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  • 1
    Online Resource
    Online Resource
    Factors Associated with Neurologists’ Provision of MS Patient Care
    Hindawi Limited ; 2014
    In:  Multiple Sclerosis International Vol. 2014 ( 2014), p. 1-14
    Details
    In: Multiple Sclerosis International, Hindawi Limited, Vol. 2014 ( 2014), p. 1-14
    Abstract: Neurologists are central to providing quality care for individuals with MS. However, neurologist shortages may restrict access to care for MS patients. To examine factors influencing neurologists’ provision of MS care, we surveyed 1,700 US neurologists to assess demographic/practice characteristics, training, and attitudes toward MS care. The study population consisted of 573 respondents: 87 (15.2%) MS subspecialists and 486 (84.8%) “other neurologists,” including subspecialists in other neurology areas (i.e., non-MS) and general neurologists. MS subspecialists indicating they “enjoy interacting with MS patients” had a significantly greater rate of MS patients seen per week. In separate analyses of the “other neurologists” group, the rate of MS patients seen was lower among neurologists in university-based groups or those practicing in major cities; female neurologists; and neurologists who indicated lack of sufficient knowledge regarding MS patient care. Rates of MS patients seen were significantly greater for other neurologists who agreed that MS care involved “ability to improve patient outcomes and quality of life”; “dynamic area with evolving treatment options”; and “enjoy interacting with MS patients.” Understanding factors influencing MS patient care by neurologists and developing policies for appropriate access to care is critical for optimal outcomes among this population.
    Type of Medium: Online Resource
    ISSN: 2090-2654 , 2090-2662
    URL: Article
    DOI: 10.1155/2014/624790
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2603577-7
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  • 2
    Online Resource
    Online Resource
    Decision Analysis Modelling of Costs and Outcomes following Cefepime Monotherapy in Canada
    Hindawi Limited ; 1997
    In:  Canadian Journal of Infectious Diseases Vol. 8, No. 1 ( 1997), p. 19-27
    Details
    In: Canadian Journal of Infectious Diseases, Hindawi Limited, Vol. 8, No. 1 ( 1997), p. 19-27
    Abstract: OBJECTIVE: To evaluate the comparative cost of treatment and intermediate outcomes (percentage resistant organisms, days in hospital, etc) among cefepime and alternative parenteral antibiotics used for empiric monotherapy. DESIGN: Decision analysis model, based on published literature, clinical trial results and information from infectious disease clinicians. SETTING: A Canadian tertiary care hospital. INTERVENTION: Comparison of cefepime, ceftazidime, ceftriaxone, cefotaxime and ciprofloxacin in the treatment of lower respiratory tract infections, urinary tract infections, skin/soft tissue infections, septicemia and febrile neutropenia. MAIN RESULTS: Cefepime treatment results in the lowest average cost per patient when used as initial empiric therapy for lower respiratory tract infections and for skin/soft tissue infections. Cefepime therapy is among the lowest cost treatments for the other infectious disease conditions and has the lowest cost for a weighted ‘average’ condition. Sensitivity analysis indicates that model results are most sensitive to duration of hospitalization. CONCLUSIONS: Initial empiric monotherapy with cefepime for serious infectious disease conditions may result in cost savings compared with alternative parenteral agents.
    Type of Medium: Online Resource
    ISSN: 1180-2332
    URL: Article
    DOI: 10.1155/1997/106462
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 1997
    detail.hit.zdb_id: 2207109-X
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  • 3
    Online Resource
    Online Resource
    Admission Circulating Cell-Free DNA Levels as a Prognostic Factor in Pediatric Burns
    Hindawi Limited ; 2022
    In:  BioMed Research International Vol. 2022 ( 2022-6-8), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2022 ( 2022-6-8), p. 1-7
    Abstract: Background. Burn injuries in children are a major physical and psychological trauma, often a severe condition with long-term consequences. Current methods of assessing the extent of burn injuries on admission are inaccurate. Circulating cell-free DNA (cfDNA) is a potential marker of tissue damage that may be useful in burn care. Objective. To explore the use of cfDNA admission levels as a prognostic marker of pediatric burn severity and outcome. Methods. cfDNA levels of 38 pediatric burn patients (otherwise healthy) and 12 matched pediatric controls (minor elective surgery patients) admitted to our center were quantified by a direct fluorometric assay. Results. We found significantly higher admission cfDNA levels in the patient group (median 724 ng/ml, range 44-4405), compared to the control group (median 423 ng/ml, range 206-970, Mann–Whitney, P = 0.03 ) and a significant difference between cfDNA levels of partial-thickness burns (median 590 ng/ml, range 44-2909) and full-thickness burns (median 2394 ng/ml, range 528-4405, Mann–Whitney, P = 0.01 ). We also found significant correlations between cfDNA levels and hospitalization duration (Spearman, R = 0.42 , P 〈 0.01 ) and undergoing surgical procedures (Spearman, R = 0.40 , P 〈 0.01 ). PICU admission did not correlate to cfDNA levels (Spearman, R = 0.14 , P = NS ). Discussion. Admission cfDNA levels may be a valuable objective tool for assessing the severity of pediatric burn injuries on admission, including correlations with the length of hospitalization and surgical burden. Conclusion. Admission cfDNA levels may be a promising novel pediatric burn assessment method. Further investigation of cfDNA levels in healthy children standardized to age and larger cohorts are needed to establish cfDNA as a valuable prognostic factor for pediatric burn injury.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2022/5004282
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2698540-8
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