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  • Hindawi Limited  (10)
  • 1
    Online Resource
    Online Resource
    Impacts of Mobile Media on the Ideological and Political Education in Colleges under 5G
    Hindawi Limited ; 2022
    In:  Mobile Information Systems Vol. 2022 ( 2022-5-24), p. 1-11
    Details
    In: Mobile Information Systems, Hindawi Limited, Vol. 2022 ( 2022-5-24), p. 1-11
    Abstract: With the advancement of digital technology, new tools and methods in education are being developed to improve teaching and learning. The use of technology in educational activities improves the functional, cognitive, and psychomotor skills of students. This study investigated the application of mobile media in the improvement of ideological and political education. The concepts, features, and types of the new media under 5G are defined, and specific forms, opportunities, and challenges of applications of new media in the ideological and political education of colleges are analyzed. The use of new media applications among college students is investigated using the “xuexi.cn” application software. Results show that various mobile applications of new media have the best foreground in the media technologies. Applying new media technologies to ideological and political education is not just an innovation in the method of ideological and political education but also is an extension and supplement to traditional ideological and political classes. Colleges should use new media technologies effectively and scientifically to create a good environment for college students and help them get a better knowledge of ideological and political education.
    Type of Medium: Online Resource
    ISSN: 1875-905X , 1574-017X
    URL: Article
    DOI: 10.1155/2022/1640831
    RVK:
    QA 10000
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2187808-0
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  • 2
    Online Resource
    Online Resource
    BMP4/LIF or RA/Forskolin Suppresses the Proliferation of Neural Stem Cells Derived from Adult Monkey Brain
    Hindawi Limited ; 2017
    In:  Stem Cells International Vol. 2017 ( 2017), p. 1-11
    Details
    In: Stem Cells International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-11
    Abstract: Monkeys are much closer to human and are the most common nonhuman primates which are used in biomedical studies. Neural progenitor cells can originate from the hippocampus of adult monkeys. Despite a few reports, the detailed properties of monkey neural stem cells (NSCs) and their responses to cytokine are still unclear. Here, we derive NSCs from an adult monkey brain and demonstrate that BMP4 inhibits cell proliferation and affects cell morphology of monkey NSCs. Combined treatment of BMP4 and LIF or RA and Forskolin represses the proliferation of monkey NSCs. We also show that BMP4 may promote monkey NSC quiescence. Our study therefore provides implications for NSC-based cell therapy of brain injury in the future.
    Type of Medium: Online Resource
    ISSN: 1687-966X , 1687-9678
    URL: Article
    DOI: 10.1155/2017/7012405
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2573856-2
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  • 3
    Online Resource
    Online Resource
    Mean Empirical Likelihood Inference for Response Mean with Data Missing at Random
    Hindawi Limited ; 2020
    In:  Discrete Dynamics in Nature and Society Vol. 2020 ( 2020-12-15), p. 1-12
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2020 ( 2020-12-15), p. 1-12
    Abstract: We extend the mean empirical likelihood inference for response mean with data missing at random. The empirical likelihood ratio confidence regions are poor when the response is missing at random, especially when the covariate is high-dimensional and the sample size is small. Hence, we develop three bias-corrected mean empirical likelihood approaches to obtain efficient inference for response mean. As to three bias-corrected estimating equations, we get a new set by producing a pairwise-mean dataset. The method can increase the size of the sample for estimation and reduce the impact of the dimensional curse. Consistency and asymptotic normality of the maximum mean empirical likelihood estimators are established. The finite sample performance of the proposed estimators is presented through simulation, and an application to the Boston Housing dataset is shown.
