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  • 1
    Online Resource
    Online Resource
    Risk Factors of Bacteremia following Multiple Traumas
    Hindawi Limited ; 2020
    In:  Emergency Medicine International Vol. 2020 ( 2020-04-06), p. 1-7
    Details
    In: Emergency Medicine International, Hindawi Limited, Vol. 2020 ( 2020-04-06), p. 1-7
    Abstract: Background . Bacteremia is a major nosocomial infection that frequently occurs in trauma patients, increasing morbidity and mortality. The aim of this study was to identify risk factors and to describe epidemiological patterns for early onset (EOB) and late onset (LOB) bacteremia after trauma. Methods . We retrospectively reviewed medical records of all trauma patients admitted to the surgical intensive care unit and general ward between January 2011 and December 2015. The information was collected for each patient and recorded in a computer database: early onset bacteremia (EOB) was defined as when onset occurred within 7 days after trauma, and late onset bacteremia (LOB) was defined as when onset occurred after 7 days from trauma. Results . Thirty-four patients of 859 (4%) developed bacteremia during their hospital stay: 4 (11.8%) developed EOB, 26 (76.4%) LOB, and 4 (11.8%) patients developed both of them. Sixty events of bacteremia happened to these patients: 9 (15.0%) EOB and 51 (85.0%) LOB. Gram-positive cocci were isolated more frequently than Gram-negative bacilli in both groups. Gram-positive cocci were more frequently isolated in EOB than in LOB; otherwise, there was no statistical significance (77.8% vs. 64.7%, p = 0.683 ). Central line-associated blood stream infection (CLABSI) and surgical site infection (SSI) were the most common identified source for LOB. Presence of liver (OR: 2.66, p = 0.035 ) and pelvic injury (OR: 2.25, p = 0.038 ), gastrointestinal tract perforation (OR: 5.48, p = 0.002 ), and massive transfusion (OR: 3.36, p = 0.006 ) represented risk factors for bacteremia. Conclusions . Presence of pelvic and liver injury on arrival in emergency department, gastrointestinal tract perforation, and massive transfusion within the first 24 hours after trauma appears to be significant risk factors for bacteremia.
    Type of Medium: Online Resource
    ISSN: 2090-2840 , 2090-2859
    URL: Article
    DOI: 10.1155/2020/9217949
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2596429-X
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  • 2
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    Impact of an Acute Care Surgery Model on the Management of Acute Appendicitis in South Korea: A Retrospective Cohort Study
    Hindawi Limited ; 2021
    In:  Emergency Medicine International Vol. 2021 ( 2021-03-26), p. 1-5
    Details
    In: Emergency Medicine International, Hindawi Limited, Vol. 2021 ( 2021-03-26), p. 1-5
    Abstract: Background. The acute care surgery (ACS) system is a new model for the prompt management of diseases that require rapid treatment in patients with acute abdomen. This study compared the outcomes and characteristics of the ACS system and traditional on-call system (TROS) for acute appendicitis in South Korea. Methods. This single-center, retrospective study included all patients (aged ≥18 years) who underwent surgery for acute appendicitis in 2016 and 2018. The TROS and ACS system were used for the 2016 and 2018 groups, respectively. We retrospectively obtained data on each patient from the electrical medical records. The independent samples t-test and Mann–Whitney U-test were used for continuous and nonnormally distributed data, respectively. Results. In total, 126 patients were included. The time taken to get from the emergency room admission to the operating room, operation times, and postoperative complication rates were similar between both groups. However, the length of the hospital stay was shorter in the ACS group than in the TROS group (4.3 ± 3.2 days vs. 7.2 ± 9.6 days, p = 0.039 ). Conclusions. Since the introduction of the ACS system, the length of hospital stay for surgical patients has decreased. This may be due to the application of an integrated medical procedure, such as a new clinical pathway, rather than differences in the surgical techniques.
