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  • Hindawi Limited  (22)
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  • Hindawi Limited  (22)
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  • 1
    Online Resource
    Online Resource
    Deep Learning Reconstruction Algorithm-Based MRI Image Evaluation of Edaravone in the Treatment of Lower Limb Ischemia-Reperfusion Injury
    Hindawi Limited ; 2022
    In:  Contrast Media & Molecular Imaging Vol. 2022 ( 2022-8-31), p. 1-10
    Details
    In: Contrast Media & Molecular Imaging, Hindawi Limited, Vol. 2022 ( 2022-8-31), p. 1-10
    Abstract: This research aimed to evaluate the therapeutic effect of edaravone on lower limb ischemia-reperfusion injury by MRI images of graph patch-based directional curvelet transform (GPBDCT), compression reconstruction algorithm. 200 patients with lower limb ischemia-reperfusion injury after replantation of severed limb were randomly divided into the observation group (edaravone treatment) and control group (Mailuoning injection treatment), with 100 cases in each group. MRI scanning and image processing using the GPBDCT algorithm were used to evaluate the therapeutic effect of the two groups of patients. The results showed that the signal noise ratio (SNR) (22.01), relative l 2 norm error (RLNE) (0.0792), and matching degree γ (0.9997) of the compression and reconstruction algorithm based on GPBDCT were superior to those of the conventional compression and reconstruction algorithm ( P 〈 0.05 ). MRI examination showed that the decrease of bleeding signal after treatment in the observation group was superior to that in the control group. The levels of superoxide dismutase (SOD) (15 ± 2.02), malondialdehyde (MDA) (2.27 ± 1.02), B cell lymphoma-2 (Bcl-2) (8.5 ± 1.02), Bcl-2-associated X (Bax) (3.7 ± 0.42), and Caspase-3 protein (35.9 ± 5.42) in the observation group before and after treatment were significantly higher than those in the control group ( P 〈 0.05 ). In conclusion, the GPBDCT-based compression reconstruction algorithm has a better effect on MRI image processing, and edaravone can better remove free radicals and alleviate apoptosis.
    Type of Medium: Online Resource
    ISSN: 1555-4317 , 1555-4309
    URL: Article
    DOI: 10.1155/2022/1408156
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2222967-X
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  • 2
    Online Resource
    Online Resource
    lncRNA TRPM2-AS Promotes Colorectal Cancer Progression by Regulating miR-22-3p and FSTL1
    Hindawi Limited ; 2022
    In:  Journal of Oncology Vol. 2022 ( 2022-10-11), p. 1-12
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2022 ( 2022-10-11), p. 1-12
    Abstract: Background. In recent years, long noncoding RNAs (lncRNAs) relate to many biological processes, which affect the progression of tumors. Transient receptor potential melastatin 2 antisense RNA (TRPM2-AS) is reported to play an oncogene-like role in tumors. TRPM2-AS is highly expressed in colorectal cancer (CRC), but the mechanism of TRPM2-AS is still unclear. The regulatory mechanism of TRPM2-AS in the occurrence of CRC was explored, so as to find new markers and therapeutic targets for CRC. Methods. TRPM2-AS and miR-22-3p expression in CRC cells were measured through reverse-transcription quantitative polymerase chain reaction (RT-qPCR). Then, TRPM2-AS knockdown cell lines were constructed, and cell counting kit-8 (CCK-8), clone formation, wound healing, and invasion assays were used to detect cell malignant behavior. Follistatin-like 1 (FSTL1) protein was detected by western blotting. The interaction between miR-22-3p and TRPM2-AS or FSTL1 was verified by the luciferase reporter and RNA immunoprecipitation (RIP) assay. Subcutaneous xenografts were performed using animal experiments. Results. TRPM2-AS expression in CRC cells was increased, and miR-22-3p expression was decreased in CRC cells. TRPM2-AS inhibition inhibited cell malignant behavior. miR-22-3p has a targeting relationship with TRPM2-AS and FSTL1. In cells, downregulation of TRPM2-AS expression promoted miR-22-3p and inhibited FSTL1 expression, while mimics inhibited FSTL1 expression. miR-22-3p inhibition or FSTL1 overexpression could offset the inhibition of TRPM2-AS downregulation on CRC cells. Conclusions. The TRPM2-AS/miR-22-3p/FSTL1 regulation axis could regulate CRC cell malignant behavior, which may provide a new perspective for interpreting the mechanism of CRC development.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2022/1366511
