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  • Hindawi Limited  (37)
  • 1
    Online Resource
    Online Resource
    Effect of modified soy protein isolate on dough rheological properties and noodle qualities
    Hindawi Limited ; 2022
    In:  Journal of Food Processing and Preservation Vol. 46, No. 3 ( 2022-03)
    Details
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 46, No. 3 ( 2022-03)
    Type of Medium: Online Resource
    ISSN: 0145-8892 , 1745-4549
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpp.v46.3
    DOI: 10.1111/jfpp.16371
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2175273-4
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  • 2
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    Highly Effective Crosslinker for Redox-Sensitive Gene Carriers
    Hindawi Limited ; 2021
    In:  Advances in Polymer Technology Vol. 2021 ( 2021-12-14), p. 1-9
    Details
    In: Advances in Polymer Technology, Hindawi Limited, Vol. 2021 ( 2021-12-14), p. 1-9
    Abstract: Polyethyleneimine (PEI) has been extensively used as a common gene carrier due to its high gene transfection efficiency. PEI1.8k shows significantly lower cytotoxicity than its high molecular weight counterparts. However, it also has the problem of low gene transfection efficiency. To address the dilemma, a highly effective crosslinker (DTME) was synthesized to react with PEI1.8k to obtain CS-PEI1.8k. The reaction showed several advantages, such as a fast process in room temperature within nine hours with the product which can directly complex with DNA after removing the solvent. The ability of CS-PEI1.8k to agglomerate with DNA was proven by particle size, zeta potential, and gel retardation assays. The cytotoxic in vitro transfection ability and cell internalization capacity of CS-PEI1.8k were tested to verify the transfection capacity of CS-PEI1.8k. Moreover, we also studied the mechanism of the relatively high level of gene transfection by this binary complex compared with PEI25k.
    Type of Medium: Online Resource
    ISSN: 1098-2329 , 0730-6679
    URL: Article
    DOI: 10.1155/2021/5635981
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2014633-4
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  • 3
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    Spatiotemporal Assessment of Temperature Data Products for the Detection of Warming Trends and Abrupt Transitions over the Largest Irrigated Area of Pakistan
    Hindawi Limited ; 2020
    In:  Advances in Meteorology Vol. 2020 ( 2020-09-02), p. 1-19
    Details
    In: Advances in Meteorology, Hindawi Limited, Vol. 2020 ( 2020-09-02), p. 1-19
    Abstract: Reliable and accurate temperature data acquisition is not only important for hydroclimate research but also crucial for the management of water resources and agriculture. Gridded data products (GDPs) offer an opportunity to estimate and monitor temperature indices at a range of spatiotemporal resolutions; however, their reliability must be quantified by spatiotemporal comparison against in situ records. Here, we present spatial and temporal assessments of temperature indices ( T max , T min , T mean , and DTR) products against the reference data during the period of 1979–2015 over Punjab Province, Pakistan. This region is considered as a center for agriculture and irrigated farming. Our study is the first spatiotemporal statistical evaluation of the performance and selection of potential GDPs over the study region and is based on statistical indicators, trend detection, and abrupt change analysis. Results revealed that the CRU temperature indices ( T max , T min , T mean , and DTR) outperformed the other GDPs as indicated by their higher CC and R 2 but lower bias and RMSE. Furthermore, trend and abrupt change analysis indicated the superior performances of the CRU T min and T mean products. However, the T max and DTR products were less accurate for detecting trends and abrupt transitions in temperature. The tested GDPs as well as the reference data series indicate significant warming during the period of 1997–2001 over the study region. Differences between GDPs revealed discrepancies of 1-2°C when compared with different products within the same category and with reference data. The accuracy of all GDPs was particularly poor in the northern Punjab, where underestimates were greatest. This preliminary evaluation of the different GDPs will be useful for assessing inconsistencies and the capabilities of the products prior to their reliable utilization in hydrological and meteorological applications particularly over arid and semiarid regions.
