GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Ultrasensitive Detection of Lysozyme upon Conformational Change of DNA Duplex
    Hindawi Limited ; 2022
    In:  Journal of Nanomaterials Vol. 2022 ( 2022-8-26), p. 1-12
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2022 ( 2022-8-26), p. 1-12
    Abstract: We report a simple, cost-effective, and ultrasensitive approach for colorimetric detection of lysozyme based on target-induced conformational change of DNA duplex. The detection method utilizes the interaction between DNA aptamer and its target leading to the dissociation of DNA aptamer from the DNA duplex and forms a structured complex. The complementary DNA that detached from the DNA duplex adsorbed on the AuNPs surface protects the nanoparticles against salt-induced aggregation, resulting in maintaining the red dispersed state of AuNPs. Such an approach allowed the femtomolar detection of lysozyme with a wide linear scale ranging from 0.1 to 200 pM by simple spectroscopic analysis with detection time of ~40 min. In case of naked eye detection, the detection limit of nanoaptasensor corresponds to ~0.5 pM. The nanoaptasensor demonstrated high specificity with regard to lysozyme in the presence of a variety of nonspecific proteins. In case of lysozyme detection in simulated saliva samples, the average recoveries were in the range of 90.47 to 105.90%, with the relative standard deviations (RSD) of 3.45-4.89% that suggests a good reproducibility. The results clearly indicated the reliability and applicability of the proposed assay for the simple and rapid detection of lysozyme in real samples. Compared with existing diagnostic assays, the proposed nanoaptasensor showed many advantages regarding simplicity, versatility, cost, and time for analysis. This approach demonstrated a great potential for ultrasensitive and on-site analysis of a wide range of protein biomarkers using plasmonic nanoparticles.
    Type of Medium: Online Resource
    ISSN: 1687-4129 , 1687-4110
    URL: Article
    DOI: 10.1155/2022/1107081
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2229480-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Therapeutic Potential of Polyscias fruticosa (L.) Harms Leaf Extract for Parkinson’s Disease Treatment by Drosophila melanogaster Model
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-5-19), p. 1-18
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-5-19), p. 1-18
    Abstract: Parkinson’s disease (PD) is characterized by progressive locomotive defects and loss of dopaminergic neurons. Polyscias fruticosa leaves are used by Vietnamese as herbal medicines to support the treatment of some diseases related to neurodegeneration such as Parkinson’s and Alzheimer’s diseases. However, recent scientific data have not provided sufficient evidence for the use of P. fruticosa leaves to treat PD or decelerate PD progression. In the present study, the capacity of P. fruticosa leaf extract for PD treatment on the dietary supplementation was investigated using dUCH-knockdown Drosophila model. The results indicated that P. fruticosa leaf extract decelerated dopaminergic neuron degeneration induced by dUCH knockdown in not only the larval stage but also the adult stage, which might result in the amelioration in locomotor ability of dUCH-knockdown larvae and flies. Furthermore, antioxidant activities and some key phytochemicals such as saponins, polyphenols, and flavonoids that might contribute to the effects of the P. fruticosa leaf extract were identified.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/5262677
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Fabrication of Porous Hydroxyapatite Granules as an Effective Adsorbent for the Removal of Aqueous Pb(II) Ions
    Hindawi Limited ; 2019
    In:  Journal of Chemistry Vol. 2019 ( 2019-02-21), p. 1-10
    Details
    In: Journal of Chemistry, Hindawi Limited, Vol. 2019 ( 2019-02-21), p. 1-10
    Abstract: Porous hydroxyapatite (HAp) granules have been successfully fabricated from a HAp powder precursor and polyvinyl alcohol (PVA) additive by a simple sintering process. The composition and microstructures of the HAp were characterized by X-ray diffraction (XRD) and scanning electron microscope (SEM) equipped with an energy dispersive X-ray (EDX) spectrometer. The effects of sintering temperature and PVA/HAp mass ratios on color, water stability, morphology, and chemical composition of HAp are discussed. Optimum conditions for the fabrication of HAp granules were found to be a PVA/HAp mass ratio of 3/20 and a sintering temperature of 600°C for 4 h. Accordingly, the obtained HAp is white in color, is in the granular form with a size of about 2 × 10 mm, and has a specific surface area of 70.6 m 2 /g. The adsorption of Pb 2+ onto the as-prepared HAp granules was carried out in aqueous solution by varying the pH, the adsorbent dose, the initial concentration of Pb 2+ , and the contact time. The results of adsorption stoichiometry of Pb 2+ on the HAp granule adsorbent were fitted to the Langmuir adsorption isotherm model ( R 2  = 0.99). The adsorption capacity and removal efficiency of the HAp granule adsorbent for Pb 2+ under optimal conditions were found to be 7.99 mg/g and 95.92%, respectively. The adsorption process obeyed a pseudo-second-order kinetic model with R 2 ∼1. The porous HAp granules studied in this work showed potential for the removal of Pb 2+ from industrial wastewater.
