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  • Hindawi Limited  (22)
  • 1
    Online Resource
    Online Resource
    Redefinition of Cost-Benefit Efficiency of Land-Use Projects: Focusing on Environmental Cost
    Hindawi Limited ; 2019
    In:  Mathematical Problems in Engineering Vol. 2019 ( 2019-11-21), p. 1-14
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2019 ( 2019-11-21), p. 1-14
    Abstract: The cost-benefit efficiency of projects is often wrongly evaluated due to the neglect of projects’ impact on the environment. In this paper, we aim to establish a model to measure such an impact and hence propose a more reasonable approach to evaluating cost-benefit efficiency of projects. We divide the total cost of a certain project into two parts: Business Cost (BC) and Environmental Cost (EC). BC is the explicit cost that can be approached from financial statements, while EC is the implicit cost which we try to quantify. EC is composed of three parts: (1) the Ecosystem Service Value (ESV), (2) the Restoration Cost (RC) to treat the pollution caused by the projects, and (3) the Disaster Cost (DC), potential losses caused by disasters due to launch of new projects. In order to make a cost-benefit efficiency analysis, we introduce profitability index, which is further developed into an adjusted profitability index by taking time value into consideration. Two case studies are conducted to evaluate the effectiveness of the model. A regional case of a coal-mining project proves that RC and DC play a significant role in cost-benefit efficiency analysis, while a nationwide case of high-speed rail shows that project scale matters. Additionally, we put our attention on the intensity of the project, which is a created measurement to characterize the project. Based on the study of intensity, the mechanism of cost-benefit break-even is further explained and some suggestions are proposed to policy makers.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2019/3126172
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 2
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    Assessment of Combined Karyotype Analysis and Chromosome Microarray Analysis in Prenatal Diagnosis: A Cohort Study of 3710 Pregnancies
    Hindawi Limited ; 2022
    In:  Genetics Research Vol. 2022 ( 2022-12-29), p. 1-7
    Details
    In: Genetics Research, Hindawi Limited, Vol. 2022 ( 2022-12-29), p. 1-7
    Abstract: Objective. The current study aimed to compare the characteristics of chromosome abnormalities detected by conventional G-banding karyotyping, chromosome microarray analysis (CMA), or fluorescence in situ hybridization (FISH)/CNVplex analysis and further explore the application value of combined karyotype analysis and CMA in prenatal diagnosis with a larger sample size. Methods. From March 2019 to March 2021, 3710 amniocentesis samples were retrospectively collected from women who accepted prenatal diagnosis at 16 to 22 + 6 weeks of pregnancy. The pregnant women underwent karyotype analysis and CMA. In the case of fetal chromosomal mosaicism, FISH or CNVplex analysis was utilized for validation. Results. In total, 3710 G-banding karyotype results and CMA results from invasive prenatal diagnosis were collected. Of these, 201 (5.41%) fetuses with an abnormal karyotype were observed. The CMA analysis showed that the abnormality rate was 9.14% (340/3710). The detection rate of CMA combined with karyotype analysis was 0.35% higher than that of CMA alone and 4.08% higher than that of karyotyping alone. Additionally, 12 cases had abnormal karyotype analysis, despite normal CMA results. To further detect the chromosome mosaicism, we used FISH analysis to correct the karyotype results of case 1. Correspondingly, a total of 157 cases showed abnormal CMA results but normal karyotype analysis. We also found chromosomal mosaicism in 4 cases using CMA. Moreover, CNVplex and CMA demonstrated that representative case 15 was mosaicism for trisomy 2. Conclusions. Conventional G-banding karyotyping and CMA have their own advantages and limitations. A combination of karyotype analysis and CMA can increase the detection rate of chromosome abnormalities and make up for the limitation of signal detection.
