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  • 1
    Online Resource
    Online Resource
    Severe Periodontitis Is a Major Contributory Factor to Unmet Dental Healthcare Needs among Rheumatoid Arthritis Patients in Hong Kong
    Hindawi Limited ; 2022
    In:  International Journal of Dentistry Vol. 2022 ( 2022-12-2), p. 1-11
    Details
    In: International Journal of Dentistry, Hindawi Limited, Vol. 2022 ( 2022-12-2), p. 1-11
    Abstract: Objective. This study aimed to examine the frequency and predictive factors of adverse oral and dental outcomes in patients with rheumatoid arthritis (RA) with the goal to address their unmet dental healthcare needs in the metropolitan city of Hong Kong. Methods. 238 RA patients followed up at local public hospitals were recruited in this cross-sectional study. A full dental examination was performed. Data were compared with the retrospective data collected from age-matched control groups in the community conducted in a territory-wide oral health survey in 2011. Predictive factors for severe periodontitis including various demographic and disease-specific factors were examined by multiple logistic regression analysis. Results. Loose teeth and gum bleeding were frequent dental complaints. Only 85.0% of RA patients had 〉 20 natural teeth. Total edentulism was observed in 3.8% of patients, which was higher among adult (22–64 years) and elderly ( 〉 65 years old) RA patients than their respective age-matched community control groups. RA patients had a higher decayed, missing, and filled tooth score. Adult RA patients had a 5.3-fold increase in risk of severe periodontitis than their community counterparts. The plaque index was the main predisposing factor for severe periodontitis (odds ratio 17.5, p = 0.001 ), which was worse among the 22–34 age group of patients. More RA patients required tooth extraction compared to dental filling for their community controls. Conclusion. Severe periodontitis is a major cause of unmet dental healthcare needs among RA patients in Hong Kong. It is recommended that dental care plans for RA patients be commenced early among newly diagnosed patients.
    Type of Medium: Online Resource
    ISSN: 1687-8736 , 1687-8728
    URL: Article
    DOI: 10.1155/2022/8710880
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2546524-7
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  • 2
    Online Resource
    Online Resource
    Evaluation and Early Warning Simulation of Personnel Unsafe Behavior in Mines Prone to Coal-Rock Dynamic Disasters
    Hindawi Limited ; 2022
    In:  Geofluids Vol. 2022 ( 2022-5-16), p. 1-20
    Details
    In: Geofluids, Hindawi Limited, Vol. 2022 ( 2022-5-16), p. 1-20
    Abstract: At present, aging mines are faced with development bottlenecks such as lack of national policy support, serious problems left over from history, and difficulties in enterprise transformation and development, which seriously restrict the safe production and sustainable development of aging mines. In order to deeply analyze the influencing factors of group unsafe behavior in aging mines, the evolution law of unsafe behavior is qualitatively simulated and quantitatively analyzed to realize the safety evaluation of group unsafe behavior in aging mines. Based on this analysis of the emergence mechanism and influencing factors of unsafe behavior in aging mines, the evaluation index of unsafe behavior in the aging mine population was established. These include six criterion layers and 30 index layers; the mutation level value of the target layer is 0.9405. Group dynamic effect and safety management factors are the two important factors restricting their development and safety. The unsafe behavior of the aging mine groups was evaluated based on game theory and system dynamics—dynamic game simulation on the influence of unsafe behavior in aging coal mines. A qualitative simulation analysis was also performed using the QSIM algorithm. The evolution law of the safety psychology and behavior of aging mine workers are analyzed. This paper shows the importance of the unsafe behavior of aging mines, which helps the safety production and clarifies the safety psychology and the behavior evolution law. This paper puts forward new methods and theories on the safety psychology and behavior evolution law of the safety behavior and provides a reference for the sustainable development of aging mines.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2022/1822894
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 3
    Online Resource
    Online Resource
    Antitumor activity of alantolactone in lung cancer cell lines NCI‐H1299 and Anip973
