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  • Hindawi Limited  (11)
  • 1
    Online Resource
    Online Resource
    Characterizing Unipolar and Bipolar Depression by Alterations in Inflammatory Mediators and the Prefrontal-Limbic Structural Network
    Hindawi Limited ; 2023
    In:  Depression and Anxiety Vol. 2023 ( 2023-5-24), p. 1-11
    Details
    In: Depression and Anxiety, Hindawi Limited, Vol. 2023 ( 2023-5-24), p. 1-11
    Abstract: Objective. The prefrontal-limbic system is closely associated with emotion processing in both unipolar depression (UD) and bipolar depression (BD). Evidence for this link is derived mostly from task-fMRI studies, with limited support from structural findings. Therefore, this study explores the differences in the emotional circuit in these two disorders on a structural, large-scale network basis, coupled with the highly noted inflammatory and growth factors. Methods. In this study, 31 BD patients, 37 UD patients, and 61 age-, sex-, and education-matched healthy controls (HCs) underwent diffusion-weighted imaging (DWI) scanning and serum cytokine sampling. The study compared cytokine levels and prefrontal-limbic network alterations among the three groups and explored potential biological and neurobiological markers to distinguish the two disorders using graph theory, network-based statistics (NBS), and logistic regression. Results. Compared to BD patients, UD patients showed greater s-100β protein levels, higher efficiency of the right amygdala, and significantly elevated prefrontal-cingulate-amygdala subnetwork intensity. Importantly, the altered prefrontal-cingulate-amygdala subnetwork, nodal efficiency of the right amygdala, IL-8, IL-17, and s-100β levels were risk factors for the diagnosis of UD, whereas anxiety symptoms tended to closely correlate with BD. Moreover, binary logistic regression manifested these factors achieved an area under the curve (AUC) of the receiver operating characteristics (ROC) of 0.949, with 0.875 sensitivity and 0.938 specificity in UD vs. BD classification. Conclusions. These findings narrow the gap in the structural network of emotional circuits in bipolar and unipolar depression, pointing to distinct emotion-processing mechanisms in both disorders.
    Type of Medium: Online Resource
    ISSN: 1520-6394 , 1091-4269
    URL: Article
    DOI: 10.1155/2023/5522658
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2001248-2
    SSG: 5,2
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  • 2
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    Online Resource
    Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy
    Hindawi Limited ; 2020
    In:  Mediators of Inflammation Vol. 2020 ( 2020-06-28), p. 1-12
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2020 ( 2020-06-28), p. 1-12
    Abstract: Psoriasis is a common immune-mediated, chronic inflammatory genetic-related disease that affects patients’ quality of life. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of progenitor and immature myeloid cells which are expanded in psoriatic skin lesions and peripheral blood. However, the role of MDSCs in the pathogenesis of psoriasis remains unclear. Here, we confirmed that the accumulation of human MDSCs is remarkably increased in skin lesions of psoriasis patients by flow cytometry. Depleting MDSCs by Gemcitabine significantly suppresses IMQ-induced psoriatic inflammation and epidermal thickening as well as Th17 and Treg cell accumulation. Moreover, through the RNA-Seq technique, we validated some differentially expressed genes on CD4 + T-cells of IMQ-induced-MDSC-depleted mice such as IL-21 and Timd2, which are involved in Th17-cell differentiation or T-cell activation. Interestingly, neutralizing IL-21R by antibody reduces IMQ-induced epidermal thickening through downregulating the infiltration of MDSCs and Th17 cells. Our data suggest that targeting myeloid-derived suppressor cells is a novel strategy for antipsoriasis therapy. IL-21 may be a potential therapeutic target in psoriasis.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2020/8567320
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2008065-7
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  • 3
    Online Resource
