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  • Hindawi Limited  (272)
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  • Hindawi Limited  (272)
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  • 1
    Online-Ressource
    Online-Ressource
    Netting Gut Disease: Neutrophil Extracellular Trap in Intestinal Pathology
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-10-19), p. 1-10
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-10-19), p. 1-10
    Kurzfassung: Many gut disease etiologies are attributed to the presence of robust inflammatory cell recruitment. The recruitment of neutrophils plays a vital role in inflammatory infiltration. Neutrophils have various antimicrobial effector mechanisms, including phagocytosis, oxidative burst, and degranulation. It is suggested that neutrophils could release neutrophil extracellular traps (NETs) to kill pathogens. However, recent evidence indicates that neutrophil infiltration within the gut is associated with disrupted local immunological microenvironment and impaired epithelial barrier. Growing evidence implies that NETs are involved in the progression of many diseases, including cancer, diabetes, thrombosis, and autoimmune disease. Increased NET formation was found in acute or chronic conditions, including infection, sterile inflammation, cancer, and ischemia/reperfusion injury (IRI). Here, we present a comprehensive review of recent advances in the understanding of NETs, focusing on their effects in gut disease. We also discuss NETs as a potential therapeutic target in gut disease.
    Materialart: Online-Ressource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/5541222
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2021
    ZDB Id: 2455981-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Comparison of Two Different Accesses Single Orifice Percutaneous Endoscopic Surgery in Diagnosis of Ascites of Unknown Origin: A Retrospective Study
    Hindawi Limited ; 2022
    In:  Journal of Oncology Vol. 2022 ( 2022-4-4), p. 1-9
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2022 ( 2022-4-4), p. 1-9
    Kurzfassung: Background. Ascites is a common clinical finding caused by many different diseases, so we developed a technique termed single orifice percutaneous endoscopic surgery (SOPES) which can access peritoneal cavity through the contralateral McBurney’s point or umbilicus to seek the underlying causes. In this study, we describe the initial clinical experience of SOPES and compare the application of two accesses. Methods. This is a retrospective study performed between 2007 and 2018. Patients with ascites of unknown origin who underwent these two kinds of SOPES were included. Main outcomes were measured by diagnostic accuracy, complication rate, procedure time, time till stitches removal, length of hospital stay, and hospital cost. Results. 148 patients successfully undergone SOPES via the contralateral McBurney’s point (IM group, n = 70 ) or the umbilicus (UM group, n = 78 ). 63 patients in the IM group and 71 patients in the UM group reached clear diagnosis (90.0% vs. 91.0%, p = 0.831 ). The overall complication rate was 5.4%, while the UM group was higher than the IM group (10.3% vs. 0%, p = 0.017 ). All complications were resolved after medical treatment, and no mortality resulted from this procedure. The procedure time and the time until stitches removal in the UM group were longer than that in the IM group. There were no significant differences in length of hospital stay and hospital cost between the two groups. Conclusions. SOPES, which combines the strength of minimally invasive single orifice incision and flexible angles of examination and instrumentation, is a newly developed flexible endoscopic surgical modality that provides new important clinical valuable in evaluation of ascites of unknown origin. Moreover, SOPES via the contralateral McBurney’s point was safer than the umbilicus approach.
    Materialart: Online-Ressource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2022/1127400
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2461349-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Survival Mechanisms and Influence Factors of Circulating Tumor Cells
    Hindawi Limited ; 2018
    In:  BioMed Research International Vol. 2018 ( 2018-11-01), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2018 ( 2018-11-01), p. 1-9
    Kurzfassung: Circulating tumor cells (CTCs) are cancer cells shed from either the primary tumor or its metastases that circulate in the peripheral blood. The CTCs are regarded as the source of tumor recurrence and metastasis and speculated as the indicators of residual tumors, thereby indicating a poor prognosis. Although CTCs play a vital role in tumor metastasis and recurrence, little is known about the underlying survival mechanisms in the blood circulation. The accumulating evidence has revealed that CTCs might survive in the peripheral blood by overcoming the mechanical damage due to shear stress, resistance to anoikis, evasion of immune destruction, and resistance to chemotherapy. The present review addresses the putative survival mechanisms underlying the formation and migration of CTCs according to their biological characteristics and blood microenvironment. In addition, the relationship between CTCs and microenvironment is illustrated, and the influencing factors related to the interactions of CTCs with various components in the peripheral blood are reviewed with respect to the platelets, immune cells, cytokines, and circulating tumor microemboli (CTM). Furthermore, the recent advances in the new treatment strategies targeting the survival mechanisms of CTCs are also discussed.