    Type of Medium: Online Resource
    ISSN: 2090-2859 , 2090-2840
    URL: Article
    DOI: 10.1155/2021/5522523
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2596429-X
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  • 3
    Online Resource
    Online Resource
    A polymorphism in AGT and AGTR1 gene is associated with lead-related high blood pressure
    Hindawi Limited ; 2015
    In:  Journal of the Renin-Angiotensin-Aldosterone System Vol. 16, No. 4 ( 2015-12), p. 712-719
    Details
    In: Journal of the Renin-Angiotensin-Aldosterone System, Hindawi Limited, Vol. 16, No. 4 ( 2015-12), p. 712-719
    Type of Medium: Online Resource
    ISSN: 1470-3203 , 1752-8976
    URL: Article
    DOI: 10.1177/1470320313516174
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2261873-9
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  • 4
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    Comparable Clinical Outcome Using Small or Large Gross Tumor Volume-to-Clinical Target Volume Margin Expansion in Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Carcinoma
    Hindawi Limited ; 2022
    In:  Journal of Oncology Vol. 2022 ( 2022-6-3), p. 1-10
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2022 ( 2022-6-3), p. 1-10
    Abstract: The purpose of this study was to evaluate the feasibility of small primary gross tumor volume (GTV)-to-clinical target volume (CTV) margin expansion in neoadjuvant chemoradiation for esophageal squamous cell carcinoma. Medical records of 139 patients with locally advanced esophageal squamous cell carcinoma who underwent neoadjuvant chemoradiation and radical esophagectomy were retrospectively reviewed. Patients treated with longitudinal primary GTV-to-CTV margin expansion of 2 cm and no additional expansion of the CTV through the esophagus were classified into a small margin (SM) group (37 patients). The remaining 102 patients were classified as a large margin (LM) group. Patterns of recurrence including local and out-field regional recurrence rates were compared between the two groups. Clinical outcomes including rates of local control, regional control, failure-free survival, and overall survival were also compared. More patients in the SM group underwent paclitaxel + carboplatin, Mckeown esophagectomy, and intensity-modulated radiation therapy than in the LM group. With a median follow-up of 25.6 months, there was no significant difference in the crude rate of local recurrence (10.8% vs. 6.9%, P = 0.694 ), out-field regional recurrence (27.0% vs. 19.6%, P = 0.480 ), or out-field regional recurrence without in-field recurrence (10.8% vs. 12.7%, P = 0.988 ) between the two groups. There was no significant difference in failure-free survival (5-year, 34.4% vs. 30.6%, P = 0.652 ) or overall survival (44.1% vs. 38.5%, P = 1.000 ), either. Esophageal fistula was not reported in the SM group (0.0% vs. 7.9%, P = 0.176 ). In conclusion, a radiation field with 2 cm of longitudinal primary GTV-to-CTV was feasible in the neoadjuvant setting for esophageal squamous cell carcinoma treatment.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2022/5635071
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2461349-6
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  • 5
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    Multiparametric Monitoring of Early Response to Antiangiogenic Therapy: A Sequential Perfusion CT and PET/CT Study in a Rabbit VX2 Tumor Model
    Hindawi Limited ; 2014
    In:  The Scientific World Journal Vol. 2014 ( 2014), p. 1-10
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2014 ( 2014), p. 1-10
    Abstract: Objectives. To perform dual analysis of tumor perfusion and glucose metabolism using perfusion CT and FDG-PET/CT for the purpose of monitoring the early response to bevacizumab therapy in rabbit VX2 tumor models and to assess added value of FDG-PET to perfusion CT. Methods. Twenty-four VX2 carcinoma tumors implanted in bilateral back muscles of 12 rabbits were evaluated. Serial concurrent perfusion CT and FDG-PET/CT were performed before and 3, 7, and 14 days after bevacizumab therapy (treatment group) or saline infusion (control group). Perfusion CT was analyzed to calculate blood flow (BF), blood volume (BV), and permeability surface area product (PS); FDG-PET was analyzed to calculate SUVmax, SUVmean, total lesion glycolysis (TLG), entropy, and homogeneity. The flow-metabolic ratio (FMR) was also calculated and immunohistochemical analysis of microvessel density (MVD) was performed. Results. On day 14, BF and BV in the treatment group were significantly lower than in the control group. There were no significant differences in all FDG-PET-derived parameters between both groups. In the treatment group, FMR prominently decreased after therapy and was positively correlated with MVD. Conclusions. In VX2 tumors, FMR could provide further insight into the early antiangiogenic effect reflecting a mismatch in intratumor blood flow and metabolism.