    Type of Medium: Online Resource
    ISSN: 2090-9063 , 2090-9071
    URL: Article
    DOI: 10.1155/2019/8620181
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2393625-3
    detail.hit.zdb_id: 2703077-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications
    Hindawi Limited ; 2021
    In:  Journal of Nanomaterials Vol. 2021 ( 2021-10-28), p. 1-9
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2021 ( 2021-10-28), p. 1-9
    Abstract: We report on the synthesis and characterization of folic acid-conjugated silica-modified TbPO4·H2O nanorods for biomedical applications. The uniform shape TbPO4·H2O nanorods with a hexagonal phase were successfully synthesized by wet chemical methods. A novel TbPO4·H2O@silica-NH2 nanocomplex was then formed by functionalizing these nanorods with silica and conjugating with biological agents. The field emission scanning electron microscopy, energy-dispersive X-ray, and X-ray diffraction reveal the morphology and structure of the nanorods, with their controllable sizes (500-800 nm in length and 50-80 nm in diameter). The Fourier transform infrared spectroscopy was employed to identify chemical substances or functional groups of the TbPO4·H2O@silica-NH2 nanocomplex. The photoluminescence spectra show the four emission lines of TbPO4·H2O@silica-NH2 in folic acid at 488, 540, 585, and 621 nm under 355 nm laser excitation, which could be attributed to the 5D4-7 F j ( J = 6 , 5 , 4 , 3 ) transitions of Tb3+. The TbPO4·H2O@silica-NH2 nanorods were conjugated with folic acid for the detection of MCF7 breast cancer cells. The obtained results show a promising possibility for the recognition of living cells that is of crucial importance in biolabeling.
    Type of Medium: Online Resource
    ISSN: 1687-4129 , 1687-4110
    URL: Article
    DOI: 10.1155/2021/9888856
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2229480-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Determination of Pharmaceutical Residues by UPLC-MS/MS Method: Validation and Application on Surface Water and Hospital Wastewater
    Hindawi Limited ; 2021
    In:  Journal of Analytical Methods in Chemistry Vol. 2021 ( 2021-1-8), p. 1-12
    Details
    In: Journal of Analytical Methods in Chemistry, Hindawi Limited, Vol. 2021 ( 2021-1-8), p. 1-12
    Abstract: In this study, an analytical method for the simultaneous determination of 7 major pharmaceutical residues in Vietnam, namely, carbamazepine, ciprofloxacin, ofloxacin, ketoprofen, paracetamol, sulfamethoxazole, and trimethoprim, in surface water and hospital wastewater has been developed. The method includes enrichment and clean-up steps by solid phase extraction using mix-mode cation exchange, followed by identification and quantification using an ultrahigh-performance liquid chromatography and tandem mass spectrometry and employing electrospray ionization (UPLC-ESI-MS/MS). Seven target compounds were separated on the reversed phase column and detected in multiple reaction monitoring (MRM) mode within 6 minutes. The present study also optimized the operating parameters of the mass spectrometer to achieve the highest analytical signals for all target compounds. All characteristic parameters of the analytical method were investigated, including linearity range, limit of detection, limit of quantification, precision, and accuracy. The important parameter in UPLC-ESI-MS/MS, matrix effect, was assessed and implemented via preextraction and postextraction spiking experiments. The overall recoveries of all target compounds were in the ranges from 55% to 109% and 56 % to 115% for surface water and hospital wastewater, respectively. Detection limits for surface water and hospital wastewater were 0.005–0.015 µg L−1 and 0.014–0.123 µg L−1, respectively. The sensitivity of the developed method was allowed for determination of target compounds at trace level in environmental water samples. The in-house validation of the developed method was performed by spiking experiment in both the surface water and hospital wastewater matrix. The method was then applied to analyze several surface water and hospital wastewater samples taken from West Lake and some hospitals in Vietnam, where the level of these pharmaceutical product residues was still missed. Sulfamethoxazole was present at a high detection frequency in both surface water (33% of analyzed samples) and hospital wastewater (81% of analyzed samples) samples.