    Type of Medium: Online Resource
    ISSN: 1607-887X , 1026-0226
    URL: Article
    DOI: 10.1155/2020/8893594
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2033014-5
    SSG: 11
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  • 4
    Online Resource
    Online Resource
    Analysis of Factors Influencing Stability of Overlying Soil Layer on Thin Bedrock Based on Crack Development-Closure Test
    Hindawi Limited ; 2019
    In:  Advances in Civil Engineering Vol. 2019 ( 2019-12-31), p. 1-20
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2019 ( 2019-12-31), p. 1-20
    Abstract: The water-blocking properties of the clay layer at the bottom of the Cenozoic overburden in China are an important factor influencing the safety of thin bedrock coal seam mining. Clay has remolding properties that are unlike the nonreversible characteristics of cracks in brittle rock, and failure cracks in clay can reclose or continue to expand under the influence of different external factors. In this work, the soil layer on top of thin bedrock is the research object, and the influences of the particle composition, water content, soil layer thickness, and crack width on the crack development-closure state of soil layer are analyzed by the orthogonal test method. Visual analysis shows that the order of influence of each factor on the stability of soil layer is the crack width, particle composition, soil layer thickness, and water content. The stability of soil layer decreases with increasing crack width and sand content and decreasing soil layer thickness; in addition, soil layer stability decreases first and then increases with increasing water content. Further variance analysis shows that the crack width and particle composition are key factors that impact the stability of soil layer and that the soil layer thickness has some influence, while the water content has little effect on the stability of soil layer. In addition, the crack will reclose when the sand content in soil is less than 50% and the crack width is less than or equal to 1.0 mm, and the soil layer is prone to further failure when the sand content in soil is more than 50% and the crack width is greater than or equal to 3.0 mm; when the soil layer thickness is 15.0 cm, its stability is better than when the soil layer thickness is 10.0 cm or 5.0 cm.
    Type of Medium: Online Resource
    ISSN: 1687-8086 , 1687-8094
    URL: Article
    DOI: 10.1155/2019/3648650
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2449760-5
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  • 5
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    Online Resource
    Location Optimization for Community Smart Parcel Lockers Based on Bilevel Programming
    Hindawi Limited ; 2023
    In:  Journal of Advanced Transportation Vol. 2023 ( 2023-6-2), p. 1-18
    Details
    In: Journal of Advanced Transportation, Hindawi Limited, Vol. 2023 ( 2023-6-2), p. 1-18
    Abstract: With the rapid development of e-commerce and the dramatic upsurge in direct-to-consumer deliveries, the last-mile problem has become increasingly apparent. With the distinct advantages of bringing economies of scale and providing 24/7 contactless self-service, smart parcel lockers play a critical role in solving the last-mile problem. However, due to a lack of planning, myopia expansion, and an ambiguous profit model, smart parcel locker suppliers in China have been suffering huge economic losses, restricting their further development. In the study, on the basis of an in-depth analysis of the cost elements and major revenue sources of smart parcel lockers, we propose a bilevel programming model to optimize the location of community smart parcel lockers with the upper-level model maximizing the profit of a third-party smart parcel locker supplier and the lower-level model maximizing user satisfaction. Then, a solution algorithm based on the genetic algorithm is proposed. Finally, some numerical experiments are carried out based on a medium-scale residential community in Jiading District, Shanghai. The sensitivity analyses conducted in this study reveal how the user satisfaction evaluation and the investment budget influence the expected profit. The modelling framework and numerical results can provide third-party smart parcel locker suppliers with significant theoretical support and practical guidance on planning the investment budget and optimizing the smart parcel locker locations to maximize their profit.
    Type of Medium: Online Resource
    ISSN: 2042-3195 , 0197-6729
    URL: Article
    DOI: 10.1155/2023/1998188
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2553327-7
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  • 6
    Online Resource
    Online Resource
    Studies Based on Preparation, Physical Characteristics, and Cellular Pharmacological Activities of Thin PLGA Film Loaded with Geniposide
    Hindawi Limited ; 2014
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2014 ( 2014), p. 1-8
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2014 ( 2014), p. 1-8
    Abstract: In this primary study, thin polylactic-co-glycolic acid (PLGA) film loaded with geniposide was first prepared and demonstrated on both physical and pharmacological aspects for its potential application on drug-eluting vascular stents. Physical parameters of geniposide-loaded thin film, such as crystal structure, molecular spectral characteristics, and release behavior in the whole process were detected. From X-Ray diffraction, the characteristic peak of crystal geniposide disappeared on geniposide-loaded PLGA film (GLPF) after it formed, which meant there was no agglomeration phenomenon, as geniposide was distributed in the form of single molecule. According to scanning electron microscopy (SEM) figure, the GLPF was more flat and uniform with better compactness. It inferred that release behavior of geniposide at the early stage (0~15 d) was in the form of free diffusion. Carrier PLGA began to degrade 15 days later, so the residual geniposide was also dissolved. Cellular pharmacological effects of geniposide on endothelial cells (ECs) and smooth muscle cells (SMCs) were also demonstrated on GLPF. 5% and 10% (w/w) geniposide-loaded PLGA (60 : 40) membrane indicated its significant effect on ECs promotion and SMCs inhibition. All provided feasible evidences for the development of new geniposide-coating vascular stent using PLGA as carrier.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2014/352423