    Type of Medium: Online Resource
    ISSN: 1687-9309 , 1687-9317
    URL: Article
    DOI: 10.1155/2020/3584030
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2486777-9
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  • 4
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    MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy
    Hindawi Limited ; 2018
    In:  Journal of Diabetes Research Vol. 2018 ( 2018), p. 1-11
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2018 ( 2018), p. 1-11
    Abstract: Renal tubulointerstitial fibrosis (TIF) is a major feature of diabetic nephropathy (DN). There is increasing evidence demonstrating that microRNAs act as key players in the regulation of autophagy and are involved in DN. However, the exact link among microRNAs, autophagy, and TIF in DN is largely unknown. In this study, our results showed that TIF was observed in DN rats together with obvious autophagy suppression. Moreover, microRNA-22 (miR-22) was upregulated and associated with reduced expression of its target gene phosphatase and tensin homolog (PTEN) in both the kidneys of DN rats and high glucose-cultured NRK-52E cells. Intriguingly, induction of autophagy by rapamycin antagonized high glucose-induced collagen IV (Col IV) and α -SMA expression. In addition, ectopic expression of miR-22 suppressed autophagic flux and induced the expression of Col IV and α -SMA, whereas the inhibition of endogenous miR-22 effectively relieved high glucose-induced autophagy suppression and the expression of Col IV and α -SMA in NRK-52E cells. Overexpression of PTEN protectively antagonized high glucose- and miR-22-induced autophagy suppression and the expression of Col IV. Therefore, our findings indicated that miR-22 may promote TIF by suppressing autophagy partially via targeting PTEN and represents a novel and promising therapeutic target for DN.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2018/4728645
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2711897-6
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  • 5
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    Liangxue Tongyu Prescription Alleviates Brain Damage in Acute Intracerebral Hemorrhage Rats by Regulating Intestinal Mucosal Barrier Function
    Hindawi Limited ; 2022
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2022 ( 2022-12-17), p. 1-15
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2022 ( 2022-12-17), p. 1-15
    Abstract: Background. Liangxue Tongyu prescription (LTP) is a commonly used formula for acute intracerebral hemorrhage (AICH) in clinical practice that has significant ameliorative effects on neurological deficits and gastrointestinal dysfunction, yet the mechanism remains elusive. The aim of this study was to investigate the pathway by which LTP alleviates brain damage in AICH rats. Methods. The AICH rat models were established by autologous caudal arterial blood injection. The neurological function scores were evaluated before and after treatment. The water content and the volume of Evans blue staining in the brain were measured to reflect the degree of brain damage. RT-PCR was used to detect the inflammatory factors of the brain. Western blotting was used to detect the expression of the tight junction proteins zonula occludens 1 (ZO-1), occludin (OCLN), and claudin (CLDN) in the brain and colon, followed by mucin 2 (MUC2), secretory immunoglobulin A (SIgA), and G protein-coupled receptor 43 (GPR43) in the colon. Flow cytometry was used to detect the ratios of helper T cells 17 (Th17) and regulatory T cells (Treg) in peripheral blood, and the vagus nerve (VN) discharge signals were collected. Results. LTP reduced the brain damage of the AICH rats. Compared with the model group, LTP significantly improved the permeability of the colonic mucosa, promoted the secretion of MUC2, SigA, and GPR43 in the colon, and regulated the immune balance of peripheral T cells. The AICH rats had significantly faster VN discharge rates and lower amplitudes than normal rats, and these abnormalities were corrected in the LTP and probiotics groups. Conclusion. LTP can effectively reduce the degree of brain damage in AICH rats, and the mechanism may be that it can play a neuroprotective role by regulating the function of the intestinal mucosal barrier.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2022/2197763
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2148302-4
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  • 6
