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  • Hindawi Limited  (33)
  • 1
    Online Resource
    Online Resource
    Analysis of Hydrogeochemical Characteristics of Tunnel Groundwater Based on Multivariate Statistical Technology
    Hindawi Limited ; 2021
    In:  Geofluids Vol. 2021 ( 2021-12-6), p. 1-16
    Details
    In: Geofluids, Hindawi Limited, Vol. 2021 ( 2021-12-6), p. 1-16
    Abstract: Following tunnel excavation, which is influenced by hydraulic fracturing and geological structure, a series of hydrochemical reactions occur in the karst aquifer, which has a significant impact on groundwater hydrology and the earth process. Based on five sets of 38 samples collected in the Tongzi Tunnel in 2020 and 2021, the main geochemical processes and water quality conditions of the karst aquifer system during tunnel construction were revealed by multivariate statistical analysis and graphical methods. The results showed that water-rock action is the main mechanism controlling groundwater chemistry in the study area; HCO3-, Ca2+, and Mg2+ are associated with the widely distributed carbonate rocks in the study area. SO42- is derived from gypsum and sulfate rocks and special strata, which are another important source of Ca2+. Sodium-containing silicates and reverse cation exchange as the causal mechanisms of Na+ whereas F- is derived from fluorite. According to the mineral saturation index calculations, the dissolution and precipitation of minerals such as alum, gypsum, calcite, dolomite, and salt rock have an important influence on the main chemical components in water. The 38 samples were subjected to cluster analysis, and the results could be classified into seven categories. The representative clusters 1, 3, and 5 were selected for principal component analysis. Clusters 1 and 5 of groundwater represent weathering, dissolution, and ion exchange of carbonate and sulfate rocks and are closely related to the lithologic limestone, limestone intercalated with carbonaceous mudstone, carbonaceous mudstone, and coal-measure strata in the aquifer. Cluster 3 is dominated by upper surface river water and characterizes the geochemistry in natural water bodies dominated by the dissolution of carbonate, sulfate, and salt rocks. Finally, groundwater quality is mostly found in Class IV, with NO3- and F- being the main contaminants in the water.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2021/4867942
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 2
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    Online Resource
    Predictive Value of Globulin to Prealbumin Ratio for 3-Month Functional Outcomes in Acute Ischemic Stroke Patients
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-3-17), p. 1-8
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-3-17), p. 1-8
    Abstract: Objective. We aimed to evaluate and compare the association between globulin to albumin ratio (GAR) and globulin to prealbumin ratio (GPR) and 3-month functional prognosis of acute ischemic stroke (AIS) patients receiving intravenous thrombolysis therapy. Methods.234 AIS patients undergoing intravenous thrombolysis were retrospectively enrolled with acute ischemic stroke from February 2016 to October 2019. Blood sample was collected within 24 h after admission. Poor outcome was defined as the modified Rankin   Scale   mRS ≥ 3 and a favorable outcome as mRS 〈 3 . Severe stroke was defined as the National   Institutes   of   Health   Stroke   Scale   NIHSS   score 〉 10 on admission. Student’s t -test, Mann–Whitney U test, Chi-square test, logistics’ regression analysis, and receiver operating characteristic (ROC) analysis were performed. Results. Patients with poor functional outcome had higher GAR and GPR levels compared with favorable functional group ( p = 0.001 , p 〈 0.001 , respectively). Severe stroke was also associated with these two increasing variables. After adjustment for confounding factors, multivariate logistic regression analysis indicated that GPR was an independent indicator predictor of AIS. Conclusions. The 24 h GPR level can predict the 3-month functional outcome in AIS patients accepting recombinant tissue plasminogen activator (r-tPA) intravenous thrombosis.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/1120192
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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  • 3
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    Study on the Relationship between Fracture Morphology and Splitting Strength of Granite Based on Fabric Distribution
    Hindawi Limited ; 2021
    In:  Geofluids Vol. 2021 ( 2021-7-31), p. 1-12
    Details
    In: Geofluids, Hindawi Limited, Vol. 2021 ( 2021-7-31), p. 1-12
