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  • 1
    Online Resource
    Online Resource
    De Novo Sequencing and Characterization of the Transcriptome of Dwarf Polish Wheat ( Triticum polonicum L.)
    Hindawi Limited ; 2016
    In:  International Journal of Genomics Vol. 2016 ( 2016), p. 1-6
    Details
    In: International Journal of Genomics, Hindawi Limited, Vol. 2016 ( 2016), p. 1-6
    Abstract: Construction as well as characterization of a polish wheat transcriptome is a crucial step to study useful traits of polish wheat. In this study, a transcriptome, including 76,014 unigenes, was assembled from dwarf polish wheat (DPW) roots, stems, and leaves using the software of Trinity. Among these unigenes, 61,748 (81.23%) unigenes were functionally annotated in public databases and classified into differentially functional types. Aligning this transcriptome against draft wheat genome released by the International Wheat Genome Sequencing Consortium (IWGSC), 57,331 (75.42%) unigenes, including 26,122 AB-specific and 2,622 D-specific unigenes, were mapped on A, B, and/or D genomes. Compared with the transcriptome of T. turgidum , 56,343 unigenes were matched with 103,327 unigenes of T. turgidum . Compared with the genomes of rice and barley, 14,404 and 7,007 unigenes were matched with 14,608 genes of barley and 7,708 genes of rice, respectively. On the other hand, 2,148, 1,611, and 2,707 unigenes were expressed specifically in roots, stems, and leaves, respectively. Finally, 5,531 SSR sequences were observed from 4,531 unigenes, and 518 primer pairs were designed.
    Type of Medium: Online Resource
    ISSN: 2314-436X , 2314-4378
    URL: Article
    DOI: 10.1155/2016/5781412
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2711883-6
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization
    Hindawi Limited ; 2019
    In:  Journal of Immunology Research Vol. 2019 ( 2019-12-19), p. 1-12
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2019 ( 2019-12-19), p. 1-12
    Abstract: Immunosenescence comprises a set of dynamic changes occurring in innate and adaptive immune systems, and macrophage aging plays an important role in innate and adaptive immunosenescence. However, function and polarization changes in aging macrophages have not been fully evaluated, and no effective method for delaying macrophage senescence is currently available. The results of this study reveal that D-galactose (D-gal) can promote J774A.1 macrophage senescence and induce macrophage M1 polarization differentiation. Bifidobacterium lactis BB-12 can significantly inhibit J774A.1 macrophage senescence induced by D-gal. IL-6 and IL-12 levels in the BB-12 groups remarkably decreased compared with that in the D-gal group, and the M2 marker, IL-10, and Arg-1 mRNA levels increased in the BB-12 group. BB-12 inhibited the expression of p-signal transducer and activator of transcription 1 (STAT1) and promoted p-STAT6 expression. In summary, the present study indicates that BB-12 can attenuate the J774A.1 macrophage senescence and induce M2 macrophage polarization, thereby indicating the potential of BB-12 to slow down immunosenescence and inflamm-aging.
    Type of Medium: Online Resource
    ISSN: 2314-8861 , 2314-7156
    URL: Article
    DOI: 10.1155/2019/4657928
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2817541-4
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  • 3
    Online Resource
    Online Resource
    A Tesla-type long-pulse generator with wide flat-top width based on a double-width pulse-forming line
    Hindawi Limited ; 2018
    In:  Laser and Particle Beams Vol. 36, No. 1 ( 2018-03), p. 115-120
    Details
    In: Laser and Particle Beams, Hindawi Limited, Vol. 36, No. 1 ( 2018-03), p. 115-120
    Abstract: To produce pulses with good flat-top quality, pulse-forming lines (PFLs) have been widely used in the field of Tesla-type pulse generators. To shorten the physical length of the PFL, a double-width PFL (DWPFL) is proposed that doubles the output pulse width while maintaining flat-top quality. A repetitively 10 GW Tesla-type long-pulse generator producing pulses with flat-top width of about 110 ns was developed with a coaxial DWPFL to produce high-current electron beams. Electron beams of about 10 GW with flat-top widths of about 110 ns were obtained on a planar vacuum diode load. With this pulse generator and a C-band high-power microwave system, microwaves of ~2.2 GW power and full-width at half-maximum of 101 ns were generated. The experiment demonstrates the feasibility and ideal output waveform quality of the DWPFL.
