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  • 1
    Online-Ressource
    Online-Ressource
    The Evaluation of Different Radiological Measurement Parameters of the Degree of Collapse of the Vertebral Body in Vertebral Compression Fractures
    Hindawi Limited ; 2019
    In:  Applied Bionics and Biomechanics Vol. 2019 ( 2019-05-08), p. 1-5
    Details
    In: Applied Bionics and Biomechanics, Hindawi Limited, Vol. 2019 ( 2019-05-08), p. 1-5
    Kurzfassung: For compression fracture, vertebral body height loss (VBHL) and kyphotic angle (KA) are two important imaging parameters for determining the prognosis and appropriate treatment. This study used previous measurement methods to assess the degree of VBHL and KA, compare and examine differences between various measurement methods, and examine the correlation between relevant measurement parameters and intravertebral cleft (IVC) in the vertebral body. The radiographic images (lateral view of the T-L spine) of 18 patients with a single-level vertebral compression fracture were reviewed. We measured 9 characteristic lengths and angles on plain radiographs, including anterior vertebral height (AVH) and AVH of the adjacent upper and lower levels, middle vertebral height (MVH) and MVH of the adjacent upper and lower levels, posterior vertebral height (PVH), and vertebral body width, and assessed 6 parameters, including vertebral compression ratio (VBCR), percentage of anterior height compression (PAHC), percentage of middle height compression (PMHC), kyphotic angle (KA), calculated kyphotic angle (CKA), and IVC. The results showed that VBCR is a simple and rapid method of VBHL assessment, but it may result in an underestimation of the degree of VBHL compared to PAHC. When PMHC 〈 40 % or kyphotic   angle 〉 15 ° , the probability of IVC occurring on the vertebral body was higher which means the higher risk of vertebral body instability. The results of this study could provide a reference for surgeons when using imaging modalities to assess the degree of vertebral body collapse.
    Materialart: Online-Ressource
    ISSN: 1176-2322 , 1754-2103
    URL: Article
    DOI: 10.1155/2019/4021640
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2019
    ZDB Id: 2179924-6
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    A Cornea Substitute Derived from Fish Scale: 6-Month Followup on Rabbit Model
    Hindawi Limited ; 2014
    In:  Journal of Ophthalmology Vol. 2014 ( 2014), p. 1-6
    Details
    In: Journal of Ophthalmology, Hindawi Limited, Vol. 2014 ( 2014), p. 1-6
    Kurzfassung: A fish scale-derived cornea substitute (Biocornea) is proposed as an alternative for human donor corneal tissue. We adopt a regenerative medicine approach to design a primary alternative to the use of fish scale for restoring sight by corneal replacement. Biocornea with corneal multilayer arrangement collagen was implanted to rabbits by pocket implantation. Our study demonstrated the safety and detailed morphologic and physiologic results from the 6 months of followup of rabbit model. In the peripheral Biocornea, the collagen fibrils were arranged in reticular fashion. Slit lamp examination showed that haze and an ulcer were not observed in all groups at 3 months postoperatively while all corneas with Biocornea were clear at both 3 months and 6 months postoperatively. The interface of Biocornea and stromal tissue were filled successfully and without observable immune cells at postoperative day 180. Moreover, the Biocornea was not dissolved and degenerated but remained transparent and showed no apparent fragmentation. Our study demonstrated that the Biocornea derived from fish scale as a good substitute had high biocompatibility and support function after a long-term evaluation. This revealed that the new approach of using Biocornea may yield an ideal artificial cornea substitute for long-term inlay placement.
    Materialart: Online-Ressource
    ISSN: 2090-004X , 2090-0058
    URL: Article
    DOI: 10.1155/2014/914542
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2014
    ZDB Id: 2546525-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    The Incidence and Risk Factors of Hip Fracture after Liver Transplantation (LT): A Nationwide Population-Based Study
    Hindawi Limited ; 2019
    In:  BioMed Research International Vol. 2019 ( 2019-12-26), p. 1-5
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2019 ( 2019-12-26), p. 1-5
    Kurzfassung: Background . Osteoporosis and fragility fracture are the major complications after liver transplantation (LT). The aim of the study was to determine the incidence and risk factors of hip fracture after LT. Methods . We conducted a retrospective population-based cohort study, enrolling the patients receiving LT between January 1999 and December 2010. Control subjects were randomly matched to every recipient by age and sex by 1 : 10 ratios. Results . During the follow-up period, 17 recipients (0.77%) and 70 (0.32%) control subjects suffered from hip fractures. The incident rates (per 10000 person-years) were 21.49 for recipients and 7.52 for controls (adjusted hazard ratio = 2.71; 95% confidence interval = 1.21–6.05). The cumulative incidence of hip fracture was significantly higher among the recipients ( p 〈 0.0001 ). Among the recipients, the subjects aged 〉 65 years at transplantation and with pretransplant steroid use are more susceptible to posttransplant hip fracture. Immunosuppressive agents did not significantly affect the risk of hip fracture among recipients. Conclusions . Liver transplantation is a risk factor for hip fractures. Aged 〉 65 years at transplantation and pretransplant steroid use are risk factors for posttransplant hip fractures among the recipients.
