In:
BioMed Research International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-9
Abstract:
Recently, numerous studies indicate that H19 plays a key role in tumorigenesis, but the results have been disputed, especially in the aspects of tumor progression and metastasis. Therefore, we performed this meta-analysis to systematically summarize the relationship between H19 and cancers. We searched PubMed, the Cochrane Library, CNKI, and Chinese Wan Fang to identify eligible studies. Odds ratios and 95% confidence intervals were calculated to assess the effect size. A total of 13 studies were enrolled in this meta-analysis, which was performed by Revman5.3 and Stata11.0 software. Our meta-analysis showed that the expression of H19 was associated with distant metastasis in nongastrointestinal tumors (OR = 3.85, 95% CI = 1.31–11.36, P = 0.01 ) and, in gastrointestinal tumors (OR = 0.34, 95% CI = 0.15–0.78, P = 0.01 ), lymph node metastasis (OR = 2.04, 95% CI = 1.19–3.48, P = 0.009 ). Moreover, in gastric cancer, H19 expression was significantly related to histological grade (OR = 0.50, 95% CI = 0.29–0.86, P = 0.01 ), TNM stage (OR = 0.19, 95% CI = 0.11–0.33, P 〈 0.01 ), and tumor invasion depth (OR = 0.11, 95% CI = 0.04–0.27, P 〈 0.01 ). Therefore, H19 could serve as a potential marker for progression and metastasis evaluation of cancers.
Type of Medium:
Online Resource
ISSN:
2314-6133
,
2314-6141
DOI:
10.1155/2016/5902678
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2016
detail.hit.zdb_id:
2698540-8
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