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  • Hindawi Limited  (6)
  • 1
    Online Resource
    Online Resource
    Serum miR-375 Levels Are Closely Related to Disease Progression from HBV Infection to HBV-Related Hepatocellular Carcinoma
    Hindawi Limited ; 2020
    In:  BioMed Research International Vol. 2020 ( 2020-04-21), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-04-21), p. 1-9
    Abstract: Background . There is an urgent need to identify ideal serological biomarkers that not only are closely related to disease progression from hepatitis B virus (HBV) infection to hepatocellular carcinoma (HCC) but also have high specificity and sensitivity. We conducted this study to analyze whether miR-375 has a potential value in the early prediction of the progression from HBV-related hepatitis or cirrhosis to HCC. Methods . A total of 177 participants were enrolled. Receiver operating characteristic (ROC) curve was used to evaluate the predictive capability of selected miR-375 for HBV-HCC. We upregulated the miR-375 expression in HepG2, HepG2.2.15, and HepAD38 cells to determine its effect on cellular proliferation and migration, in vitro using Cell Counting Kit-8 (CCK-8) assays. Results . Serum miR-375 levels decreased in order from healthy controls to chronic hepatitis B (CHB) without cirrhosis, followed by cirrhosis, and finally, HBV-HCC patients. miR-375 levels were significantly lower in HBeAg-positive and HBV DNA-positive patients than negative ( P 〈 0.05 ) and significantly lower in patients with elevated alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) than normal levels ( P 〈 0.05 ). miR-375 might be a biomarker for HBV-HCC, with a high area under the curve (AUC) of 0.838 (95% confidence interval (CI) 0.780 to 0.897; sensitivity: 73.9%; specificity: 93.0%). The AUC (0.768 vs. 0.584) and sensitivity (93.8% vs. 75.0%) for miR-375 were higher than those for AFP. The overexpression of miR-375 noticeably inhibited proliferation and migration in HepG2, HepG2.2.15, and HepAD38, especially in HepG2.2.15 and HepAD38, which are stably infected with HBV. Conclusions . Serum miR-375 levels are closely related to disease progression from HBV-related hepatitis or cirrhosis to HCC.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2020/5819385
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2698540-8
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  • 2
    Online Resource
    Online Resource
    Corrigendum to “The Effect of Arch Height and Material Hardness of Personalized Insole on Correction and Tissues of Flatfoot”
    Hindawi Limited ; 2018
    In:  Journal of Healthcare Engineering Vol. 2018 ( 2018), p. 1-1
    Details
    In: Journal of Healthcare Engineering, Hindawi Limited, Vol. 2018 ( 2018), p. 1-1
    Type of Medium: Online Resource
    ISSN: 2040-2295 , 2040-2309
    URL: Article
    DOI: 10.1155/2018/4136246
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2545054-2
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  • 3
    Online Resource
    Online Resource
    The Effect of Arch Height and Material Hardness of Personalized Insole on Correction and Tissues of Flatfoot
    Hindawi Limited ; 2017
    In:  Journal of Healthcare Engineering Vol. 2017 ( 2017), p. 1-9
    Details
    In: Journal of Healthcare Engineering, Hindawi Limited, Vol. 2017 ( 2017), p. 1-9
    Abstract: Flat foot is one of the common deformities in the youth population, seriously affecting the weight supporting and daily exercising. However, there is lacking of quantitative data relative to material selection and shape design of the personalized orthopedic insole. This study was to evaluate the biomechanical effects of material hardness and support height of personalized orthopedic insole on foot tissues, by in vivo experiment and finite element modeling. The correction of arch height increased with material hardness and support height. The peak plantar pressure increased with the material hardness, and these values by wearing insoles of 40° were apparently higher than the bare feet condition. Harder insole material results in higher stress in the joint and ligament stress than softer material. In the calcaneocuboid joint, the stress increased with the arch height of insoles. The material hardness did not apparently affect the stress in the ankle joints, but the support heights of insole did. In general, insole material and support design are positively affecting the correction of orthopedic insole, but negatively resulting in unreasonable stress on the stress in the joint and ligaments. There should be an integration of improving correction and reducing stress in foot tissues.
    Type of Medium: Online Resource
    ISSN: 2040-2295 , 2040-2309
    URL: Article
    DOI: 10.1155/2017/8614341
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2545054-2
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  • 4
    Online Resource
    Online Resource
    Using the Rheological Index to Quantitatively Evaluate the Mechanical Performance of High-Elasticity Modified Asphalt
    Hindawi Limited ; 2021
    In:  Advances in Materials Science and Engineering Vol. 2021 ( 2021-4-13), p. 1-8
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2021 ( 2021-4-13), p. 1-8
    Abstract: High-elasticity modified asphalt is widely used in OGFC and bridge deck paving due to its high viscosity and strong displacement recovery capacity. It can improve the high-temperature deformation resistance and elastic recovery ability of the pavement. Especially in bridge deck pavement, high-elastic modified asphalt can inhibit the formation of reflective cracks and extend the service life. In order to quantitatively evaluate properties of the high-elasticity modified asphalt, rheological properties are studied by using a dynamic shear rheometer (DSR) test. The parameters were fitted with the Burgers model, and the constitutive equation was established. The 3 s elastic recovery rate E r was proposed to quantitatively evaluate the elastic recovery of high-elasticity modified asphalt. The experimental results show that the instantaneous modulus of elasticity G 0 and the delayed modulus of elasticity G 1 can be used to evaluate the elastic capacity. E r can quantitatively evaluate the elastic resilience of high-elasticity modified asphalt. The correlation coefficient between the test results of high-elasticity modified asphalt and those of impact toughness evaluation reached 0.9966, and the 3 s elastic recovery rate E r could be used to evaluate the elastic recovery ability of high-elasticity modified asphalt.
