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  • Hindawi Limited  (8)
  • 1
    Online Resource
    Online Resource
    Associations of Genetic Polymorphisms of mTOR rs2295080 T/G and rs1883965 G/A with Susceptibility of Urinary System Cancers
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-1-17), p. 1-16
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-1-17), p. 1-16
    Abstract: Background. Genetic polymorphisms in mammalian target of rapamycin (mTOR) signaling axis can influence the susceptibility of cancer. The relationship between mTOR gene variants rs2295080 T/G and rs1883965 G/A and the risk of cancer remains inconsistent. The present study is aimed at comprehensively investigating the association between mTOR polymorphisms and susceptibility to cancer. Methods. We conducted a comprehensive assessment using odds ratios (ORs), corresponding 95% confidence intervals (CIs), and in silico tools to evaluate the effect of mTOR variations. Immunohistochemical staining (IHS) and GSEA analysis were used to investigate the expression of mTOR in urinary system cancer. Results. The pooled analysis involved 22 case-control studies including 14,747 cancer patients and 16,399 controls. The rs2295080 T/G polymorphism was associated with the risk of cancer (G-allele versus T-allele, OR = 0.89 , 95 % CI = 0.80 –0.98, P = 0.023 ; GT versus TT, OR = 0.88 , 95 % CI = 0.81 –0.96, P = 0.004 ; GG+GT versus TT, OR = 0.87 , 95 % CI = 0.78 –0.96, P = 0.008 ), especially for cancers of the urinary system, breast, and blood. Variation rs1883965 G/A was associated with cancer susceptibility, especially for digestive cancer. IHS analysis showed that mTOR was upregulated in prostate and bladder cancer. GSEA revealed that the insulin signaling pathway, lysine degradation pathway, and mTOR signaling pathway were enriched in the high mTOR expression group. Conclusions. The mTOR rs2295080 T/G polymorphism may be associated with susceptibility of urinary cancer. The expression of mTOR is positively correlated with tumor malignancy in prostate cancer.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/1720851
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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  • 2
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    Online Resource
    Hepatoma-Targeted Radionuclide Immune Albumin Nanospheres: 131 I-antiAFPMcAb-GCV-BSA-NPs
    Hindawi Limited ; 2016
    In:  Analytical Cellular Pathology Vol. 2016 ( 2016), p. 1-8
    Details
    In: Analytical Cellular Pathology, Hindawi Limited, Vol. 2016 ( 2016), p. 1-8
    Abstract: An effective strategy has been developed for synthesis of radionuclide immune albumin nanospheres ( 131 I-antiAFPMcAb-GCV-BSA-NPs). In vitro as well as in vivo targeting of 131 I-antiAFPMcAb-GCV-BSA-NPs to AFP-positive hepatoma was examined. In cultured HepG2 cells, the uptake and retention rates of 131 I-antiAFPMcAb-GCV-BSA-NPs were remarkably higher than those of 131 I alone. As well, the uptake rate and retention ratios of 131 I-antiAFPMcAb-GCV-BSA-NPs in AFP-positive HepG2 cells were also significantly higher than those in AFP-negative HEK293 cells. Compared to 131 I alone, 131 I-antiAFPMcAb-GCV-BSA-NPs were much more easily taken in and retained by hepatoma tissue, with a much higher T/NT. Due to good drug-loading, high encapsulation ratio, and highly selective affinity for AFP-positive tumors, the 131 I-antiAFPMcAb-GCV-BSA-NPs are promising for further effective radiation-gene therapy of hepatoma.