    Online Resource
    Aldosterone-induced inflammatory response of mesangial cells via angiotension II receptors
    Hindawi Limited ; 2015
    In:  Journal of the Renin-Angiotensin-Aldosterone System Vol. 16, No. 4 ( 2015-12), p. 739-748
    Details
    In: Journal of the Renin-Angiotensin-Aldosterone System, Hindawi Limited, Vol. 16, No. 4 ( 2015-12), p. 739-748
    Type of Medium: Online Resource
    ISSN: 1470-3203 , 1752-8976
    URL: Article
    DOI: 10.1177/1470320313519486
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2261873-9
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  • 4
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    The Crosstalk between Calcium Ions and Aldosterone Contributes to Inflammation, Apoptosis, and Calcification of VSMC via the AIF-1/NF-κB Pathway in Uremia
    Hindawi Limited ; 2020
    In:  Oxidative Medicine and Cellular Longevity Vol. 2020 ( 2020-12-4), p. 1-20
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2020 ( 2020-12-4), p. 1-20
    Abstract: Vascular calcification is a major complication of maintenance hemodialysis patients. Studies have confirmed that calcification mainly occurs in the vascular smooth muscle cells (VSMC) of the vascular media. However, the exact pathogenesis of VSMC calcification is still unknown. This study shows that the crosstalk between calcium and aldosterone via the allograft inflammatory factor 1 (AIF-1) pathway contributes to calcium homeostasis and VSMC calcification, which is a novel mechanism of vascular calcification in uremia. In vivo results showed that the level of aldosterone and inflammatory factors increased in calcified arteries, whereas no significant changes were observed in peripheral blood. However, the expression of inflammatory factors markedly increased in the peripheral blood of uremic rats without aortic calcification and gradually returned to normal levels with aggravation of aortic calcification. In vitro results showed that there was an interaction between calcium ions and aldosterone in macrophages or VSMC. Calcium induced aldosterone synthesis, and in turn, aldosterone also triggered intracellular calcium content upregulation in macrophages or VSMC. Furthermore, activated macrophages induced inflammation, apoptosis, and calcification of VSMC. Activated VSMC also imparted a similar effect on untreated VSMC. Finally, AIF-1 enhanced aldosterone- or calcium-induced VSMC calcification, and NF-κB inhibitors inhibited the effect of AIF-1 on VSMC. These in vivo and in vitro results suggest that the crosstalk between calcium ions and aldosterone plays an important role in VSMC calcification in uremia via the AIF-1/NF-κB pathway. Local calcified VSMC induced the same pathological process in surrounding VSMC, thereby contributing to calcium homeostasis and accelerating vascular calcification.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2020/3431597
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2455981-7
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  • 5
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    The Influence of Three Statistical Variables on Self-Similarity in Complex Networks
    Hindawi Limited ; 2020
    In:  Discrete Dynamics in Nature and Society Vol. 2020 ( 2020-01-13), p. 1-14
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2020 ( 2020-01-13), p. 1-14
    Abstract: The reason for the self-similarity property of complex network is still an open issue. In this paper, we focus on the influence of degree, betweenness, and coreness on self-similarity of complex network. Some nodes are removed from the original network based on the definitions of degree, betweenness, and coreness in the ascending and descending order. And then, some new networks are obtained after removing nodes. The self-similarities of original network and new networks are compared. Moreover, two real networks are used for numerical simulation, including a USAir network and the yeast protein interaction ( YPI ) network. The effects of the three statistical variables on the two real networks are considered. The results reveal that the nodes with large degree and betweenness have great effects on self-similarity, and the influence of coreness on self-similarity is small.
