In:
Experimental Diabetes Research, Hindawi Limited, Vol. 2011 ( 2011), p. 1-6
Kurzfassung:
Objective . Gestational diabetes mellitus (GDM) influences fetal development and offspring's metabolic risk. We evaluated this association in 17-year-old offspring adjusting for birth weight (BW) and prepregnancy maternal BMI (mBMI). Study Design . The JPS birth cohort contains extensive data on 92,408 births from 1964 to 1976. Offspring's BMI and blood pressure (BP) were obtained from military records. For a subcohort born between 1974 and 1976, prepregnancy mBMI was available. Offspring were classified as born to mothers with GDM () or born to mothers without recorded GDM (). Results . GDM offspring had higher mean BMI and systolic and diastolic BP compared to no-recorded-GDM offspring. After adjusting for BW, GDM remained significantly associated with offspring BMI and diastolic BP ( = 1.169 and 1.520, resp.). In the subcohort, when prepregnancy mBMI was entered to the models, it markedly attenuated the associations with GDM. Conclusions . Maternal characteristics have long-term effects on cardiometabolic outcomes of their offspring aged 17 years.
Materialart:
Online-Ressource
ISSN:
1687-5214
,
1687-5303
Sprache:
Englisch
Verlag:
Hindawi Limited
Publikationsdatum:
2011
ZDB Id:
2465179-5
ZDB Id:
2711897-6
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