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  • 1
    Online Resource
    Online Resource
    Association between Oxidative Stress and Outcome in Different Subtypes of Acute Ischemic Stroke
    Hindawi Limited ; 2014
    In:  BioMed Research International Vol. 2014 ( 2014), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2014 ( 2014), p. 1-7
    Abstract: Objectives . This study investigated serum thiobarbituric acid-reactive substances (TBARS) and free thiol levels in different subtypes of acute ischemic stroke (AIS) and evaluated their association with clinical outcomes. Methods . This prospective study evaluated 100 AIS patients, including 75 with small-vessel and 25 with large-vessel diseases. Serum oxidative stress (TBARS) and antioxidant (thiol) were determined within 48 hours and days 7 and 30 after stroke. For comparison, 80 age- and sex-matched participants were evaluated as controls. Results . Serum TBARS was significantly higher and free thiol was lower in stroke patients than in the controls on days 1 and 7 after AIS. The level of free thiol was significantly lower in the large-vessel disease than in the small-vessel disease on day 7 after stroke. Using the stepwise logistic regression model for potential variables, only stroke subtype, NIHSS score, and serum TBARS level were independently associated with three-month outcome. Higher TBARS and lower thiol levels in the acute phase of stroke were associated with poor outcome. Conclusions . Patients with large-vessel disease have higher oxidative stress but lower antioxidant defense compared to those with small-vessel disease after AIS. Serum TBARS level at the acute phase of stroke is a potential predictor for three-month outcome.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2014/256879
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
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  • 2
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    Online Resource
    Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-26
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-26
    Abstract: We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different stages of hepatocarcinogenesis. In spite of the use of chemotherapy and radiotherapy in treating HCC, patients with HCC still face poor prognosis because of the nature of multidrug resistance and toxicity derived from chemotherapy and radiotherapy. Flavonoids can be found in many vegetables, fruits, and herbal medicines that exert their different anticancer effects via different intracellular signaling pathways and serve as antioxidants. In this review, we will discuss seven common flavonoids that exert different biological effects against HCC via different pathways.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/840542
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
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  • 3
    Online Resource
    Online Resource
    Muscle Strength, Physical Fitness, Balance, and Walking Ability at Risk of Fall for Prefrail Older People
    Hindawi Limited ; 2022
    In:  BioMed Research International Vol. 2022 ( 2022-12-7), p. 1-12
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2022 ( 2022-12-7), p. 1-12
    Abstract: Aim. This study was to explore the relationship of older adults’ demographic information, physiological indices, and stages of frailty with their risk of falling. Methods. In the cross-sectional study, a total of 221 older adults with the mean age 74.9 ( SD = 6.8 ) years old were surveyed by senior fitness test. Results. Results were observed in terms of participants’ physical fitness, with significant differences being observed in the correlations of left-hand grip strength ( t = 5.05 , p 〈 .000 ), right-hand grip strength ( t = 6.03 , p 〈 .000 ), and total grip strength ( t = 5.70 , p 〈 .000 ), time up and go test ( t = − 6.25 , p 〈 .000 ), and 30-sec chair stand test ( t = 7.19 , p 〈 .000 ) with the risk of falling. According to the logistic regression analysis results, long-term medication ( OR = 0.12 , 95% CI =0.02-0.62, p 〈 .01 ) and right-hand grip strength ( OR = 0.86 , 95% CI =0.76-0.97, p 〈 .01 ) are the main predictors of older adults’ risk of falling. Conclusions. Older females with low education, history of falls, weaker grip strengths; taking longer to finish the TUG test; and standing fewer times during the 30-second chair stand test were at risk of fall. In prediction, older people using long-term medication were at lower risk of falling, and the greater the hand grip strength was, the lower the fall risk was. According to the research results, nursing personnel must develop care programs and improve older adults’ risk of falls.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2022/4581126
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
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  • 4
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    Online Resource