    Type of Medium: Online Resource
    ISSN: 1026-0226 , 1607-887X
    URL: Article
    DOI: 10.1155/2020/7860126
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2033014-5
    SSG: 11
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  • 6
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    Sustainable Development of Tourism under the Background of Low-Carbon and Green Economy
    Hindawi Limited ; 2021
    In:  Advances in Materials Science and Engineering Vol. 2021 ( 2021-8-5), p. 1-8
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2021 ( 2021-8-5), p. 1-8
    Abstract: The development of tourism industry not only promotes social and economic progress and the improvement of people’s happiness index but also causes resource damage and environmental pollution, which not only affects our living environment but also directly threatens the survival and development of mankind. Therefore, how tourism will develop in the context of low-carbon green economy has become the main problem of tourism development. Based on the above background, in order to solve the development problem of tourism in the future under the low-carbon green economy, based on the research results at home and abroad, starting from the starting point of sustainable development of tourism, this paper introduces the concept of “tourism consumption separation rate” and uses Kaya traditional accounting method. The structural decomposition analysis method and cointegration relationship test method are used to calculate, analyze, and test the tourism carbon emissions and influencing factors at the overall level of China and the middle, western, and eastern regions. Through this method, the accuracy of the calculation results is improved by 30%, which increases the accuracy of the experimental data and is more practical.
    Type of Medium: Online Resource
    ISSN: 1687-8442 , 1687-8434
    URL: Article
    DOI: 10.1155/2021/8587024
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2501025-6
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  • 7
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    Increased Insular Connectivity and Enhanced Empathic Ability Associated with Dance/Music Training
    Hindawi Limited ; 2019
    In:  Neural Plasticity Vol. 2019 ( 2019-05-06), p. 1-13
    Details
    In: Neural Plasticity, Hindawi Limited, Vol. 2019 ( 2019-05-06), p. 1-13
    Abstract: Dance and music are expressive art forms. Previous behavioural studies have reported that dancers/musicians show a better sensorimotor ability and emotional representation of others. However, the neural mechanism behind this phenomenon is not completely understood. Recently, intensive researches have identified that the insula is highly enrolled in the empathic process. Thus, to expand the knowledge of insular function associated with empathy under the dance/music training background, we mapped the insular network and its associated brain regions in 21 dancers, 20 musicians, and 24 healthy controls using resting-state functional connectivity (FC) analysis. Whole brain voxel-based analysis was performed using seeds from the posterior insula (PI), the ventral anterior insula (vAI), and the dorsal anterior insula (dAI). The training effects of dance and music on insular subnetworks were then evaluated using one-way analysis of variance ANOVA. Increased insular FC with those seeds was found in dancers/musicians, including PI and anterior cingulated cortex (ACC), vAI and middle temporal gyrus (MTG) and middle cingulated cortex (MCC), and dAI and ACC and MTG. In addition, significant associations were found between discrepant insular FC patterns and empathy scores in dancers and musicians. These results indicated that dance/music training might enhance insular subnetwork function, which would facilitate integration of intero/exteroceptive information and result in better affective sensitivity. Those changes might finally facilitate the subjects’ empathic ability.
    Type of Medium: Online Resource
    ISSN: 2090-5904 , 1687-5443
    URL: Article
    DOI: 10.1155/2019/9693109
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2236872-3
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  • 8
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    Risk Assessment of Building Foundation Pit Construction Based on Fuzzy Hierarchical Comprehensive Evaluation Method
    Hindawi Limited ; 2022
    In:  Geofluids Vol. 2022 ( 2022-5-21), p. 1-12
    Details
    In: Geofluids, Hindawi Limited, Vol. 2022 ( 2022-5-21), p. 1-12