    Abstract: Because of the requirement of the mechanical properties of the damaged surrounding granite rock and the existence of the fracture water in hydraulic fracturing engineering, the strength of granite is related to the fabric, and the roughness of the section is also related to the liquid flow rate, a method of roughly determining the strength of the specimen by observing the failure mode of rock is needed. Considering that the physical and mechanical properties of granite are obviously affected by the fabric, the discrete element numerical simulation method was used to reconstruct the granite fabric based on the spatial correlation function to simulate the splitting experiment to investigate the failure mode of the specimen. The relationship between strength, the fractal value of cross-section, and the fabric was analyzed, which was verified through experiment. The results show that (1) the Voronoi GBM model with spatial correlation function of the discrete element can effectively simulate the controllable granite fabric and carry out micromechanical analysis. (2) The strength of the granite specimen and the fractal value of the cross-section have an obvious linear relationship with the fabric; besides, there is also a certain linear relationship between the strength of the specimen and the fractal value, which is influenced by granite fabric. (3) The predicted strength of the specimen according to the fractal value of the section is in good agreement with the actual strength with the error rate of 30%. In a word, this method can predict the strength of the specimen through the failure section and analyze the hydraulic fracture section and water pressure.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2021/9985919
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 4
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    Online Resource
    Cover Image, Volume 11, Issue 5
    Hindawi Limited ; 2017
    In:  Journal of Tissue Engineering and Regenerative Medicine Vol. 11, No. 5 ( 2017-05), p. i-i
    Details
    In: Journal of Tissue Engineering and Regenerative Medicine, Hindawi Limited, Vol. 11, No. 5 ( 2017-05), p. i-i
    Type of Medium: Online Resource
    ISSN: 1932-6254
    URL: Issue
    URL: Article
    DOI: 10.1002/term.v11.5
    DOI: 10.1002/term.2469
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2316155-3
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  • 5
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    Wnt1a maintains characteristics of dermal papilla cells that induce mouse hair regeneration in a 3D preculture system : Wnt1a hair regeneration 3D preculture system
    Hindawi Limited ; 2017
    In:  Journal of Tissue Engineering and Regenerative Medicine Vol. 11, No. 5 ( 2017-05), p. 1479-1489
    Details
    In: Journal of Tissue Engineering and Regenerative Medicine, Hindawi Limited, Vol. 11, No. 5 ( 2017-05), p. 1479-1489
    Type of Medium: Online Resource
    ISSN: 1932-6254
    URL: Issue
    URL: Article
    DOI: 10.1002/term.v11.5
    DOI: 10.1002/term.2046
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2316155-3
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  • 6
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    Online Resource
    Enterprise Financial Risk Management Using Information Fusion Technology and Big Data Mining
    Hindawi Limited ; 2021
    In:  Wireless Communications and Mobile Computing Vol. 2021 ( 2021-12-15), p. 1-13
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2021 ( 2021-12-15), p. 1-13
    Abstract: This paper aims to study enterprise Financial Risk Management (FRM) through Big Data Mining (BDM) and explore effective FRM solutions by introducing information fusion technology. Specifically, big data technology, Support Vector Machine (SVM), Logistic regression, and information fusion approaches are employedto study the enterprise financial risks in-depth.Among them, the selection offinancial risk indexes has a great impact on the monitoring results of the SVM-based FRM model; the Logistic regression-based FRM model can efficientlyclassify financial risks; theinformation fusion-based FRM model uses a fusion algorithm to fuse different information sources. The results show that the SVM-based and Logistic regression-based FRM models can manage and classify enterprise financial risks effectively in practice, with a classification accuracy of 90.22% and 90.88%, respectively; by comparison, the information fusion-based FRM modelbeats SVM-based and Logistic regression-based FRM models by presenting a classification accuracy as high as 95.18%. Therefore, it is concluded that the information fusion-based FRM is better than the SVM-based and Logistic regression-based models; it can integrate and calculate multiple enterprise financial risk data from different sources and obtain higher accuracy; besides, big data technology can provide important research methods for enterprise financial risk problems; SVM-based FRM model and Logistic regression-based FRM model can well classify enterprise financial risks, with relatively high accuracy.