    Type of Medium: Online Resource
    ISSN: 2090-8873 , 2090-8865
    URL: Article
    DOI: 10.1155/2021/6628285
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2654178-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Zinc/Cobalt-Based Zeolite Imidazolate Frameworks for Simultaneously Degrading Dye and Inhibiting Bacteria
    Hindawi Limited ; 2022
    In:  Journal of Nanomaterials Vol. 2022 ( 2022-9-30), p. 1-11
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2022 ( 2022-9-30), p. 1-11
    Abstract: In this work, the zinc/cobalt-based zeolite imidazolate frameworks ((Co/Zn)ZIFs) were synthesized with the solvothermal method. The obtained material was characterized by utilizing scanning electron microscopy (SEM), X-ray diffraction (XRD), UV-Vis diffusive reflectance spectroscopy, and nitrogen adsorption-desorption isotherms. XRD and SEM analyses show that (Co/Zn)ZIFs are composed of nanocrystals with polyhedral shapes of around 50–100 nm and belong to the I-43m space group as those of ZIF-8 and ZIF-67. Optical studies demonstrate a red shift in the absorbance spectrum of (Co/Zn)ZIFs compared with individual components of ZIF-67 or ZIF-8. (Co/Zn)ZIF composite was utilized as photocatalytic material to treat a model aqueous solution containing rhodamine B and bacteria. It was found that (Co/Zn)ZIFs could simultaneously degrade rhodamine B and inhibit bacteria (E. coli and S. aureus). The manufactured composite could catalyze the mineralization of rhodamine B and also exhibited good antibacterial activity against Gram-negative E. coli (93.32% inhibition rate) and Gram-positive S. aureus (90.86% inhibition rate) in the visible-light region within four hours of irradiation. Gram-negative bacteria were more resistant to (Co/Zn)ZIFs than Gram-positive bacteria. (Co/Zn)ZIFs can be used as light-driven catalysts for water and environmental detoxification from organic compounds like dyes and bacteria.
    Type of Medium: Online Resource
    ISSN: 1687-4129 , 1687-4110
    URL: Article
    DOI: 10.1155/2022/8630685
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2229480-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Designs, Synthesis, Docking Studies, and Biological Evaluation of Novel Berberine Derivatives Targeting Zika Virus
    Hindawi Limited ; 2021
    In:  Journal of Chemistry Vol. 2021 ( 2021-4-18), p. 1-10
    Details
    In: Journal of Chemistry, Hindawi Limited, Vol. 2021 ( 2021-4-18), p. 1-10
    Abstract: The World Health Organization has designated Zika virus (ZIKV) as a dangerous, mosquito-borne flaviviral pathogen that was recently found to be responsible for a dramatically increased number of microcephaly cases and other congenital abnormalities in fetuses and newborns. There is neither a vaccine to prevent nor a drug to treat ZIKA virus infections, at the present time. Berberine (BBR) is a promising drug approved by FDA against flaviviral dengue virus, and BBR derivatives are of great interest in antiviral drug development. In this study, we synthesized eight BBR derivatives by introducing benzyl groups at the C-13 position of BBR and converting to respective 8-oxoberberine derivatives, performed molecular docking analysis, and evaluated their anti-Zika virus activity utilizing a cell‐based phenotypic assay. Binding mode analysis, absolute binding free energy calculation, and structure-activity relationship studies of these compounds with ZIKV NS3 receptor were collected. Amongst these studied compounds, compound 4d with a structure of 13-(2,6-difluoro)-benzylberberine showed high binding affinity (docking score of −7.31 kcal/mol) towards ZIKV NS2B-NS3 protease with critical binding formed within the active site. In the cell-based assay, compound 4d displayed the highest antiviral efficacy against ZIKV with a selective index (SI) of 15.3, with 3.7-fold greater than that of berberine. Together, our study suggests that the potential ZIKV NS2B-NS3 protease inhibitor, compound 4d, is the best alternative to BBR and, further, extends an assuring platform for developing antiviral competitive inhibitors against ZIKV infection.
