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  • Hindawi Limited  (66)
  • 1
    Online-Ressource
    Online-Ressource
    Comparison of Immediate and 2-Year Outcomes between Excimer Laser-Assisted Angioplasty with Spot Stent and Primary Stenting in Intermediate to Long Femoropopliteal Disease
    Hindawi Limited ; 2013
    In:  The Scientific World Journal Vol. 2013 ( 2013), p. 1-8
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2013 ( 2013), p. 1-8
    Kurzfassung: Background . To compare the clinical outcomes between excimer laser-assisted angioplasty (ELA) with spot stent (group A) and primary stenting (group B) in intermediate to long femoropopliteal disease. Methods . Outcomes of 105 patients totaling 119 legs treated with two different strategies were analyzed retrospectively in a prospectively maintained database. Results . Baseline characteristics were similar in both groups. Better angiographic results and lesser increase of serum C-reactive protein levels (0.60 ± 0.72 versus 2.98 ± 0.97 mg/dL, P 〈 0.001 ) after the intervention were obtained in Group B. Group A had inferior 1-year outcomes due to higher rate of binary restenosis (67% versus 32%, P = 0.001 ) and lower rate of primary patency (40% versus 58%, P = 0.039 ). Rates of amputation-free survival, target vessel revascularization, assisted primary patency, and stent fracture at 24 months were similar in both groups (80% versus 82%, P = 0.979 , 65% versus 45%, P = 0.11 , 78% versus 80%, P = 0.75 and 6.3% versus 6.8%, P = 0.71 , resp.). Conclusion . Greater vascular inflammation after ELA with spot stent resulted in earlier restenosis and inferior 1-year clinical outcomes than primary stenting. This benefit was lost in the primary stenting group at 2 years due to late catch-up restenosis. Active surveillance with prompt intervention was required to maintain the vessel patency.
    Materialart: Online-Ressource
    ISSN: 1537-744X
    URL: Article
    DOI: 10.1155/2013/247102
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2013
    ZDB Id: 2075968-X
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Discovery of Specific Inhibitors for Intestinal E. coli    β -Glucuronidase through In Silico Virtual Screening
    Hindawi Limited ; 2015
    In:  The Scientific World Journal Vol. 2015 ( 2015), p. 1-8
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2015 ( 2015), p. 1-8
    Kurzfassung: Glucuronidation is a major metabolism process of detoxification for carcinogens, 4-(methylnitrosamino)-1-(3-pyridy)-1-butanone (NNK) and 1,2-dimethylhydrazine (DMH), of reactive oxygen species (ROS). However, intestinal E. coli    β -glucuronidase (e β G) has been considered pivotal to colorectal carcinogenesis. Specific inhibition of e β G may prevent reactivating the glucuronide-carcinogen and protect the intestine from ROS-mediated carcinogenesis. In order to develop specific e β G inhibitors, we found that 59 candidate compounds obtained from the initial virtual screening had high inhibition specificity against e β G but not human β G. In particular, we found that compounds 7145 and 4041 with naphthalenylidene-benzenesulfonamide (NYBS) are highly effective and selective to inhibit e β G activity. Compound 4041   ( I C 50 = 2.8  μ M) shows a higher inhibiting ability than compound 7145   ( I C 50 = 31.6  μ M) against e β G. Furthermore, the molecular docking analysis indicates that compound 4041 has two hydrophobic contacts to residues L361 and I363 in the bacterial loop, but 7145 has one contact to L361. Only compound 4041 can bind to key residue (E413) at active site of e β G via hydrogen-bonding interactions. These novel NYBS-based e β G specific inhibitors may provide as novel candidate compounds, which specifically inhibit e β G to reduce e β G-based carcinogenesis and intestinal injury.
