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  • Hindawi Limited  (49)
  • 1
    Online Resource
    Online Resource
    Link-Based Similarity Measures Using Reachability Vectors
    Hindawi Limited ; 2014
    In:  The Scientific World Journal Vol. 2014 ( 2014), p. 1-13
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2014 ( 2014), p. 1-13
    Abstract: We present a novel approach for computing link-based similarities among objects accurately by utilizing the link information pertaining to the objects involved. We discuss the problems with previous link-based similarity measures and propose a novel approach for computing link based similarities that does not suffer from these problems. In the proposed approach each target object is represented by a vector. Each element of the vector corresponds to all the objects in the given data, and the value of each element denotes the weight for the corresponding object. As for this weight value, we propose to utilize the probability of reaching from the target object to the specific object, computed using the “Random Walk with Restart” strategy. Then, we define the similarity between two objects as the cosine similarity of the two vectors. In this paper, we provide examples to show that our approach does not suffer from the aforementioned problems. We also evaluate the performance of the proposed methods in comparison with existing link-based measures, qualitatively and quantitatively, with respect to two kinds of data sets, scientific papers and Web documents. Our experimental results indicate that the proposed methods significantly outperform the existing measures.
    Type of Medium: Online Resource
    ISSN: 2356-6140 , 1537-744X
    URL: Article
    DOI: 10.1155/2014/741608
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2075968-X
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  • 2
    Online Resource
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    A Case of Primary Breast Diffuse Large B-Cell Lymphoma Treated with Chemotherapy Followed by Elective Field Radiation Therapy: A Brief Treatment Pattern Review from a Radiation Oncologist’s Point of View
    Hindawi Limited ; 2015
    In:  Case Reports in Oncological Medicine Vol. 2015 ( 2015), p. 1-6
    Details
    In: Case Reports in Oncological Medicine, Hindawi Limited, Vol. 2015 ( 2015), p. 1-6
    Abstract: We here report a case of primary breast lymphoma (PBL). A 44-year-old woman presented with a painless mass in the right breast. Fine needle aspiration cytology and excisional biopsy were performed. Excisional biopsy revealed low grade lymphoma, which was subsequently confirmed with histopathology and diagnosed as diffuse large B-cell lymphoma (DLBCL). A chest computed tomography scan revealed a 3.5 cm sized breast mass with skin thickening and a small sized lymphadenopathy in the ipsilateral axilla. Radiation therapy including the right whole breast and ipsilateral axilla and supraclavicular lymph node was performed after the patient received four courses of R-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone plus rituximab) chemotherapy. At the follow-up period of 42 months, the patient is surviving with no evidence of disease. No morbidities occurred in this patient during the follow-up period. We also briefly review the current practice pattern in PBL patients with DLBCL.
    Type of Medium: Online Resource
    ISSN: 2090-6706 , 2090-6714
    URL: Article
    DOI: 10.1155/2015/907978
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2629911-2
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  • 3
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    NF- κ B/AP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton
    Hindawi Limited ; 2014
    In:  Mediators of Inflammation Vol. 2014 ( 2014), p. 1-11
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2014 ( 2014), p. 1-11
    Abstract: AP736 was identified as an antimelanogenic drug that can be used for the prevention of melasma, freckles, and dark spots in skin by acting as a suppressor of melanin synthesis and tyrosinase expression. Since macrophage-mediated inflammatory responses are critical for skin health, here we investigated the potential anti-inflammatory activity of AP736. The effects of AP736 on various inflammatory events such as nitric oxide (NO)/prostaglandin (PG) E 2 production, inflammatory gene expression, phagocytic uptake, and morphological changes were examined in RAW264.7 cells. AP736 was found to strongly inhibit the production of both NO and PGE 2 in lipopolysaccharide- (LPS-) treated RAW264.7 cells. In addition, AP736 strongly inhibited both LPS-induced morphological changes and FITC-dextran-induced phagocytic uptake. Furthermore, AP736 also downregulated the expression of multiple inflammatory genes, such as inducible NO synthase (iNOS), cyclooxygenase- (COX-) 2, and interleukin- (IL-) 1 β in LPS-treated RAW264.7 cells. Transcription factor analysis, including upstream signalling events, revealed that both NF- κ B and AP-1 were targeted by AP736 via inhibition of the IKK/I κ B α and IRAK1/TAK1 pathways. Therefore, our results strongly suggest that AP736 is a potential anti-inflammatory drug due to its suppression of NF- κ B-IKK/I κ B α and AP-1-IRAK1/TAK1 signalling, which may make AP736 useful for the treatment of macrophage-mediated skin inflammation.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2014/354843