    Type of Medium: Online Resource
    ISSN: 2356-6140 , 1537-744X
    URL: Article
    DOI: 10.1155/2014/701954
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2075968-X
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  • 6
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    Facile fabrication of polyacrylonitrile‐derived porous carbon beads via electron beam irradiation as anode materials for Li‐ion batteries
    Hindawi Limited ; 2021
    In:  International Journal of Energy Research Vol. 45, No. 6 ( 2021-05), p. 9530-9540
    Details
    In: International Journal of Energy Research, Hindawi Limited, Vol. 45, No. 6 ( 2021-05), p. 9530-9540
    Type of Medium: Online Resource
    ISSN: 0363-907X , 1099-114X
    URL: Issue
    URL: Article
    DOI: 10.1002/er.v45.6
    DOI: 10.1002/er.6479
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 1480879-1
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  • 7
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    Preparation and Properties of Thermoresponsive P(N-Isopropylacrylamide-co-butylacrylate) Hydrogel Materials for Smart Windows
    Hindawi Limited ; 2019
    In:  International Journal of Polymer Science Vol. 2019 ( 2019-11-13), p. 1-7
    Details
    In: International Journal of Polymer Science, Hindawi Limited, Vol. 2019 ( 2019-11-13), p. 1-7
    Abstract: Thermoresponsive polymers that exhibit phase transition in response to temperature change can be used as material for smart windows because they can control solar light transmission depending on the outside temperature. The development of thermoresponsive polymers for a smart window that can be used over a wide temperature range is required. Therefore, to obtain smart window materials that can be used at various temperatures, three-dimensional thermoresponsive P(NIPAm-co-BA) hydrogels were prepared by free radical polymerization from main monomer N-isopropylacrylamide, comonomer butyl acrylate, and crosslinking agent N,N ′ -methylenebisacrylamide (MBAm) in this study. This study examined the effect of BA content on the lower critical solution temperature (LCST) and the solar light transmittance of crosslinked P(NIPAm-co-BA) hydrogel films. The LCST of hydrogel films was found to be significantly decreased from 34.3 to 29.5°C with increasing BA content from 0 to 20 mol%. It was found that the transparent films at T = 25 ° C ( T 〈 LCST ) were converted to translucent films at a higher temperature ( T = 45 ° C ) ( T 〉 LCST ). These results suggested that the crosslinked P(NIPAm-co-BA) hydrogel materials prepared in this study could have high potential for application in smart window materials.
    Type of Medium: Online Resource
    ISSN: 1687-9422 , 1687-9430
    URL: Article
    DOI: 10.1155/2019/3824207
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2520688-6
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  • 8
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    Online Resource
    Improving Osteogenesis Activity on BMP-2-Immobilized PCL Fibers Modified by the γ -Ray Irradiation Technique
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-10
    Abstract: The purpose of this study was to demonstrate the ability of BMP-2-immobilized polycaprolactone (PCL) fibers modified using the γ -ray irradiation technique to induce the osteogenic differentiation of MG-63 cells. Poly acrylic acid (AAc) was grafted onto the PCL fibers by the γ -ray irradiation technique. BMP-2 was then subsequently immobilized onto the AAc-PCL fibers (BMP-2/AAc-PCL). PCL and surface-modified PCL fibers was characterized by evaluation with a scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and contact angle. The biological activity of the PCL and surface-modified PCL fibers were characterized by alkaline phosphatase (ALP) activity, calcium deposition, and the mRNA expression of osteocalcin and osteopontin in MG-63 cells. Successfully grafted AAc and PCL fibers with immobilized BMP-2 were confirmed by XPS results. The results of the contact angle showed that BMP-2/AAc-PCL fibers have more hydrophilic properties in comparison to PCL fibers. The ALP activity, calcium deposition, and gene expressions of MG-63 cells grown on BMP-2/AAc-PCL fibers showed greatly induced osteogenic differentiation in comparison to the PCL fibers. In conclusion, these results demonstrated that BMP-2/AAc-PCL fibers have the potential to effectively induce the osteogenic differentiation of MG-63 cells.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/302820
