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  • Hindawi Limited  (7)
  • 1
    In: Journal of Oncology, Hindawi Limited, Vol. 2022 ( 2022-3-15), p. 1-9
    Abstract: Background. Cytogenetic abnormalities are considered initiating events in the pathogenesis of multiple myeloma (MM) and are assumed to be of clinical significance. Methods. Fluorescence in situ hybridization (FISH) was used to analyze chromosomal architecture in 101 patients with MM. We evaluated overall patient survival and assessed the cytotoxicity of imatinib against MM cells using a CCK8 assay. Results. ABL gene amplification was detected in 67 patients (66.3%). However, ABL gene amplification was not associated with clinical features, cytogenetic abnormalities (c-Myc amplification, IGH rearrangement, RB1 deletion, p53 deletion, or 1q21 amplification), or overall survival. ABL amplification in MM cell lines (LP-1 and U266) was revealed by FISH. Furthermore, the ABL protein was easily detectable in MM cell lines and some tumor cells by western blotting. A CCK8 assay indicated limited cytotoxicity of imatinib against MM cells. Conclusions. Our study firstly discussed ABL gene amplification was prevalent in MM cells, and we believe that the ABL gene would potentially be a useful target in the treatment of combination strategy for MM with ABL amplification in the future.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2461349-6
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  • 2
    Online Resource
    Online Resource
    Hindawi Limited ; 2018
    In:  BioMed Research International Vol. 2018 ( 2018), p. 1-7
    In: BioMed Research International, Hindawi Limited, Vol. 2018 ( 2018), p. 1-7
    Abstract: Objective . To characterize and evaluate CT and MRI features of extremity soft tissue adult fibrosarcoma. Methods . CT and MRI images from 10 adult patients with pathologically proven fibrosarcomas were retrospectively analyzed with regard to tumor location, size, number, shape, margins, attenuation, signal intensity, and enhancement patterns on MR images. Additionally, the relationships between lesions, deep fascia, and change in adjacent bones were also assessed. Results . Nineteen tumor lesions in 10 patients were selected for this study. Eighteen lesions were lobulated and one was oval in shape. Most cases were located under the deep fascia, including seven cases that had a nodular lump adjacent to the deep fascia and one case that had broken lesion through the deep fascia. On CT, the adult fibrosarcomas mostly showed iso-attenuated soft tissue masses ( n = 6 ). On MRI, all the cases ( n = 9 ) displayed low signal on T1-weighted imaging (T1WI) and heterogeneous low and high intensity signals on T2-weighted imaging (T2WI), with band-like areas of low signal on both T1WI and T2WI. On contrast-enhanced MRI images, three cases showed heterogeneous peripheral enhancement and one case demonstrated a spoke-wheel-like enhancement. Eight cases showed muscle edema signals in the peritumoral muscle and one case involved adjacent bone. Conclusion . CT and MR imaging have respective advantages in diagnosing adult fibrosarcoma. Combined application of CT and MR is recommended for patients with suspected adult fibrosarcoma.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2698540-8
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  • 3
    Online Resource
    Online Resource
    Hindawi Limited ; 2022
    In:  BioMed Research International Vol. 2022 ( 2022-11-21), p. 1-9
    In: BioMed Research International, Hindawi Limited, Vol. 2022 ( 2022-11-21), p. 1-9
    Abstract: The critical medicine residency training in China started in 2020, but no investigation on the practice of tracheal intubation in ICUs in China has been conducted. A survey was sent to the adult ICUs in public hospitals in Shenzhen (SZ) city and Xinjiang (XJ) province using a WeChat miniprogram to be completed by intensive care physicians. It included questions on training on intubation, intubation procedures, and changes in the use of personal protective equipment due to COVID-19. We analyzed 301 valid questionnaires which were from 72 hospitals. A total of 37% of respondents had completed training in RSI (SZ, 40% vs. XJ, 30%; p = 0.066 ), and 50% had participated in a course on the emergency front of the neck airway (SZ, 47% vs. XJ, 54%; p = 0.256 ). Video laryngoscopy was preferred by 75% of respondents. Manual ventilation (56%) and noninvasive positive pressure ventilation (34%) were the first-line options for preoxygenation. For patients with a high risk of aspiration, nasogastric decompression (47%) and cricoid pressure (37%) were administered. Propofol (82%) and midazolam (70%) were the most commonly used induction agents. Only 19% of respondents routinely used neuromuscular blocking agents. For patients with difficult airways, a flexible endoscope was the most commonly used device by 76% of respondents. Most participants (77%) believed that the COVID-19 pandemic had significantly increased their awareness of the need for personal protective equipment during tracheal intubation. Our survey demonstrated that the ICU doctors in these areas lack adequate training in airway management.