    Materialart: Online-Ressource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2018/6304701
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2018
    ZDB Id: 2698540-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Blood Absolute T Cell Counts may Predict 2-Month Treatment Response in Patients with Pulmonary Tuberculosis
    Hindawi Limited ; 2010
    In:  Disease Markers Vol. 28, No. 6 ( 2010), p. 343-352
    Details
    In: Disease Markers, Hindawi Limited, Vol. 28, No. 6 ( 2010), p. 343-352
    Kurzfassung: Background and objective: Little is known about the usefulness of lymphocyte subsets as early predictors of anti-tuberculosis (TB) treatment response in immuno-competent patients. Methods: Among a total of 64 patients with culture positive pulmonary TB, 29 remained sputum smear/culture positive or had delayed resolution on CXR (slow responders (SR)), and 35 had sputum culture conversion to negative and rapid resolution on CXR (fast responders (FR)) after two months of anti-tuberculosis treatment. Clinical parameters and lymphocyte subsets were investigated. Results: A larger proportion of patients in the SR group had cavities on CXR, bilateral lung involvement, positive acid-fast bacilli stains, and complaint of cough at diagnosis than those in the FR group. Absolute counts of CD3 + T cells ( p = 0.016) and CD8 + T cells ( p = 0.012) at diagnosis were both significantly higher in the SR group. This trend was present throughout the 6-month treatment course. Absolute T cell counts (odds ratio (OR) 1.002, 95% confidence interval (CI) 1.0–1.004), positive sputum acid fast bacilli stain (OR 6.69, 95% CI 1.37–32.77) and bilateral lung involvemment on CXR (OR 13.114, 95% CI 1.87–92.14) at diagnosis were independent predictors for a slow response. Combining these three predictors, a prediction score (PS) could be calculated to display an optimal discrimination for slow response (area under the curve (AUC) = 0.855, p 〈 0.001) whereas absolute T cell counts yielded the highest discriminative value on an individual level (AUC = 0.676, p = 0.015). Conclusions: A higher T cell count at diagnosis in patients with TB may predict a slow response to two months of treatment. The calculation of a PS further increased predictive accuracy and performance.
    Materialart: Online-Ressource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2010/246451
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2010
    ZDB Id: 2033253-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    A Road Environment Prediction System for Intelligent Vehicle
    Hindawi Limited ; 2021
    In:  Wireless Communications and Mobile Computing Vol. 2021 ( 2021-4-29), p. 1-13
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2021 ( 2021-4-29), p. 1-13
    Kurzfassung: The road environment prediction is an essential task for intelligent vehicle. In this study, we provide a flexible system that focuses on freespace detection and road environment prediction to host vehicle. The hardware of this system includes two parts: a binocular camera and a low-power mobile platform, which is flexible and portable for a variety of intelligent vehicle. We put forward a multiscale stereo matching algorithm to reduce the computing cost of the hardware unit. Based on disparity space and points cloud, we propose a weighted probability grid map to detect freespace region and a state model to describe the road environment. The experiments show that the proposed system is accurate and robust, which indicates that this technique is fully competent for road environment prediction for intelligent vehicle.