    Type of Medium: Online Resource
    ISSN: 1530-8677 , 1530-8669
    URL: Article
    DOI: 10.1155/2021/3835652
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045240-8
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  • 7
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    Ginsenoside Rb1 Prevents Oxidative Stress-Induced Apoptosis and Mitochondrial Dysfunction in Muscle Stem Cells via NF-κB Pathway
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-11-24), p. 1-17
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-11-24), p. 1-17
    Abstract: Sarcopenia, featured by the progressive loss of skeletal muscle function and mass, is associated with the impaired function of muscle stem cells (MuSCs) caused by increasing oxidative stress in senescent skeletal muscle tissue during aging. Intact function of MuSCs maintains the regenerative potential as well as the homeostasis of skeletal muscle tissues during aging. Ginsenoside Rb1, a natural compound from ginseng, exhibited the effects of antioxidation and against apoptosis. However, its effects of restoring MuSC function during aging and improving age-related sarcopenia remained unknown. In this study, we investigated the role of Rb1 in improving MuSC function and inhibiting apoptosis by reducing oxidative stress levels. We found that Rb1 inhibited the accumulation of reactive oxygen species (ROS) and protected the cells from oxidative stress to attenuate the H2O2-induced cytotoxicity. Rb1 also blocked oxidative stress-induced apoptosis by inhibiting the activation of caspase-3/9, which antagonized the decrease in mitochondrial content and the increase in mitochondrial abnormalities caused by oxidative stress via promoting the protein expression of genes involved in mitochondrial biogenesis. Mechanistically, it was proven that Rb1 exerted its antioxidant effects and avoided the apoptosis of myoblasts by targeting the core regulator of the nuclear factor-kappa B (NF-κB) signal pathway. Therefore, these findings suggest that Rb1 may have a beneficial role in the prevention and treatment of MuSC exhaustion-related diseases like sarcopenia.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/9159101
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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  • 8
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    Real-Time Multipath Mitigation in Multi-GNSS Short Baseline Positioning via CNN-LSTM Method
    Hindawi Limited ; 2021
    In:  Mathematical Problems in Engineering Vol. 2021 ( 2021-1-4), p. 1-12
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2021 ( 2021-1-4), p. 1-12
    Abstract: Multipath is the main systematic error of the Global Navigation Satellite System (GNSS) short baseline positioning. Multipath cannot be eliminated by the double-differenced technique and is difficult to parameterize, which severely restrict the high-precision GNSS positioning application. Based on the spatiotemporal repeatability of multipath, the sidereal filtering in coordinate-domain (SF-CD), the sidereal filtering in observation-domain (SF-OD), and the multipath hemispherical map (MHM) can be used to mitigate the multipath in real-time. However, the multipath model with large matrix for multi-GNSS multipath mitigation is difficult to achieve lightweight calculation and the SF-CD cannot be applied to mitigate the multi-GNSS multipath. In this paper, we propose a new multipath mitigation strategy in the coordinate-domain that shakes off the formation mechanism of multipath, a CNN (convolutional neural network)-LSTM (long short-term memory) method is used to mine the deep multipath features in GNSS coordinate series. Furthermore, multipath will be mitigated in real-time by constantly predicting the value of the next epoch. The experimental results show that the CNN-LSTM effectively mitigates the multi-GNSS multipath. The method can reduce the average RMS (root-mean square) of multi-GNSS positioning errors in the east, north, and vertical directions by 62.3%, 70.8%, and 66.0%. Moreover, comparing with the SF-CD, SF-OD, and MHM, CNN-LSTM can more effectively mitigate the effects of the GPS multipath, and the ability of multipath mitigation is almost not affected over time.