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2461349-6
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  • 3
    Online Resource
    Online Resource
    Glucagon-Like Peptide-1 Analog Liraglutide Protects against Diabetic Cardiomyopathy by the Inhibition of the Endoplasmic Reticulum Stress Pathway
    Hindawi Limited ; 2013
    In:  Journal of Diabetes Research Vol. 2013 ( 2013), p. 1-8
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2013 ( 2013), p. 1-8
    Abstract: Aim . This study aimed to investigate whether the glucagon-like peptide-1 analog liraglutide (LIRA) can protect against diabetic cardiomyopathy and explore the related mechanism. Methods . Rats were divided into 6 groups: a nondiabetic group, diabetic cardiomyopathy rats without LIRA treatment, diabetic cardiomyopathy rats with LIRA treatment (with high-, medium-, and low-dose, resp.), and diabetic cardiomyopathy rats treated with insulin. Cardiac function was examined by echocardiography before and after treatment. The histopathology of the heart was examined with H & E staining. The mRNA levels of XBP1, ATF4, and TRAF2 were analyzed by RT-PCR, and the expression of glucose-regulated protein 78 (Grp78), enhancer-binding protein homologous protein (CHOP), caspase-3, and caspase-12 was detected by western blot. Results . LIRA strongly improved cardiac function from both echocardiographic and histopathologic analyses, but insulin only partly increased cardiac function by improving FS and LVPW values. LIRA treatment can significantly decrease the expression of XBP1, ATF4, and TRAF2 ( P 〈 0.01 ). LIRA also significantly downregulates the expression of Grp78, caspase-3 ( P 〈 0.01 ), CHOP, and caspase-12 ( P 〈 0.05 ). Conclusions . LIRA can protect against diabetic cardiomyopathy by inactivating the ER stress pathway. The improvement in cardiac function by LIRA is independent of glucose control.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2013/630537
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2711897-6
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  • 4
    Online Resource
    Online Resource
    Fast Screening Method for an Important Transmission Line in Electrical Power System Uniting Internet Thinking and Physical Features
    Hindawi Limited ; 2022
    In:  Mobile Information Systems Vol. 2022 ( 2022-3-29), p. 1-11
    Details
    In: Mobile Information Systems, Hindawi Limited, Vol. 2022 ( 2022-3-29), p. 1-11
    Abstract: In the electrical power system, a few transmission lines may have cascading failures and even lead to severe blackout accidents. In order to further prevent the electrical power system from cascading failures and being enlightened by Internet thinking, based on the complex network theory, this paper proposes the TL-SALSA (transmission line-stochastic approach for link structure analysis) algorithm combining Internet thinking and physical characteristics of the electrical power system for screening the important transmission lines. The TL-SALSA algorithm not only retains the low-computational complexity advantage of the SALSA (stochastic approach for link structure analysis) algorithm but considers the impact relational among transmission lines and the electrical power system operation mode. The IEEE 39-bus power system and IEEE 118-bus power system are simulated and compared with the electric betweenness algorithm, and the results further evidence the effectiveness of the TL-SALSA algorithm. The results also show that the TL-SALSA algorithm can improve the screening efficiency by nearly three orders of magnitude compared with the electric betweenness algorithm, which proves the potential of the TL-SALSLA algorithm for screening important transmission lines in large-scale electrical power systems.
