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  • 1
    Online Resource
    Online Resource
    In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications
    Hindawi Limited ; 2019
    In:  International Journal of Polymer Science Vol. 2019 ( 2019-03-21), p. 1-10
    Details
    In: International Journal of Polymer Science, Hindawi Limited, Vol. 2019 ( 2019-03-21), p. 1-10
    Abstract: Silver nanoparticles have attracted great interests widely in medicine due to its great characteristics of antibacterial activity. In this research, the antibacterial activity and biocompatibility of a topical gel synthesized from polyvinyl alcohol, chitosan, and silver nanoparticles were studied. Hydrogels with different concentrations of silver nanoparticles (15 ppm, 30 ppm, and 60 ppm) were evaluated to compare their antibacterial activity, nanoparticles’ sizes, and in vivo behaviors. The resulted silver nanoparticles in the hydrogel were characterized by TEM showing the nanoparticles’ sizes less than 22 nm. The in vitro results prove that the antibacterial effects of all of the samples are satisfied. However, the in vivo results demonstrate the significant difference among different hydrogels in wound healing, where hydrogel with 30 ppm shows the best healing rate.
    Type of Medium: Online Resource
    ISSN: 1687-9422 , 1687-9430
    URL: Article
    DOI: 10.1155/2019/7382717
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2520688-6
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  • 2
    Online Resource
    Online Resource
    Ultrasensitive Detection of Lysozyme upon Conformational Change of DNA Duplex
    Hindawi Limited ; 2022
    In:  Journal of Nanomaterials Vol. 2022 ( 2022-8-26), p. 1-12
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2022 ( 2022-8-26), p. 1-12
    Abstract: We report a simple, cost-effective, and ultrasensitive approach for colorimetric detection of lysozyme based on target-induced conformational change of DNA duplex. The detection method utilizes the interaction between DNA aptamer and its target leading to the dissociation of DNA aptamer from the DNA duplex and forms a structured complex. The complementary DNA that detached from the DNA duplex adsorbed on the AuNPs surface protects the nanoparticles against salt-induced aggregation, resulting in maintaining the red dispersed state of AuNPs. Such an approach allowed the femtomolar detection of lysozyme with a wide linear scale ranging from 0.1 to 200 pM by simple spectroscopic analysis with detection time of ~40 min. In case of naked eye detection, the detection limit of nanoaptasensor corresponds to ~0.5 pM. The nanoaptasensor demonstrated high specificity with regard to lysozyme in the presence of a variety of nonspecific proteins. In case of lysozyme detection in simulated saliva samples, the average recoveries were in the range of 90.47 to 105.90%, with the relative standard deviations (RSD) of 3.45-4.89% that suggests a good reproducibility. The results clearly indicated the reliability and applicability of the proposed assay for the simple and rapid detection of lysozyme in real samples. Compared with existing diagnostic assays, the proposed nanoaptasensor showed many advantages regarding simplicity, versatility, cost, and time for analysis. This approach demonstrated a great potential for ultrasensitive and on-site analysis of a wide range of protein biomarkers using plasmonic nanoparticles.
    Type of Medium: Online Resource
    ISSN: 1687-4129 , 1687-4110
    URL: Article
    DOI: 10.1155/2022/1107081
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2229480-6
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  • 3
    Online Resource
    Online Resource
    Treatment of Cutting Oil-in-Water Emulsion by Combining Flocculation and Fenton Oxidation
    Hindawi Limited ; 2021
    In:  Journal of Chemistry Vol. 2021 ( 2021-05-28), p. 1-9
    Details
    In: Journal of Chemistry, Hindawi Limited, Vol. 2021 ( 2021-05-28), p. 1-9
    Abstract: Recently, the disposal of waste oil-in-water cutting emulsion has become an urgent issue because of its extremely high chemical oxygen demand (COD). The present work focuses on treating the waste cutting emulsion generated from the Samsung Thai-Nguyen factory in Vietnam. This work used multistage methods to treat the waste cutting emulsion to meet the wastewater disposal requirement and characterize the oil recovered. The multistage methods consist of the flocculation method (stage 1) and Fenton oxidation (stage 2). The wastewater after stage 1 treatment has a COD reduction efficiency of 98.24% at the condition of pH 5, Al2(SO4)3 2 g/L, C-PAM 12 mg/L, stirring speed 50 rpm, and stirring time 15 minutes. At that condition, the COD value decreased from 147200 mg/L to 2484 mg/L. After stage 2, the COD value further decreased from 2484 mg/L to 85.4 mg/L with total COD removal efficiency increasing to 99.9% at the optimum conditions of pH 3, H2O2 : FeSO4 concentration ratio of 10 : 1, and FeSO4 concentration of 14.04 g/L. After the stage 2 treatment, the wastewater with the COD value of 85.4 mg/L and BOD5 value of 30 mg/L satisfied the Vietnam standard grade B and grade A, respectively, for industrial wastewater. The oil recovered from the treatment has a heating value of 38095 ± 8 kJ/kg, and thus, it could be reusable as fuel gas.
