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  • 1
    Online Resource
    Online Resource
    Analysis of Epidemiology and Risk Factors of Atopic Dermatitis in Korean Children and Adolescents from the 2010 Korean National Health and Nutrition Examination Survey
    Hindawi Limited ; 2017
    In:  BioMed Research International Vol. 2017 ( 2017), p. 1-6
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-6
    Abstract: Background. Atopic dermatitis (AD) is a common chronic inflammatory skin disease, but only few studies involved samples of children and adolescents that are representative of the entire Korean population. This study aimed to estimate the prevalence and risk factors of AD among children and adolescents in Korea by using nationally representative data. Methods. We used data from the fifth Korean National Health and Nutrition Examination Survey in 2010 and retrospectively evaluated 2,116 children and adolescents. Logistic regression analysis was performed to determine the relationship between AD and other variables, including IgE levels. Results. The prevalence rate of AD in children and adolescents was 15.0%. In the multivariate analysis of ages from 1 to 18 years, age (adjusted odds ratio [aOR], 0.96; p 〈 0.01 ) was related to AD. From age of 12 to 18 years, smoking (aOR, 8.99; p 〈 0.01 ) and elevated total IgE serum level (aOR, 5.31; p 〈 0.01 ) were related to AD. Conclusion. Age, smoking, and elevated total IgE level were related to AD in the children and adolescents. Thus, an antismoking policy and public education are necessary for reducing the prevalence of allergic diseases. In addition, measurement of total IgE level and age may be helpful in the diagnosis of AD.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2017/5142754
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2698540-8
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  • 2
    Online Resource
    Online Resource
    Neural Compensatory Response During Complex Cognitive Function Tasks in Mild Cognitive Impairment: A Near-Infrared Spectroscopy Study
    Hindawi Limited ; 2019
    In:  Neural Plasticity Vol. 2019 ( 2019-06-19), p. 1-8
    Details
    In: Neural Plasticity, Hindawi Limited, Vol. 2019 ( 2019-06-19), p. 1-8
    Abstract: The present pilot study was aimed at conducting a comparative analysis of the level of activation in the prefrontal cortex among a normal elderly group and amnestic and nonamnestic mild cognitive impairment (MCI) groups and investigating the presence of neural compensatory mechanisms according to types of MCI and different cognitive tasks. We performed functional near-infrared spectroscopy (fNIRS) along with cognitive tasks, including two-back test, Korean color word Stroop test, and semantic verbal fluency task (SVFT), to investigate hemodynamic response and the presence of neural compensation and neuroplasticity in the prefrontal cortex of patients with amnestic and nonamnestic MCI compared with a healthy elderly group. During the two-back test, there was no significant difference in the bilateral region-of-interest (ROI) analysis in the three groups. During the Stroop test, right-sided hyperactivation compared to the left side during the task was shown in the nonamnestic MCI and normal groups with statistical significance. Mean acc ∆ HbO 2   on the right side was highest in the nonamnestic MCI group (0.30 μM) followed by the normal group (0.07 μM ) and the amnestic MCI group (-0.10 μM ). Otherwise, intergroup ROI analysis of acc ∆ HbO 2 in these activated right sides showed no significant difference. During the VFT test, there was no significant difference in the bilateral region-of-interest analysis in the three groups. The highest mean acc ∆ HbO 2 was shown in the normal group (0.79 μM ) followed by the nonamnestic MCI group (0.52 μM ) and the amnestic MCI group (0.21 μM) . Otherwise, there was no significant difference between groups. The hemodynamic response during fNIRS showed different findings according to MCI types and cognitive tasks. Among the three tasks, the Stroop test showed results that were suggestive of neural compensatory mechanisms in the prefrontal cortex in nonamnestic MCI.