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2148302-4
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  • 7
    Online Resource
    Online Resource
    Risk Factor Analysis and Prediction of Severe Hypocalcemia after Total Parathyroidectomy without Auto-Transplantation in Patients with Secondary Hyperparathyroidism
    Hindawi Limited ; 2023
    In:  International Journal of Endocrinology Vol. 2023 ( 2023-1-16), p. 1-9
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2023 ( 2023-1-16), p. 1-9
    Abstract: Objective. Our study aimed to develop and validate a nomogram to predict severe hypocalcemia (SH) before total parathyroidectomy (TPTX) without auto-transplantation in patients with secondary hyperparathyroidism. Methods. A total of 299 consecutive patients who underwent TPTX without transplantation for secondary hyperparathyroidism were selected from the General Hospital of Northern Theater Command between January 2013 and December 2021. Of these, patients who underwent surgery between January 2013 and December 2020 formed the training cohort (n = 208) to develop a nomogram, and those who underwent surgery thereafter formed the validation cohort (n = 91) to validate the performance of this nomogram. Univariate and multivariate logistic regression analyses were used to identify the risk factors associated with SH, and then, a nomogram was constructed. Results. The incidence of postoperative SH was 27.9% and 35.2% in the training and validation cohorts, respectively. The preoperative factors associated with SH were younger age, lower serum calcium (Ca) level, higher intact parathyroid hormone (iPTH) level, and higher serum alkaline phosphatase (ALP) level. Incorporating these 4 factors, the nomogram achieved good concordance indexes of 0.866 (95%CI, 0.816–0.916) and 0.867 (95% CI, 0.793–0.941) in predicting SH in the training and validation cohorts, respectively, and had well-fitted calibration curves. The positive predictive values of the nomogram were 64.7% (54.1%–78.4%) and 75.0% (58.6%–88.5%), and negative predictive values of the nomogram were 90.0% (82.9%–93.6%) and 86.4% (73.5%–94.0%) for the training and validation cohorts, respectively. Conclusions. We developed and validated a nomogram for the prediction of SH in patients who underwent TPTX without auto-transplantation for secondary hyperparathyroidism. Our nomogram may facilitate the identification of high-risk SH in patients after TPTX and optimization of preoperative decision-making.
    Type of Medium: Online Resource
    ISSN: 1687-8345 , 1687-8337
    URL: Article
    DOI: 10.1155/2023/1901697
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2502951-4
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  • 8
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    Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis Patients
    Hindawi Limited ; 2022
    In:  Journal of Ophthalmology Vol. 2022 ( 2022-6-7), p. 1-7
    Details
    In: Journal of Ophthalmology, Hindawi Limited, Vol. 2022 ( 2022-6-7), p. 1-7
    Abstract: Purpose. To investigate the longitudinal changes and associated factors of axial length (AL) in congenital ectopia lentis (CEL) patients. Methods. In this retrospective study, medical records of CEL patients were reviewed from January 2014 to December 2019 at the Zhongshan Ophthalmic (ZOC) in China. Patients were divided into the surgery group and the nonsurgery group. Data of refractive power, best-corrected visual acuity (BCVA), and intraocular pressure (IOP) as well as ocular biometrics including AL, corneal curvature, white-to-white (WTW), and central corneal thickness (CCT) were collected at baseline and each follow-up visit. Multiple linear regression was performed to assess the potential associated factors for axial length growth in congenital ectopia lentis patients. Results. Compared with the nonsurgery group, the change rate of AL among children aged 3 to 6 years old was slower in the surgery group (0.443 ± 0.340 mm/year vs. 0.278 ± 0.227 mm/year, P 〈 0.05 ). However, no statistically significant difference for the change rate of AL was detected between the surgery group and the nonsurgery group ( P 〉 0.05 ) among patients aged 7 years or older. For the surgery group, the results of the linear regression model showed that a higher change rate of AL was associated with younger age (older age: β = −0.009, 95% CI: −0.014 to −0.003, and P = 0.002 ) and worse baseline BCVA (logMAR) (β = 0.256, 95% CI: 0.072 to 0.439, and P = 0.007 ). As for the nonsurgery group, younger baseline age (older age: β = −0.027, 95% CI: −0.048 to −0.007, and P = 0.01 ) and longer baseline AL (β = 0.073, 95% CI: 0.023 to 0.122, and P = 0.006 ) were associated with a higher change rate of AL. Conclusions. The AL change rate was clearly associated with age both in the surgery group and in the nonsurgery group. Intervention strategies such as surgery should be performed earlier for CEL that meets the surgical criteria. Worse baseline BCVA and longer baseline AL are associated factors that would affect the growth rate of AL in the surgery and nonsurgery group, respectively.