    Type of Medium: Online Resource
    ISSN: 2090-9071 , 2090-9063
    URL: Article
    DOI: 10.1155/2021/7248402
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2393625-3
    detail.hit.zdb_id: 2703077-5
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  • 4
    Online Resource
    Online Resource
    Fabrication of Hyaluronan-Poly(vinylphosphonic acid)-Chitosan Hydrogel for Wound Healing Application
    Hindawi Limited ; 2016
    In:  International Journal of Polymer Science Vol. 2016 ( 2016), p. 1-9
    Details
    In: International Journal of Polymer Science, Hindawi Limited, Vol. 2016 ( 2016), p. 1-9
    Abstract: A new hydrogel made of hyaluronan, poly(vinylphosphonic acid), and chitosan (HA/PVPA/CS hydrogel) was fabricated and characterized to be used for skin wound healing application. Firstly, the component ratio of hydrogel was studied to optimize the reaction effectiveness. Next, its microstructure was observed by light microscope. The chemical interaction in hydrogel was evaluated by nuclear magnetic resonance spectroscopy and Fourier transform-infrared spectroscopy. Then, a study on its degradation rate was performed. After that, antibacterial activity of the hydrogel was examined by agar diffusion method. Finally, in vivo study was performed to evaluate hydrogel’s biocompatibility. The results showed that the optimized hydrogel had a three-dimensional highly porous structure with the pore size ranging from about 25  µ m to less than 125  µ m. Besides, with a degradation time of two weeks, it could give enough time for the formation of extracellular matrix framework during remodeling stages. Furthermore, the antibacterial test showed that hydrogel has antimicrobial activity against E. coli. Finally, in vivo study indicated that the hydrogel was not rejected by the immune system and could enhance wound healing process. Overall, HA/PVPA/CS hydrogel was successfully fabricated and results implied its potential for wound healing applications.
    Type of Medium: Online Resource
    ISSN: 1687-9422 , 1687-9430
    URL: Article
    DOI: 10.1155/2016/6723716
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2520688-6
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  • 5
    Online Resource
    Online Resource
    Evaluation of the Morphology and Biocompatibility of Natural Silk Fibers/Agar Blend Scaffolds for Tissue Regeneration
    Hindawi Limited ; 2018
    In:  International Journal of Polymer Science Vol. 2018 ( 2018), p. 1-7
    Details
    In: International Journal of Polymer Science, Hindawi Limited, Vol. 2018 ( 2018), p. 1-7
    Abstract: This study was aimed to develop a tissue engineering scaffold by incorporation of Bombyx mori silk fiber (BMSF) and agar. This promised the improvement in enhancing their advantageous properties as well as limiting their defects without occurring chemical reactions or crosslink formation. The morphology and chemical structure of scaffolds were observed using scanning electron microscope (SEM) observation and Fourier transform infrared (FT-IR) spectra. The SEM results show that scaffolds containing BMSF have microporous structures, which are suitable for cell adhesion. Agar scaffolds, by contrast, had much more flat morphology. FT-IR spectra confirm that no modifications to BMSF happened in scaffolds, which indicates that there was no chemical reaction or crosslink formation between silk and agar in this process. Furthermore, the biocompatibility of scaffolds was performed in the mouse’s subcutaneous part of the dorsal region for 15 days, followed by Haematoxylin and Eosin (H & E) staining. H & E staining results demonstrate that scaffolds had good biocompatibility and there was no sign of the body rejection in all of samples. The results from animal study show that SA scaffolds have the most stable structure for cell adhesion compared with those single materials.
    Type of Medium: Online Resource
    ISSN: 1687-9422 , 1687-9430
    URL: Article
    DOI: 10.1155/2018/5049728
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2520688-6
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  • 6
    Online Resource
    Online Resource
    Conjugated Linoleic Acid Grafting Improved Hemocompatibility of the Polycaprolactone Electrospun Membrane
    Hindawi Limited ; 2020
    In:  International Journal of Polymer Science Vol. 2020 ( 2020-06-16), p. 1-8
    Details
    In: International Journal of Polymer Science, Hindawi Limited, Vol. 2020 ( 2020-06-16), p. 1-8
    Abstract: Polycaprolactone (PCL) is a versatile biomaterial with a wide range of medical applications, but its use in blood-contacting devices is hampered due to insufficient hemocompatibility. In this work, electrospun polycaprolactone (PCL) membranes were chemically grafted with conjugated linoleic acid (CLA) to prevent induced blood coagulation. The density of grafted CLA and its effects on the morphology and wettability of the membranes were examined. The study also investigated how the membrane interacted with human whole blood and platelets to determine its antithrombotic properties. As the results suggested, the grafting caused a negligible effect on the physical properties of the membrane but greatly improved its compatibility with blood, showing that the approach can be investigated further for blood-contacting applications.
    Type of Medium: Online Resource
    ISSN: 1687-9422 , 1687-9430
    URL: Article
    DOI: 10.1155/2020/8127570
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2520688-6
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  • 7
    Online Resource
    Online Resource
    Investigate the Effect of Thawing Process on the Self-Assembly of Silk Protein for Tissue Applications
    Hindawi Limited ; 2017
    In:  BioMed Research International Vol. 2017 ( 2017), p. 1-16
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-16
    Abstract: Biological self-assembly is a process in which building blocks autonomously organize to form stable supermolecules of higher order and complexity through domination of weak, noncovalent interactions. For silk protein, the effect of high incubating temperature on the induction of secondary structure and self-assembly was well investigated. However, the effect of freezing and thawing on silk solution has not been studied. The present work aimed to investigate a new all-aqueous process to form 3D porous silk fibroin matrices using a freezing-assisted self-assembly method. This study proposes an experimental investigation and optimization of environmental parameters for the self-assembly process such as freezing temperature, thawing process, and concentration of silk solution. The optical images demonstrated the possibility and potential of −80ST48 treatment to initialize the self-assembly of silk fibroin as well as controllably fabricate a porous scaffold. Moreover, the micrograph images illustrate the assembly of silk protein chain in 7 days under the treatment of −80ST48 process. The surface morphology characterization proved that this method could control the pore size of porous scaffolds by control of the concentration of silk solution. The animal test showed the support of silk scaffold for cell adhesion and proliferation, as well as the cell migration process in the 3D implantable scaffold.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2017/4263762
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2698540-8
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