    Type of Medium: Online Resource
    ISSN: 0263-0346 , 1469-803X
    URL: Article
    DOI: 10.1017/S0263034618000034
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2021816-3
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  • 4
    Online Resource
    Online Resource
    The Protective Effect of Salidroside on Hypoxia-Induced Corpus Cavernosum Smooth Muscle Cell Phenotypic Transformation
    Hindawi Limited ; 2017
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2017 ( 2017), p. 1-11
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2017 ( 2017), p. 1-11
    Abstract: Salidroside, a major active ingredient isolated from Rhodiola rosea , has a long application in Chinese medical history. It has widely demonstrated effects on fatigue, psychological stress, and depression and exhibits potential antihypoxia activity. Emerging evidence shows that hypoxia is an important independent risk factor for erectile dysfunction (ED). The aim of this study was to clarify the effect of salidroside on hypoxia-induced phenotypic transformation of corpus cavernosum smooth muscle cells (CCSMCs). Our results showed that salidroside decreased the hypoxia-induced expression of collagen and content of vimentin, a corpus cavernosum smooth muscle synthetic protein, in vitro. Simultaneously, salidroside increased expression of the CCSMC contractile proteins, α -smooth muscle actin ( α -SMA) and desmin. In vivo, similarly, the expressions of collagen and hypoxia-inducible factor-1 α were increased in bilateral cavernous neurectomy (BCN) rats while they were decreased in the salidroside group. Among the phenotypic proteins, α -SMA and desmin increased and vimentin decreased after treating BCN rats with salidroside compared with the BCN alone group. Overall, our results demonstrate that salidroside has the ability to oppose hypoxia and can inhibit the CCSMC phenotypic transformation induced by hypoxia. Salidroside may provide a new treatment method for ED.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2017/3530281
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2148302-4
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  • 5
    Online Resource
    Online Resource
    Naringenin: A Promising Therapeutic Agent against Organ Fibrosis
    Hindawi Limited ; 2021
    In:  Oxidative Medicine and Cellular Longevity Vol. 2021 ( 2021-11-11), p. 1-13
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2021 ( 2021-11-11), p. 1-13
    Abstract: Fibrosis is the final common pathology of most chronic diseases as seen in the heart, liver, lung, kidney, and skin and contributes to nearly half of death in the developed countries. Fibrosis, or scarring, is mainly characterized by the transdifferentiation of fibroblasts into myofibroblasts and the excessive accumulation of extracellular matrix (ECM) secreted by myofibroblasts. Despite immense efforts made in the field of organ fibrosis over the past decades and considerable understanding of the occurrence and development of fibrosis gained, there is still lack of an effective treatment for fibrotic diseases. Therefore, identifying a new therapeutic strategy against organ fibrosis is an unmet clinical need. Naringenin, a flavonoid that occurs naturally in citrus fruits, has been found to confer a wide range of pharmacological effects including antioxidant, anti-inflammatory, and anticancer benefits and thus potentially exerting preventive and curative effects on numerous diseases. In addition, emerging evidence has revealed that naringenin can prevent the pathogenesis of fibrosis in vivo and in vitro via the regulation of various pathways that involved signaling molecules such as transforming growth factor-β1/small mother against decapentaplegic protein 3 (TGF-β1/Smad3), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), sirtuin1 (SIRT1), nuclear factor-kappa B (NF-κB), or reactive oxygen species (ROS). Targeting these profibrotic pathways by naringenin could potentially become a novel therapeutic approach for the management of fibrotic disorders. In this review, we present a comprehensive summary of the antifibrotic roles of naringenin in vivo and in vitro and their underlying mechanisms of action. As a food derived compound, naringenin may serve as a promising drug candidate for the treatment of fibrotic disorders.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2021/1210675
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2455981-7
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  • 6
    Online Resource
    Online Resource
    Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
    Abstract: Between June 2010 and June 2011, 176 patients were divided into 2 groups: a group with spinal metastasis of solid tumors ( n = 157 ) and a group with multiple myeloma ( n = 19 ). Both groups were further divided into 2 subgroups: a group receiving zoledronic acid before surgery and a control group. The zoledronic acid subgroup of the solid tumors group was group A ( n = 81 ), the control subgroup of the solid tumors group was group B ( n = 76 ), the zoledronic acid subgroup of the multiple myeloma group was group C ( n = 10 ), and the control subgroup of the multiple myeloma group was group D ( n = 9 ). The average intraoperative blood loss during spinal surgery was as follows: 1311 ± 691  mL in group A and 1752 ± 740  mL in group B ( P = 0 . 000 ) and 1994 ± 810  mL in group C and 3134 ± 795  mL in group D ( P = 0 . 000 ). Patients receiving zoledronic acid before surgery had significantly less intraoperative bleeding than those who did not receive it. Preoperative use of zoledronic acid can effectively reduce intraoperative bleeding during surgery for the treatment of spinal tumors.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/936307
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 7
    Online Resource
    Online Resource
    Image Watermark Based on Extended Shearlet and Insertion Using the Largest Information Entropy on Horizontal Cone
    Hindawi Limited ; 2015
    In:  Mathematical Problems in Engineering Vol. 2015 ( 2015), p. 1-10
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2015 ( 2015), p. 1-10
