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  • Hindawi Limited  (2)
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  • Hindawi Limited  (2)
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  • 1
    Online Resource
    Online Resource
    A New Proposed Return Guide Vane for Compact Multistage Centrifugal Pumps
    Hindawi Limited ; 2013
    In:  International Journal of Rotating Machinery Vol. 2013 ( 2013), p. 1-11
    Details
    In: International Journal of Rotating Machinery, Hindawi Limited, Vol. 2013 ( 2013), p. 1-11
    Abstract: For widely used multistage centrifugal pumps, their former structures are so bulky that nowadays growing interest has been shifted to the development of more compact structures. Following this trend, a compact pump structure is provided and analysed. To maintain the pump’s pressure recovery, as well as to meet the water flow from the impeller, a circumferential twisted return guide vane (RGV) is proposed. To validate this design method, the instantaneous CFD simulations are performed to investigate the rotor-stator interventions. Within the impeller, the pressure fluctuation is cyclic symmetry, where the impeller frequency dominates. At the zone where flow leaves impeller for RGV, the pressure fluctuation is nonperiodic, the impeller frequency is major, and the rotation frequency is secondary. Within RGV, the periodic symmetric fluctuation is recovered, where the rotation frequency is governing. The fluctuation decreases from seven cycles within impeller to two cycles within RGV, indicating that the flow from impeller is well handled by RGV. To examine the pump’s performance, a prototype multistage pump is designed. The testing shows that the pump efficiency is 57.5%, and the stage head is 9 m, which is comparable to former multistage centrifugal pumps. And this design is more advantageous in developing compact multistage centrifugal pumps.
    Type of Medium: Online Resource
    ISSN: 1023-621X , 1542-3034
    URL: Article
    DOI: 10.1155/2013/683713
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2032559-9
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  • 2
    Online Resource
    Online Resource
    Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway
    Hindawi Limited ; 2019
    In:  BioMed Research International Vol. 2019 ( 2019-04-18), p. 1-13
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2019 ( 2019-04-18), p. 1-13
    Abstract: Objective . Observe the protective effect of chlorogenic acid on dextran sulfate-induced ulcerative colitis in mice and explore the regulation of MAPK/ERK/JNK signaling pathway. Methods . Seventy C57BL/6 mice (half males and half females) were randomly divided into 7 groups, 10 in each group: control group (CON group), UC model group (UC group), and sulfasalazine-positive control group (SASP group), chlorogenic acid low dose group (CGA-L group), chlorogenic acid medium dose group (CGA-M group), chlorogenic acid high dose group (CGA-H group), and ERK inhibitor + chlorogenic acid group (E+CGA group). The effects of chlorogenic acid on UC were evaluated by colon mucosa damage index (CMDI), HE staining, immunohistochemistry, ELISA, and Western blot. The relationship between chlorogenic acid and MAPK/ERK/JNK signaling pathway was explored by adding ERK inhibitor. Results . The UC models were established successfully by drinking DSS water. Chlorogenic acid reduces DSS-induced colonic mucosal damage, inhibits DSS-induced inflammation, oxidative stress, and apoptosis in colon, and reduces ERK1/2, p -ERK, p38, p-p38, JNK, and p-JNK protein expression. ERK inhibitor U0126 reversed the protective effect of chlorogenic acid on colon tissue. Conclusion . Chlorogenic acid can alleviate DSS-induced ulcerative colitis in mice, which can significantly reduce tissue inflammation and apoptosis, and its mechanism is related to the MAPK/ERK/JNK signaling pathway.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2019/6769789
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2698540-8
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