    Type of Medium: Online Resource
    ISSN: 1469-5073
    URL: Article
    DOI: 10.1155/2022/6791439
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2412684-6
    detail.hit.zdb_id: 1472156-9
    SSG: 12
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  • 3
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    Safety and Efficacy in Relapsed or Refractory Classic Hodgkin’s Lymphoma Treated with PD-1 Inhibitors: A Meta-Analysis of 9 Prospective Clinical Trials
    Hindawi Limited ; 2019
    In:  BioMed Research International Vol. 2019 ( 2019-12-18), p. 1-13
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2019 ( 2019-12-18), p. 1-13
    Abstract: Background . Classic Hodgkin’s lymphoma (cHL) is characterized by the unique biology in which rare Hodgkin-Reed-Sternberg cells propagate an immunosuppressive microenvironment. Checkpoint inhibitors that target the interaction of PD-1 immune checkpoint receptors have demonstrated remarkable activities in various cancers, such as cHL. This study aims to evaluate the safety and efficacy of PD-1 inhibitors in treating relapsed or refractory cHL (rrHL). Methods . We searched PubMed, MEDLINE, Embase, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Wanfang, Chinese Biological Medical Literature, and Abstracts of Conference proceedings of annual meetings without any language restrictions to limit language bias (up to January 2019) for prospective clinical trials that evaluate PD-1 inhibitors in treating relapsed or refractory cHL. Results . A total of 9 prospective clinical trials with 731 patients were included in the meta-analysis. The pooled risks of all-grade and grade ≥3 adverse events (AEs) were 0.86 (95% CI: 0.66–0.98) and 0.21 (95% CI: 0.17–0.24), respectively. The pooled response, complete response, partial response, and stable disease rates were 0.74 (95% CI: 0.70–0.79), 0.24 (95% CI: 0.18–0.34), 0.48 (95% CI: 0.41–0.55), and 0.15 (95% CI: 0.12–0.17), respectively. The pooled 6-month progression-free survival and 1-year overall survival rates were 0.76 (95% CI: 0.72–0.79) and 0.93 (95% CI: 0.90–0.96), correspondingly. Conclusions . Our meta-analysis suggested that anti-PD1 monoclonal antibodies improve the outcomes of response and survival rates with tolerable AEs in cHL. However, evidence of immune checkpoint inhibitors for patients with cHL remained insufficient. Well-designed randomized controlled trials or at least nonrandomized trials with a control group should be conducted to confirm the findings of this meta-analysis.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2019/9283860
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2698540-8
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  • 4
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    Diagnostic Value of the Methylation of Multiple Gene Promoters in Serum in Hepatitis B Virus-Related Hepatocellular Carcinoma
    Hindawi Limited ; 2017
    In:  Disease Markers Vol. 2017 ( 2017), p. 1-6
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2017 ( 2017), p. 1-6
    Abstract: This study sought to evaluate the diagnostic value of the methylation of multiple gene promoters in serum in hepatitis B virus- (HBV-) related hepatocellular carcinoma (HCC). A total of 343 participants were enrolled, including 98 patients with HCC, 75 patients with liver cirrhosis (LC), 90 patients with chronic hepatitis B (CHB), and 80 healthy individuals. RASSF1A , APC , BVES , TIMP3 , GSTP1 , and HOXA9 were selected as the candidate genes. The MethyLight method was used to assay promoter methylation statuses. The diagnostic performances of markers were assessed by constructing receiver operating characteristic (ROC) curves. The prevalences of methylation for RASSF1A , APC , BVES , HOXA9 , GSTP1 , and TIMP3 were 52.04%, 36.73%, 29.59%, 20.41%, 17.35%, and 11.22%, respectively. APC methylation completely overlapped with RASSF1A methylation. The area under the curve (AUC) for RASSF1A methylation (0.718) was better than the corresponding AUC for AFP (0.609) in distinguishing HCC from CHB. When RASSF1A , BVES , HOXA9 , and AFP were combined, the AUC was 0.852 (95% CI = 0.796–0.908, P = 0.028 ), and the sensitivity and specificity were 83.7% and 78.9%, respectively. In conclusion, an assay that combines methylation of the RASSF1A , BVES , and HOXA9 gene promoters in serum and AFP could significantly improve HBV-related HCC diagnoses.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2017/2929381
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2033253-1
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  • 5
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    Kirkpatrick's evaluation of the effect of a nursing innovation team training for clinical nurses
    Hindawi Limited ; 2022
    In:  Journal of Nursing Management Vol. 30, No. 7 ( 2022-10), p. 2165-2175
    Details
    In: Journal of Nursing Management, Hindawi Limited, Vol. 30, No. 7 ( 2022-10), p. 2165-2175
    Type of Medium: Online Resource
    ISSN: 0966-0429 , 1365-2834
    URL: Issue
    URL: Article
    DOI: 10.1111/jonm.v30.7
    DOI: 10.1111/jonm.13504
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2007566-2
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  • 6
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    Effects of flow velocity on growth and physiology of juvenile largemouth bass ( Micropterus salmoides ) in recirculating aquaculture systems
    Hindawi Limited ; 2021
    In:  Aquaculture Research Vol. 52, No. 7 ( 2021-07), p. 3093-3100
    Details
    In: Aquaculture Research, Hindawi Limited, Vol. 52, No. 7 ( 2021-07), p. 3093-3100
    Type of Medium: Online Resource
    ISSN: 1355-557X , 1365-2109
    URL: Issue
    URL: Article
    DOI: 10.1111/are.v52.7
    DOI: 10.1111/are.15153
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2207423-5
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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  • 7
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    Risk Assessment of EPB Shield Construction Based on the Nonlinear FAHP Method
    Hindawi Limited ; 2022
    In:  Advances in Civil Engineering Vol. 2022 ( 2022-4-7), p. 1-14
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2022 ( 2022-4-7), p. 1-14
    Abstract: There are many risk factors in EPB shield construction. The traditional fuzzy analytic hierarchy process (FAHP) method usually uses a linear analysis method to determine the risk level, but there are often some risk factors with prominent influence, which will reduce the accuracy of the evaluation results. In this paper, a new risk assessment model of Earth pressure balance (EPB) shield construction based on a nonlinear FAHP method is established by introducing nonlinear factors into the comprehensive calculation of the traditional FAHP. First, the new model establishes the framework of EPB shield construction risk analysis based on the work breakdown structure (WBS) and risk breakdown structure (RBS) methods. Then, it constructs an EPB shield construction risk index system by coupling the units of the WBS and RBS. The model constructs a fuzzy consistent judgment matrix, which replaces the 1∼9 scale. Finally, the nonlinear operator is introduced into the FAHP comprehensive calculation, considering the influence of some prominent risk factors, which improves the accuracy of the risk assessment. By applying the new model to the risk analysis of the EPB shield construction section of a tunnel project in Hangzhou, the effectiveness of the model is further verified.