    Type of Medium: Online Resource
    ISSN: 1687-8442 , 1687-8434
    URL: Article
    DOI: 10.1155/2021/6614644
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2501025-6
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  • 5
    Online Resource
    Online Resource
    Increased Risk of Toxoplasma gondii Infection in Patients with Colorectal Cancer in Eastern China: Seroprevalence, Risk Factors, and a Case–Control Study
    Hindawi Limited ; 2020
    In:  BioMed Research International Vol. 2020 ( 2020-10-6), p. 1-6
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-10-6), p. 1-6
    Abstract: The aim of this study was to explore the epidemiology of Toxoplasma gondii infection in patients with colorectal cancer (CRC) in eastern China. Therefore, 287 primary CRC patients and 287 age-matched healthy control subjects were recruited to estimate the seroprevalence of T. gondii and identify the risk factors of infection. Enzyme-linked immunoassays were used to test for anti-T. gondii immunoglobulin G (IgG) and IgM antibodies. Forty-six (16%) samples were positive for anti-T. gondii IgG antibodies in patients with CRC, compared with 26 (9.1%) in the healthy controls, a significant difference ( P = 0.007 ). By contrast, eight (2.8%) patients tested positive for T. gondii IgM antibodies, compared with three (1.1%) in the controls, a difference that was not significant ( P = 0.13 ). Multivariable backward stepwise logistic regression analysis revealed that a rural residence (OR 2.83; 95% CI 1.15–7.01; P = 0.024 ) and treatment with chemotherapy (OR 2.16; 95% CI 1.02–4.57; P = 0.045 ) were risk factors for T. gondii infection in patients with CRC. Thus, T. gondii infection is serious in patients with CRC, and a rural residence and treatment with chemotherapy are independent risk factors for infection by this parasite. Therefore, medical professionals should be aware of this pathogen in patients with CRC, and the causes of T. gondii infection in these patients need to be explored further.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2020/2539482
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2698540-8
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  • 6
    Online Resource
    Online Resource
    Selenium Yeast Alleviates Ochratoxin A-Induced Apoptosis and Oxidative Stress via Modulation of the PI3K/AKT and Nrf2/Keap1 Signaling Pathways in the Kidneys of Chickens
    Hindawi Limited ; 2020
    In:  Oxidative Medicine and Cellular Longevity Vol. 2020 ( 2020-02-20), p. 1-12
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2020 ( 2020-02-20), p. 1-12
    Abstract: The purpose of this study was to investigate the protective effect and mechanism of yeast selenium (Se-Y) on ochratoxin- (OTA-) induced nephrotoxicity of chickens. A total of 80 one-day-old healthy chickens were randomly divided into 4 equal groups: control, OTA (50  μ g/kg OTA), Se-Y (0.4 mg/kg Se-Y), and OTA+Se-Y (50  μ g/kg OTA+0.4 mg/kg Se-Y). In the OTA chickens, differences in body weight, kidney coefficient, biochemical histological analysis, antioxidant capability, and the expression levels of the PI3K/AKT and Nrf2/Keap1 signaling pathway-related genes were observed. The levels of total superoxide dismutase (T-SOD), antioxidant capacity (T-AOC), catalase (CAT), and glutathione (T-GSH) significantly decreased, but the malondialdehyde (MDA) level of the kidneys significantly increased in the OTA treatment group. More importantly, treatment with Se-Y improved the antioxidant enzyme activities within the kidneys of chickens exposed to OTA. In addition, administration of OTA resulted in apoptosis and was associated with decreased expression of AKT, PI3K, and Bcl-2, which in turn enhanced expression of Caspase3, Bax, and P53. However, Se-Y improved the antioxidant defense system through activation of the Nrf2/Keap1 signaling pathway. Gene expression of Nrf2 and its target genes (HO-1, GSH-px, GLRX2, MnSOD, and CAT) was downregulated following OTA exposure. Conversely, Se-Y treatment resulted in a significant upregulation of the same genes. Besides, significant downregulations of protein expression of HO-1, CAT, MnSOD, Nrf2, and Bcl-2 and a significant upregulation of Caspase3 and Bax levels were observed after contaminated with OTA. Notably, OTA-induced apoptosis and oxidative damage in the kidney of chickens were reverted back to normal level in the OTA+Se-Y group. Taken together, the data suggest that Se-Y alleviates OTA-induced nephrotoxicity in chickens, possibly through the activation of the PI3K/AKT and Nrf2/Keap1 signaling pathways.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2020/4048706
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2455981-7
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