    Type of Medium: Online Resource
    ISSN: 2210-7177 , 2210-7185
    URL: Article
    DOI: 10.1155/2016/9142198
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2584078-2
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  • 3
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    Online Resource
    The Possible Mechanisms of HSV-TK/Hyperthermia Combined with 131I-antiAFPMcAb-GCV Nanospheres to Treat Hepatoma
    Hindawi Limited ; 2018
    In:  Analytical Cellular Pathology Vol. 2018 ( 2018-05-03), p. 1-15
    Details
    In: Analytical Cellular Pathology, Hindawi Limited, Vol. 2018 ( 2018-05-03), p. 1-15
    Abstract: Our previous findings showed a good therapeutic effect of the combination of suicide gene HSV-TK, nuclide 131I, and magnetic fluid hyperthermia (MFH) on hepatoma by using magnetic nanoparticles as linkers, far better than any monotherapy involved, with no adverse effects. This combination therapy might be an eligible strategy to treat hepatic cancer. However, it is not clear how the combination regimen took the therapeutic effects. In the current study, to explore the possible mechanisms of radionuclide-gene therapy combined with MFH to treat hepatoma at tissue, cellular, and molecular levels and to provide theoretical and experimental data for its clinical application, we examined the apoptosis induction of the combination therapy and investigated the expression of the proteins related to apoptosis such as survivin, livin, bcl-2, p53, and nucleus protein Ki67 involved in cell proliferation, detected VEGF, and MVD involved in angiogenesis of tumor tissues and analyzed the pathologic changes after treatment. The results showed that the combination therapy significantly induced the hepatoma cell apoptosis. The expression of survivin, VEGF, bcl-2, p53, livin, Ki67, and VEGF proteins and microvascular density (MVD) were all decreased after treatment. The therapeutic mechanisms may be involved in the downregulation of Ki67 expression leading to tumor cell proliferation repression and inhibition of survivin, bcl-2, p53, and livin protein expression inducing tumor cell apoptosis, negatively regulating VEGF protein expression, and reducing vascular endothelial cells, which results in tumor angiogenesis inhibition and microvascular density decrease and tumor cell necrosis. These findings offer another basic data support and theoretical foundation for the clinical application of the combination therapy.
    Type of Medium: Online Resource
    ISSN: 2210-7177 , 2210-7185
    URL: Article
    DOI: 10.1155/2018/8941908
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2584078-2
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  • 4
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    Online Resource
    Ginsenosides: A Potential Neuroprotective Agent
    Hindawi Limited ; 2018
    In:  BioMed Research International Vol. 2018 ( 2018), p. 1-11
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2018 ( 2018), p. 1-11
    Abstract: Ginseng is a traditional Chinese medicine with a wide range of pharmacological activities. Ginsenosides are the major constituents of ginseng. Ginsenosides have the unique biological activity and medicinal value, such as antitumor, anti-inflammatory, antioxidation, and inhibition of cell apoptosis. With the increase of stress in life, the incidence of nervous system diseases is also increasing. Neurological diseases pose a huge burden on people’s life and health. In recent years, some studies have shown that ginsenosides have a certain role in the prevention and treatment of neurological diseases. However, the research is still in its infancy, and the relevant mechanisms are complex. In the paper, we review the effects and mechanisms of ginsenosides on epilepsy, depression, cerebral ischemia reperfusion injury, Alzheimer’s disease, and Parkinson’s disease. We hope to provide a theoretical basis for the treatment of nervous system diseases by ginsenosides.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2018/8174345
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2698540-8
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  • 5
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    Online Resource
    The Recent Advances of Magnetic Nanoparticles in Medicine
    Hindawi Limited ; 2018
    In:  Journal of Nanomaterials Vol. 2018 ( 2018), p. 1-8
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2018 ( 2018), p. 1-8
    Abstract: With the progress of nanotechnology and molecular biology, nanoparticles have been widely studied and applied in biomedicine. Particularly, characterized by unique magnetic property, targeting, and biocompatibility, magnetic nanoparticles have become one of the research hotspots in the nanomedical field. Herein, we summarized the recent advances of magnetic nanoparticles in medicine, including the property, carrier function, MRI, and tumor magnetic inductive hyperthermia of magnetic nanoparticles.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2018/7805147
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2229480-6
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  • 6
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    Online Resource
    Biological Characteristics and Carrier Functions of Pegylated Manganese Zinc Ferrite Nanoparticles
    Hindawi Limited ; 2019
    In:  Journal of Nanomaterials Vol. 2019 ( 2019-11-18), p. 1-10