    Type of Medium: Online Resource
    ISSN: 1875-905X , 1574-017X
    URL: Article
    DOI: 10.1155/2022/9670009
    RVK:
    QA 10000
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2187808-0
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  • 5
    Online Resource
    Online Resource
    Study on the Mechanical Behavior and Acoustic Emission Properties of Granite under Triaxial Compression
    Hindawi Limited ; 2021
    In:  Geofluids Vol. 2021 ( 2021-9-21), p. 1-17
    Details
    In: Geofluids, Hindawi Limited, Vol. 2021 ( 2021-9-21), p. 1-17
    Abstract: To study the rock mechanical behaviors and damage process mechanism of granite samples under triaxial stress, conventional triaxial compression tests were carried out on an RMT-150B rock mechanics testing machine and acoustic emission detector. The test results show that the strength of the granite sample has a good linear relationship with the confining pressure, the cohesion force c of the granite samples is 29.37 MPa, and the internal friction angle is 54.23° by calculation based on the Mohr-Coulomb strength criterion. The larger the initial confining pressure of the rock sample is, the larger the crack initiation stress ( σ ci ) and dilatancy stress ( σ cd ) of the granite specimen are, the larger the energy values at the crack initiation point and dilatancy point are, and the larger the peak energy storage and energy release rate at the failure are. In the case of a small initial confining pressure, the AE ringdowning counts and the cumulative AE ringing counts increase to their maximum instantaneously at the peak stress point, and the damage of the sample develops rapidly. While the initial confining pressure is high, the AE ringing counts and the cumulative AE ringing counts of the granite specimens increase evenly, and the deformation damage of the granite specimens is slow. Before the crack initiation point, AE signals are mainly low-energy and low-frequency friction-type AE events, while after the dilatation point, AE signals of samples are mainly high-frequency and high-energy fracture-type AE events. The failure mode of granite samples judged by acoustic emission parameters according to the distribution of characteristic values of AE parameters RA and AF is consistent with the reality. The AE b value of the granite sample is large when the confining pressure is low, and there will be a sudden drop, the decrease time is late, and the decrease rate is large. Under the same stress level, the larger the confining pressure is, the larger the damage variable D is.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2021/3954097
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 6
    Online Resource
    Online Resource
    Scalp Acupuncture Enhances the Functional Connectivity of Visual and Cognitive-Motor Function Network of Patients with Acute Ischemic Stroke
    Hindawi Limited ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-12-2), p. 1-11
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2020 ( 2020-12-2), p. 1-11
    Abstract: Object. To explore the specific effect of the international standard scalp acupuncture (ISSA) on patients with brain dysfunction after acute ischemic stroke (AIS) based on resting-state functional magnetic resonance imaging (Rs-fMRI). Design. A parallel-group randomized controlled trial. Participants. 30 hemiplegic patients with middle cerebral artery acute infarction of the dominant hemisphere. Interventions. 30 patients were divided into 2 groups randomly. 15 patients in the treatment group (TG) were treated with ISSA, needling at the parietal midline (MS5) and left anterior/posterior parietal-temporal oblique lines (MS6 and MS7), combined with western routine treatment. While another 15 patients in the control group (CG) received routine treatment only. Main Outcome Measures. (1) Functional connectivity (FC): patients received brain scan using 3.0 T MRI after the treatment for 1 week. Based on the Matlab2012a platform, SPM12 software and DPABI software were used to process the scanning data and finally the functional connectivity of the brain was obtained. (2) National Institute of Health Stroke Scale (NIHSS) score. Results. The difference in the NIHSS score between the two groups of patients before and after treatment was statistically significant (tNIHSS = 2.225; PNIHSS = 0.038), indicating that TG had a better effect. Centered to the seed region of the left supplementary motor area (SMA) (−5.32, 4.85, 61.38), FC increased at the left middle cerebellar peduncle, left cerebellum posterior lobe (uvula and declive), vermis, fusiform gyrus, lingual gyrus, inferior occipital gyrus, calcarine, cuneus, precuneus, BA7, BA18 and BA19, etc. Centered to the seed region of the left parahippocampal gyrus (PG) (−21.17, −15.95, −20.70), FC increased at the left precuneus, inside-paracingulate, inferior parietal gyrus, paracentral lobule, BA5, BA6, BA7, and BA40, right median cingulate, precuneus, BA19, BA23, and BA31, etc. Conclusions. It is indicated that ISSA can regulate the brain functional connection in patients with middle cerebral artery acute infarction in the dominant hemisphere and specifically strengthen the connections between visual, cognitive, motor control, and planning-related brain regions, which may be related to the recovery of movement in the mechanism. This trial is registered with ChiCTR-IOR-15007672.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2020/8836794