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 9
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    Evaluation of Alternative Transport Media for RT-qPCR-Based SARS-CoV-2 Testing
    Hindawi Limited ; 2022
    In:  International Journal of Analytical Chemistry Vol. 2022 ( 2022-8-10), p. 1-7
    Details
    In: International Journal of Analytical Chemistry, Hindawi Limited, Vol. 2022 ( 2022-8-10), p. 1-7
    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), is still rapidly spreading as of March 2022. An accurate and rapid molecular diagnosis is essential to determine the exact number of confirmed cases. Currently, the viral transport medium (VTM) required for testing is in short supply due to a sharp increase in the laboratory tests performed, and alternative VTMs are needed to alleviate the shortage. Guanidine thiocyanate-based media reportedly inactivate SARS-CoV-2 and are compatible with quantitative reverse transcription polymerase chain reaction (RT-qPCR) assays, but the compatibility and the viral detection capacity have not been fully validated. To evaluate the guanidine thiocyanate-based Gene Transport Medium (GeneTM) as an alternative VTM, we prepared 39 SARS-CoV-2-positive and 7 SARS-CoV-2-negative samples in GeneTM, eNAT™, and phosphate-buffered saline (PBS). The cycle threshold (Ct) values of three SARS-CoV-2 targets (the S, RdRP, and N genes) were analyzed using RT-qPCR testing. The comparison of Ct values from the positive samples showed a high correlation (R2= 0.95–0.96) between GeneTM and eNAT™, indicating a comparable viral detection capacity. The delta Ct values of the SARS-CoV-2 genes in each transport medium were maintained for 14 days at cold (4°C) or room (25°C) temperatures, suggesting viral samples were stably preserved in the transport media for 14 days. Together, GeneTM is a potential alternative VTM with comparable RT-qPCR performance and stability to those of standard media.
    Type of Medium: Online Resource
    ISSN: 1687-8779 , 1687-8760
    URL: Article
    DOI: 10.1155/2022/5020255
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2494714-3
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  • 10
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    Efficacy and Safety of Transdermal Buprenorphine versus Oral Tramadol/Acetaminophen in Patients with Persistent Postoperative Pain after Spinal Surgery
    Hindawi Limited ; 2017
    In:  Pain Research and Management Vol. 2017 ( 2017), p. 1-11
    Details
    In: Pain Research and Management, Hindawi Limited, Vol. 2017 ( 2017), p. 1-11
    Abstract: Purpose . Control of persistent pain following spinal surgery is an unmet clinical need. This study compared the efficacy and safety of buprenorphine transdermal system (BTDS) to oral tramadol/acetaminophen (TA) in Korean patients with persistent, moderate pain following spinal surgery. Methods . Open-label, interventional, randomized multicenter study. Adults with persistent postoperative pain (Numeric Rating Scale [NRS] ≥ 4 at 14–90 days postsurgery) were enrolled. Patients received once-weekly BTDS ( n = 47 ; 5  μ g/h titrated to 20  μ g/h) or twice-daily TA ( n = 40 ; tramadol 37.5 mg/acetaminophen 325 mg, one tablet titrated to 4 tablets) for 6 weeks. The study compared pain reduction with BTDS versus TA at week 6. Quality of life (QoL), treatment satisfaction, medication compliance, and adverse events (AEs) were assessed. Findings . At week 6, both groups reported significant pain reduction (mean NRS change: BTDS −2.02; TA −2.76, both P 〈 0.0001 ) and improved QoL (mean EQ-5D index change: BTDS 0.10; TA 0.19, both P 〈 0.05 ). The BTDS group achieved better medication compliance (97.8% versus 91.0%). Incidence of AEs (26.1% versus 20.0%) and adverse drug reactions (20.3% versus 16.9%) were comparable between groups. Implications . For patients with persistent pain following spinal surgery, BTDS is an alternative to TA for reducing pain and supports medication compliance. This trial is registered with Clinicaltrials.gov: NCT01983111 .
    Type of Medium: Online Resource
    ISSN: 1203-6765 , 1918-1523
    URL: Article
    DOI: 10.1155/2017/2071494
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2048409-4
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