    Type of Medium: Online Resource
    ISSN: 2090-0058 , 2090-004X
    URL: Article
    DOI: 10.1155/2022/4032283
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2546525-9
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  • 9
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    Online Resource
    Analysis of a High-Dimensional Mathematical Model for Plant Virus Transmission with Continuous and Impulsive Roguing Control
    Hindawi Limited ; 2021
    In:  Discrete Dynamics in Nature and Society Vol. 2021 ( 2021-12-14), p. 1-26
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2021 ( 2021-12-14), p. 1-26
    Abstract: Roguing and replanting are the most common strategies to control plant diseases and pests. How to build the mathematical models of plant virus transmission and consider the impact of roguing and replanting strategies on plant virus eradication is of great practical significance. In the present paper, we propose the mathematical models for plant virus transmission with continuous and impulsive roguing control. For the model with continuous control strategies, the threshold values for the existences and stabilities of multiple equilibria have been given, and the effect of roguing strategies on the threshold values is also addressed. Furthermore, the model with impulsive roguing control tactics is proposed, and the existence and stability of the plant-only and disease-free periodic solutions of the model are investigated by calculating several threshold values. Moreover, when selecting the design control strategy to minimize the threshold, we systematically analyze the existence of the optimal times of roguing infected plants within a replanting cycle, which is of great significance to the design and optimization of the prevention and control strategy of plant virus transmission. Finally, numerical investigations are given to reveal the main conclusions, and the biological implications of the main results are briefly discussed in the last section.
    Type of Medium: Online Resource
    ISSN: 1607-887X , 1026-0226
    URL: Article
    DOI: 10.1155/2021/6177132
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2033014-5
    SSG: 11
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  • 10
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    Development of Pineapple Microsatellite Markers and Germplasm Genetic Diversity Analysis
    Hindawi Limited ; 2013
    In:  BioMed Research International Vol. 2013 ( 2013), p. 1-11
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2013 ( 2013), p. 1-11
    Abstract: Two methods were used to develop pineapple microsatellite markers. Genomic library-based SSR development: using selectively amplified microsatellite assay, 86 sequences were generated from pineapple genomic library. 91 (96.8%) of the 94 Simple Sequence Repeat (SSR) loci were dinucleotide repeats (39 AC/GT repeats and 52 GA/TC repeats, accounting for 42.9% and 57.1%, resp.), and the other three were mononucleotide repeats. Thirty-six pairs of SSR primers were designed; 24 of them generated clear bands of expected sizes, and 13 of them showed polymorphism. EST-based SSR development: 5659 pineapple EST sequences obtained from NCBI were analyzed; among 1397 nonredundant EST sequences, 843 were found containing 1110 SSR loci (217 of them contained more than one SSR locus). Frequency of SSRs in pineapple EST sequences is 1SSR/3.73 kb, and 44 types were found. Mononucleotide, dinucleotide, and trinucleotide repeats dominate, accounting for 95.6% in total. AG/CT and AGC/GCT were the dominant type of dinucleotide and trinucleotide repeats, accounting for 83.5% and 24.1%, respectively. Thirty pairs of primers were designed for each of randomly selected 30 sequences; 26 of them generated clear and reproducible bands, and 22 of them showed polymorphism. Eighteen pairs of primers obtained by the one or the other of the two methods above that showed polymorphism were selected to carry out germplasm genetic diversity analysis for 48 breeds of pineapple; similarity coefficients of these breeds were between 0.59 and 1.00, and they can be divided into four groups accordingly. Amplification products of five SSR markers were extracted and sequenced, corresponding repeat loci were found and locus mutations are mainly in copy number of repeats and base mutations in the flanking region.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2013/317912
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2698540-8
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