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2148302-4
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  • 7
    Online Resource
    Online Resource
    Tunable oxygen deficient in MoO 3 ‐x / MoO 2 heterostructure for enhanced lithium storage properties
    Hindawi Limited ; 2022
    In:  International Journal of Energy Research Vol. 46, No. 5 ( 2022-04), p. 5789-5799
    Details
    In: International Journal of Energy Research, Hindawi Limited, Vol. 46, No. 5 ( 2022-04), p. 5789-5799
    Type of Medium: Online Resource
    ISSN: 0363-907X , 1099-114X
    URL: Issue
    URL: Article
    DOI: 10.1002/er.v46.5
    DOI: 10.1002/er.7522
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 1480879-1
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  • 8
    Online Resource
    Online Resource
    Red yeast rice prevents chronic alcohol‐induced liver disease by attenuating oxidative stress and inflammatory response in mice
    Hindawi Limited ; 2021
    In:  Journal of Food Biochemistry Vol. 45, No. 4 ( 2021-04)
    Details
    In: Journal of Food Biochemistry, Hindawi Limited, Vol. 45, No. 4 ( 2021-04)
    Type of Medium: Online Resource
    ISSN: 0145-8884 , 1745-4514
    URL: Issue
    URL: Article
    DOI: 10.1111/jfbc.v45.4
    DOI: 10.1111/jfbc.13672
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2174913-9
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  • 9
    Online Resource
    Online Resource
    Double functionalization of Mo 2 C and NiMn‐LDH assembling g‐C 3 N 4 as efficient bifunctional electrocatalysts for selective electrocatalytic reactions and overall water splitting
    Hindawi Limited ; 2022
    In:  International Journal of Energy Research Vol. 46, No. 9 ( 2022-07), p. 12406-12416
    Details
    In: International Journal of Energy Research, Hindawi Limited, Vol. 46, No. 9 ( 2022-07), p. 12406-12416
    Type of Medium: Online Resource
    ISSN: 0363-907X , 1099-114X
    URL: Issue
    URL: Article
    DOI: 10.1002/er.v46.9
    DOI: 10.1002/er.8006
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 1480879-1
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  • 10
    Online Resource
    Online Resource
    Screening Genes Promoting Exit from Naive Pluripotency Based on Genome-Scale CRISPR-Cas9 Knockout
    Hindawi Limited ; 2020
    In:  Stem Cells International Vol. 2020 ( 2020-02-03), p. 1-15
    Details
    In: Stem Cells International, Hindawi Limited, Vol. 2020 ( 2020-02-03), p. 1-15
    Abstract: Two of the main problems of stem cell and regenerative medicine are the exit of pluripotency and differentiation to functional cells or tissues. The answer to these two problems holds great value in the clinical translation of stem cell as well as regenerative medicine research. Although piling researches have revealed the truth about pluripotency maintenance, the mechanisms underlying pluripotent cell self-renewal, proliferation, and differentiation into specific cell lineages or tissues are yet to be defined. To this end, we took full advantage of a novel technology, namely, the genome-scale CRISPR-Cas9 knockout (GeCKO). As an effective way of introducing targeted loss-of-function mutations at specific sites in the genome, GeCKO is able to screen in an unbiased manner for key genes that promote exit from pluripotency in mouse embryonic stem cells (mESCs) for the first time. In this study, we successfully established a model based on GeCKO to screen the key genes in pluripotency withdrawal. Our strategies included lentiviral package and infection technology, lenti-Cas9 gene knockout technology, shRNA gene knockdown technology, next-generation sequencing, model-based analysis of genome-scale CRISPR-Cas9 knockout (MAGeCK analysis), GO analysis, and other methods. Our findings provide a novel approach for large-scale screening of genes involved in pluripotency exit and offer an entry point for cell fate regulation research.
    Type of Medium: Online Resource
    ISSN: 1687-966X , 1687-9678
    URL: Article
    DOI: 10.1155/2020/8483035
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2573856-2
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