    Chlorella sorokiniana Extract Prevents Cisplatin-Induced Myelotoxicity In Vitro and In Vivo
    Hindawi Limited ; 2020
    In:  Oxidative Medicine and Cellular Longevity Vol. 2020 ( 2020-01-25), p. 1-14
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2020 ( 2020-01-25), p. 1-14
    Abstract: Cisplatin chemotherapy causes myelosuppression and often limits treatment duration and dose escalation in patients. Novel approaches to circumvent or lessen myelotoxicity may improve clinical outcome and quality of life in these patients. Chlorella sorokiniana (CS) is a freshwater unicellular green alga and exhibits encouraging efficacy in immunomodulation and anticancer in preclinical studies . However, the efficacy of CS on chemoprotection remains unclear. We report here, for the first time, that CS extract (CSE) could protect normal myeloid cells and PBMCs from cisplatin toxicity. Also, cisplatin-induced apoptosis in HL-60 cells was rescued through reservation of mitochondrial function, inhibition of cytochrome c release to cytosol, and suppression of caspase and PARP activation. Intriguingly, cotreatment of CSE attenuated cisplatin-evoked hypocellularity of bone marrow in mice. Furthermore, we observed the enhancement of CSF-GM activity in bone marrow and spleen in mice administered CSE and cisplatin, along with increased CD11b levels in spleen. In conclusion, we uncovered a novel mechanism of CSE on myeloprotection, whereby potentially supports the use of CSE as a chemoprotector against cisplatin-induced bone marrow toxicity. Further clinical investigation of CSE in combination with cisplatin is warranted.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2020/7353618
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2455981-7
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  • 5
    Online Resource
    Online Resource
    Modeling Multilevel Supplier Selection Problem Based on Weighted-Directed Network and Its Solution
    Hindawi Limited ; 2017
    In:  Discrete Dynamics in Nature and Society Vol. 2017 ( 2017), p. 1-12
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2017 ( 2017), p. 1-12
    Abstract: With the rapid development of economy, the supplier network is becoming more and more complicated. It is important to choose the right suppliers for improving the efficiency of the supply chain, so how to choose the right ones is one of the important research directions of supply chain management. This paper studies the partner selection problem from the perspective of supplier network global optimization. Firstly, this paper discusses and forms the evaluation system to estimate the supplier from the two indicators of risk and greenness and then applies the value as the weight of the network between two nodes to build a weighted-directed supplier network; secondly, the study establishes the optimal combination model of supplier selection based on the global network perspective and solves the model by the dynamic programming-tabu search algorithm and the improved ant colony algorithm, respectively; finally, different scale simulation examples are given to testify the efficiency of the two algorithms. The results show that the ant colony algorithm is superior to the tabu search one as a whole, but the latter is slightly better than the former when network scale is small.
    Type of Medium: Online Resource
    ISSN: 1026-0226 , 1607-887X
    URL: Article
    DOI: 10.1155/2017/8470147
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2033014-5
    SSG: 11
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  • 6
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    Online Resource
    Plantar Purpura as the Initial Presentation of Viridians Streptococcal Shock Syndrome Secondary to Streptococcus gordonii Bacteremia
    Hindawi Limited ; 2016
    In:  Canadian Journal of Infectious Diseases and Medical Microbiology Vol. 2016 ( 2016), p. 1-5
    Details
    In: Canadian Journal of Infectious Diseases and Medical Microbiology, Hindawi Limited, Vol. 2016 ( 2016), p. 1-5
    Abstract: Viridians streptococcal shock syndrome is a subtype of toxic shock syndrome. Frequently, the diagnosis is missed initially because the clinical features are nonspecific. However, it is a rapidly progressive disease, manifested by hypotension, rash, palmar desquamation, and acute respiratory distress syndrome within a short period. The disease course is generally fulminant and rarely presents initially as a purpura over the plantar region. We present a case of a 54-year-old female hospital worker diagnosed with viridians streptococcal shock syndrome caused by Streptococcus gordonii . Despite aggressive antibiotic treatment, fluid hydration, and use of inotropes and extracorporeal membrane oxygenation, the patient succumbed to the disease. Early diagnosis of the potentially fatal disease followed by a prompt antibiotic regimen and appropriate use of steroids are cornerstones in the management of this disease to reduce the risk of high morbidity and mortality.