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2698540-8
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  • 4
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2017 ( 2017), p. 1-6
    Abstract: Our colleagues have reported previously that human pancreatic progenitor cells can readily differentiate into insulin-containing cells. Particularly, transplantation of these cell clusters upon in vitro induction for 3-4 w partially restores hyperglycemia in diabetic nude mice. In this study, we used human fetal pancreatic progenitor cells to identify the forkhead protein FoxO1 as the key regulator for cell differentiation. Thus, induction of human fetal pancreatic progenitor cells for 1 week led to increase of the pancreatic β cell markers such as Ngn3, but decrease of stem cell markers including Oct4, Nanog, and CK19. Of note, FoxO1 knockdown or FoxO1 inhibitor significantly upregulated Ngn3 and insulin as well as the markers such as Glut2, Kir6.2, SUR1, and VDCC, which are designated for mature β cells. On the contrary, overexpression of FoxO1 suppressed the induction and reduced expression of these β cell markers. Taken together, these results suggest that FoxO1 may act as a repressor to inhibit cell differentiation in human fetal pancreatic progenitor cells.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2711897-6
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  • 5
    In: BioMed Research International, Hindawi Limited, Vol. 2021 ( 2021-10-12), p. 1-1
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2698540-8
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  • 6
    Online Resource
    Online Resource
    Hindawi Limited ; 2012
    In:  Journal of Control Science and Engineering Vol. 2012 ( 2012), p. 1-2
    In: Journal of Control Science and Engineering, Hindawi Limited, Vol. 2012 ( 2012), p. 1-2
    Type of Medium: Online Resource
    ISSN: 1687-5249 , 1687-5257
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2267501-2
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  • 7
    Online Resource
    Online Resource
    Hindawi Limited ; 2023
    In:  Wireless Communications and Mobile Computing Vol. 2023 ( 2023-5-24), p. 1-18
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2023 ( 2023-5-24), p. 1-18
    Abstract: As explainable artificial intelligence (XAI) has grown in popularity, it has become possible to more clearly explain the functional correspondence between airspace and traffic flow, which can alleviate the contradiction between the continuously increasing traffic demand in the terminal area and the limited airspace capacity; this paper studies the three-dimensional sectorization in the terminal area based on the airspace function. First, trajectory clustering is adopted to classify the functions of air traffic flows. Then, a functional sectorization framework is proposed to enable different airspace sectors with varied functions, where specifically the functional consistency objective between the airspace sector and the traversed air traffic flows is proposed. Third, a corresponding efficient algorithm is designed to generate functional sectors with an accurate scope that can well separate different traffic flows. Finally, the proposed method is evaluated by the actual operation datasets in the Shanghai terminal area. The results show that the method proposed in this paper can not only generate three-dimensional sectors with specific functions according to the prevailing traffic flow in the complex terminal area, which is conducive to the construction of controllers’ situational awareness, but also can reduce potential conflicts and traffic density variance, increasing average sector flight time a lot.
    Type of Medium: Online Resource
    ISSN: 1530-8677 , 1530-8669
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2045240-8
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