not considerable.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2020/6675531
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 6
    Online Resource
    Online Resource
    Trajectory-Based Hierarchical Adaptive Forwarding in Vehicular Ad Hoc Networks
    Hindawi Limited ; 2017
    In:  Journal of Sensors Vol. 2017 ( 2017), p. 1-8
    Details
    In: Journal of Sensors, Hindawi Limited, Vol. 2017 ( 2017), p. 1-8
    Abstract: This paper proposes a Trajectory-Based Hierarchical Adaptive Forwarding (THAF) scheme, tailored and optimized for the efficient multihop vehicle-to-vehicle (v2v) data delivery in vehicular ad hoc networks. We utilize the trajectories of vehicles provided by GPS-based navigation systems to predict forward delay and access area in a privacy-preserving manner. Different from existing trajectory-based forwarding schemes, we establish a hierarchical VANET topology to optimize forwarding path and adopt adaptive diffusion strategy to forward data in light-traffic situations. Through theoretical analysis and extensive simulation, it is shown that our design performs better than the existing schemes.
    Type of Medium: Online Resource
    ISSN: 1687-725X , 1687-7268
    URL: Article
    DOI: 10.1155/2017/4236789
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2397931-8
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  • 7
    Online Resource
    Online Resource
    VEGF Family Gene Expression as Prognostic Biomarkers for Alzheimer’s Disease and Primary Liver Cancer
    Hindawi Limited ; 2021
    In:  Computational and Mathematical Methods in Medicine Vol. 2021 ( 2021-11-20), p. 1-15
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2021 ( 2021-11-20), p. 1-15
    Abstract: Background. To analyze the expression of vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC) and cognitive impairment, explore the relationship between the expression of VEGF family genes and prognosis of patients with HCC, and evaluate the predictive ability of VEGF in cognitive impairment using computerized methods. Methods. VEGF expression in liver cancer tissues and normal tissues was analyzed using bioinformatics methods. The Kaplan-Meier survival analysis method was also used to analyze the relationship between VEGF expression and the prognosis of patients with HCC. Furthermore, immune infiltration assessment and gene set enrichment analysis were performed. Meanwhile, the differential expression of VEGF family genes between patients with Alzheimer’s disease (AD) and healthy controls was also checked. Results. Based on The Cancer Genome Atlas (TCGA) database, the VEGF family genes (VEFGA, VEGFB, VEGFC, and VEGFD) were highly expressed in cancer tissues and were significantly associated with poor prognosis in HCC. In HCC, the VEGF family genes showed significant heterogeneity in their functional and immune infiltration characteristics. Finally, VEGF family genes were identified as prognostic biomarkers in AD and risk prediction markers in HCC. Conclusions. VEGF is highly expressed in patients with HCC and lowly expressed in patients with AD. VEGF has opposite opposing roles in the treatment of tumors and cognitive impairment.
    Type of Medium: Online Resource
    ISSN: 1748-6718 , 1748-670X
    URL: Article
    DOI: 10.1155/2021/3422393
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2256917-0
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  • 8
    Online Resource
    Online Resource
    Efficacy and Safety of Jueyin Granules for Patients with Mild-to-Moderate Psoriasis Vulgaris: Protocol for a Multicenter Randomized Placebo-Controlled Trial
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-04-09), p. 1-9
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-04-09), p. 1-9
    Abstract: Introduction . The etiology and pathogenesis of psoriasis are complex. Blood-heat syndrome is the core pathogenesis of psoriasis. Based on theories of Chinese medicine (CM), heat-clearing and blood-cooling (HCBC) are the primary treatment. Very few studies have investigated the pharmacological mechanism of the CM HCBC method for treating psoriasis. This multicenter randomized controlled trial will focus on treating psoriasis blood-heat syndrome with the HCBC method using Jueyin granules (JYKL). This will be an objective and standardized evaluation of the efficacy, safety, and reproducibility of the HCBC method to obtain objective evidence meeting international standards that aim to establish a clinical standard suitable for the popular application of CM for treating psoriasis. Methods and Analysis . A five-center randomized double-blind placebo-controlled clinical design will be used in this study. At least 196 participants will be randomly assigned to receive either JYKL or placebo treatment approximately 30 minutes after meals in the morning and evening (one sachet per time, twice daily for 8 consecutive weeks). The study duration will be 17 weeks, including 1 week of screening, 8 weeks of intervention, and 8 weeks of follow-up. The patients will be evaluated every 2 weeks, and the measures will be compared with baseline values. The primary outcome measure will be the psoriasis lesion area severity index. We will also observe the recurrence rate, body surface area, physician global assessment, dermatology life quality index, quality of life index, visual analogue scale score, CM symptom score, combined drug use, and adverse events. This trial is registered with NCT03961230 .