    Type of Medium: Online Resource
    ISSN: 1687-8094 , 1687-8086
    URL: Article
    DOI: 10.1155/2022/9233833
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2449760-5
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  • 8
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    A Promising Insight: The Potential Influence and Therapeutic Value of the Gut Microbiota in GI GVHD
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-5-5), p. 1-13
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-5-5), p. 1-13
    Abstract: Allogeneic hematopoietic cell transplantation (allo-HSCT) is a reconstruction process of hematopoietic and immune functions that can be curative in patients with hematologic malignancies, but it carries risks of graft-versus-host disease (GVHD), thrombotic microangiopathy (TMA), Epstein–Barr virus (EBV) infection, cytomegalovirus infection, secondary hemophagocytic lymphohistiocytosis (sHLH), macrophage activation syndrome (MAS), bronchiolitis obliterans, and posterior reversible encephalopathy syndrome (PRES). Gastrointestinal graft-versus-host disease (GI GVHD), a common complication of allo-HSCT, is one of the leading causes of transplant-related death because of its high treatment difficulty, which is affected by preimplantation, antibiotic use, dietary changes, and intestinal inflammation. At present, human trials and animal studies have proven that a decrease in intestinal bacterial diversity is associated with the occurrence of GI GVHD. Metabolites produced by intestinal bacteria, such as lipopolysaccharides, short-chain fatty acids, and secondary bile acids, can affect the development of GVHD through direct or indirect interactions with immune cells. The targeted damage of GVHD on intestinal stem cells (ISCs) and Paneth cells results in intestinal dysbiosis or dysbacteriosis. Based on the effect of microbiota metabolites on the gastrointestinal tract, the clinical treatment of GI GVHD can be further optimized. In this review, we describe the mechanisms of GI GVHD and the damage it causes to intestinal cells and we summarize recent studies on the relationship between intestinal microbiota and GVHD in the gastrointestinal tract, highlighting the role of intestinal microbiota metabolites in GI GVHD. We hope to elucidate strategies for immunomodulatory combined microbiota targeting in the clinical treatment of GI GVHD.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/2124627
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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  • 9
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    Rare mutations in the autophagy‐regulating gene AMBRA1 contribute to human neural tube defects
    Hindawi Limited ; 2020
    In:  Human Mutation Vol. 41, No. 8 ( 2020-08), p. 1383-1393
    Details
    In: Human Mutation, Hindawi Limited, Vol. 41, No. 8 ( 2020-08), p. 1383-1393
    Type of Medium: Online Resource
    ISSN: 1059-7794 , 1098-1004
    URL: Issue
    URL: Article
    DOI: 10.1002/humu.v41.8
    DOI: 10.1002/humu.24028
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 1498165-8
    SSG: 12
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  • 10
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    Study of the Gastrointestinal Heat Retention Syndrome in Children: From Diagnostic Model to Biological Basis
    Hindawi Limited ; 2019
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2019 ( 2019-12-16), p. 1-12
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2019 ( 2019-12-16), p. 1-12
    Abstract: Gastrointestinal heat retention syndrome (GHRS) refers to a condition that is associated with increased gastrointestinal heat caused by a metabolic block in energy. It is common in children and is closely related to the occurrence and development of recurrent respiratory tract infection, pneumonia, recurrent functional abdominal pain, etc. However, there are no standardized diagnostic criteria to differentiate the GHRS. Therefore, this study is aimed to establish a diagnostic model for children’s GHRS and explore the possible biological basis by using systems biology to achieve. Furthermore, Delphi method and the clinical data of Lasso analysis were used to screen out the core symptoms. Nineteen core symptoms of GHRS in children were screened including digestive symptoms such as dry stool, poor appetite, vomiting, and some nervous system symptoms such as night restlessness and irritability. Based on the core symptoms, a GHRS diagnosis model was established using the eXtreme Gradient Boosting (XGBoost) method, and the accuracy of internal verification reached 93.03%. Relevant targets of the core symptoms in the Human Phenotype Ontology (HPO) were retrieved, and target interactions were linked through the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database, and core targets were selected after topological analysis using Cytoscape. Relevant biological processes and pathways were analyzed by applying the DAVID and KEGG databases. The enriched biological processes focused on the cell proliferation, differentiation, apoptosis, and mitochondrial metabolism, which were mainly associated with PI3K-AKT, MAPK network pathways, and the Wnt signaling pathway. In conclusion, we established a diagnosis model of GHRS in children based on the core symptoms and provided an objective standard for its clinical diagnosis. And, the Wnt signaling pathway and the estrogen receptor-activated PI3K-AKT and MAPK network pathways may play important roles in the GHRS processing.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2019/5303869
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2148302-4
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