    Type of Medium: Online Resource
    ISSN: 2090-5904 , 1687-5443
    URL: Article
    DOI: 10.1155/2019/7845104
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2236872-3
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  • 3
    Online Resource
    Online Resource
    Suberoylanilide Hydroxamic Acid Attenuates Autoimmune Arthritis by Suppressing Th17 Cells through NR1D1 Inhibition
    Hindawi Limited ; 2019
    In:  Mediators of Inflammation Vol. 2019 ( 2019-10-24), p. 1-11
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2019 ( 2019-10-24), p. 1-11
    Abstract: Rheumatoid arthritis (RA) is a type of systemic autoimmune arthritis that causes joint inflammation and destruction. One of the pathological mechanisms of RA is known to involve histone acetylation. Although the histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) can attenuate arthritis in animal models of RA, the mechanism underlying this effect is poorly understood. This study was performed to examine whether SAHA has therapeutic potential in an animal model of RA and to investigate its mechanism of action. Collagen-induced arthritis (CIA) mice were orally administered SAHA daily for 8 weeks and examined for their arthritis score and incidence of arthritis. CD4 + T cell regulation following SAHA treatment was confirmed in splenocytes cultured under type 17 helper T (Th17) cell differentiation conditions. Clinical scores and the incidence of CIA were lower in mice in the SAHA treatment group compared to the controls. In addition, SAHA inhibited Th17 cell differentiation, as well as decreased expression of the Th17 cell-related transcription factors pSTAT3 Y705 and pSTAT3 S727. In vitro experiments showed that SAHA maintained regulatory T (Treg) cells but specifically reduced Th17 cells. The same results were obtained when mouse splenocytes were cultured under Treg cell differentiation conditions and then converted to Th17 cell differentiation conditions. In conclusion, SAHA was confirmed to specifically inhibit Th17 cell differentiation through nuclear receptor subfamily 1 group D member 1 (NR1D1), a factor associated with Th17 differentiation. The results of the present study suggested that SAHA can attenuate CIA development by inhibition of the Th17 population and maintenance of the Treg population through NR1D1 inhibition. Therefore, SAHA is a potential therapeutic candidate for RA.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2019/5648987
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2008065-7
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  • 4
    Online Resource
    Online Resource
    WEIGHT REDUCTION EFFECTS OF YEAST HYDROLYSATE BELOW 10 kDa ON OBESE YOUNG WOMEN : ANTIOBESITY AND YEAST HYDROLYSATE 10 kDa
    Hindawi Limited ; 2011
    In:  Journal of Food Biochemistry Vol. 35, No. 2 ( 2011-04), p. 337-350
    Details
    In: Journal of Food Biochemistry, Hindawi Limited, Vol. 35, No. 2 ( 2011-04), p. 337-350
    Type of Medium: Online Resource
    ISSN: 0145-8884
    URL: Issue
    URL: Article
    DOI: 10.1111/jfbc.2011.35.issue-2
    DOI: 10.1111/j.1745-4514.2010.00385.x
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2011
    detail.hit.zdb_id: 2174913-9
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  • 5
    Online Resource
    Online Resource
    Characterization of Waste Generated from Nuclide Management Process in Waste Burden Minimization Technology for Spent Nuclear Fuel
    Hindawi Limited ; 2022
    In:  Science and Technology of Nuclear Installations Vol. 2022 ( 2022-7-30), p. 1-14
    Details
    In: Science and Technology of Nuclear Installations, Hindawi Limited, Vol. 2022 ( 2022-7-30), p. 1-14
    Abstract: To reduce the environmental burden caused by the disposal of spent nuclear fuel, waste burden minimization technology is currently being developed at the Korea Atomic Energy Research Institute. The technology includes a nuclide management process that can maximize disposal efficiency by selectively separating and collecting major nuclides in spent nuclear fuel. To manufacture a waste form of high durability, the characteristics of the waste generated during the process should be evaluated. In this study, the physical, radiological, and thermal characteristics of the waste and waste forms for major nuclides (Cs, Sr, I, transuranic/rare earth, and Tc/Se) generated in the nuclide management process were analyzed. In the case of Cs nuclides, characterization was conducted according to the capture rate of the adsorbent in the high-temperature heat treatment process; meanwhile, in the case of Sr nuclides, characterization was performed by considering the ratio of similar nuclides in the chlorination process. For I nuclide, analysis was performed based on the available waste form, and for TRU/RE and Tc/Se nuclides, analysis was performed by considering chlorination and mid-temperature heat treatment. The radioactivity and heat generation rate of each waste and waste form were evaluated over a period of 1,000 years. The results of this study could be used to derive the centerline temperature for the thermal stability evaluation of waste forms and for the feasibility evaluation of each disposal system considered in the waste burden minimization technology.
    Type of Medium: Online Resource
    ISSN: 1687-6083 , 1687-6075
    URL: Article
    DOI: 10.1155/2022/4764825
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2397941-0
    SSG: 3,6
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