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2008065-7
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  • 4
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    Useful Reduction Mammoplasty Technique in Oncoplastic Breast Surgery and Reconstruction
    Hindawi Limited ; 2022
    In:  The Breast Journal Vol. 2022 ( 2022-10-21), p. 1-10
    Details
    In: The Breast Journal, Hindawi Limited, Vol. 2022 ( 2022-10-21), p. 1-10
    Abstract: Background. A combination of the reduction mammoplasty technique and breast reconstruction allows surgeons to lift ptotic breasts through local flaps and skin reduction during surgery for breast cancer. This study presents a reliable course for the combination of partial and skin or nipple-sparing mastectomy with reduction-reconstruction surgery. Methods. Fifty-seven patients underwent a partial mastectomy before reduction mammoplasty of both breasts during the same time period between 2014 and 2021 at our institution and thirteen patients underwent skin or nipple-sparing mastectomy, breast reconstruction with an extended latissimus dorsi flap or silicone implant, and aesthetic reduction mammoplasty of the contralateral breast during the same time period. Additional photos were obtained preoperatively, immediately after the operation, and at one, three, six, and twelve months postoperatively. Patient satisfaction was evaluated preoperatively and postoperatively and postoperative complications were noted. Results. Among the patients who underwent a partial mastectomy, the mean age was 45.18 ± 11.05 years, the mean body mass index (BMI) was 26.74 ± 3.53 kg/m2, and the mean preoperative right and left breast volumes were 663.85 (±28.12) cc and 664.34 (±37.13) cc, respectively, and the mean excised mass weight was 177.74 (±213.93) g. Among the patients who underwent a skin-sparing mastectomy, the mean age was 51.62 ± 8.96 years, the mean BMI was 26.91 ± 4.34 kg/m2, and the mean preoperative right and left breast volumes were 624.17 (±98.52) cc and 562.31 (±80.81) cc, respectively, and the mean excised mass weight was 618.05 (±338.17) g. Four patients (5.3%) in the partial mastectomy group had fat necrosis. The mean patient satisfaction score was higher postoperatively in both groups. Conclusion. Patients with breast cancer and large and/or ptotic breasts can successfully undergo reduction mammoplasty for both breasts immediately following partial mastectomy and nipple or skin-sparing mastectomy.
    Type of Medium: Online Resource
    ISSN: 1524-4741 , 1075-122X
    URL: Article
    DOI: 10.1155/2022/2952322
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2020959-9
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  • 5
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    Benefits of extracorporeal shock waves for keloid treatment: A pilot study
    Hindawi Limited ; 2020
    In:  Dermatologic Therapy Vol. 33, No. 4 ( 2020-07)
    Details
    In: Dermatologic Therapy, Hindawi Limited, Vol. 33, No. 4 ( 2020-07)
    Type of Medium: Online Resource
    ISSN: 1396-0296 , 1529-8019
    URL: Issue
    URL: Article
    DOI: 10.1111/dth.v33.4
    DOI: 10.1111/dth.13653
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2020064-X
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  • 6
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    Current Iodine Nutrition Status and Awareness of Iodine Deficiency in Tuguegarao, Philippines
    Hindawi Limited ; 2014
    In:  International Journal of Endocrinology Vol. 2014 ( 2014), p. 1-7
    Details
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2014 ( 2014), p. 1-7
    Abstract: The Philippines is one of the countries where adequate iodine status has been achieved. However, iodine deficiency still remains an important public health problem in this country. In this study, we evaluated iodine nutrition status and investigated an awareness status of iodine deficiency targeting high school students of Tuguegarao, Philippines. A total of 260 students provided samples for urinary iodine analysis, among which 146 students completed thyroid volume measurement by ultrasonography and answering the questionnaires. The median urinary iodine level was 355.3  µ g/L and only 3.8% of the students were in the range of iodine deficiency status according to the ICCIDD criteria. Although 62.3% of students answered that they can list problems resulting from iodine deficiency, a majority of students (70.5%) were unable to identify problems other than goiter. They did not appreciate that adequate iodine levels are important during pregnancy and for development of children. 33.6% of students answered that they did not use iodized salt and the biggest reason was that they did not find it necessary. Based on these results, we suggest that a future strategy should be focused on vulnerable groups to completely eliminate iodine deficiency, including women at their reproductive ages and during pregnancy.