    Materialart: Online-Ressource
    ISSN: 2356-6140 , 1537-744X
    URL: Article
    DOI: 10.1155/2015/740815
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2015
    ZDB Id: 2075968-X
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    2,3,5,4′-Tetrahydroxystilbene-2-O- β -glucoside Isolated from Polygoni Multiflori Ameliorates the Development of Periodontitis
    Hindawi Limited ; 2016
    In:  Mediators of Inflammation Vol. 2016 ( 2016), p. 1-12
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2016 ( 2016), p. 1-12
    Kurzfassung: Periodontitis, a chronic infection by periodontopathic bacteria, induces uncontrolled inflammation, which leads to periodontal tissue destruction. 2,3,5,4′-Tetrahydroxystilbene-2-O-beta-glucoside (THSG), a polyphenol extracted from Polygoni Multiflori, reportedly has anti-inflammatory properties. In this study, we investigated the mechanisms of THSG on the Porphyromonas gingivalis -induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. Human gingival fibroblast cells were treated with lipopolysaccharide (LPS) extracted from P. gingivalis in the presence of resveratrol or THSG to analyze the expression of TNF- α , IL-1 β , and IL-6 genes. Increased AMP-activated protein kinase (AMPK) activation and SirT1 expression were induced by THSG. Treatment of THSG decreased the expression of LPS-induced inflammatory cytokines, enhanced AMPK activation, and increased the expression of SirT1. In addition, it suppressed the activation of NF- κ B when cells were stimulated with P. gingivalis LPS. The anti-inflammatory effect of THSG and P. Multiflori crude extracts was reproduced in ligature-induced periodontitis animal modeling. In conclusion, THSG inhibited the inflammatory responses of P. gingivalis -stimulated human gingival fibroblasts and ameliorated ligature-induced periodontitis in animal model.
    Materialart: Online-Ressource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2016/6953459
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2016
    ZDB Id: 2008065-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    The Association between Skull Bone Fractures and the Mortality Outcomes of Patients with Traumatic Brain Injury
    Hindawi Limited ; 2022
    In:  Emergency Medicine International Vol. 2022 ( 2022-6-7), p. 1-7
    Details
    In: Emergency Medicine International, Hindawi Limited, Vol. 2022 ( 2022-6-7), p. 1-7
    Kurzfassung: Introduction. Skull fractures are often found in patients with traumatic brain injury (TBI). Although skull fractures may indicate greater force impact and are associated with local or diffuse brain injuries, the prognostic value of skull fractures remains unclear. This retrospective study aimed to assess the association between skull fractures and mortality in patients with TBI. Methods. This study included 5,430 TBI patients registered in the trauma registry system from January 2009 to December 2018. Clinical and demographic data including age, sex, trauma mechanisms, comorbidities, Glasgow Coma Scale (GCS) score, abbreviated injury score (AIS)-head, injury severity score (ISS), and in-hospital mortality were acquired. Multiple logistic regression and propensity score matching were used to elucidate the effect of skull fractures on mortality outcomes of TBI patients. Results. Compared to TBI patients without skull fracture, patients with skull fractures were predominantly male, younger, had lower GCS upon arrival at the emergency room, and had higher AIS-head, ISS, and in-hospital mortality. The patients with skull fracture had 1.7-fold adjusted odds of mortality (95% confidence interval (CI): 1.27–2.25; p 〈 0.001 ) than those without skull fracture, controlling for age, sex, comorbidities, and AIS-head. Additionally, the propensity score-matched analysis of 1,023 selected paired patients revealed that skull fracture was significantly associated with increased 1.4-fold odds of risk for mortality (95% CI: 1.02–1.88; p = 0.036 ). Conclusions. Using a propensity score-matched cohort to attenuate the confounding effect of age, comorbidities, and injury severity, skull fracture was identified as a significant independent risk factor for mortality in patients with TBI.
    Materialart: Online-Ressource
    ISSN: 2090-2859 , 2090-2840
    URL: Article
    DOI: 10.1155/2022/1296590
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2596429-X
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Efficacy of Traditional Chinese Medicine in Xerostomia and Quality of Life during Radiotherapy for Head and Neck Cancer: A Prospective Pilot Study
    Hindawi Limited ; 2016
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2016 ( 2016), p. 1-10
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2016 ( 2016), p. 1-10
    Kurzfassung: Xerostomia is one of the most common acute and late complications of radiotherapy for head and neck cancer, and it affects quality of life. We conducted a prospective study to evaluate the efficacy of traditional Chinese medicine (TCM) in toxicities and quality of life during radiotherapy. Head and neck cancer patients who were scheduled for radiotherapy were checked for inclusion/exclusion criteria before enrollment. Patients in the study group (inpatients) were hospitalized in a Chinese medicine ward and received concomitant TCM intervention during radiotherapy, while those in the control group (outpatients) received only conventional cancer treatments at the Western outpatient department. The primary end point was amelioration of postradiotherapy side effects. The secondary end points were quality of life during the cancer therapy and occurrence of adverse events following the TCM treatments. Thirty inpatients and 50 outpatients completed the study. Compared to the control group, those in the TCM group had decreased severity of xerostomia. There was no treatment-related impairment of renal or hepatic function among TCM group. Although better outcomes of social contact, dyspnea, physical and emotional function, and financial problems were found in the TCM group, we need further confirmation about the impact of hospitalization itself on these results.