    Materialart: Online-Ressource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2019/5845709
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2019
    ZDB Id: 2698540-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Levels of Circulating Microparticles in Lung Cancer Patients and Possible Prognostic Value
    Hindawi Limited ; 2013
    In:  Disease Markers Vol. 35 ( 2013), p. 301-310
    Details
    In: Disease Markers, Hindawi Limited, Vol. 35 ( 2013), p. 301-310
    Kurzfassung: Background . Endothelial-derived microparticles (EDMPs) and platelet-derived microparticles (PDMPs) have been reported to be increasing in various diseases including malignant diseases. Here, we investigated whether these MPs may be useful biomarkers for predicting lung cancer (LC) disease status, cell type, or metastasis. Methods and Results . One hundred and thirty LC patients were prospectively enrolled into the study between April 2011 and February 2012. Flow cytometric analysis demonstrated that the circulating levels of platelet-derived activated MPs (PDAc-MPs), platelet-derived apoptotic MPs (PDAp-MPs), endothelial-derived activated MPs (EDAc-MPs), and endothelial-derived apoptotic MPs (EDAp-MPs) were significantly higher in LC patients than in 30 age- and gender-matched normal control subjects (all P 〈 0.05 ). Additionally, circulating level of PDAc-MPs was significantly lower ( P = 0.031 ), whereas the circulating levels of the other three biomarkers did not differ (all P 〉 0.1 ) in early stage versus late stage LC patients. Furthermore, the circulating levels of the four types of MPs did not differ among patients with different disease statuses (i.e., disease controlled, disease progression, and disease without treatment, i.e., fresh case) (all P 〉 0.2 ) or between patients with or without LC metastasis (all P 〉 0.5 ). Moreover, only the circulating level of EDAp-MPs was significantly associated with the different cell types (i.e., squamous cell carcinoma, adenocarcinoma, and small cell carcinoma) of LC ( P = 0.045 ). Conclusion . Circulating MP levels are significantly increased in LC patients as compared with normal subjects. Among the MPs, only an increased level of EDAp-MPs was significantly associated with different LC cell types.
    Materialart: Online-Ressource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2013/715472
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2013
    ZDB Id: 2033253-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Combined Liver Stiffness and Α-fetoprotein Further beyond the Sustained Virologic Response Visit as Predictors of Long-Term Liver-Related Events in Patients with Chronic Hepatitis C
    Hindawi Limited ; 2022
    In:  Canadian Journal of Gastroenterology and Hepatology Vol. 2022 ( 2022-7-4), p. 1-14
    Details
    In: Canadian Journal of Gastroenterology and Hepatology, Hindawi Limited, Vol. 2022 ( 2022-7-4), p. 1-14
    Kurzfassung: Aims. Long-term risk stratification using combined liver stiffness (LS) and clinically relevant blood tests acquired at the baseline further beyond the sustained virologic response (SVR) visit for chronic hepatitis C (CHC) has not been thoroughly investigated. This study retrospectively investigated the prognostics of liver-related events (LREs) further beyond the SVR visit. Methods. Cox regression and random forest models identified the key factors, including longitudinal LS and noninvasive test results, that could predict LREs, including hepatocellular carcinoma, during prespecified follow-ups from 2010 to 2021. Kaplan–Meier survival analysis estimated the significance of between-group risk stratification. Results. Of the entire eligible cohort (n = 520) of CHC patients with SVR to antiviral therapy, 28 (5.4%) patients developed post-SVR LREs over a median follow-up period of 6.1 years (interquartile range = 3.5–8.7). The multivariate Cox regression analysis identified two significant predictors of LREs after the year 3 post-SVR (Y3PSVR) baseline (LRE, n = 15 of 28, 53.6%, median follow-up = 4.1 [1.6–6.4] years after Y3PSVR): LS at Y3PSVR (adjusted hazard ratio [aHR] = 3.980, 95% confidence interval [CI]  = 2.085–7.597, P 〈 0.001 ), and α-fetoprotein (AFP) at Y3PSVR (aHR = 1.017, 95% CI = 1.001–1.034, P = 0.034 ). LS ≥1.45 m/s and AFP ≥3.00 ng/mL for Y3PSVR yielded positive likelihood ratios of 4.24 and 2.62, respectively. Kaplan–Meier analysis revealed that among the stratified subgroups, the subgroup with concurrent LS ≥1.45 m/s and AFP ≥3.00 ng/mL at Y3PSVR exhibited the highest risk of LREs after Y3PSVR (log-rank P 〈 0.001 ). Conclusion. We recommend the combined use of concurrent LS and AFP in future prediction models for LREs in CHC. Patients with concurrently high LS and AFP values further beyond the SVR visit may require a recall policy involving intense surveillance.
