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  • Hindawi Limited  (3)
  • 1
    Online Resource
    Online Resource
    Blockade of Transient Receptor Potential Vanilloid 4 Enhances Antioxidation after Myocardial Ischemia/Reperfusion
    Hindawi Limited ; 2019
    In:  Oxidative Medicine and Cellular Longevity Vol. 2019 ( 2019-06-16), p. 1-17
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2019 ( 2019-06-16), p. 1-17
    Abstract: Antioxidative stress provides a cardioprotective effect during myocardial ischemia/reperfusion (I/R). Previous research has demonstrated that the blockade of transient receptor potential vanilloid 4 (TRPV4) attenuates myocardial I/R injury. However, the underlying mechanism remains unclear. The current study is aimed at investigating the antioxidative activity of TRPV4 inhibition and elucidating the underlying mechanisms in vitro and ex vivo . We found that the inhibiting TRPV4 by the selective TRPV4 blocker HC-067047 or specific TRPV4-siRNA significantly reduces reactive oxygen species (ROS) and methane dicarboxylic aldehyde (MDA) levels in H9C2 cells exposed to hypoxia/reoxygenation (H/R). Meanwhile, the activity of antioxidative enzymes, particularly superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), is enhanced. Furthermore, after H/R, HC-067047 treatment increases the expression of P-Akt and the translocation of nuclear factor E2-related factor 2 (Nrf2) and related antioxidant response element (ARE) mainly including SOD, GSH-Px, and catalase (CAT). LY294002, an Akt inhibitor, suppresses HC-067047 and specific TRPV4-siRNA-induced Nrf2 expression and its nuclear accumulation. Nrf2 siRNA attenuates HC-067047 and specific TRPV4-siRNA-induced ARE expression. In addition, treatment with LY294002 or Nrf2 siRNA significantly attenuates the antioxidant and anti-injury effects of HC-067047 in vitro . Finally, in experiments on isolated rat hearts, we confirmed the antioxidative stress roles of TRPV4 inhibition during myocardial I/R and the application of exogenous H 2 O 2 . In conclusion, the inhibition of TRPV4 exerts cardioprotective effects through enhancing antioxidative enzyme activity and expressions via the Akt/Nrf2/ARE pathway.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2019/7283683
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2455981-7
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Survivability Evaluation Method for Cascading Failure of Electric Cyber Physical System Considering Load Optimal Allocation
    Hindawi Limited ; 2019
    In:  Mathematical Problems in Engineering Vol. 2019 ( 2019-07-15), p. 1-15
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2019 ( 2019-07-15), p. 1-15
    Abstract: The scale of the electric cyber physical system (ECPS) is continuously extending, and the existing cascade failure models ignore both the information flow and power flow transferring characteristics and also lack effective survivability analysis. In this paper, the quantitative evaluation method for cascading failure of ECPS survivability considering optimal load allocation is proposed. Firstly, according to the system topological structure and correlation, the degree-betweenness weighted correlation matrix of ECPS is established by defining the degree function as well as the electric betweenness, and the formal representation of coupled ECPS network model is realized. Secondly, based on the structural connectivity change and risk propagation range of ECPS cascade failure, the survivability evaluation model is designed by taking into account the constraints such as node load capacity limitation, information flow optimal allocation strategy, power flow optimization equation, and system safety operation. Finally, the firefly algorithm with chaotic Lévy flight is proposed to solve the evaluation model efficiently. The case study vividly shows that the evaluation method can effectively quantify the survivability of ECPS and thus enhance the evaluation efficiency of large-scale coupled systems.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2019/2817586
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 3
    Online Resource
    Online Resource
    Complex dynamics and chaos control of electricity markets with heterogeneous expectations : BIDDING DECISIONS WITH HETEROGENEOUS EXPECTATIONS, DYNAMIC MODEL
    Hindawi Limited ; 2014
    In:  International Transactions on Electrical Energy Systems Vol. 24, No. 7 ( 2014-07), p. 1047-1064
    Details
    In: International Transactions on Electrical Energy Systems, Hindawi Limited, Vol. 24, No. 7 ( 2014-07), p. 1047-1064
    Type of Medium: Online Resource
    ISSN: 2050-7038
    URL: Issue
    URL: Article
    DOI: 10.1002/etep.v24.7
    DOI: 10.1002/etep.1773
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2702272-9
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