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  • 1
    Online Resource
    Online Resource
    Andrographis paniculata Extract and Andrographolide Modulate the Hepatic Drug Metabolism System and Plasma Tolbutamide Concentrations in Rats
    Hindawi Limited ; 2013
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2013 ( 2013), p. 1-11
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2013 ( 2013), p. 1-11
    Abstract: Andrographolide is the most abundant terpenoid of A. paniculata which is used in the treatment of diabetes. In this study, we investigated the effects of A. paniculata extract (APE) and andrographolide on the expression of drug-metabolizing enzymes in rat liver and determined whether modulation of these enzymes changed the pharmacokinetics of tolbutamide. Rats were intragastrically dosed with 2 g/kg/day APE or 50 mg/kg/day andrographolide for 5 days before a dose of 20 mg/kg tolbutamide was given. APE and andrographolide reduced the AUC 0 – 12   h of tolbutamide by 37% and 18%, respectively, compared with that in controls. The protein and mRNA levels and enzyme activities of CYP2C6/11, CYP1A1/2, and CYP3A1/2 were increased by APE and andrographolide. To evaluate whether APE or andrographolide affected the hypoglycemic action of tolbutamide, high-fat diet-induced obese mice were used and treated in the same manner as the rats. APE and andrographolide increased CYP2C6/11 expression and decreased plasma tolbutamide levels. In a glucose tolerance test, however, the hypoglycemic effect of tolbutamide was not changed by APE or andrographolide. These results suggest that APE and andrographolide accelerate the metabolism rate of tolbutamide through increased expression and activity of drug-metabolizing enzymes. APE and andrographolide, however, do not impair the hypoglycemic effect of tolbutamide.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2013/982689
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2148302-4
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  • 2
    Online Resource
    Online Resource
    A Prospective Randomized Study of Brain Tissue Oxygen Pressure-Guided Management in Moderate and Severe Traumatic Brain Injury Patients
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-8
    Abstract: The purpose of this study was to compare the effect of PbtO 2 -guided therapy with traditional intracranial pressure- (ICP-) guided treatment on the management of cerebral variables, therapeutic interventions, survival rates, and neurological outcomes of moderate and severe traumatic brain injury (TBI) patients. From 2009 to 2010, TBI patients with a Glasgow coma scale 〈 12 were recruited from 6 collaborative hospitals in northern Taiwan, excluding patients with severe systemic injuries, fixed and dilated pupils, and other major diseases. In total, 23 patients were treated with PbtO 2 -guided management (PbtO 2 〉 20 mmHg), and 27 patients were treated with ICP-guided therapy (ICP 〈 20 mmHg and CPP 〉 60 mmHg) in the neurosurgical intensive care unit (NICU); demographic characteristics were similar across groups. The survival rate in the PbtO 2 -guided group was also significantly increased at 3 and 6 months after injury. Moreover, there was a significant correlation between the PbtO 2 signal and Glasgow outcome scale-extended in patients from 1 to 6 months after injury. This finding demonstrates that therapy directed by PbtO 2 monitoring is valuable for the treatment of patients with moderate and severe TBI and that increasing PaO 2 to 150 mmHg may be efficacious for preventing cerebral hypoxic events after brain trauma.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/529580
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 3
    Online Resource
    Online Resource
    Proteomic Profiling of Neuroblastoma Cells Adhesion on Hyaluronic Acid-Based Surface for Neural Tissue Engineering
    Hindawi Limited ; 2016
    In:  BioMed Research International Vol. 2016 ( 2016), p. 1-13
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-13
    Abstract: The microenvironment of neuron cells plays a crucial role in regulating neural development and regeneration. Hyaluronic acid (HA) biomaterial has been applied in a wide range of medical and biological fields and plays important roles in neural regeneration. PC12 cells have been reported to be capable of endogenous NGF synthesis and secretion. The purpose of this research was to assess the effect of HA biomaterial combining with PC12 cells conditioned media (PC12 CM) in neural regeneration. Using SH-SY5Y cells as an experimental model, we found that supporting with PC12 CM enhanced HA function in SH-SY5Y cell proliferation and adhesion. Through RP-nano-UPLC-ESI-MS/MS analyses, we identified increased expression of HSP60 and RanBP2 in SH-SY5Y cells grown on HA-modified surface with cotreatment of PC12 CM. Moreover, we also identified factors that were secreted from PC12 cells and may promote SH-SY5Y cell proliferation and adhesion. Here, we proposed a biomaterial surface enriched with neurotrophic factors for nerve regeneration application.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2016/1917394
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2698540-8
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  • 4
    Online Resource
    Online Resource
    Genetic Deletion of Soluble Epoxide Hydrolase Attenuates Inflammation and Fibrosis in Experimental Obstructive Nephropathy
    Hindawi Limited ; 2015
    In:  Mediators of Inflammation Vol. 2015 ( 2015), p. 1-12
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2015 ( 2015), p. 1-12
    Abstract: Soluble epoxide hydrolase (sEH) is abundantly expressed in kidney and plays a potent role in regulating inflammatory response in inflammatory diseases. However, the role of sEH in progression of chronic kidney diseases such as obstructive nephropathy is still elusive. In current study, wild-type (WT) and sEH deficient ( sEH −/− ) mice were subjected to the unilateral ureteral obstruction (UUO) surgery and the kidney injury was evaluated by histological examination, western blotting, and ELISA. The protein level of sEH in kidney was increased in UUO-treated mice group compared to nonobstructed group. Additionally, UUO-induced hydronephrosis, renal tubular injury, inflammation, and fibrosis were ameliorated in sEH −/− mice with the exception of glomerulosclerosis. Moreover, sEH −/− mice with UUO showed lower levels of inflammation-related and fibrosis-related protein such as monocyte chemoattractant protein-1, macrophage inflammatory protein-2, interleukin-1 β (IL-1 β ), IL-6, inducible nitric oxide synthase, collagen 1A1, and α -actin. The levels of superoxide anion radical and hydrogen peroxide as well as NADPH oxidase activity were also decreased in UUO kidneys of sEH −/− mice compared to that observed in WT mice. Collectively, our findings suggest that sEH plays an important role in the pathogenesis of experimental obstructive nephropathy and may be a therapeutic target for the treatment of obstructive nephropathy-related diseases.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2015/693260