    Materialart: Online-Ressource
    ISSN: 2291-2797 , 2291-2789
    URL: Article
    DOI: 10.1155/2022/5201443
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2022
    ZDB Id: 2762184-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Wireless Stimulus-on-Device Design for Novel P300 Hybrid Brain-Computer Interface Applications
    Hindawi Limited ; 2018
    In:  Computational Intelligence and Neuroscience Vol. 2018 ( 2018-07-18), p. 1-13
    Details
    In: Computational Intelligence and Neuroscience, Hindawi Limited, Vol. 2018 ( 2018-07-18), p. 1-13
    Kurzfassung: Improving the independent living ability of people who have suffered spinal cord injuries (SCIs) is essential for their quality of life. Brain-computer interfaces (BCIs) provide promising solutions for people with high-level SCIs. This paper proposes a novel and practical P300-based hybrid stimulus-on-device (SoD) BCI architecture for wireless networking applications. Instead of a stimulus-on-panel architecture (SoP), the proposed SoD architecture provides an intuitive control scheme. However, because P300 recognitions rely on the synchronization between stimuli and response potentials, the variation of latency between target stimuli and elicited P300 is a concern when applying a P300-based BCI to wireless applications. In addition, the subject-dependent variation of elicited P300 affects the performance of the BCI. Thus, an adaptive model that determines an appropriate interval for P300 feature extraction was proposed in this paper. Hence, this paper employed the artificial bee colony- (ABC-) based interval type-2 fuzzy logic system (IT2FLS) to deal with the variation of latency between target stimuli and elicited P300 so that the proposed P300-based SoD approach would be feasible. Furthermore, the target and nontarget stimuli were identified in terms of a support vector machine (SVM) classifier. Experimental results showed that, from five subjects, the performance of classification and information transfer rate were improved after calibrations (86.00% and 24.2 bits/ min before calibrations; 90.25% and 27.9 bits/ min after calibrations).
    Materialart: Online-Ressource
    ISSN: 1687-5265 , 1687-5273
    URL: Article
    DOI: 10.1155/2018/2301804
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2018
    ZDB Id: 2388208-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Engineering Change Orders Design Using Multiple Variables Linear Programming for VLSI Design
    Hindawi Limited ; 2014
    In:  VLSI Design Vol. 2014 ( 2014-08-24), p. 1-5
    Details
    In: VLSI Design, Hindawi Limited, Vol. 2014 ( 2014-08-24), p. 1-5
    Kurzfassung: An engineering change orders design using multiple variable linear programming for VLSI design is presented in this paper. This approach addresses the main issues of resource between spare cells and target cells. We adopt linear programming technique to plan and balance the spare cells and target cells to meet the new specification according to logic transformation. The proposed method solves the related problem of resource for ECO problems and provides a well solution. The scheme shows new concept to manage the spare cells to meet possible target cells for ECO research.