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    Effects of ethanol fumigation on inhibiting fresh‐cut yam enzymatic browning and microbial growth
    Hindawi Limited ; 2018
    In:  Journal of Food Processing and Preservation Vol. 42, No. 2 ( 2018-02), p. e13434-
    Details
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 42, No. 2 ( 2018-02), p. e13434-
    Type of Medium: Online Resource
    ISSN: 0145-8892 , 1745-4549
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpp.2018.42.issue-2
    DOI: 10.1111/jfpp.13434
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2175273-4
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  • 7
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    Bushen Jianpi Quyu Formula Alleviates Myelosuppression of an Immune-Mediated Aplastic Anemia Mouse Model via Inhibiting Expression of the PI3K/AKT/NF-κB Signaling Pathway
    Hindawi Limited ; 2022
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2022 ( 2022-4-14), p. 1-10
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2022 ( 2022-4-14), p. 1-10
    Abstract: Bushen Jianpi Quyu Formula (BSJPQYF), an experienced formula, has been used to treat aplastic anemia (AA) more than three decades. To determinate the effect of BSJPQYF on AA, we constructed an immune-mediated AA mouse model. All mice were divided into four groups: control, model, low dose (0.85 g/mL), and high dose (1.7 g/mL BSJPQYF) group. They were administered with different concentrations of BSJPQYF or normal saline for 14 days. Besides, components of BSJPQYF were analyzed by electrospray ionization and mass spectrometry (ESI-MS). Subsequently, mouse peripheral blood and femurs were collected, and bone marrow mesenchymal stem cells (BMSCs) were isolated by fluorescence-activated cell sorting (FACS). Among them, tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), and interferon-γ (IFN-γ) were measured by ELISA assay, PI3K, AKT, p-AKT, NF-κB, p-NF-κB, TNF-α, and cleaved caspase-3 proteins were detected by western blot. Compared with standard compounds, we identified three compounds of BSJPQYF, namely, icariin, kaempferol and tanshinone iia, as potentially effective compounds for the treatment of AA. Through an in vivo study, we found the administration of BSJPQYF in high dose for 14 days could significantly increase peripheral blood count and bone marrow (BM) cells, meanwhile decrease TNF-α, TGF-β, and IFN-γ levels. Besides, it could suppress the protein expression of PI3K and the phosphorylation of AKT and NF-κB to restrict the protein expression of TNF-α, eventually reduce the protein expression of cleaved caspase-3. This study demonstrated the therapeutic effects of BSJPQYF in AA, which could alleviate myelosuppression through inhibiting the expression of the PI3K/AKT/NF-κB signaling pathway.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2022/9033297
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2148302-4
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  • 8
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    Analysis of Bank Customer Default Risk Based on Embedded Microprocessor Wireless Communication
    Hindawi Limited ; 2022
    In:  Security and Communication Networks Vol. 2022 ( 2022-3-17), p. 1-11
    Details
    In: Security and Communication Networks, Hindawi Limited, Vol. 2022 ( 2022-3-17), p. 1-11
    Abstract: Bank personal credit is affected by factors such as inadequate management and lagging risk information management system. Bank default risk analysis is needed to improve the ability of bank credit risk management. Therefore, a bank customer default risk analysis based on embedded microprocessor wireless communication is proposed. Firstly, it analyzes the risk assessment parameter evaluation system of personal credit, constructs the quantitative analysis model of personal credit risk, calculates the grade gradient value in the bank’s personal credit risk standard, carries out the mathematical modeling of bank customer default risk assessment, strengthens the implementation of “three checks,” tracks and manages the borrower, supervises the use of credit funds, improves the social credit investigation system, and on this basis, optimizes the mathematical model of bank customer default risk assessment. The experimental results show that this method can realize the bank’s quantitative evaluation and control of personal credit risk, improve the bank’s credit risk prevention and control ability, and provide a reliable basis for the bank’s credit risk evaluation operation and management.