    Type of Medium: Online Resource
    ISSN: 1563-5147 , 1024-123X
    URL: Article
    DOI: 10.1155/2021/6573230
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 9
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    The Effect of Adipose-Derived Stem Cells on Full-Thickness Skin Grafts
    Hindawi Limited ; 2016
    In:  BioMed Research International Vol. 2016 ( 2016), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2016 ( 2016), p. 1-10
    Abstract: Background. The purpose of this study was to evaluate the effects of ASCs on full-thickness skin grafts. Specifically, we investigated the anti-inflammatory effects of ASCs that are mediated via regulation of the phenotypes of activated macrophages. Methods. ASCs were isolated, cultured, and injected under full-thickness skin grafts in 15 rats (ASC group). An additional 15 rats served as controls (PBS group). Skin graft survival assessment and vascularization detection were assessed with H & E staining and laser Doppler blood flowmetry (LDF). The effects of ASCs on angiogenesis, anti-inflammation, collagen accumulation-promoting, and antiscarring were assessed. Results. We found that the skin graft survival rate was significantly increased in the ASC group. The neovascularization, collagen deposition, collagen type I to type III ratio, and levels of VEGF and TGF- β 3 in the ASC group were markedly higher than those in the PBS group at day 14. Additionally, in the ASC group, the levels of iNOS, IL-1 β , and TNF- α were remarkably decreased, whereas the levels of IL-10 and Arg-1 were substantially increased. Conclusions. Our results confirm that ASCs transplantation can effectively improve full-thickness skin graft survival. Additionally, the anti-inflammatory role of ASCs may indirectly contribute to skin graft survival via its effect on macrophage polarization.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2016/1464725
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2698540-8
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  • 10
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    Quantitative Proteomic Analysis Reveals the Deregulation of Nicotinamide Adenine Dinucleotide Metabolism and CD38 in Inflammatory Bowel Disease
    Hindawi Limited ; 2019
    In:  BioMed Research International Vol. 2019 ( 2019-04-23), p. 1-11
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2019 ( 2019-04-23), p. 1-11
    Abstract: Inflammatory bowel disease (IBD) has become a major health challenge worldwide. However, the precise etiological and pathophysiological factors involved in IBD remain unclear. Proteomics can be used for large-scale protein identification analysis. In the current study, using tandem mass tag- (TMT-) based shotgun proteomics, proteomic differences between intestinal tissue from health controls, patients with Crohn’s disease (CD), and patients with ulcerative colitis (UC) were compared. Proteins with fold change 〉 2 or 〈 0.5 and P value 〈 0.05 between groups were considered differentially expressed. ProteinAtlas was used to analyze the tissue specificity of differentially expressed proteins (DEPs). Reactome pathway analysis was applied to cluster functional pathways. A total of 4786 proteins were identified, with 59 proteins showing higher levels and 43 showing lower levels in patients with IBD than in controls. Seventeen proteins, including angiotensin converting enzyme 2 (ACE2) and angiotensin converting enzyme 1 (ACE), showed higher levels in CD than in UC. Several novel proteins such as CD38, chitinase 3-like 1 (CHI3L1), olfactomedin 4 (OLFM4), and intelectin 1 were screened out between patients with IBD and controls. When proteins with fold change 〉 1.2 or 〈 0.84 and P value 〈 0.05 between groups were considered differentially expressed, the expression of 10 proteins, including CD38, involved in the nicotinamide adenine dinucleotide (NAD) metabolism and signaling pathway showed significant changes in IBD. Using the NCBI GEO database, we confirmed increased CD38 mRNA expression in patients with UC and in mouse colitis models. Protein CD38 expression was higher in CD and UC than in normal controls. CD38 expression was higher in inflamed tissues than in noninflamed tissues, and CD38 was located in F4/80-positive cells. Our study may provide novel insights into the molecular pathogenesis of IBD. Further studies are required on the role of NAD metabolism and CD38 in intestinal inflammation.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2019/3950628
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2698540-8
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