    Materialart: Online-Ressource
    ISSN: 1065-514X , 1563-5171
    URL: Article
    DOI: 10.1155/2014/698041
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2014
    ZDB Id: 2022068-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Meckel’s Diverticulum Diagnosed by Balloon-Assisted Enteroscopy: A Multicenter Report from the Taiwan Association for the Study of Small Intestinal Diseases (TASSID)
    Hindawi Limited ; 2021
    In:  Gastroenterology Research and Practice Vol. 2021 ( 2021-11-18), p. 1-10
    Details
    In: Gastroenterology Research and Practice, Hindawi Limited, Vol. 2021 ( 2021-11-18), p. 1-10
    Kurzfassung: Background and Aims. Patients with Meckel’s diverticulum (MD) are difficult to preoperatively diagnose because of its endoscopic inaccessibility. Balloon-assisted enteroscopy (BAE) allows endoscopic access to the entire small intestine. The aim of the current study was to investigate patients with MD diagnosed by BAE in Taiwan. Methods. We conducted a retrospective, multicenter study of patients with MD who were diagnosed by BAE in Taiwan. The clinical characteristics, endoscopic features, histopathological findings, treatment methods, and outcomes were analyzed. Results. A total of 55 patients with MD were enrolled (46 males and 9 females). The mean age at diagnosis was 34.1 years. Overt gastrointestinal bleeding (87.3%) was the primary indication for BAE, followed by abdominal pain (9.1%), suspected small bowel tumor (1.8%), and Crohn’s disease follow-up (1.8%). The mean distance between the ileocecal valve and MD was 71.6 cm (regarding diagnostic yields: BAE—100%, capsule endoscopy—40%, Meckel’s scan—35.7%, computed tomography—14.6%, small bowel series—12.5%, and angiography—11.1%; regarding endoscopic features of MD: a large ostium—89.1%, a small ostium—7.3%, and a polypoid mass—3.6%). Surgical treatment was performed in 76.4% patients, and conservative treatment was performed in 23.6% patients. The mean length of MD in 42 patients who underwent surgical resection was 5.2 cm (in 43 patients of MD with available histopathology: heterotopic gastric tissue, 42.4%, heterotopic gastric and pancreatic tissues, 7%; heterotopic pancreatic tissue, 4.7%; heterotopic colonic tissue, 2.3%; and a neuroendocrine tumor, 2.3%). Conclusions. The current study showed BAE is a very useful modality for detecting MD compared with other conventional modalities.
    Materialart: Online-Ressource
    ISSN: 1687-630X , 1687-6121
    URL: Article
    DOI: 10.1155/2021/9574737
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2021
    ZDB Id: 2435460-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
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    Online-Ressource
    Comparison of Immediate and 2-Year Outcomes between Excimer Laser-Assisted Angioplasty with Spot Stent and Primary Stenting in Intermediate to Long Femoropopliteal Disease
    Hindawi Limited ; 2013
    In:  The Scientific World Journal Vol. 2013 ( 2013), p. 1-8
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2013 ( 2013), p. 1-8
    Kurzfassung: Background . To compare the clinical outcomes between excimer laser-assisted angioplasty (ELA) with spot stent (group A) and primary stenting (group B) in intermediate to long femoropopliteal disease. Methods . Outcomes of 105 patients totaling 119 legs treated with two different strategies were analyzed retrospectively in a prospectively maintained database. Results . Baseline characteristics were similar in both groups. Better angiographic results and lesser increase of serum C-reactive protein levels (0.60 ± 0.72 versus 2.98 ± 0.97 mg/dL, P 〈 0.001 ) after the intervention were obtained in Group B. Group A had inferior 1-year outcomes due to higher rate of binary restenosis (67% versus 32%, P = 0.001 ) and lower rate of primary patency (40% versus 58%, P = 0.039 ). Rates of amputation-free survival, target vessel revascularization, assisted primary patency, and stent fracture at 24 months were similar in both groups (80% versus 82%, P = 0.979 , 65% versus 45%, P = 0.11 , 78% versus 80%, P = 0.75 and 6.3% versus 6.8%, P = 0.71 , resp.). Conclusion . Greater vascular inflammation after ELA with spot stent resulted in earlier restenosis and inferior 1-year clinical outcomes than primary stenting. This benefit was lost in the primary stenting group at 2 years due to late catch-up restenosis. Active surveillance with prompt intervention was required to maintain the vessel patency.
    Materialart: Online-Ressource
    ISSN: 1537-744X
    URL: Article
    DOI: 10.1155/2013/247102
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2013
    ZDB Id: 2075968-X
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    The value of losartan suppression test in the confirmatory diagnosis of primary aldosteronism in patients over 50 years old
    Hindawi Limited ; 2015
    In:  Journal of the Renin-Angiotensin-Aldosterone System Vol. 16, No. 3 ( 2015-09), p. 587-598
    Details
    In: Journal of the Renin-Angiotensin-Aldosterone System, Hindawi Limited, Vol. 16, No. 3 ( 2015-09), p. 587-598
    Materialart: Online-Ressource
    ISSN: 1470-3203 , 1752-8976
    URL: Article
    DOI: 10.1177/1470320313498632
    Sprache: Englisch
    Verlag: Hindawi Limited
    Publikationsdatum: 2015
    ZDB Id: 2261873-9
    Standort Signatur Einschränkungen Verfügbarkeit
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