    Abstract: Extended discrete shearlet provides a directional multiresolution decomposition. It has been mathematically shown that extended discrete shearlet is a more efficient representation for the signals containing distributed discontinuities such as edges, compared to discrete wavelet. Multiresolution analyses such as curvelet and ridgelet share similar properties, yet their directional representations are significantly different from that of extended discrete shearlet. Taking advantage of the unique properties of directional representation of extended discrete shearlet, we develop an image watermark algorithm based on the largest information entropy. In proposed algorithm, firstly, 1-level extended discrete shearlet transform decomposes the test image into directional components on horizontal cone; each directional component reflects directional features and textured features differently. Next, the directional component whose information entropy is the highest is selected to carry watermark. Compared with related algorithms based on DWT and DCT, the proposed algorithm tends to obtain preferable invisibility when it is robust against common attacks.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2015/450819
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 8
    Online Resource
    Online Resource
    SEMA5A-PLXNB3 Axis Promotes PDAC Liver Metastasis Outgrowth through Enhancing the Warburg Effect
    Hindawi Limited ; 2023
    In:  Journal of Immunology Research Vol. 2023 ( 2023-1-27), p. 1-18
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2023 ( 2023-1-27), p. 1-18
    Abstract: Patients bearing liver metastasis of pancreatic adeno carcinoma (PDAC) suffer from poor prognosis due to its short duration and high mortality. Complex tumor microenvironment (TME) exists in liver metastatic niches, and tumor-associated macrophages (TAMs) have play vital roles in metastasis generation and outgrowth. We have discovered that M2 type TAM-derived SEMA5A could bind to its tumor cell-expressed receptor PLXNB3 to promote tumor cell proliferation and outgrowth. We utilized liver metastasis samples of PDAC patients, intrasplenic injection mouse models, and KrasG12D/Trp53R172H/Pdx1-Cre (KPC) mouse models for in vivo study. In mechanism investigation, we have discovered that SEMA5A-PLXNB3 axis could achieve tumor cell proliferation and survival via enhancing aerobic glycolysis termed as the Warburg effects. Targeting this axis may be a potential therapeutic approach for PDAC patients with unresectable liver metastasis.
    Type of Medium: Online Resource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2023/3274467
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2817541-4
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  • 9
    Online Resource
    Online Resource
    Texture Directionality-Based Digital Watermarking in Nonsubsample Shearlet Domain
    Hindawi Limited ; 2017
    In:  Mathematical Problems in Engineering Vol. 2017 ( 2017), p. 1-14
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2017 ( 2017), p. 1-14
    Abstract: Digital watermarking is a technique used to protect an author’s copyright and has become widespread due to the rapid development of multimedia technologies. In this paper, a novel watermarking algorithm using the nonsubsample shearlet transform is proposed, which combines the directional edge features of an image. A shearlet provides an optimal multiresolution and multidirectional representation of an image based on distributed discontinuities such as edges, which ensures that the embedded watermark does not blur the image. In the proposed algorithm, the nonsubsample shearlet transform is used to decompose the cover image into directional subbands, where different directional subbands represent different directional and textured features. The subband whose texture directionality is strongest is selected to carry the watermark and is thus suitable for the human visual system. Next, singular value decomposition is performed on the selected subband image. Finally, the watermark is embedded in the singular value matrix, which is beneficial for the watermarking robustness and invisibility. In comparison with related watermarking algorithms based on discrete wavelet transforms and nonsubsample contourlet transform domains, experimental results demonstrate that the proposed scheme is highly robust against scaling, cropping, and compression.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2017/6581279
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 10
    Online Resource
    Online Resource
    Application of 3D Printing in the Surgical Planning of Trimalleolar Fracture and Doctor-Patient Communication
    Hindawi Limited ; 2016
    In:  BioMed Research International Vol. 2016 ( 2016), p. 1-5
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-5
    Abstract: To evaluate the effect of 3D printing in treating trimalleolar fractures and its roles in physician-patient communication, thirty patients with trimalleolar fractures were randomly divided into the 3D printing assisted-design operation group (Group A) and the no-3D printing assisted-design group (Group B). In Group A, 3D printing was used by the surgeons to produce a prototype of the actual fracture to guide the surgical treatment. All patients underwent open reduction and internal fixation. A questionnaire was designed for doctors and patients to verify the verisimilitude and effectiveness of the 3D-printed prototype. Meanwhile, the operation time and the intraoperative blood loss were compared between the two groups. The fracture prototypes were accurately printed, and the average overall score of the verisimilitude and effectiveness of the 3D-printed prototypes was relatively high. Both the operation time and the intraoperative blood loss in Group A were less than those in Group B ( P 〈 0.05 ). Patient satisfaction using the 3D-printed prototype and the communication score were 9.3 ± 0.6 points. A 3D-printed prototype can faithfully reflect the anatomy of the fracture site; it can effectively help the doctors plan the operation and represent an effective tool for physician-patient communication.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2016/2482086
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2698540-8
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