    Materialart: Online-Ressource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2016/8359251
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2016
    ZDB Id: 2148302-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Removal of Endobronchial Malignant Mass by Cryotherapy Improved Performance Status to Receive Chemotherapy
    Hindawi Limited ; 2014
    In:  The Scientific World Journal Vol. 2014 ( 2014), p. 1-6
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2014 ( 2014), p. 1-6
    Kurzfassung: Although malignant endobronchial mass (MEM) has poor prognosis, cryotherapy is reportedly a palliative treatment. Clinical data on postcryotherapy MEM patients in a university-affiliated hospital between 2007 and 2011 were evaluated. Survival curve with or without postcryotherapy chemotherapy and performance status (PS) improvement of these subjects were analyzed using the Kaplan-Meier method. There were 59 patients (42 males), with median age of 64 years (range, 51–76, and median performance status of 2 (interquartile range [IQR], 2-3). Postcryotherapy complications included minor bleeding ( n = 12 ) and need for multiple procedures ( n = 10 ), while outcomes were relief of symptoms ( n = 51 ), improved PS ( n = 45 ), and ability to receive chemotherapy ( n = 40 ). The survival of patients with chemotherapy postcryotherapy was longer than that of patients without such chemotherapy (median, 534 versus 106 days; log-rank test, P = 0.007 ; hazard ratio, 0.25; 95% confidence interval, 0.10–0.69). The survival of patients with PS improvement postcryotherapy was longer than that of patients without PS improvement (median, 406 versus 106 days; log-rank test, P = 0.02 ; hazard ratio, 0.28; 95% confidence interval, 0.10–0.81). Cryotherapy is a feasible treatment for MEM. With better PS after cryotherapy, further chemotherapy becomes possible for patients to improve survival when MEM caused dyspnea and poor PS.
    Materialart: Online-Ressource
    ISSN: 2356-6140 , 1537-744X
    URL: Article
    DOI: 10.1155/2014/369739
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2014
    ZDB Id: 2075968-X
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Increased Asymmetry of Lower Limbs and Leading Joint Angles during Crossing Obstacles in Healthy Male with Cold Exposure
    Hindawi Limited ; 2022
    In:  Applied Bionics and Biomechanics Vol. 2022 ( 2022-10-15), p. 1-9
    Details
    In: Applied Bionics and Biomechanics, Hindawi Limited, Vol. 2022 ( 2022-10-15), p. 1-9
    Kurzfassung: Lower ambient temperatures impair neuromuscular function and balance. However, whether lower ambient temperatures could alter joint angles and symmetry of lower limbs during crossing obstacles in males still remains unknown. Therefore, we investigated whether there is reduction of ambient temperature (20°C; 15°C; 10°C) on lower limbs joint angles and symmetry when crossing obstacles in males. On three different occasions, eighteen male participants underwent 30 min exposure to three different environmental temperatures (10°C, 15°C, and 20°C), which was followed by the obstacle crossing test at 10%, 20%, and 30% of the participant leg length. In each trial, we assessed joint angles and symmetry of lower limbs when crossing obstacles at 10%, 20%, and 30% of the participants’ leg length. The results showed that leading limb maximum joint angles were greater in 10°C than in 15°C and 20°C when leading limb crossed obstacle heights of 20% and 30% leg length ( p 〈 0.05 ). Trailing limb maximum joint angles were not different ( p 〉 0.05 ). Lower limb asymmetry increased when participants crossed obstacle heights of 20% and 30% leg length at 10°C ( p 〈 0.05 ). This study concluded that in male participants, cold exposure can increase lower limb asymmetry to increase falling risk when crossing obstacles. Also, the increased leading limb joint angles and constant trailing limb joint angles increase safety during crossing obstacles.