    Hindawi Limited ; 2019
    In:  Journal of Food Biochemistry Vol. 43, No. 9 ( 2019-09)
    Details
    In: Journal of Food Biochemistry, Hindawi Limited, Vol. 43, No. 9 ( 2019-09)
    Type of Medium: Online Resource
    ISSN: 0145-8884 , 1745-4514
    URL: Issue
    URL: Article
    DOI: 10.1111/jfbc.v43.9
    DOI: 10.1111/jfbc.12972
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2174913-9
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  • 4
    Online Resource
    Online Resource
    Thermodynamic performance study on a novel absorption‐ compression cascade refrigeration activated by an internal combustion engine
    Hindawi Limited ; 2021
    In:  International Journal of Energy Research Vol. 45, No. 6 ( 2021-05), p. 9595-9612
    Details
    In: International Journal of Energy Research, Hindawi Limited, Vol. 45, No. 6 ( 2021-05), p. 9595-9612
    Type of Medium: Online Resource
    ISSN: 0363-907X , 1099-114X
    URL: Issue
    URL: Article
    DOI: 10.1002/er.v45.6
    DOI: 10.1002/er.6484
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 1480879-1
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  • 5
    Online Resource
    Online Resource
    Dynamic simulation and experimental verification on absorption refrigeration driven by vehicle waste heat
    Hindawi Limited ; 2020
    In:  International Journal of Energy Research Vol. 44, No. 7 ( 2020-06-10), p. 5287-5304
    Details
    In: International Journal of Energy Research, Hindawi Limited, Vol. 44, No. 7 ( 2020-06-10), p. 5287-5304
    Type of Medium: Online Resource
    ISSN: 0363-907X , 1099-114X
    URL: Issue
    URL: Article
    DOI: 10.1002/er.v44.7
    DOI: 10.1002/er.5278
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 1480879-1
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  • 6
    Online Resource
    Online Resource
    Salidroside Ameliorates Mitochondria-Dependent Neuronal Apoptosis after Spinal Cord Ischemia-Reperfusion Injury Partially through Inhibiting Oxidative Stress and Promoting Mitophagy
    Hindawi Limited ; 2020
    In:  Oxidative Medicine and Cellular Longevity Vol. 2020 ( 2020-07-23), p. 1-22
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2020 ( 2020-07-23), p. 1-22
    Abstract: Ischemia-reperfusion injury is the second most common injury of the spinal cord and has the risk of neurological dysfunction and paralysis, which can seriously affect patient quality of life. Salidroside (Sal) is an active ingredient extracted from Herba Cistanche with a variety of biological attributes such as antioxidant, antiapoptotic, and neuroprotective activities. Moreover, Sal has shown a protective effect in ischemia-reperfusion injury of the liver, heart, and brain, but its effect in ischemia-reperfusion injury of the spinal cord has not been elucidated. Here, we demonstrated for the first time that Sal pretreatment can significantly improve functional recovery in mice after spinal cord ischemia-reperfusion injury and significantly inhibit the apoptosis of neurons both in vivo and in vitro . Neurons have a high metabolic rate, and consequently, mitochondria, as the main energy-supplying suborganelles, become the main injury site of spinal cord ischemia-reperfusion injury. Mitochondrial pathway-dependent neuronal apoptosis is increasingly confirmed by researchers; therefore, Sal’s effect on mitochondria naturally attracted our attention. By means of a range of experiments both in viv o and in vitro , we found that Sal can reduce reactive oxygen species production through antioxidant stress to reduce mitochondrial permeability and mitochondrial damage, and it can also enhance the PINK1-Parkin signaling pathway and promote mitophagy to eliminate damaged mitochondria. In conclusion, our results show that Sal is beneficial to the protection of spinal cord neurons after ischemia-reperfusion injury, mainly by reducing apoptosis associated with the mitochondrial-dependent pathway, among which Sal’s antioxidant and autophagy-promoting properties play an important role.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2020/3549704
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2455981-7
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  • 7
    Online Resource
    Online Resource
    Maternal Probiotic or Synbiotic Supplementation Modulates Jejunal and Colonic Antioxidant Capacity, Mitochondrial Function, and Microbial Abundance in Bama Mini-piglets
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-5-4), p. 1-14
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-5-4), p. 1-14