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2008065-7
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  • 5
    Online Resource
    Online Resource
    Scheduling Problems with Due Date Assignment
    Hindawi Limited ; 2015
    In:  Discrete Dynamics in Nature and Society Vol. 2015 ( 2015), p. 1-2
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2015 ( 2015), p. 1-2
    Type of Medium: Online Resource
    ISSN: 1026-0226 , 1607-887X
    URL: Article
    DOI: 10.1155/2015/683269
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2033014-5
    SSG: 11
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  • 6
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    Online Resource
    Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-26
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-26
    Abstract: We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different stages of hepatocarcinogenesis. In spite of the use of chemotherapy and radiotherapy in treating HCC, patients with HCC still face poor prognosis because of the nature of multidrug resistance and toxicity derived from chemotherapy and radiotherapy. Flavonoids can be found in many vegetables, fruits, and herbal medicines that exert their different anticancer effects via different intracellular signaling pathways and serve as antioxidants. In this review, we will discuss seven common flavonoids that exert different biological effects against HCC via different pathways.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/840542
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 7
    Online Resource
    Online Resource
    Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro
    Hindawi Limited ; 2013
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2013 ( 2013), p. 1-10
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2013 ( 2013), p. 1-10
    Abstract: Liriope spicata is a well-known herb in traditional Chinese medicine, and its root has been clinically demonstrated to be effective in the treatment of metabolic and neural disorders. The constituents isolated from Liriope have also recently been shown to possess anticancer activity, although the mechanism of which remains largely unknown. Here, we illustrate the anticancer activity of LPRP-9, one of the active fractions we fractionated from the Liriope platyphylla root part (LPRP) extract. Treatment with LPRP-9 significantly inhibited proliferation of cancer cell lines MCF-7 and Huh-7 and down-regulated the phosphorylation of AKT. LPRP-9 also activates the stress-activated MPAK, JNK, p38 pathways, the p53 cell-cycle checkpoint pathway, and a series of caspase cascades while downregulating expression of antiapoptotic factors Bcl-2, Bcl-XL, and survivin. Such activities strongly suggest a role for LPRP-9 in apoptosis and autophagy. We further purified and identified the compound (−)-Liriopein B from LPRP-9, which is capable of inhibiting AKT phosphorylation at low concentration. The overall result highlights the anticancer property of LPRP-9, suggests its mechanism for inhibition of proliferation and promotion of cell death for cancer cells via regulation of multitarget pathways, and denotes the importance of purifying components of fraction LPRP-9 to aid cancer therapy.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2013/857929
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2148302-4
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  • 8
    Online Resource
    Online Resource
    Analysis of Mutual Influence Relationships of Purchase Intention Factors of Electric Bicycles: Application of DEMATEL Taking into Account Information Uncertainty and Expert Confidence
    Hindawi Limited ; 2022
    In:  Complexity Vol. 2022 ( 2022-9-13), p. 1-13
    Details
    In: Complexity, Hindawi Limited, Vol. 2022 ( 2022-9-13), p. 1-13
    Abstract: As the negative environmental impacts of transportation systems become more severe, governments and environmental groups are seeking more sustainable transportation options, such as replacing fuel-powered vehicles with electric vehicles and expanding public transportation systems to reduce the number of people driving on their own, in order to reduce the environmental impacts of transportation systems. At present, the rapid expansion of public transportation systems is not an easy task and requires a long period of time to plan for expansion and construction, so people are increasingly looking to find means of transportation that meet sustainable conditions as solutions. In this context, electric bicycles are one of the solutions that people can choose, with benefits such as energy saving, carbon reduction, effective air pollution reduction, and simple and labor-saving riding. However, in Taiwan, despite the many benefits of electric bicycles, their popularity is not high. Therefore, this study focuses on the factors that affect the purchase of electric bicycles in Taiwan. The Influential Network Relation Map (INRM) generated by the Z-based Decision-making Trial and Evaluation Laboratory (Z-DEMATEL) technique is used to describe the influence relationships among the factors and to establish the key evaluation criteria of electric bicycle purchase intention. The results indicate that vehicle price, safety, motor performance, battery life, and battery durability are the most important factors in purchasing electric bicycles. Furthermore, the power of motor is considered as the factor that most significantly affects other criteria, while safety and price are most likely to be affected by other criteria. This study has contributed to academia and industry, for the dependency weights of these factors are set to provide a scientific and systematic way to show how consumers think in the decision-making process and to provide more reliable information and management implications for the electric bicycle industry.