    Materialart: Online-Ressource
    ISSN: 1754-2103 , 1176-2322
    URL: Article
    DOI: 10.1155/2022/6421611
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2179924-6
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Treatment Effects of Upper Limb Action Observation Therapy and Mirror Therapy on Rehabilitation Outcomes after Subacute Stroke: A Pilot Study
    Hindawi Limited ; 2020
    In:  Behavioural Neurology Vol. 2020 ( 2020-01-02), p. 1-9
    Details
    In: Behavioural Neurology, Hindawi Limited, Vol. 2020 ( 2020-01-02), p. 1-9
    Kurzfassung: Background . Action observation therapy and mirror therapy, two promising rehabilitation strategies, are aimed at enhancing the motor learning and functional improvement of stroke patients through different patterns of visual feedback and observation. Objective . This study investigated and compared the treatment effects of the action observation therapy, mirror therapy, and active control intervention on motor and functional outcomes of stroke patients. Methods . Twenty-one patients with subacute stroke were recruited in this study. All patients were randomly assigned to the action observation therapy, mirror therapy, or active control intervention for 3 weeks. Outcome measures were conducted at baseline, immediately after treatment, and at 3-month follow-up. The primary outcome was the Fugl-Meyer Assessment, and secondary outcomes included the Box and Block Test, Functional Independence Measure, and Stroke Impact Scale. Descriptive analyses and the number of patients whose change score achieved minimal clinically important difference were reported. Results . Both the action observation therapy and active control intervention showed similar improvements on the Fugl-Meyer Assessment, Box and Block Test, and Stroke Impact Scale. Moreover, the action observation therapy had a greater improvement on the Functional Independence Measure than the other 2 groups did. However, the mirror therapy group gained the least improvements on the outcomes. Conclusion . The preliminary results found that the patients in the action observation therapy and active control intervention groups had comparable benefits, suggesting that the 2 treatments might be used as an alternative to each other. A further large-scale study with at least 20 patients in each group to validate the study findings is needed. This trial is registered with NCT02871700 .
    Materialart: Online-Ressource
    ISSN: 0953-4180 , 1875-8584
    URL: Article
    DOI: 10.1155/2020/6250524
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2020
    ZDB Id: 2035544-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    The Effect of Monochromatic Infrared Photo Energy on the Irritability of Myofascial Trigger Spot of Rabbit Skeletal Muscle
    Hindawi Limited ; 2015
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2015 ( 2015), p. 1-7
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
    Kurzfassung: Objective. To determine whether the vasodilatation effect of monochromatic infrared photo energy (MIRE) had the potential for the treatment of myofascial trigger spot (MTrS) in rabbits. Design . A randomized-controlled animal study. Subjects. Twelve adult New Zealand rabbits. Methods. For each rabbit, a MTrS (equivalent to a myofascial trigger point in humans) in one side of the biceps femoris muscle was randomly selected for MIRE treatment (experimental side), while another MTrS in the other side (control side) received a sham treatment. The intervention consisted of a daily 40 minutes treatment, three times per week for 2 weeks. The prevalence of endplate noise (EPN) loci in the MTrS was assessed before, immediately after, and one week after the completion of the 2-week treatment. Results. MIRE could suppress the prevalence of EPN in the MTrS. The degree of reduction in EPN prevalence in the MTrS between the experimental side and the control side was significantly different immediately after MIRE treatment, but not significantly different one week after MIRE treatment. Conclusion. Our study suggests that MIRE may be a useful therapeutic option for the management of the myofascial trigger point in humans.
    Materialart: Online-Ressource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2015/816956
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2015
    ZDB Id: 2148302-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
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    Online-Ressource
    Corrigendum to “Caffeic Acid Phenethyl Ester Inhibits Oral Cancer Cell Metastasis by Regulating Matrix Metalloproteinase-2 and the Mitogen-Activated Protein Kinase Pathway”
    Hindawi Limited ; 2016
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2016 ( 2016), p. 1-2
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2016 ( 2016), p. 1-2
    Materialart: Online-Ressource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2016/6728642
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2016
    ZDB Id: 2148302-4
    Standort Signatur Einschränkungen Verfügbarkeit
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