    Type of Medium: Online Resource
    ISSN: 1687-8337 , 1687-8345
    URL: Article
    DOI: 10.1155/2014/210528
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2502951-4
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  • 7
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    Dynamic Nonparametric Random Forest Using Covariance
    Hindawi Limited ; 2019
    In:  Security and Communication Networks Vol. 2019 ( 2019-03-27), p. 1-12
    Details
    In: Security and Communication Networks, Hindawi Limited, Vol. 2019 ( 2019-03-27), p. 1-12
    Abstract: As the representative ensemble machine learning method, the Random Forest (RF) algorithm has widely been used in diverse applications on behalf of the fast learning speed and the high classification accuracy. Research on RF can be classified into two categories: ( 1 ) improving the classification accuracy and ( 2 ) decreasing the number of trees in a forest. However, most of papers related to the performance improvement of RF have focused on improving the classification accuracy. Only some papers have focused on reducing the number of trees in a forest. In this paper, we propose a new Covariance-Based Dynamic RF algorithm, called C-DRF. Compared to the previous works, while ensuring the good-enough classification accuracy, the proposed C-DRF algorithm reduces the number of trees. Specifically, by computing the covariance between the number of trees in a forest and F -measure at each iteration, the proposed algorithm determines whether to increase the number of trees composing a forest. To evaluate the performance of the proposed C-DRF algorithm, we compared the learning time, the test time, and the memory usage with the original RF algorithm under the different areas of datasets. Under the same or higher classification accuracy, it is shown that the proposed C-DRF algorithm improves the performance of the original RF algorithm by as much as 58.68% at learning time, 47.91% at test time, and 68.06% in memory usage on average. As a practical application area, we also show that the proposed C-DRF algorithm is more efficient than the state-of-the-art RF algorithms in Network Intrusion Detection (NID) area.