    Materialart: Online-Ressource
    ISSN: 1530-8677 , 1530-8669
    URL: Article
    DOI: 10.1155/2021/5569295
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2021
    ZDB Id: 2045240-8
    Standort Signatur Einschränkungen Verfügbarkeit
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    Online-Ressource
  • 6
    Online-Ressource
    Online-Ressource
    Pulse Width Modulation Electro-Acupuncture on Cardiovascular Remodeling and Plasma Nitric Oxide in Spontaneously Hypertensive Rats
    Hindawi Limited ; 2011
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2011 ( 2011), p. 1-6
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2011 ( 2011), p. 1-6
    Kurzfassung: This study was designed to investigate the effect of pulse width modulation electro-acupuncture (PWM-EA) on cardiovascular remodeling and nitric oxide (NO) in spontaneously hypertensive rats (SHR). Thirty-four male SHR were randomly divided into control, captopril, and two PWM-EA groups, which were treated with 350 Hz (SHR-350 Hz) and whole audio bandwith electro-acupuncture (SHR-WAB group) respectively, on the ST 36 point located on the outside of the hind leg. Systolic blood pressure (BP), plasma and myocardial NO were measured. Histological studies were also performed on the aortic wall and the left ventricle. The BP in the SHR-350 Hz, SHR-WAB and the captopril groups was lower than in the control group following the treatment ( P 〈 .05). The average aortic media wall thickness in the two electro-acupuncture groups was less than in the control group ( P 〈 .05). The left ventricle/heart weight ratio in the captopril and SHR-350 Hz groups was less than in the control group ( P 〈 .01), but was similar between the SHR-WAB and the control group ( P 〉 .05). The plasma and myocardium NO levels were elevated in the captopril and the SHR-350 Hz group ( P 〈 .05 and .01, resp.). The plasma level of NO in the SHR-WAB group was also higher than in the control group ( P 〈 .05). We concluded that pulse width modulation electro-acupuncture on the ST 36 point prevents the progression of hypertension and diminishes the cardiovascular remodeling in SHR. It also elevates plasma and cardiac NO in this animal model.
    Materialart: Online-Ressource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1093/ecam/neq063
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2011
    ZDB Id: 2148302-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Ferulic Acid, an Angelica sinensis -Derived Polyphenol, Slows the Progression of Membranous Nephropathy in a Mouse Model
    Hindawi Limited ; 2012
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2012 ( 2012), p. 1-12
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2012 ( 2012), p. 1-12
    Kurzfassung: Membranous nephropathy (MN) is a leading cause of adult nephrotic syndrome but lacks adequate treatment. Different extracts of Angelica sinensis (AS) and one of its active compounds, ferulic acid (FA), were used to evaluate the therapeutic effects in a MN mouse model. The MN model was grouped into three subgroups: no treatment (N-T), treatment at induction of MN (Pre-T), and treatment after full-blown MN (Post-T). The results showed that the methanol (ME) layer of AS extract exhibited a therapeutic effect on MN-induced proteinuria. The ME layer-enriched compound, FA, improved the hypoalbuminemia, hyperlipidemia, and proteinuria in both Pre-T and Post-T groups. Ferulic acid also reduced the formation of oxidative protein products and increased the synthesis of antioxidant enzymes in groups Pre-T and Post-T. Regarding angiogenesis factors, the antiangiogenic factors in renal glomeruli were increased in group N-T, but, after FA treatment, only one of the antiangiogenic factors, thrombospondin-1, showed a significant decrease. Furthermore, the expression of Th2 predominant showed significant decrease in both Pre-T and Post-T groups when compared to that of N-T group. In summary, FA retarded the progression of MN, and the mechanisms involved the regulation of oxidative stresses, angiogenic and antiangiogenic factors, and attenuation of Th2 response.