    Abstract: The present study was conducted to investigate the effects of maternal probiotic or synbiotic supplementation during gestation and lactation on antioxidant capacity, mitochondrial function, and intestinal microbiota abundance in offspring weaned piglets. A total of 64 pregnant Bama mini-sows were randomly allocated into the control group (basal diet), antibiotic group ( basal   diet + 50   g/t virginiamycin), probiotic group ( basal   diet + 200  mL/d probiotics per pig), or synbiotic group ( basal   diet + 200  mL/d probiotics per pig + 500  g/t xylo-oligosaccharides). On day 30 of post-weaning, eight piglets per group with average body weight were selected for sample collection. The results showed that maternal probiotic supplementation increased the catalase (CAT) activity in plasma and glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities in plasma, jejunum, and colon of piglets while decreased the malondialdehyde (MDA) and H2O2 concentrations in plasma compared with the control group ( P 〈 0.05 ). Moreover, maternal synbiotic supplementation increased the plasma CAT activity, jejunal glutathione and GSH-Px activities, jejunal and colonic total antioxidant capacity activity, and plasma and colonic SOD activity while decreased the colonic MDA concentration of offspring piglets compared with the control group ( P 〈 0.05 ). The mRNA levels of antioxidant enzyme-related genes (copper- and zinc-containing superoxide dismutase, nuclear factor erythroid 2-related factor 1, and nuclear factor erythroid 2-related factor 2) and mitochondrial-related genes (adenosine triphosphate synthase alpha subunit, adenosine triphosphate synthase β, and mitochondrial transcription factor A) in the jejunal mucosa were significantly upregulated, while the level of colonic peroxisome proliferator-activated receptor γ coactivator-1α was downregulated by maternal synbiotic supplementation ( P 〈 0.05 ). Maternal probiotic supplementation increased ( P 〈 0.05 ) the Bacteroidetes abundance in the jejunum and Bifidobacterium abundance in the jejunum and colon, and synbiotic supplementation increased ( P 〈 0.05 ) the abundances of Firmicutes, Bacteroidetes, Bifidobacterium, and Lactobacillus in the jejunum of piglets. Furthermore, correlation analysis revealed that intestinal microbiota abundances were significantly correlated with antioxidant enzyme activities and mitochondrial-related indexes. These findings indicated that maternal probiotic or synbiotic supplementation might be a promising strategy to improve the antioxidant capacity and mitochondrial function of offspring weaned piglets by altering the intestinal microbiota.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/6618874
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
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  • 8
    Online Resource
    Online Resource
    Discovering the Graph-Based Flow Patterns of Car Tourists Using License Plate Data: A Case Study in Shenzhen, China
    Hindawi Limited ; 2020
    In:  Journal of Advanced Transportation Vol. 2020 ( 2020-08-06), p. 1-15
    Details
    In: Journal of Advanced Transportation, Hindawi Limited, Vol. 2020 ( 2020-08-06), p. 1-15
    Abstract: Identifying flow patterns from massive trajectories of car tourists is considered a promising way to improve the management of tourism traffic. Previous researches have mainly focused on tourist movements at the macro-scale, such as inbound, domestic, and urban tourism using flow maps. Compared with modeling the flow patterns of tourists at the macro-scale, modeling tourist flow at the microscale is more complicated. This paper takes Dapeng Island located in Shenzhen as the study area and uses the car recognition devices to collect traffic flow. Firstly, car tourists are separated from the mixed traffic flow after analyzing the spatial-temporal characteristics of tourists and residents. Next, daily graphs of tourist movements between road segments and tourist attractions are constructed. Finally, a frequent subgraph mining algorithm is used to extract the flow patterns of car tourists. The experimental results show that (1) car tourists have obvious preferences in the selection of trip time and tourist attractions; (2) the intercity tourists tend to take multidestination trips rather than a single destination trip in the same type of attractions; (3) car tourists are inclined to park their cars in an easy-to-access place, even if the attractions visited are changed. The main contribution of this paper is to present a new method for discovering the flow patterns of car tourists hidden in massive amounts of license plate data.