    Type of Medium: Online Resource
    ISSN: 1939-0114 , 1939-0122
    URL: Article
    DOI: 10.1155/2019/3984031
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2415104-X
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  • 8
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    Syk/Src Pathway-Targeted Inhibition of Skin Inflammatory Responses by Carnosic Acid
    Hindawi Limited ; 2012
    In:  Mediators of Inflammation Vol. 2012 ( 2012), p. 1-13
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2012 ( 2012), p. 1-13
    Abstract: Carnosic acid (CA) is a diterpene compound exhibiting antioxidative, anticancer, anti-angiogenic, anti-inflammatory, anti-metabolic disorder, and hepatoprotective and neuroprotective activities. In this study, the effect of CA on various skin inflammatory responses and its inhibitory mechanism were examined. CA strongly suppressed the production of IL-6, IL-8, and MCP-1 from keratinocyte HaCaT cells stimulated with sodium lauryl sulfate (SLS) and retinoic acid (RA). In addition, CA blocked the release of nitric oxide (NO), tumor necrosis factor (TNF)-α, and prostaglandin E 2 (PGE 2 ) from RAW264.7 cells activated by the toll-like receptor (TLR)-2 ligands, Gram-positive bacterium-derived peptidoglycan (PGN) and pam3CSK, and the TLR4 ligand, Gram-negative bacterium-derived lipopolysaccharide (LPS). CA arrested the growth of dermatitis-inducing Gram-positive and Gram-negative microorganisms such Propionibacterium acnes, Pseudomonas aeruginosa , and Staphylococcus aureus . CA also blocked the nuclear translocation of nuclear factor (NF)-κB and its upstream signaling including Syk/Src, phosphoinositide 3-kinase (PI3K), Akt, inhibitor of κBα (IκBα) kinase (IKK), and IκBα for NF-κB activation. Kinase assays revealed that Syk could be direct enzymatic target of CA in its anti-inflammatory action. Therefore, our data strongly suggest the potential of CA as an anti-inflammatory drug against skin inflammatory responses with Src/NF-κB inhibitory properties.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2012/781375
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2008065-7
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  • 9
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    Current Status of the Third-Line Helicobacter pylori Eradication
    Hindawi Limited ; 2018
    In:  Gastroenterology Research and Practice Vol. 2018 ( 2018-05-02), p. 1-7
    Details
    In: Gastroenterology Research and Practice, Hindawi Limited, Vol. 2018 ( 2018-05-02), p. 1-7
    Abstract: Antibiotic resistance is growing worldwide, and patients who have failed consecutive 1st- and 2nd-line H. pylori eradication regimens are increasing. Therefore, the role of the bacterial culture with antibiotic susceptibility testing and molecular susceptibility testing is important for avoiding the use of ineffective antibiotics. However, antibiotic susceptibility testing-guided treatment does not necessarily guarantee successful eradication, and there have been mixed results for the effectiveness of a 3rd-line rescue therapy. Therefore, providing patients with pretreatment medication instructions and education is important. It is also crucial to determine the reason of the eradication failure, including host-related factors (poor compliance to eradication regimen, smoking, and cytochrome P450 2C19 genetic polymorphism) or treatment-related factors (inadequate dosage or duration of therapy and gastric acidity), as such factors can be modified for a tailored therapy. Although the indications for H. pylori eradication have widened, patients at a high risk of gastric cancer can gain definitive benefits with a 3rd-line or even 4th-line therapy.
    Type of Medium: Online Resource
    ISSN: 1687-6121 , 1687-630X
    URL: Article
    DOI: 10.1155/2018/6523653
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2435460-0
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  • 10
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    Curcumin Alters Neural Plasticity and Viability of Intact Hippocampal Circuits and Attenuates Behavioral Despair and COX-2 Expression in Chronically Stressed Rats
    Hindawi Limited ; 2017
    In:  Mediators of Inflammation Vol. 2017 ( 2017), p. 1-9
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2017 ( 2017), p. 1-9
    Abstract: Curcumin is a major diarylheptanoid component of Curcuma longa with traditional usage for anxiety and depression. It has been known for the anti-inflammatory, antistress, and neurotropic effects. Here we examined curcumin effect in neural plasticity and cell viability. 60-channel multielectrode array was applied on organotypic hippocampal slice cultures (OHSCs) to monitor the effect of 10  μ M curcumin in long-term depression (LTD) through low-frequency stimulation (LFS) to the Schaffer collaterals and commissural pathways. Cell viability was assayed by propidium iodide uptake test in OHSCs. In addition, the influence of oral curcumin administration on rat behavior was assessed with the forced swim test (FST). Finally, protein expression levels of brain-derived neurotrophic factor (BDNF) and cyclooxygenase-2 (COX-2) were measured by Western blot in chronically stressed rats. Our results demonstrated that 10  μ M curcumin attenuated LTD and reduced cell death. It also recovered the behavior immobility of FST, rescued the attenuated BDNF expression, and inhibited the enhancement of COX-2 expression in stressed animals. These findings indicate that curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects, possibly through the upregulation of BDNF and reduction of inflammatory factors in the brain.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2017/6280925
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2008065-7
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