    Abstract: The safety of foundation pit construction is gaining widespread attention. In order to reduce the risks of foundation pit construction and avoid the safety problems brought by the pits, it is necessary to study the risks of foundation pit construction. This paper takes the actual construction of a building as the background. Firstly, the possible main risks of foundation pit construction were identified and summarized, and then, the evaluation index system was formed. Secondly, the risk levels of various types of foundation pit risks were derived through analytic hierarchy process (AHP). In the expert scoring session of the Delphi method, the influences of both the degree of risk consequences and the probability of occurrence are combined. The risk value of the risk event is obtained in combination, which overcomes the bias problem of the traditional single assignment. Finally, an affiliation matrix was established to judge the affiliation of risk indicators to the risk level. The comprehensive risk evaluation level of this foundation pit project construction was assessed as level II. It is the degree of general risk.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2022/9317700
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 9
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    Simulation of Vulnerability to Geological Disaster in Coal Mine Based on System Dynamics
    Hindawi Limited ; 2022
    In:  Geofluids Vol. 2022 ( 2022-6-16), p. 1-12
    Details
    In: Geofluids, Hindawi Limited, Vol. 2022 ( 2022-6-16), p. 1-12
    Abstract: The irrational mining of coal mines can cause damage to the geological environment, resulting in the frequent occurrence of geological disasters and high risk. In order to deeply explore the influence mechanism of coal mine geological disaster vulnerability, the three characteristic indicators of exposure, sensitivity, and adaptability proposed by the VSD vulnerability framework were taken as the starting point, and the indicator weights were determined by using the order graph method. The system dynamic model of coal mine geological disaster vulnerability was established and simulated. The results show that the exposure and sensitivity decrease gradually, and adaptability shows a gradual upward trend within one simulation period. When the parameter values of each subsystem were increased by 50%, the management subsystem was the key subsystem that affected the exposure and adaptability, and the exposure and adaptability variation decreased by 11.704% and 17.900%, respectively. The key subsystem affecting sensitivity was the equipment subsystem, and the sensitivity variation decreased by 18.958%.In order to reduce the vulnerability risk of geological disaster in coal mines and improve the safety management of the project.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2022/2248961
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 10
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    Safety and Efficacy Evaluation of Traditional Chinese Medicine (Qingre-Lishi-Yishen Formula) Based on Treatment of Regular Glucocorticoid Combined with Cyclophosphamide Pulse in Children Suffered from Moderately Severe Henoch–Schonlein Purpura Nephritis with Nephrotic Proteinuria
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-01-27), p. 1-10
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-01-27), p. 1-10
    Abstract: Objective . At present, the most appropriate management of Henoch–Schonlein purpura nephritis (HSPN) with nephrotic-range proteinuria still remains controversial; thus, the purpose of this study is to evaluate safety and efficacy of traditional Chinese medicine (TCM), Qingre-Lishi-Yishen Formula (QLYF), integrated with regular oral glucocorticoid and cyclophosphamide intravenous pulse therapeutic regimen in children suffered from moderately severe HSPN with nephrotic proteinuria. Methods . From 1 January 2012, to 1 January 2016, totally 150 hospitalized children suffered from HSPN with nephrotic proteinuria were included. All were treated with glucocorticoid and cyclophosphamide, and 100 of them were treated with integrative traditional Chinese decoction QLYF. Patients were followed up for 2 years. Rate of adverse event occurrence, short-term clinical effects, long-term clinical effects, and TCM therapeutic evaluation were all compared. Results . Total adverse event rate was lower in the QLYF group ( χ 2  = 5.357, p = 0.022 ); rates of respiratory infection, urinary infection, poor appetite, hepatotoxity, cardiotoxicity, and neutropenia were all decreased in patients who received QLYF ( p 〈 0.05 ), and no cases of hepatic and renal toxicities related to the herbal medicine were observed in the QLYF group. For short-term clinical efficacy evaluation, lower levels of 24 hour proteinuria ( p 〈 0.05 ) and urine blood cell count ( p 〈 0.05 ) were found in the QLYF group. For long-term efficacy evaluation, better clinical control rate effective rate, lower recurrence rate ( p 〈 0.05 ), and fewer TCM syndrome score ( p 〈 0.05 ) were found in the QLYF group. Conclusion . Compared with merely using regular oral glucocorticoid plus cyclophosphamide pulse therapeutic regimen, the therapeutic regimen that integrates QLYF with the abovementioned western medicine might be a safe means to decrease the occurrence rate of adverse events and improve short-term and long-term clinical effects in children who suffered from moderately severe HSPN with nephrotic proteinuria.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2020/3920735
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
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