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2019 ( 2019-11-18), p. 1-10
    Abstract: This study was performed to investigate the biocompatibility (BC), magnetothermal effect, and DNA binding biological characteristics of manganese zinc ferrite nanoparticles (Mn 0.6 Zn 0.4 Fe 2 O 4 -NPs (MZF-NPs)) coated with pegylated manganese (PEG-MZF-NPs). Their functions as gene transfer carrier for gene therapy and magnetic medium for tumor hyperthermia were also explored. The manganese zinc ferrite nanoparticles were synthesized through high temperature cracking, and their characterizations were discovered. Hemolysis test and MTT assay were performed to evaluate biocompatibility, and their self-heating effects in the alternating magnetic field were investigated. PEG-MZF-NPs with different concentrations were measured by using 7.0 T Micro-MR scanner (MRI) to calculate the T2 value and r2 relaxation rate of each sample. The CD44-shRNA plasmids were constructed, and their ability to bind PEG-MZF-NPs were examined. The DNA release from PEG-MZF-NP/DNA complex and protection of DNA from nuclease digestion were also detected. After CD44-shRNA-EGFP were transfected into the ovarian cancer SK-OV-3 cells by using PEG-MZF-NPs as carriers, the transfection efficiency was detected by a flow cytometer and expression of CD44 mRNA and protein in cells was detected using RT-PCR and Western blot, respectively. We successfully prepared PEG-MZF-NPs with favorable dispersity, magnetic responsiveness, and BC. Typically, the excellent magnetothermal effect can be used for a tumor magnetothermal therapeutic study. In vitro MRI showed the application potential for being magnetic resonance T2 relaxation contrast agents and the possibility to achieve goal of integration of targeting diagnosis and treatment. The CD44-shRNA plasmids have been successfully constructed and concluded that PEG-MZF-NPs may serve as gene transfer carriers for gene therapy.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2019/6854710
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2229480-6
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  • 7
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    Online Resource
    Corrigendum to “Biological Characteristics and Carrier Functions of Pegylated Manganese Zinc Ferrite Nanoparticles”
    Hindawi Limited ; 2020
    In:  Journal of Nanomaterials Vol. 2020 ( 2020-04-08), p. 1-1
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2020 ( 2020-04-08), p. 1-1
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2020/6069854
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2229480-6
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  • 8
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    Online Resource
    Efficacy and Mechanisms of Oleuropein in Postmenopausal Osteoporosis
    Hindawi Limited ; 2022
    In:  Computational and Mathematical Methods in Medicine Vol. 2022 ( 2022-8-25), p. 1-9
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2022 ( 2022-8-25), p. 1-9
    Abstract: Background. Postmenopausal osteoporosis (PMOP) has a supernal morbidity rate in elderly females. Objective. To appraise the effects of oleuropein on bone densitometry, bone metabolic index, oxidative stress, and inflammatory index in PMOP. In addition, the mechanism of olive bittersweet preventing bone loss was explored. Methods. We grouped 80 salubrious female Sprague-Dawley rats into four teams: (1) sham operation team (sham, N = 20 ), (2) ovariectomy (OVX, N = 20 ), (3) castrated mice fed with oleuropein (OVX+ole, N = 20 ), and (4) castrated mice fed with estrogen (OVX+E2, N = 20 ). The ovariectomized SD rats were continuously raised with 200 μg/kg/dose of oleuropein. Bone mineral density and bone metabolism indexes were recorded. In order to assess the effectiveness of oleuropein on osteopenia, an enzyme-linked immunosorbent assay (ELISA) was devoted to examining the bone marrow indexes. The bone metabolism standards of PMOP rats were appraised by assessing serum levels of calcium, alkaline phosphatase (ALP), phosphorus, malondialdehyde (MDA), and nitrate content by experimental detection methods and levels of osteoclastogenesis inhibitory factor (OPG) and receptor activator for nuclear factor-κB ligand (RANKL) by ELISA. The OPG-RANK-RANKL signal passage was examined by Western blot (WB). We measured bone mineral density using dual-energy X-rays. Results. Our animal experimental results indicated that oleuropein could significantly improve the bone mineral density of ovariectomized SD rats. In the meantime, it could reduce ending interleukin-6 (IL-6), malondialdehyde (MDA), nitrate, alkaline phosphatase (ALP), and phosphorus (P) serum concentration and would not affect Ca2+ concentration. In cell experiments, oleuropein also can promote the proliferation of osteoblasts. Furthermore, it can promote the expression of OPG protein and mRNA. In reverse, it inhibits the expression of RANKL protein and mRNA. Conclusion. Oleuropein can not only improve the inflammatory and oxidative indexes of castrated rats but also prevent osteoporosis. Oleuropein avoids bone resorption by regulating OPG/RANKL expression.
    Type of Medium: Online Resource
    ISSN: 1748-6718 , 1748-670X
    URL: Article
    DOI: 10.1155/2022/9767113
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2256917-0
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