    Materialart: Online-Ressource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2012/161235
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2012
    ZDB Id: 2148302-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Safety and efficacy of high power shorter duration ablation for atrial fibrillation: A systematic review and meta‐analysis
    Hindawi Limited ; 2021
    In:  International Journal of Clinical Practice Vol. 75, No. 4 ( 2021-04)
    Details
    In: International Journal of Clinical Practice, Hindawi Limited, Vol. 75, No. 4 ( 2021-04)
    Materialart: Online-Ressource
    ISSN: 1368-5031 , 1742-1241
    URL: Issue
    URL: Article
    DOI: 10.1111/ijcp.v75.4
    DOI: 10.1111/ijcp.13732
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2021
    ZDB Id: 2135320-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    Xiaoyao-Qingluoyin Cure Adjuvant-Induced Arthritis by Easing LPS Response-Related Pathway-Mediated Immune Abnormality
    Hindawi Limited ; 2022
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2022 ( 2022-4-25), p. 1-12
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2022 ( 2022-4-25), p. 1-12
    Kurzfassung: Qingluoyin (QLY) is a representative herbal formula prescribed for hot symptom-related rheumatoid arthritis treatment. Among its derivatives, Xiaoyao-Qingluoyin (XYQLY) attracts increasing attention due to the notable clinical efficacy. In this study, we compared its effects with QLY on adjuvant-induced arthritis (AIA) in rats and partially elucidated the antirheumatic mechanism using a network pharmacology-based strategy. After continuous oral treatments, clinical outcomes were systematically evaluated by radiographic, histological, immunohistochemical, and serological analyses. Possibly altered pathways were predicted based on reported interactions between the related chemicals and proteins/genes. The obtained conclusion was further validated by experiments in vitro. QLY and XYQLY eased polyarthritis in AIA rats after repeated doses, which reflected in reduced inflammation and bone degradation and downregulated p-p65, MMP3, and TLR4 expressions in joints. Meanwhile, they restored oxidative stress (MDA, SOD, GSH, T-AOC, and NO) and inflammatory indicators (TNF-α and CO) in serum. Synovium-based immunoblotting assay revealed that QLY and XYQLY were similarly effective in downregulating MMP3 and COX-2, but XYQLY treatment exhibited notable merit in suppressing p-p65 expression. Network pharmacology analysis hinted that XYQLY should exert greater impacts on LPS signaling and the downstream. Based on results from LC-MS analysis, we treated AIA rat-derived peripheral blood mononuclear cells with either QLY or XYQLY-based chemical combinations and confirmed that XYQLY had the better potential in inhibiting TLR4/NF-κB-controlled IL-6 production. Consequently, it led to a more profound decrease in Th17 cells counts. Overall evidence demonstrated that XYQLY was especially effective in regulating innate immunity and, therefore, improved immune environment in AIA rats as a whole.
    Materialart: Online-Ressource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2022/8536998
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2148302-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Specific Link between Lung and Large Intestine: A New Perspective on Neuropeptide Secretion in Lung with Herbal Laxative Stimulation
    Hindawi Limited ; 2013
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2013 ( 2013), p. 1-9
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2013 ( 2013), p. 1-9
    Kurzfassung: Background . To investigate the specific link between lung and large intestine. Methods . Rat COPD-like model was prepared. Mirabilite or Chinese rhubarb was administrated intragastrically to stimulate the large intestine. Histological analysis of lung inflammation was assessed. The tissues levels of SP, VIP, NK1R, VIPR1, and VIPR2 were measured by using ELISA kits. In addition, mouse model of allergic asthma was prepared. Mirabilite was administrated intragastrically to stimulate the large intestine. Airway responsiveness and lung inflammation were assessed. The tissues levels of SP, VIP, NKA, NKB, NK1R, VIPR1, and VIPR2 were measured by using ELISA kits. Results . Stimulating the intestine with Mangxiao or Dahuang, SP, NK-1R, VIP, VIPR1, and VIPR2 were significantly increased in intestine tissues of rats with COPD and mice with asthma. Meanwhile, the SP and NK1R were significantly decreased, while VIP, VIPR1, and VIPR2 were significantly increased in lung tissues. An abnormal secretion of SP and VIP can be observed in other tissues; however, no marked changes were found in the receptors. The NKA and NKB levels were similar in lung tissues of mice with asthma among groups. Conclusions . Stimulating intestine with Mangxiao or Dahuang can specifically regulate the secretion of SP, VIP, and the receptors in lung tissues.
    Materialart: Online-Ressource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2013/547837
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2013
    ZDB Id: 2148302-4
    Standort Signatur Einschränkungen Verfügbarkeit
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