    Type of Medium: Online Resource
    ISSN: 1099-0526 , 1076-2787
    URL: Article
    DOI: 10.1155/2022/3444856
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2004607-8
    SSG: 11
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  • 9
    Online Resource
    Online Resource
    Peanut Detection Using Droplet Microfluidic Polymerase Chain Reaction Device
    Hindawi Limited ; 2019
    In:  Journal of Sensors Vol. 2019 ( 2019-05-02), p. 1-9
    Details
    In: Journal of Sensors, Hindawi Limited, Vol. 2019 ( 2019-05-02), p. 1-9
    Abstract: In this study, we integrated genetic detection for polymerase chain reaction (PCR) with microfluidics technology for the detection of peanut DNA. A cross-junction microchannel was used to induce emulsion droplets of water in oil for PCR on a chip. Compared with the single-phase flow, the emulsion droplet flow exhibited a 7.24% lower evaporation amount and prevented air bubble generation. PCR results of the droplet microfluidic PCR chip for peanut DNA fragment detection was verified by comparison with a commercial PCR thermal cycler and increased fluorescence intensity in SYBR Green reagent-based PCR. Moreover, PCR on the microfluidic PCR chip was successful for sesame, Salmonella spp., and Staphylococcus aureus . The droplet microfluidic PCR device developed in this study can be applied for peanut detection in the context of food allergy.
    Type of Medium: Online Resource
    ISSN: 1687-725X , 1687-7268
    URL: Article
    DOI: 10.1155/2019/4712084
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2397931-8
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  • 10
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    Online Resource
    Magnetic Properties, Adhesion, and Nanomechanical Property of Co 40 Fe 40 W 20 Films on Si (100) Substrate
    Hindawi Limited ; 2020
    In:  Journal of Nanomaterials Vol. 2020 ( 2020-07-20), p. 1-11
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2020 ( 2020-07-20), p. 1-11
    Abstract: In this study, a Co 40 Fe 40 W 20 alloy was sputtered onto Si (100) with thicknesses ( t f ) ranging from 18 to 90 nm, and the corresponding structure, magnetic properties, adhesive characteristics, and nanomechanical properties were investigated. X-ray diffraction (XRD) patterns of the Co 40 Fe 40 W 20 films demonstrated a significant crystalline body-centered cubic (BCC) CoFe (110) structure when the thickness was 42 nm, and an amorphous status was shown when the thickness was 18 nm, 30 nm, 60 nm, and 90 nm. The saturation magnetization ( M s ) showed a saturated trend as t f was increased. Moreover, the coercivity ( H c ) showed a minimum 1.65 Oe with 30 nm. H c was smaller than 4.5 Oe owing to the small grain size distribution and amorphous structure, indicating that the Co 40 Fe 40 W 20 film had soft magnetism. The low-frequency alternating current magnetic susceptibility ( χ ac ) decreased as the frequency was increased. The χ ac revealed a thickness effect when greater thicknesses had a large χ ac . The maximum χ ac and optimal resonance frequency ( f res ) of Co 40 Fe 40 W 20 were investigated. The maximum χ ac indicated the spin sensitivity and was maximized at the optimal resonance frequency. The 90 mm thickness had the highest χ ac 0.18 value at an f res of 50 Hz. The contact angles of the Co 40 Fe 40 W 20 films are less than 90°, which indicated that the film had a good wetting effect and hydrophilicity. The surface energy was correlated with the adhesion and displayed a concave-down trend. CoFeW films can be used as a seed or buffer layer; therefore, the surface energy and adhesion are very important. The highest surface energy was 30.12 mJ/mm 2 at 42 nm and demonstrated high adhesion. High surface energy has corresponding strong adhesive performance. The increased surface roughness can induce domain wall pinning effect and high surface energy, causing a high coercivity and strong adhesion. The increase of hardness and Young’s modulus could be reasonably inferred from the thinner CoFeW films. The hardness and Young’s modulus of CoFeW films are also displayed to saturated tendency when increasing thickness.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2020/1584310
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2229480-6
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