    Type of Medium: Online Resource
    ISSN: 1712-9532 , 1918-1493
    URL: Article
    DOI: 10.1155/2016/9463895
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2207109-X
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  • 7
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    Online Resource
    Rhinacanthin C Alleviates Amyloid- β Fibrils’ Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid- β , and Interferon- γ in Glial Cells
    Hindawi Limited ; 2017
    In:  Oxidative Medicine and Cellular Longevity Vol. 2017 ( 2017-10-18), p. 1-18
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2017 ( 2017-10-18), p. 1-18
    Abstract: Neuroinflammation plays a central role in the pathophysiology of Alzheimer’s disease (AD). Compounds that suppress neuroinflammation have been identified as potential therapeutic targets for AD. Rhinacanthin C (RC), a naphthoquinone ester found in Rhinacanthus nasutus Kurz (Acanthaceae), is currently proposed as an effective molecule against inflammation. However, the exact role of RC on neuroinflammation remains to be elucidated. In the present study, we investigated RC effect on modulating lipopolysaccharides (LPS), amyloid- β peptide (A β ), or interferon- γ - (IFN- γ -) evoked pathological events in neurons and glia. Our findings demonstrated that RC prevented A β -induced toxicity in rat hippocampal neurons and attenuated LPS-activated nitric oxide (NO) production, inducible nitric oxide synthase (iNOS) expression, and NF- κ B signaling in rat glia. Likewise, RC suppressed LPS-induced neuroinflammation by reducing NO production and iNOS, IL-1 β , CCL-2, and CCL-5 mRNA levels in rat microglia. Further studies using BV-2 microglia revealed that RC inhibited LPS-, A β -, and IFN- γ -stimulated IL-6 and TNF- α secretion. Of note, NF- κ B and ERK activation was abrogated by RC in BV-2 cell response to A β or IFN- γ . Moreover, RC protected neurons from A β -stimulated microglial conditioned media-dependent toxicity. Collectively, these data highlight the beneficial effects of RC on neuroprotection and support the therapeutic implications of RC to neuroinflammation-mediated conditions.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2017/5414297
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
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  • 8
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    Online Resource
    Quantifying Dynamic Flow of Emergency Department (ED) Patient Managements: A Multistate Model Approach
    Hindawi Limited ; 2020
    In:  Emergency Medicine International Vol. 2020 ( 2020-12-3), p. 1-9
    Details
    In: Emergency Medicine International, Hindawi Limited, Vol. 2020 ( 2020-12-3), p. 1-9
    Abstract: Background. Emergency department (ED) crowding and prolonged lengths of stay continue to be important medical issues. It is difficult to apply traditional methods to analyze multiple streams of the ED patient management process simultaneously. The aim of this study was to develop a statistical model to delineate the dynamic patient flow within the ED and to analyze the effects of relevant factors on different patient movement rates. Methods. This study used a retrospective cohort available with electronic medical data. Important time points and relevant covariates of all patients between January and December 2013 were collected. A new five-state Markov model was constructed by an expert panel, including three intermediate states: triage, physician management, and observation room and two final states: admission and discharge. A day was further divided into four six-hour periods to evaluate dynamics of patient movement over time. Results. A total of 149,468 patient records were analyzed with a median total length of stay being 2.12 (interquartile range = 6.51) hours. The patient movement rates between states were estimated, and the effects of the age group and triage level on these movements were also measured. Patients with lower acuity go home more quickly (relative rate (RR): 1.891, 95% CI: 1.881–1.900) but have to wait longer for physicians (RR: 0.962, 95% CI: 0.956–0.967) and admission beds (RR: 0.673, 95% CI: 0.666–0.679). While older patients were seen more quickly by physicians (RR: 1.134, 95% CI: 1.131–1.139), they spent more time waiting for the final state (for admission RR: 0.830, 95% CI: 0.821–0.839; for discharge RR: 0.773, 95% CI: 0.769–0.776). Comparing the differences in patient movement rates over a 24-hour day revealed that patients wait longer before seen by physicians during the evening and that they usually move from the ED to admission afternoon. Predictive dynamic illustrations show that six hours after the patients’ entry, the probability of still in the ED system ranges from 28% in the evening to 38% in the morning. Conclusions. The five-state model well described the dynamic ED patient flow and analyzed the effects of relevant influential factors at different states. The model can be used in similar medical settings or incorporate different important covariates to develop individually tailored approaches for the improvement of efficiency within the health professions.