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2020/8942301
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
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  • 9
    Online Resource
    Online Resource
    The REDD1/TXNIP Complex Accelerates Oxidative Stress-Induced Apoptosis of Nucleus Pulposus Cells through the Mitochondrial Pathway
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-9-22), p. 1-22
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-9-22), p. 1-22
    Abstract: The death of nucleus pulposus (NP) cells is an important cause of intervertebral disc (IVD) degeneration. Redox disturbance caused by dysfunctional mitochondria has been considered as a vital risk for NP cell survival. It is valuable to identify key proteins maintaining mitochondrial function in NP cells. A previous study found that regulated in development and DNA damage response 1 (REDD1) are upregulated during intervertebral disc degeneration and that REDD1 can cause NP cell apoptosis. Thus, the present study further explores the effect of REDD1 on IVD degeneration. Our results showed that REDD1 promotes NP cell apoptosis via the mitochondrial pathway. Importantly, REDD1 formed a complex with TXNIP to strengthen its own action, and the combination was consolidated under H2O2-induced oxidative stress. The combined inhibition of the REDD1/TXNIP complex was better than that of REDD1 or TXNIP alone in restoring cell proliferation and accelerating apoptosis. Moreover, p53 acts as the transcription factor of REDD1 to regulate the REDD1/TXNIP complex under oxidative stress. Altogether, our results demonstrated that the REDD1/TXNIP complex mediated H2O2-induced human NP cell apoptosis and IVD degeneration through the mitochondrial pathway. Interferences on these sites to achieve mitochondrial redox homeostasis may be a novel therapeutic strategy for oxidative stress-associated IVD degeneration.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/7397516
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
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  • 10
    Online Resource
    Online Resource
    The Gut Microbiota and Its Relevance to Peripheral Lymphocyte Subpopulations and Cytokines in Patients with Rheumatoid Arthritis
    Hindawi Limited ; 2021
    In:  Journal of Immunology Research Vol. 2021 ( 2021-1-8), p. 1-9
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2021 ( 2021-1-8), p. 1-9
    Abstract: Growing experimental and clinical evidence suggests that a chronic inflammatory response induced by gut microbiome critically contribute to the development of rheumatoid arthritis (RA). Previous studies demonstrated the disturbance of lymphocyte subpopulations in RA patients. The purpose of this study was to explore the characteristics of gut microbiome and the associations between bacterium and lymphocyte subpopulations as well as cytokines in patients with RA. Fecal samples from 205 RA patients and 199 healthy controls (HCs) were collected for bacterial DNA extraction and 16S ribosomal RNA (rRNA) gene sequencing. The levels of peripheral lymphocyte subpopulation such as T, B, CD4+T, CD8+T, NK, T helper 1 (Th1), Th2, Th17, and regulatory T cells (Tregs) of these subjects were detected by flow cytometry combined with standard absolute counting beads. The serum levels of cytokines interleukin-2 (IL-2), IL-4, IL-6, IL-10, IL-17, tumour necrosis factor-α (TNF-α), and interferon-γ (INF-γ) were tested by flow cytometric bead array (CBA). Alpha and beta diversity of gut microbiome were explored by bioinformatics analysis. Spearman rank correlation test was used to explore the relationships between gut microbiome and lymphocyte subsets as well as serum cytokines. The diversity and relative abundance of intestinal microbiota in patients with RA were significantly different from those in HCs. Detailly, the abundant of phylum Proteobacteria in RA patients was more than that in HCs, while Firmicutes was less than in HCs. There was increased relative abundance of genus Clostridium_XlVa as well as genus Blautia, more abundance of Ruminococcus2 in patients with lower levels of T, B, CD4+T, and Tregs. In addition, the relative abundances of Pelagibacterium, Oxalobacter, ClostridiumXlVb, and ClostridiumXVIII were correlated with cytokines. Gut microbiome of RA patients was clearly different from that of HCs. Abnormal bacteria communities are associated with the altered levels of lymphocyte subpopulation and cytokines, which might be one of the pathogenesis of RA.
    Type of Medium: Online Resource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2021/6665563
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2817541-4
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