    Type of Medium: Online Resource
    ISSN: 1939-0122 , 1939-0114
    URL: Article
    DOI: 10.1155/2022/5635152
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2415104-X
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  • 9
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    Identification of Biomarkers Associated with Cancerous Change in Oral Leukoplakia Based on Integrated Transcriptome Analysis
    Hindawi Limited ; 2022
    In:  Journal of Oncology Vol. 2022 ( 2022-1-19), p. 1-22
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2022 ( 2022-1-19), p. 1-22
    Abstract: Objective. Oral leukoplakia (OLK) is the most common precancerous lesion in the oral cavity. This study aimed to explore key biomarkers for monitoring OLK for early diagnosis of oral squamous cell carcinoma (OSCC) and screen small-molecule drugs for the prevention of OSCC. Method. The Gene Expression Omnibus (GEO) database was explored to extract two microarray datasets, namely, GSE85195 and GSE25099. The data of the normal group, OLK group, and OSCC group were analyzed by weighted gene coexpression network analysis (WGCNA) to identify the most significant gene module and differentially expressed genes (DEGs). The intersection genes were extracted as the key genes of OLK carcinogenesis. Subsequently, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were analyzed in the module. Connectivity Map and molecular docking were used to screen small-molecule drugs. The diagnostic values of four key genes were identified and verified in the GSE26549 dataset. Results. WGCNA obtained the red module (r = −0.91, p 〈 0.05 ) with the strongest correlation with cancerous phenotype. GO enrichment analysis showed 60 pathways, including 28 biological processes, 11 cell components, and 21 molecular functions, and KEGG enrichment analysis showed 4 pathways ( p 〈 0.05 ). In the differential expression analysis, there was no intersection between the upregulated genes and the red module genes. However, the intersection of the downregulated genes and the red module genes yielded 4 key genes: dopachrome tautomerase (DCT), keratin 3 (KRT3), keratin 76 (KRT76), and FAM3 metabolic regulation signal molecule B (FAM3B). The area under the curve of the diagnostic model constructed by these four genes was 0.963 (CI = 0.913–1.000). The sensitivity was 0.933, and the specificity was 0.923. The diagnostic model was successfully verified in GSE26549 (AUC = 0.745, CI = 0.638–0.851). Compared with the diagnostic models of the previous studies, the diagnostic efficiency of this model was the highest. The small-molecule drugs, selumetinib and benidipine, were selected according to the gene expression profile and showed binding activity when docking with the above molecules. Conclusions. This study provides new targets and drugs for OLK. These targets could be used as the key diagnostic molecules for long-term follow-up of OLK. The small-molecule drugs selumetinib and benidipine could be used for the prevention and treatment of OSCC.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2022/4599305
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2461349-6
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  • 10
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    Effect of Admission Time on the Outcomes of Liver Cirrhosis with Acute Upper Gastrointestinal Bleeding: Regular Hours versus Off-Hours Admission
    Hindawi Limited ; 2018
    In:  Canadian Journal of Gastroenterology and Hepatology Vol. 2018 ( 2018-11-29), p. 1-14
    Details
    In: Canadian Journal of Gastroenterology and Hepatology, Hindawi Limited, Vol. 2018 ( 2018-11-29), p. 1-14
    Abstract: Background and Aims . Acute upper gastrointestinal bleeding (AUGIB) is a lethal complication of liver cirrhosis. We aimed to compare the outcomes of patients with liver cirrhosis and AUGIB who were admitted to hospital on regular hours and off-hours. Methods . This retrospective study screened all cirrhotic patients with AUGIB who were admitted to our hospital from January 2010 to June 2014 for the test cohort and from December 2014 to March 2018 for the validation cohort. A 1:1 propensity score matching analysis was performed to adjust the Child-Pugh and MELD scores. In-hospital mortality, 5-day rebleeding rate, length of stay, and total payment were primary outcomes. Results . Overall, 826 and 173 patients with liver cirrhosis and AUGIB were included in the test and validation cohorts, respectively. After propensity score matching, 226 and 40 patients were included in the test and validation cohorts, respectively. The overall analysis of the test cohort found significantly higher Child-Pugh score (P=0.006), 5-day rebleeding rate (18.69% versus 10.72%, P=0.001), and total payment (¥25,906.83 versus ¥22,017.42, P 〈 0.001) in patients admitted on off-hours. By contrast, the overall analysis of the validation cohort did not find any difference in Child-Pugh score, 5-day rebleeding, in-hospital mortality, length of stay, or hospital payment between patients admitted on regular hours and off-hours. Similarly, the propensity score matching analyses of both test and validation cohorts found no difference in these primary outcomes between the two groups. Conclusions . Off-hours admission might not be negatively associated with the outcomes of patients with liver cirrhosis and AUGIB.
    Type of Medium: Online Resource
    ISSN: 2291-2789 , 2291-2797
    URL: Article
    DOI: 10.1155/2018/3541365
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2762184-4
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