    Type of Medium: Online Resource
    ISSN: 2090-2859 , 2090-2840
    URL: Article
    DOI: 10.1155/2020/2059379
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2596429-X
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  • 9
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    Online Resource
    Factors Influencing Viral Clearance in Mild COVID-19 and Clinical Characteristics of Asymptomatic Patients
    Hindawi Limited ; 2021
    In:  BioMed Research International Vol. 2021 ( 2021-2-26), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2021 ( 2021-2-26), p. 1-9
    Abstract: Background. The outbreak of coronavirus disease (COVID-19) has become a global public health emergency. Objective. To evaluate the characteristics and outcomes of patients with COVID-19 in Anhui and to identify predictors of viral clearance. Methods. We retrospectively analyzed the data collected from discharged patients with laboratory-confirmed SARS-CoV-2 infections. We compared clinical features between viral clearance and viral persistence, and evaluated factors associated with SARS-CoV-2 shedding using multiple linear regression. Results. Among the 83 patients involved in the study, the median age was 43 years, while 60.2% were male, 35.4% had comorbidities, and the mortality was zero. The median time from illness onset to admission was 5 days (interquartile range (IQR), 2-7 days), and the median time from the illness onset to SARS-CoV-2 RNA detection was 16 days (IQR, 13-18 days). The factors influencing viral clearance were as follows: (1) delayed admission (beta 1.057, 95% CI 0.810-1.304; p ≤ 0.001 ) and (2) underlying comorbidities (beta 1.907, 95% CI 0.198-3.616; p = 0.029 ). No significant differences were observed in the length of stay ( p = 0.246 ) and pneumonia between asymptomatic and symptomatic patients based on computed tomography (CT) ( p = 0.124 ). Conclusions. Delayed admission and underlying comorbidities may effectively predict SARS-CoV-2 RNA clearance. For those infected with SARS-CoV-2, even asymptomatic patients without any clinical symptoms should be traced and isolated. This practice may reduce the spread of SARS-CoV-2 and slow the COVID-19 pandemic caused by the virus. Clinical Trial Registration Number: This trial is registered with 2020-051.
    Type of Medium: Online Resource
    ISSN: 2314-6141 , 2314-6133
    URL: Article
    DOI: 10.1155/2021/5909612
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
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  • 10
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    Online Resource
    Asymptotic Stability for a Class of Nonlinear Difference Equations
    Hindawi Limited ; 2010
    In:  Discrete Dynamics in Nature and Society Vol. 2010 ( 2010), p. 1-10
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2010 ( 2010), p. 1-10
    Abstract: We study the global asymptotic stability of the equilibrium point for the fractional difference equation x n + 1 = ( a x n - l x n - k ) / ( α + b x n - s + c x n - t ) , n = 0,1 , … , where the initial conditions x - r , x - r + 1 , … , x 1 , x 0 are arbitrary positive real numbers of the interval ( 0 , α / 2 a ) , l , k , s , t are nonnegative integers, r = max ⁡ ⁡ { l , k , s , t } and α , a , b , c are positive constants. Moreover, some numerical simulations are given to illustrate our results.
    Type of Medium: Online Resource
    ISSN: 1026-0226 , 1607-887X
    URL: Article
    DOI: 10.1155/2010/791610
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2010
    detail.hit.zdb_id: 2033014-5
    SSG: 11
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