    Type of Medium: Online Resource
    ISSN: 2090-9071 , 2090-9063
    URL: Article
    DOI: 10.1155/2021/5567111
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2393625-3
    detail.hit.zdb_id: 2703077-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Adsorption of Anionic Surfactants onto Alumina: Characteristics, Mechanisms, and Application for Heavy Metal Removal
    Hindawi Limited ; 2018
    In:  International Journal of Polymer Science Vol. 2018 ( 2018-12-13), p. 1-11
    Details
    In: International Journal of Polymer Science, Hindawi Limited, Vol. 2018 ( 2018-12-13), p. 1-11
    Abstract: We investigated adsorption of anionic surfactants, sodium dodecyl sulfate (SDS) and sodium tetradecyl sulfate (STS), onto alumina (Al 2 O 3 ) with large size in the present study. The effective conditions for SDS and STS adsorption onto Al 2 O 3 were systematically studied. The conditions for SDS and STS adsorption onto γ -Al 2 O 3 were optimized and found to be contact time 180 min, pH 4, and 1 mM NaCl. Adsorption of both SDS and STS onto large Al 2 O 3 beads increased with an increase of ionic strength, demonstrating that the adsorption is controlled by electrostatic attraction between anionic sulfate groups and positively charged Al 2 O 3 surface, as well as hydrophobic interactions between long alkyl chains of surfactant molecules. Nevertheless, the hydrophobic interaction in terms of STS adsorption is much higher than that of SDS adsorption. The obtained SDS and STS adsorption isotherms in different NaCl concentrations onto Al 2 O 3 beads were fitted well by two-step adsorption. Adsorption mechanisms were disused in detail on the basis of adsorption isotherm, the change in surface charge, and the change in functional surface groups by Fourier-transform infrared spectroscopy (FTIR). The application of surfactant adsorption onto Al 2 O 3 to remove cadmium ion (Cd 2+ ) was also studied. The optimum conditions for Cd 2+ removal using surfactant-modified alumina (SMA) are pH 6, contact time 120 min, and ionic strength 0.1 mM NaCl. Under optimum conditions, the removal efficiency of Cd 2+ using SMA increased significantly. We demonstrate that SMA is a novel adsorbent for removal of Cd 2+ from aqueous solution.
    Type of Medium: Online Resource
    ISSN: 1687-9422 , 1687-9430
    URL: Article
    DOI: 10.1155/2018/2830286
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2520688-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Determination of Total Mercury in Solid Samples by Anodic Stripping Voltammetry
    Hindawi Limited ; 2021
    In:  Journal of Chemistry Vol. 2021 ( 2021-1-12), p. 1-8
    Details
    In: Journal of Chemistry, Hindawi Limited, Vol. 2021 ( 2021-1-12), p. 1-8
    Abstract: The anodic stripping voltammetry (ASV) was investigated to determine total mercury in solid samples using a gold electrode. The mercury was deposited on the gold electrode in a preconcentration step. The oxidation peak of mercury was irreversible. The optimal conditions of the procedure were found to be as follows: 0.05 mol L−1 HCl solution, deposition potential −0.5 V vs. Ag/AgCl/KCls, deposition time 40 s, and sweep rate 0.04 V s−1. Under the optimal conditions, the peak current showed a linear dependence on Hg2+ concentration in the range from 0.01 to 0.1 mg l−1. The detection limit and quantification limit were 4.28 µg L−1 and 12.98 µg L−1, respectively. The mean recovery and relative standard deviation were 91.2% and 2.4% (n = 9). The procedure was successfully applied for determining total mercury in samples collected from Hanoi light bulb warehouse—The Rang Dong Light Source and Vacuum Flask JSC. The results were compared with cold vapor atomic absorption spectrometry (CV-AAS).
    Type of Medium: Online Resource
    ISSN: 2090-9071 , 2090-9063
    URL: Article
    DOI: 10.1155/2021/8888879
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2393625-3
    detail.hit.zdb_id: 2703077-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Facile Synthesis of Propranolol and Novel Derivatives
    Hindawi Limited ; 2020
    In:  Journal of Chemistry Vol. 2020 ( 2020-08-24), p. 1-10
    Details
    In: Journal of Chemistry, Hindawi Limited, Vol. 2020 ( 2020-08-24), p. 1-10
    Abstract: Propranolol is one of the first medications of the beta-blocker used for antihypertensive drugs. This study reports the facile route for the synthesis of propranolol and its novel derivatives. Herein, propranolol synthesis proceeded from 1-naphthol and isopropylamine under mild and less toxic conditions. Novel propranolol derivatives were designed by reactions of propranolol with benzoyl chloride, pyridinium chlorochromate, and n-butyl bromide through esterification, oxidation reduction, and alkylation, respectively. The isolation and purity of compounds were conducted using column chromatography and thin-layer chromatography. Mass spectrometry and 1 H-NMR spectroscopy were applied to identify new compounds structure. Propranolol derivatives from 2-chlorobenzoyl chloride (compound 3 ), 2-fluorobenzoyl chloride (compound 5 ), and especially acetic anhydride (compound 6 ) manifested high yields and significantly increased water solubility. Six semisynthetic propranolol derivatives promise to improve antioxidative and biological activities.
    Type of Medium: Online Resource
    ISSN: 2090-9063 , 2090-9071
    URL: Article
    DOI: 10.1155/2020/9597426
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2393625-3
    detail.hit.zdb_id: 2703077-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...