    Type of Medium: Online Resource
    ISSN: 0197-6729 , 2042-3195
    URL: Article
    DOI: 10.1155/2020/4795830
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2553327-7
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  • 9
    Online Resource
    Online Resource
    GASC1 Promotes Stemness of Esophageal Squamous Cell Carcinoma via NOTCH1 Promoter Demethylation
    Hindawi Limited ; 2019
    In:  Journal of Oncology Vol. 2019 ( 2019-03-26), p. 1-15
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2019 ( 2019-03-26), p. 1-15
    Abstract: The highest incidence of esophageal squamous cell carcinoma (ESCC) occurs in China. Cancer stem cells play key roles for tumor progression. Gene amplified in squamous cell carcinoma 1 (GASC1) is essential to maintain self-renewal and differentiation potential of embryonic stem cells. This study aimed to reveal the effect and mechanism of GASC1 on ESCC stemness. The biological function of GASC1 in ESCC was evaluated both in vitro and in vivo . ChIP assay was performed to determine the molecular mechanism of GASC1 in epigenetic regulation of NOTCH1. We found that GASC1 expression was increased in poor differentiated ESCC cells and tissues. ESCC patients with a high level of GASC1 presented a significantly worse survival rate. GASC1 expression in purified ALDH + ESCC cells was significantly higher than that in ALDH - cells. The stemness of ESCC was dramatically decreased after GASC1 blockade. Furthermore, blockade of GASC1 decreased NOTCH1 expression via increase of NOTCH1 promoter H3K9me2 and H3K9me3. Moreover, the impaired stemness after blockade of GASC1 could be reversed after transfection of NOTCH1 overexpression lentiviral vector. GASC1 promoted stemness in ESCC cells via NOTCH1 promoter demethylation. Therefore, GASC1/NOTCH1 signaling might be a potential therapeutic target for the treatment of ESCC patients.
    Type of Medium: Online Resource
    ISSN: 1687-8450 , 1687-8469
    URL: Article
    DOI: 10.1155/2019/1621054
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2461349-6
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  • 10
    Online Resource
    Online Resource
    Fermentation Characterization of Chinese Yam Polysaccharide and Its Effects on the Gut Microbiota of Rats
    Hindawi Limited ; 2009
    In:  International Journal of Microbiology Vol. 2009 ( 2009), p. 1-13
    Details
    In: International Journal of Microbiology, Hindawi Limited, Vol. 2009 ( 2009), p. 1-13
    Abstract: Rat was used to characterize Chinese Yam polysaccharides (CYPs). In Exp. 1 , maximum volume and rate of gas production in CYP 3-supplemented group were higher than other CYP-supplemented groups and control group, while pH values and NH3 contents in CYP 2-, CYP 3-, and CYP 4-supplemented groups were lower than control group. Contents of acetate, propionate and butyrate increased by supplementing CYP 3 or CYP 4 compared to other groups, except for glucose-supplemented group. Contents of isobutyrate for CYPs groups decreased compared to control group. CYP 3 enhanced beneficial gut microbiota, but suppressed bacterial pathogens. In Exp. 2 , contents of acetate and butyrate in cecal digesta of rats fed 0.25 or 0.5 g/kg CYP 3 were higher than other groups on day 7. pH values in 0.25 and 0.5 g/kg groups were lower than 1.0 g/kg group. Contents of acetate in 0.25 and 0.5 g/kg groups were greater than other 2 groups on day 21. Gut microflora in CYP 3-supplemented rats had greater diversity than non-supplemented rats. CYP 3 enriched beneficial gut microbiota, but suppressed bacterial pathogens in rat cecum. These findings suggested that CYP 3 is a good source of carbon and energy, and may improve bacterial community diversity and modulate short-chain fatty acid production in hindgut of rats.
    Type of Medium: Online Resource
    ISSN: 1687-918X , 1687-9198
    URL: Article
    DOI: 10.1155/2009/598152
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2009
    detail.hit.zdb_id: 2467270-1
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